Differential activation of the immune system by virulent Streptococcus pneumoniae strains determines recovery or death of the host

Clinical and Experimental Immunology

Volumn 134, Issue 1, 2003, Pages 23-31

  Mizrachi Nebenzahl, Yaffa ^a   Lifshitz, S ^a   Teitelbaum, R ^a   Novick, S ^a   Levi, A ^a   Benharroch, D ^a   Ling, E ^a   Dagan, R ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Disease development; Immune system; Streptococcus pneumoniae; Virulence

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTEREMIA; BACTERIAL STRAIN; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEATH; HISTOPATHOLOGY; HOST PATHOGEN INTERACTION; IMMUNE SYSTEM; INOCULATION; LUNG CONGESTION; LUNG INFECTION; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA ANALYSIS; SEPSIS; SEROTYPE; SPLEEN; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE;

ADMINISTRATION, INTRANASAL; ANIMALS; CYTOKINES; DISEASE PROGRESSION; INTERLEUKIN-4; LUNG; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MODELS, ANIMAL; PNEUMOCOCCAL INFECTIONS; RNA, MESSENGER; SPECIES SPECIFICITY; SPLEEN; STREPTOCOCCUS PNEUMONIAE; VIRULENCE;

EID: 0141762581     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2003.02261.x     Document Type: Article

References (51)

1. Austrian R. Some aspects of the pneumococcal carrier state. J Antimicrob Chemother 1986; 18 (Suppl. A):35.
2. Beachey EH, Giampapa CS, Abraham SN. Bacterial adherence: adhesin-receptor-mediated attachment of pathogenic bacteria to mucosal surfaces. Am Rev Respir Dis 1988; 138:45-8.
3. Tuomanen EI. Molecular and cellular biology of pneumococcal infection. Curr Opin Microbiol 1999; 2:35-9.
4. Ofek I, Sharon N. Adhesins as lectins: specificity and role in infection. Curr Top Microbiol Immunol 1990; 151:91-113.
5. Jenkinson HF, Lamont RJ. Streptococcal adhesion and colonization. Crit Rev Oral Biol Med 1997; 8:175-200.
6. Tuomanen EI, Austrian R, Masure HR. Pathogenenesis of pneumococcal infection. N Engl J Med 1995; 332:1280-4.
7. Ring A, Weiser JN, Tuomanen EI. Pneumococcal trafficking across the blood brain barrier. Molecular analysis of a novel bidirectional pathway. J Clin Invest 1998; 102:347-60.
8. Finlay BB, Falkow S. Common themes in microbial pathogenicity revisited. Microbiol Molec Biol Rev 1997; 61:136-69.
9. Jedrzejas MJ. Pneumococcal virulence factors: structure and function. Microb Mol Biol Rev 2001; 65:187-207.
10. Rosenow C, Ryan P, Weiser JN et al. Contribution of a novel choline-binding protein to adherence, colonization and immunogenicity. Mol Microbiol 1997; 25:819-29.
11. Wizemann TM, Admau JE, Langermann S. Adhesins as targets for vaccine development. Emerg Infect Dis 1999; 5:395-403.
12. Gosink KK, Mann ER, Guglielmo C, Tuomanen EI, Masure HR. Role of novel choline binding proteins in virulence of Streptococcus pneumoniae. Infect Immun 2000; 68:5690-5.
13. Alonso De Velasco E., Verheul AF, Verhoef J., Snippe H. Streptococcus pneumoniae: virulence factors, pathogenesis, and vaccine. Microbiol Rev 1995; 59:591-603.
14. Gingles NA, Alexander JE, Kadioglu A et al. Role of genetic resistance in invasive pneumococcal infection, identificaion and study of susceptibility and resistance in inbred mouse strains. Infect Immun 2000; 69:426-34.
15. Diamond G, Legarda D, Ryan LK. The innate immune response of the respiratory epithelium. Immun Rev 2000; 173:27-38.
16. Hill AV. The immunogenetics of human infectious diseases. Annu Rev Immunol 1998; 16:593-617.
17. Mosmann TR, Sad S. The expanding universe of T cells subsets: Th1, Th2 and more. Immunol Today 1996; 17:138-46.
18. Klebanoff SJ, Vadas MA, Harlan JM et al. Stimulation of neutrophils by tumor necrosis factor. J Immunol 1986; 136:4220-5.
19. Sriskandan S, Cohen J. Gram positive sepsis mechanisms differences from gram negative sepsis 1999. Infect Dis Clin North Am 1999; 13:397-412.
20. O'Brien DP, Briles DE, Szalai AJ et al. Tumor necrosis alpha-receptor I is important for survival from Steptococcus pneumoniae infection. Infect Immun 1999; 67:595-601.
21. Schmitt E, Hoehn P, Huels C et al. T helper cells type 1 development of naive CD4- T cells requires the coordinate action of interleukin 12 and interferon gamma and is inhibited by transforming growth factor beta. Eur J Immunol 1994; 24:793-8.
22. Kehrl JH, Wakefield LM, Roberts AB et al. The production of TGF-β1 by human T lymphocytes and its potential role in regulation of T cell growth. J Exp Med 1986; 163:1037-50.
23. Kobayashi M, Fitz L, Ryan M et al. Identification and purification of natural killer cells stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes. J Exp Med 1989; 170:827-45.
24. Kobayashi K, Kai M, Gidoh M et al. The possible role of interleukin (IL)-12 and interferon-gamma-inducing factor/IL-18 in protection against experimental Mycobacterial leprae infection in mice. Clin Immunol Immunopathol 1998; 88:226-31.
25. Scott P. IL-12: initiation cytokine for cell-mediated immunity. Science 1993; 260:496-7.
26. Murray HW. Interferon-gamma, the activated macrophage, and host defense against microbial challenge. Ann Intern Med 1988; 108:595-608.
27. Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse helper T. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989; 170:2081-95.
28. Brown MA, Hural J. Function of IL-4 and control of its expression. Crit Rev Immunol 1997; 17:1-32.
29. Watson DA, Kapur V, Musher DM, Jacobson JW, Musser JM. Identification, cloning and sequencing of DNA essential for encapsulation of Streptococcus pneumoniae. Curr Microbiol 1995; 31:251-9.
30. Watson DA, Musher DM. Interruption of capsule production in Streptococcus pneumoniae serotype 3 by insertion of transposon Tn916. Infect Immun 1990; 58:3135-8.
31. Brooks-Walter A, Briles DE, Hollingshead SK. The pspC gene of Streptococcus pneumoniae encodes polymorphic protein, PspC, which elicits cross-reactive antibodies to PspA and provides immunity to pneumococcal bacteraemia. Infect Immun 1999; 67:6533-42.
32. Ulett G, Ketheesan N, Hirst R. Cytokine gene expression in innately susceptible BALB/c mice and relatively resistant C57BL/6 mice during infection with virulent Burkholderia pseudomallei. Infect Immun 2000; 68:2034-42.
33. Scott J, Hall A, Dagan R et al. Serotype-specific epidemiology of Streptococcus pneumoniae: association with age, sex, and geography in 7000 episodes of invasive disease. Clin Infect Dis 1996; 22:973-81.
34. Magee A, Yother J. Requirement for capsule in colonization by Streptococcus pneumoniae. Infect Immun 2001; 69:3755-61.
35. Hausdorff WP, Bryant J, Kloek C, Paradiso PR, Siber GR. The contribution of specific pneumococcal serogroups to different disease manifestations: implication for conjugate vaccine formulation and use. Part II. Clin Infect Dis 2000; 30:122-40.
36. Hausdorff WP, Bryant J, Paradiso FR, Siber GR. Which pneumococcal serogroup cause the most invasive disease. Implication for cojugate vaccine formulation and use, Part I. Clin Infect Dis 2000; 30:100-21.
37. Kelly T, Dillard JP, Yother J. Effects of genetic switching of capsular type on virulence of Streptococcus pneumoniae. Infect Immun 1994; 62:1813-9.
38. Kadioglu A, Taylor S, Iannelli F, Pozzi G, Mitchell TJ, Andrew PW. Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type. Infect Immun 2002; 70:2886-90.
39. McLeod R, Buschman E, Arbuckle LD, Skamene E. Immunogenetics in the analysis of resistance to intracellular pathogens. Curr Opin Immunol 1995; 7:539-52.
40. Thompson-Snipes L, Skamene E, Radzioch D. Acquired resistance but not innate resistance to Mycobacterium bovis bacillus Calmette-Guerin is compromised by interleukin-12 ablation. Infect Immun 1998; 66:5268-74.
41. Wakeham J, Wang J, Xing Z. Genetically determined disparate innate and aduptive cell-mediated immune response to pulmonary Micobacterium bovis BCG infection in C57BL/6 and BALB/c mice. Infect Immun 2000; 68:6946-53.
42. Briles DE, Schroer K, Baker P, Davie J. Susceptibility of (CBA/NXDBA/2) F1 male mice to infection with type 3 (Streptococcus pneumoniae). In: Skamene E, ed. Perspectives in immunology: genetic control of natural resistance to infection and malignancy. London: Academic Press, 1980:173.
43. Benton KA, Van Cott JL, Briles DE. Role of tumor necrosis alpha in host response to bacteraemia caused by pneumolysin-deficient Streptococcus pneumoniae. Infect Immun 1998; 66:839-42.
44. Tsao N, Chang WW, Liu CC, Lei HY. Development of hematogenous pneumococcal meningitis in adult mice: the role of TNF-α. FEMS Immunol Med Microbiol 2002; 32:133-40.
45. Kerr AR, Irvine JJ, Search JJ et al. Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection. Infect Immun 2002; 70:1547-57.
46. Paulnock DM. Macrophage activation by T cells. Curr Opin Immunol 1992; 4:344-9.
47. Derynck R, Choy L. Transforming growth factor-β and its receptors. In: Thomson A, ed. The cytokine handbook. London: Academic Press, 1998:593.
48. Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D. Cutting edge, recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol 1999; 163:1-5.
49. Trinchieri G. Interleukin 12: a proinflamatory cytokine with immunoregulatory functions that bridge innate resistance and antigen specific adaptive immunity. Ann Rev Immunol 1995; 13:251-76.
50. Rijneveld AW, Lauw FN, Schultz MJ et al. The role of interferon-γ in murine pneumococcal pneumonia. J Infect Dis 2002; 185:91-7.
51. Kahn AQ, Shen Y, Wu ZQ, Wynn TA, Snapper CM. Endogenous pro- and anti-inflammatory cytokine differentially regulate an in vivo humoral response to Streptococcus pneumoniae. Infect Immun 2002; 70:749-61.