Apolipoprotein E4 decreases whereas apolipoprotein E3 increases the level of secreted amyloid precursor protein after closed head injury

Neuroscience

Volumn 121, Issue 2, 2003, Pages 315-325

  Ezra, Y ^a   Oron, L ^a   Moskovich, L ^a   Roses, A D ^b   Beni, S M ^c   Shohami, E ^c   Michaelson, D M ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Amyloid precursor protein; Apolipoprotein E; Apolipoprotein E transgenic mice; Head trauma

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; ISOPROTEIN; PROTEIN SUBUNIT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENOTYPE; HEAD INJURY; HIPPOCAMPUS; HUMAN; IMMUNOBLOTTING; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN SECRETION; STATISTICAL SIGNIFICANCE;

EID: 0141756277     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(03)00436-6     Document Type: Article

References (61)

1. Arai H., Schmidt M.L., Lee V.M., Hurtig H.I., Greenberg B.D., Adler C.H., Trojanowski J.Q. Epitope analysis of senile plaque components in the hippocampus of patients with Parkinson's disease. Neurology. 42:1992;1315-1322.
2. Barger S.W., Mattson M.P. Isoform specific modulation by apolipoprotein E of the activities of secreted β amyloid precursor protein. J Neurochem. 69:1997;60-68.
3. Buttini M., Orth M., Bellosta S., Akeefe H., Pitas R.E., Wyss-Coray T., Mucke L., Mahley R.W. Expression of human apolipoprotein E3 or E4 in the brains of apoE-/- mice isoform-specific effects on neurodegeneration . J Neurosci. 19:1999;4867-4880.
4. Bramlett H.M., Kraydich S., Green E.J., Dietrich W.D. Temporal and regional patterns of axonal damage following traumatic brain injury a beta-amyloid precursor protein immunocytochemical study in rats . J Neuropathol Exp Neurol. 56:1997;132-141.
5. Chapman J., Estupinan J., Asherov A., Goldfarb L.G. A simple and efficient method for apolipoprotein E genotype determination. Neurology. 46:1996;1484-1485.
6. Chen Y., Lomnitski L., Michaelson D.M., Shohami E. Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury. Neuroscience. 80:1997;1255-1262.
7. Crawford F.C., Vanderploeg R.D., Freeman M.J., Singh S., Waisman M., Michaelis L., Abdullah L., Warden D., Lipsky R., Salazar A., Mullen M.J. ApoE genotype influences acquisition and recall following traumatic brain injury. Neurology. 58:2002;1115-1118.
8. Desdouits-Magnen J., Desdouits F., Takeda S., Syu L.-J., Saltiel A.R., Buxbaum J.D., Czernik A.J., Neiren A.C., Greengard P. Regulation of secretion of Alzheimer amyloid precursor protein by the mitogen-activated protein kinase cascade. J Neurochem. 70:1998;524-530.
9. Erlich S., Shohami E., Pinkas-Kramarski R. Closed head injury induces up-regulation of ErbB-4 receptor at the site of injury. Mol Cell Neurosci. 16:2000;597-608.
10. Friedman G., Froom P., Sazbon L., Grinblatt I., Shochina M., Tsenter J., Babaya S., Yehuda B., Groswasser Z. Apolipoprotein E-epsilon 4 genotype predicts a poor outcome in survivors of traumatic brain injury. Neurology. 52:1999;244-248.
11. Genis I., Fisher A., Michaelson D.M. Site-specific dephosphorylation of tau of apolipoprotein E-deficient and control mice by M1 muscarinic agonist treatment. J Neurochem. 72:1999;206-213.
12. Graham D.I., Gentleman S.M., Nicoll J.A., Royston M.C., McKenzie J.E., Roberts G.W., Griffin W.S. Altered beta-APP metabolism after head injury and its relationship to the aetiology of Alzheimer's disease. Acta Neurochir Suppl (Wien). 66:1996;96-102.
13. Graham D.I., Gentleman S.M., Nicoll J.A., Royston M.C., McKenzie J.E., Roberts G.W., Mrak R.E., Griffin W.S. Is there a genetic basis for the deposition of beta-amyloid after fatal head injury? Cell Mol Neurobiol. 19:1999;19-30.
14. Grziwa B., Grimm M.D.W., Masters C.L., Beyreuther K., Hartmann T., Lichtenthaler S.F. The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted. J Biol Chem. 278:2003;6803-6808.
15. Guo Z., Cupples L.A., Kurz A., Auerbach S.H., Volicer L., Chui H., Green R.C., Sadovnik A.D., Duara R., DeCarli C., Johnson K., Go R.C., Growdon J.H., Haines J.L., Kukull W.A., Farrer L.A. Head injury and the risk of AD in the MIRAGE study. Neurology. 54:2000;1316-1323.
16. Greenfield J., Gross R.S., Gouras G.K., Xu H. Cellular and molecular basis of β-amyloid precursor protein metabolism. Frontiers Biosci. 5:2000;72-83.
17. Hartman R.E., Laurer H., Longhi L., Bales K.R., Paul S.M., McIntosh T.K., Holtzman D.M. Apolipoprotein E influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease. J Neurosci. 22:2002;10083-10087.
18. Hass S., Fresser F., Kochl S., Beyreuther K., Utermann G., Baier G. Physical interaction of apoE with amyloid precursor protein independent of the amyloid beta region in vitro. J Biol Chem. 273:1998;13892-13897.
19. Herz J. Lipoprotein receptors beacons to neurons . Trends Neurosci. 24:2001;193-195.
20. Hilbich C., Manning U., Grund C., Masters C.L., Beyreuther K. Amyloid like properties of peptides flanking the epitope of amyloid precursor protein-specific monoclonal antibody 22C11. J Biol Chem. 15:1993;26571-26577.
21. Howell B.W., Herz J. The LDL receptor gene family signaling functions during development . Curr Opin Neurobiol. 11:2001;74-81.
22. Jin L.W., Ninomaya H., Roch J.M., Schubert D., Masliah E., Otero D.A., Saitoh T. Peptides containing the RERMS sequence of amyloid β/A4 protein precursor bind cell surfaces and promote neurite extension. J Neurosci. 14:1994;5461-5470.
23. Jordan B.D., Relkin N.R., Ravdin L., Jacobs A.R., Bennett A., Gandy S. Apolipoprotein E4 associates with chronic traumatic brain injury in boxing. JAMA. 278:1997;136-140.
24. Knouff C., Hinsdale M.E., Mezdour H., Altenburg M.K., Watanabe M., Quarfordt S.H., Sullivan P.M., Maida N. ApoE Structure determines VLDL clearance and atherosclerosis risk in mice. J Clin Invest. 103:1999;1579-1584.
25. Kutner K.C., Erlanger D.M., Tsai J., Jordan B., Nelkin N.R. Lower cognitive performance of older football players possessing apolipoprotein E4. Neurosurgery. 44:2000;651-657.
26. Levy O, Jongen-Pelo AL, Feldon J, Roses AD, Michaelson DM (2003) ApoE4 impairs hippocampal plasticity isoform specifically and blocks the environmental stimulation of memory. Neurobiol Dis, in press.
27. Lewen A., Li G.L., Olsson Y., Hillered L. Changes in microtubule-associated protein 2 and amyloid precursor protein immunoreactivity following traumatic brain injury in rat influence of MK-801 treatment . Brain Res. 719:1996;161-171.
28. Liberman J.N., Stewart W.F., Wosnes K., Trouscosi J. Apolipoprotein E4 and short term recovery from predominantly mild brain injury. Neurology. 58:2002;1038-1044.
29. Lichtman S.W., Seliger G., Tycko B., Marder K. Apolipoprotein E and functional recovery from brain injury following postacute rehabilitation. Neurology. 55:2000;1536-1539.
30. MacFarlane D.P., Nicoll J.A., Smith C., Graham D.I. ApoE epsilon 4 allele and amyloid beta-protein deposition in long term survivors of head injury. Neuroreport. 10:1999;3945-3948.
31. Mattson M.P. Cellular actions of β-amyloid precursor protein and its soluble fibrillogenic derivatives. Physiol Rev. 77:1997;1081-1132.
32. Mayeux R., Ottman R., Mastre G., Ngai C., Tang M.X., Ginsberg H., Chun M., Tycko B., Shelanski M. Synergistic effects of traumatic head injury and apolipoprotein-ε4 in patients with Alzheimer's disease. Neurology. 45:1995;555-557.
33. Mills J., Reiner P.B. Regulation of amyloid precursor protein cleavage. J Neurochem. 72:1999;443-460.
34. Mucke L., Abraham C.R., Masliah E. Neurotrophic and neuroprotective effects of hAPP in transgenic mice. Am NY Acad Sci. 777:1996;82-88.
35. 2+ channel. Brain Pathol. 8:1998;641-653.
36. Nicoll J.A., Roberts G.W., Graham D.I. Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta protein following head injury. Nat Med. 1:1995;135-137.
37. O'Meara E.S., Kukull W.A., Sheppard L., Bowen J.D., McCormick W.C., Teri L., Pfanschmidt M., Thompson J.D., Schellenburg G.D., Larson E.B. Head injury and risk of Alzheimer's disease by apolipoprotein E genotype. Am J Epidemiol. 146:1997;373-384.
38. Ophir G., Meilin S., Efrati M., Chapman J., Karussis D., Roses A., Michaelson D.M. Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice. Neurobiol Dis. 12:2003;56-64.
39. Oron L., Efrati M., Michaelson D.M. Secretion of the amyloid precursor protein is elevated isoform-specifically by apolipoprotein E4. J Neural Transm. 59:2000;163-169.
40. Permanne B., Perez C., Soto C., Frangione B., Wisniewski T. Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants. Biochem Biophys Res Commun. 240:1997;715-720.
41. Pierce J.E., Trojanowski J.Q., Graham D.I., Smith D.H., McIntosh T.K. Immunohistochemical characterization of alterations in the distribution of amyloid precursor proteins and beta-amyloid peptide after experimental brain injury in the rat. J Neurosci. 16:1996;1083-1090.
42. Plassman B.L., Havlik R.J., Steffens D.C., Helms M.J., Newman T.N., Drosdick D., Phillips C., Gau B.A., Welsh-Bohmer K.A., Burke J.R., Guralnik J.M., Breitner J.C. Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias. Neurology. 55:2000;1158-1166.
43. Price D.L., Tanzi R.E., Borchelt D.R., Sisodia S.S. Alzheimer's disease genetic studies and transgenic models . Annu Rev Genet. 32:1998;32461-32493.
44. Raber J., Wong D., Buttini M., Orth M., Bellosta S., Pitas R.E., Mahley R.W., Mucke L. Isoform-specific effects of human apolipoprotein E on brain function revealed in apoE knockout mice increased susceptibility of females . Proc Natl Acad Sci USA. 95:1998;10914-10919.
45. Rebeck G.W., Hyman B.T. Apolipoprotein E and Alzheimer disease. Terry R.D., Katzman R., Bick K.L., Sisodia S.S. Alzheimer disease. 1999;339-346 Lippincott Williams, Philadelphia.
46. Roses A.D. Apolipoprotein E alleles as risk factors in Alzheimer disease. Annu Rev Med. 47:1996;47387-47400.
47. Sabo T., Lomnitski L., Nyska A., Beni S., Maronpot R.R., Shohami E., Roses A.D., Michaelson D.M. Susceptibility of transgenic mice expressing human apolipoprotein E to closed head injury the allele E3 is neuroprotective whereas E4 increases fatalities . Neuroscience. 101:2000;879-884.
48. Schmechel D.E., Saunders A.M., Strittmatter W.J., Crain B.J., Hulette C.M., Joo S.H., Pericak-Vance M.A., Goldgaber D., Roses A.D. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci USA. 90:1993;9649-9653.
49. Selkoe D.J. Alzheimer's disease genes, proteins and therapy . Physiol Rev. 81:2001;741-766.
50. Shohami E., Kaufer D., Chen Y., Seidman S., Cohen O., Ginsberg D., Melamed-Boppk N., Yirmiya R., Soreq H. Antisense prevention of neuronal damages following head injury in mice. J Mol Med. 78:2000;228-236.
51. Skovronsky D.M., Moore D.B., Milla M.E., Doms R.W., Lei V.M.Y. Protein kinase C-dependent α secretase competes with β secretase for cleavage of amyloid-β precursor protein in the Trans-Golgi network. J Biol Chem. 275:2000;2568-2575.
52. Smith D.H., Nakamuya M., McIntosh T.K., et al. Brain trauma induces massive hippocampal neuron death linked to a surge in beta-amyloid levels in mice overexpressing mutant amyloid precursor protein. Am J Pathol. 153:1998;1005-1010.
53. Sullivan P.M., Mizdour H., Quarfordt S.H., Maida N. Type III hyperlipoprotein and spontaneous atherosclerosis in mice resulting from gene replacement of mouse apoE with human apoE2. J Clin Invest. 102:1998;130-135.
54. Sun Y., Wu S., Bu G., Onifade M.K., Patel S.H., Lady M.J., Fagan A.M., Holtzman D.M. Glial fibrillary acidic protein-apolipoprotein E (apoE) -transgenic mice astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins . J Neurosci. 18:1998;3261-3272.
55. Tang M.X., Maestre G., Tsai W.Y., Liu X.H., Feng L., Chung W.Y., Chun M., Schofield P., Stern Y., Tycko B., Mayeux R. Effects of age, ethnicity and head injury on the association between APOE genotype and Alzheimer's disease. Ann NY Acad Sci. 802:1996;6-15.
56. Teasdale G.M., Nicoll J.A., Murray G., Fiddes M. Association of apolipoprotein E polymorphism with outcome after head injury. Lancet. 350:1997;1069-1071.
57. Van den Heuvel C., Blumbergs P.C., Finnie J., Manavis J., Jones N.R., Reilly P.L., Rosemarie A.P. Upregulation of amyloid precursor protein messenger RNA in response to traumatic brain injury an ovine head impact model . Exp Neurol. 159:1999;441-450.
58. Veinbergs I., Everson A., Sagara Y., Masliah E. Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis. J Neurosci Res. 67:2002;379-387.
59. Vincent B., Smith J.D. Astrocytes downregulate neuronal β amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner. J Neurosci. 14:2001;256-266.
60. Xu P.-T., Schmechel D., Rothrock-Christian T., Burkhart D.S., Qiu H.-L., Popko B., Sullivan P., Maeda N., Saunders A.M., Roses A.D., Gilbert J.R. Human apolipoprotein E2, E3 and E4 isoform-specific transgenic mice human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice . Neurobiol Dis. 3:1996;229-245.
61. Yamamoto K., Myoshi T., Yal T., Kawashima K., Araki H., Hamada K., Otero D.A., Roch J.M., Saitoh T. The survival of rat cerebral cortical neurons in the presence of trophic APP peptides. J Neurobiol. 25:1994;585-594.