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1
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0030779037
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Bacterial meningitis in the United States
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Schuchat A, Robinson K, Wenger JD, Harrison LH, Farley M, Reingold AL, Lefkowitz L, Perkins BA Bacterial meningitis in the United States. N Engl J Med. 337:1997;970-976.
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(1997)
N Engl J Med
, vol.337
, pp. 970-976
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Schuchat, A.1
Robinson, K.2
Wenger, J.D.3
Harrison, L.H.4
Farley, M.5
Reingold, A.L.6
Lefkowitz, L.7
Perkins, B.A.8
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2
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0031431208
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Surveillance of antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States in 1996-1997 respiratory season
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Thornsberry C, Ogilvie P, Kahn J, Mauriz Y Surveillance of antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States in 1996-1997 respiratory season. Diag Microbial Infect Dis. 29:1997;249-257.
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(1997)
Diag Microbial Infect Dis
, vol.29
, pp. 249-257
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Thornsberry, C.1
Ogilvie, P.2
Kahn, J.3
Mauriz, Y.4
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3
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0031887641
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Capsular transformation of a multidrug-resistant Streptococcus pneumoniae in vivo
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The ability of pneumococci to naturally take up DNA has suggested that it will readily escape selection pressure from vaccines directed at only a few serotypes. This articles confirms this by documenting that highly virulent strains can enter a population, in this case a day care center, as one serotype and emerge as another without loss of virulence.
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Nesin M, Ramirez M, Tomasz A Capsular transformation of a multidrug-resistant Streptococcus pneumoniae in vivo. J Infect Dis. 177:1998;707-713. The ability of pneumococci to naturally take up DNA has suggested that it will readily escape selection pressure from vaccines directed at only a few serotypes. This articles confirms this by documenting that highly virulent strains can enter a population, in this case a day care center, as one serotype and emerge as another without loss of virulence.
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(1998)
J Infect Dis
, vol.177
, pp. 707-713
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Nesin, M.1
Ramirez, M.2
Tomasz, A.3
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4
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0031404355
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Horizontal gene transfer and the evolution of resistance and virulence determinants in Streptococcus
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A comprehensive review of the mechanisms of evolution of the mosaic resistance gene cassettes that circulate amongst antibiotic resistant pneumococci.
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Dowson C, Barcus B, King S, Pickerill P, Whatmore A, Yeo M Horizontal gene transfer and the evolution of resistance and virulence determinants in Streptococcus. J Applied Microbiol. 83:1997;42S-51S. A comprehensive review of the mechanisms of evolution of the mosaic resistance gene cassettes that circulate amongst antibiotic resistant pneumococci.
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(1997)
J Applied Microbiol
, vol.83
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Dowson, C.1
Barcus, B.2
King, S.3
Pickerill, P.4
Whatmore, A.5
Yeo, M.6
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5
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0031899844
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Capsule genetics in Streptococcus pneumoniae and a possible role for transposition in the generation of the type 3 locus
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A detailed analysis of a capsular carbohydrate synthetic locus and its potential for gene shuffling.
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Caimano MJ, Hardy GG, Yother J Capsule genetics in Streptococcus pneumoniae and a possible role for transposition in the generation of the type 3 locus. Microb Drug Res. 4:1998;11-23. A detailed analysis of a capsular carbohydrate synthetic locus and its potential for gene shuffling.
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(1998)
Microb Drug Res
, vol.4
, pp. 11-23
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Caimano, M.J.1
Hardy, G.G.2
Yother, J.3
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6
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0032566032
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An outbreak of multidrug-resistant pneumococcal pneumonia and bacteremia among unvaccinated nursing home residents
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An important study showing that highly drug-resistant pneumococcal strains can cause epidemics. This confirms that drug resistance does not compromise virulence.
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Nuorti JP, Burler JC, Crutcher JM, Guevara R, Welch D, Hoder P, Elliott JA An outbreak of multidrug-resistant pneumococcal pneumonia and bacteremia among unvaccinated nursing home residents. N Engl J Med. 238:1998;1861-1868. An important study showing that highly drug-resistant pneumococcal strains can cause epidemics. This confirms that drug resistance does not compromise virulence.
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(1998)
N Engl J Med
, vol.238
, pp. 1861-1868
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Nuorti, J.P.1
Burler, J.C.2
Crutcher, J.M.3
Guevara, R.4
Welch, D.5
Hoder, P.6
Elliott, J.A.7
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7
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17344374327
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Drug-resistant Streptococcus pneumoniae
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Campbell GD Jr., Silberman R Drug-resistant Streptococcus pneumoniae. Clin Infect Dis. 26:1998;1188-1195.
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(1998)
Clin Infect Dis
, vol.26
, pp. 1188-1195
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Campbell G.D., Jr.1
Silberman, R.2
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8
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0031906480
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Association of intrastrain phase variation in quantity of capsular polysaccharide and teichoic acid with the virulence of Streptococcus pneumoniae
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A beginning for a molecular understanding of the ability of pneumococci to switch from virulent to avirulent phenotypes
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Kim JO, Weiser JN Association of intrastrain phase variation in quantity of capsular polysaccharide and teichoic acid with the virulence of Streptococcus pneumoniae. J Infect Dis. 177:1998;368-377. A beginning for a molecular understanding of the ability of pneumococci to switch from virulent to avirulent phenotypes.
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(1998)
J Infect Dis
, vol.177
, pp. 368-377
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Kim, J.O.1
Weiser, J.N.2
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9
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0031415231
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Autolysis and cell wall degradation in a choline-independent strain of Streptococcus pneumoniae
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Severin A, Horne D, Tomasz A Autolysis and cell wall degradation in a choline-independent strain of Streptococcus pneumoniae. Microb Drug Res. 3:1997;391-400.
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(1997)
Microb Drug Res
, vol.3
, pp. 391-400
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Severin, A.1
Horne, D.2
Tomasz, A.3
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10
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0031925094
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Generation and properties of a Streptococcus pneumoniae mutant which does not require choline or analogs for growth
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Yother J, Leopold K, White J, Fischer W Generation and properties of a Streptococcus pneumoniae mutant which does not require choline or analogs for growth. J Bacteriol. 180:1998;2093-2101.
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(1998)
J Bacteriol
, vol.180
, pp. 2093-2101
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Yother, J.1
Leopold, K.2
White, J.3
Fischer, W.4
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12
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0032536372
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Phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae contributes to persistence in the respiratory tract and sensitivity to serum killing mediated by C-reactive protein
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Choline is recognized by C-reactive protein that in turn leads to opsonization and bacterial clearance. The shared ability of H. influenzae and pneumococcus to vary the amount of surface choline suggests a common mechanism to evade pulmonary and intravascular defenses for two respiratory pathogens.
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Weiser JN, Pan N, McGowan KL, Musher D, Martin A, Richards J Phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae contributes to persistence in the respiratory tract and sensitivity to serum killing mediated by C-reactive protein. J Exp Med. 187:1998;631-640. Choline is recognized by C-reactive protein that in turn leads to opsonization and bacterial clearance. The shared ability of H. influenzae and pneumococcus to vary the amount of surface choline suggests a common mechanism to evade pulmonary and intravascular defenses for two respiratory pathogens.
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(1998)
J Exp Med
, vol.187
, pp. 631-640
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Weiser, J.N.1
Pan, N.2
McGowan, K.L.3
Musher, D.4
Martin, A.5
Richards, J.6
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13
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0031613807
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Avirulence genes in animal pathogens
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Galan JE Avirulence genes in animal pathogens. Trends Microbiol. 6:1998;3-6.
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(1998)
Trends Microbiol
, vol.6
, pp. 3-6
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Galan, J.E.1
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14
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0031923636
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DNA sequence sampling of the Streptococcus pneumoniae genome to identify novel targets for antibiotic development
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•] illustrate how the availability of the genome sequence accelerates discovery of novel targets.
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•] illustrate how the availability of the genome sequence accelerates discovery of novel targets.
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(1998)
Microb Drug Res
, vol.4
, pp. 1-9
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Baltz, R.H.1
Norris, F.H.2
Matsushima, P.3
Dehoff, B.S.4
Rockery, P.5
Proter, G.6
Burgett, S.7
Peery, R.8
Hoskins, J.9
Braverman, L.10
Jenkins, I.11
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16
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0030868591
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Competence and virulence of Streptococcus pneumoniae: Adc and PsaA mutants exhibit a requirement for An and Mn resulting from inactivation of putative ABC metal permeases
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Dintilhac A, Alloing G, Granadel C, Claverys JP Competence and virulence of Streptococcus pneumoniae: Adc and PsaA mutants exhibit a requirement for An and Mn resulting from inactivation of putative ABC metal permeases. Mol Microbiol. 25:1997;727-739.
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(1997)
Mol Microbiol
, vol.25
, pp. 727-739
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Dintilhac, A.1
Alloing, G.2
Granadel, C.3
Claverys, J.P.4
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17
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0031689661
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Penicillin tolerance genes of Streptococcus pneumoniae: The ABC-type manganese permease complex PsaA
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in press
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Novak R, Braun J, Charpentier E, Tuomanen E: Penicillin tolerance genes of Streptococcus pneumoniae: the ABC-type manganese permease complex PsaA Mol Microbiol 1998, in press.
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(1998)
Mol Microbiol
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Novak, R.1
Braun, J.2
Charpentier, E.3
Tuomanen, E.4
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18
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0031406266
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Molecular and cellular biology of pneumococcal infection
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A summary of the molecular events involved in the progression of pneumoccocal colonization and disease.
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Tuomanen EI, Masure RH Molecular and cellular biology of pneumococcal infection. Microb Drug Res. 3:1997;297-308. A summary of the molecular events involved in the progression of pneumoccocal colonization and disease.
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(1997)
Microb Drug Res
, vol.3
, pp. 297-308
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Tuomanen, E.I.1
Masure, R.H.2
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20
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0030983804
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Contribution of a novel choline binding protein to adherence, colonization, and immunogenicity of Streptococcus pneumoniae
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This paper describes the first pneumococcal adhesive protein and potential new vaccine candidate, CbpA.
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Rosenow C, Ryan P, Weiser JN, Johnson S, Fontan P, Ortqvist A, Masure HR Contribution of a novel choline binding protein to adherence, colonization, and immunogenicity of Streptococcus pneumoniae. Mol Microbiol. 25:1997;819-829. This paper describes the first pneumococcal adhesive protein and potential new vaccine candidate, CbpA.
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(1997)
Mol Microbiol
, vol.25
, pp. 819-829
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Rosenow, C.1
Ryan, P.2
Weiser, J.N.3
Johnson, S.4
Fontan, P.5
Ortqvist, A.6
Masure, H.R.7
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23
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0030939064
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Molecular analysis of putative pneumococcal virulence proteins
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Paton JC, Berry AM, Lock RA Molecular analysis of putative pneumococcal virulence proteins. Microb Drug Res. 3:1997;1-10.
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(1997)
Microb Drug Res
, vol.3
, pp. 1-10
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Paton, J.C.1
Berry, A.M.2
Lock, R.A.3
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24
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0032020385
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Novel pneumococcal surface proteins: Role in virulence and vaccine potential
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A summary of pneumococcal proteins currently under study that might be suitable vaccine candidates to add to capsule based vaccines or to stand alone.
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Paton JC Novel pneumococcal surface proteins: role in virulence and vaccine potential. Trends Microbiol. 6:1998;85-87. A summary of pneumococcal proteins currently under study that might be suitable vaccine candidates to add to capsule based vaccines or to stand alone.
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(1998)
Trends Microbiol
, vol.6
, pp. 85-87
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Paton, J.C.1
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25
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0031885031
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Amino acid changes affecting the activity of pneumolysin alter the behaviour of pneumococci in pneumonia
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Alexander JE, Berry AM, Paton JC, Rubins JB, Andrew PW, Mitchell TJ Amino acid changes affecting the activity of pneumolysin alter the behaviour of pneumococci in pneumonia. Microb Pathog. 24:1998;167-174.
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(1998)
Microb Pathog
, vol.24
, pp. 167-174
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Alexander, J.E.1
Berry, A.M.2
Paton, J.C.3
Rubins, J.B.4
Andrew, P.W.5
Mitchell, T.J.6
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26
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0030814940
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A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs
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The cytolysin of pneumococcus kills many cell types and this contributes to disease in the ear and lung, in particular.
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Winter AJ, Comis SD, Osborne MP, Tarlow MJ, Stephen J, Andrew PW, Hill J, Mitchell TJ A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs. Infect Immun. 65:1997;4411-4418. The cytolysin of pneumococcus kills many cell types and this contributes to disease in the ear and lung, in particular.
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(1997)
Infect Immun
, vol.65
, pp. 4411-4418
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Winter, A.J.1
Comis, S.D.2
Osborne, M.P.3
Tarlow, M.J.4
Stephen, J.5
Andrew, P.W.6
Hill, J.7
Mitchell, T.J.8
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27
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0031606484
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Ototoxicity resulting from intracochlear perfusion of Streptococcus pneumoniae in the guinea pig
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Winter A, Comis S, Osbornes M, Hayward T, Stephen J, Tarlow M Ototoxicity resulting from intracochlear perfusion of Streptococcus pneumoniae in the guinea pig. J Infection. 36:1998;73-77.
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(1998)
J Infection
, vol.36
, pp. 73-77
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Winter, A.1
Comis, S.2
Osbornes, M.3
Hayward, T.4
Stephen, J.5
Tarlow, M.6
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28
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0030848504
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The hemolytic and complement-activating properties of pneumolysin do not contribute individually to virulence in a pneumococcal bacteremia model
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Benton KA, Paton JC, Briles DE The hemolytic and complement-activating properties of pneumolysin do not contribute individually to virulence in a pneumococcal bacteremia model. Microb Pathog. 23:1997;201-209.
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(1997)
Microb Pathog
, vol.23
, pp. 201-209
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Benton, K.A.1
Paton, J.C.2
Briles, D.E.3
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29
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0031912785
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Cytokine kinetics and other host factors in response to pneumococcal pulmonary infection in mice
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A road map of the sequential activation of the cytokine cascade during progression of pneumococcal pneumonia in animals.
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Bergeron Y, Ouellet N, Deslauriers AM, Simard M, Olivier M, Bergeron MG Cytokine kinetics and other host factors in response to pneumococcal pulmonary infection in mice. Infect Immun. 66:1998;912-922. A road map of the sequential activation of the cytokine cascade during progression of pneumococcal pneumonia in animals.
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(1998)
Infect Immun
, vol.66
, pp. 912-922
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Bergeron, Y.1
Ouellet, N.2
Deslauriers, A.M.3
Simard, M.4
Olivier, M.5
Bergeron, M.G.6
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30
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0031045654
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Passive immunization against TNF impairs host defense during pneumococcal pneumonia in mice
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van der, Poll T, Keogh CV, Buurman WA, Lowry SF Passive immunization against TNF impairs host defense during pneumococcal pneumonia in mice. Am J Resp Crit Care Med. 155:1997;603-608.
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(1997)
Am J Resp Crit Care Med
, vol.155
, pp. 603-608
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Van, D.1
Poll, T.2
Keogh, C.V.3
Buurman, W.A.4
Lowry, S.F.5
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31
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0031022234
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Role of TNF in pathogenesis of pneumococcal pneumonia in mice
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Takashima K, Tateda K, Matsumoto T, Iizawa Y, Nakao M, Yamaguchi K Role of TNF in pathogenesis of pneumococcal pneumonia in mice. Infect Immun. 65:1997;257-260.
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(1997)
Infect Immun
, vol.65
, pp. 257-260
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Takashima, K.1
Tateda, K.2
Matsumoto, T.3
Iizawa, Y.4
Nakao, M.5
Yamaguchi, K.6
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32
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0030856428
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Interleukin-6 gene deficient mice show impaired defense against pneumococcal pneumonia
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van der, Poll T, Keogh CV, Guiro X, Buurman WA, Kopf M, Lowry SF Interleukin-6 gene deficient mice show impaired defense against pneumococcal pneumonia. J Infect Dis. 176:1997;439-444.
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(1997)
J Infect Dis
, vol.176
, pp. 439-444
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Van, D.1
Poll, T.2
Keogh, C.V.3
Guiro, X.4
Buurman, W.A.5
Kopf, M.6
Lowry, S.F.7
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33
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0030794066
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Coexistance of CD14-dependent and independent pathways for stimulation of human monocytes by gram positive bacteria
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Cauwels A, Wan E, Leismann M, Tuomanen E Coexistance of CD14-dependent and independent pathways for stimulation of human monocytes by gram positive bacteria. Infect Immun. 65:1997;3255-3260.
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(1997)
Infect Immun
, vol.65
, pp. 3255-3260
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Cauwels, A.1
Wan, E.2
Leismann, M.3
Tuomanen, E.4
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34
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0031048865
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Treatment of bacterial meningitis
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A summary of considerations for antibiotics in the era of resistance and for anti-inflammatory therapy especially in the case of children.
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Quagliarello VJ, Scheld WM Treatment of bacterial meningitis. N Engl J Med. 336:1997;708-716. A summary of considerations for antibiotics in the era of resistance and for anti-inflammatory therapy especially in the case of children.
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(1997)
N Engl J Med
, vol.336
, pp. 708-716
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Quagliarello, V.J.1
Scheld, W.M.2
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35
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0031438065
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Central nervous system TNF alpha-mRNA expression during rabbit experimental pneumococcal meningitis
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Bitsch A, Trostdorf F, Bruck W, Schmidt H, Fischer R, Nau Central nervous system TNF alpha-mRNA expression during rabbit experimental pneumococcal meningitis. Neurosci Lett. 237:1997;105-108.
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(1997)
Neurosci Lett
, vol.237
, pp. 105-108
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Bitsch, A.1
Trostdorf, F.2
Bruck, W.3
Schmidt, H.4
Fischer, R.5
Nau6
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36
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0005958898
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Pneumococcal trafficking across the blood brain barrier
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The movement of pneumococci across cells was studied in vitro using cerebral capillary endothelial cells leading to the concept that these bacteria may corrupt the recycling pathway for the receptor for platelet activating factor to gain entry into cells.
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Ring A, Weiser JN, Tuomanen EI Pneumococcal trafficking across the blood brain barrier. J Clin Invest. 102:1998;1-14. The movement of pneumococci across cells was studied in vitro using cerebral capillary endothelial cells leading to the concept that these bacteria may corrupt the recycling pathway for the receptor for platelet activating factor to gain entry into cells.
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(1998)
J Clin Invest
, vol.102
, pp. 1-14
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Ring, A.1
Weiser, J.N.2
Tuomanen, E.I.3
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