Functional coupling between heterologously expressed dopamine D 2 receptors and KCNQ channels

Pflugers Archiv European Journal of Physiology

Volumn 446, Issue 6, 2003, Pages 684-694

  Ljungstrom, Trine ^a,b   Grunnet, Morten ^a   Jensen, Bo Skaaning ^b   Olesen, Søren Peter ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NEUROSEARCH A S   (Denmark)

Author keywords

Bordetella pertussis toxin; Dopamine D2 receptors; Electrophysiology; KCNQ channels; M current; Quinpirole; SH SY5Y cells; Xenopus laevis oocytes

Indexed keywords

DOPAMINE 2 RECEPTOR; POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; BORDETELLA PERTUSSIS; BRAIN REGION; CELL ACTIVATION; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC SYSTEM; ELECTROPHYSIOLOGY; FEMALE; GENETIC TRANSFECTION; HUMAN; MAMMAL; NERVE CELL EXCITABILITY; NEUROBLASTOMA CELL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; XENOPUS LAEVIS;

ANIMALS; BIOTRANSFORMATION; BRAIN NEOPLASMS; CELL LINE, TUMOR; DNA, COMPLEMENTARY; DOPAMINE AGONISTS; ELECTROPHYSIOLOGY; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; MEMBRANE POTENTIALS; NEUROBLASTOMA; NEURONS; OOCYTES; PATCH-CLAMP TECHNIQUES; PERTUSSIS TOXIN; POTASSIUM CHANNELS; RECEPTORS, DOPAMINE D2; TRANSFECTION; XENOPUS LAEVIS;

EID: 0141706355     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-003-1111-2     Document Type: Article

References (71)

1. Albin RL, Young AB, Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci 12:366-375
2. Ks cardiac potassium current. Nature 384:78-80
3. Berretta S, Sachs Z, Graybiel AM (1999) Cortically driven Fos induction in the striatum is amplified by local dopmnine D2-class receptor blockade. Eur J Neurosci 11:4309-4319
4. Biervert C, Schroeder BC, Kubisch C, Berkovic SF, Propping P, Jentsch TJ, Steinlein OK (1998) A potassium channel mutation in neonatal human epilepsy. Science 279:403-406
5. Brown BS, Yu SP (2000) Modulation and genetic identification of the M channel. Prog Biophys Mol Biol 73:135-166
6. + current in a vertebrate neurone. Nature 283:673-676
7. Brown DA, Marrion NV, Smart TG (1989) On the transduction mechanism for muscarine-induced inhibition of M-current in cultured rat sympathetic neurones. J Physiol (Lond) 413:469-488
8. Bunzow JR, Tol HH van, Grandy DK, Albert P, Salon J, Christie M, Machida CA, Neve KA, Civelli O (1988) Cloning and expression of a rat D2 dopamine receptor cDNA. Nature 336:783-787
9. Calabresi P, Saiardi A, Pisani A, Baik JH, Centonze D, Mercuri NB, Bernardi G, Borrelli E (1997) Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors. J Neurosci 17:4536-4544
10. Kir currents in the rat substantia nigra pars compacta. Eur J Neurosci 11:398-406
11. Chio CL, Hess GF, Graham RS, Huff RM (1990) A second molecular form of D2 dopamine receptor in rat and bovine caudate nucleus. Nature 343:266-269
12. Cooper EC, Aldape KD, Abosch A, Barbaro NM, Berger MS, Peacock WS, Jan YN, Jan LY (2000) Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy. Proc Natl Acad Sci USA 97:4914-4919
13. Cooper EC, Harrington E, Jan YN, Jan LY (2001) M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J Neurosci 21:9529-9540
14. Fernandez-Fernandez JM, Abogadie FC, Milligan G, Delmas P, Brown DA (2001) Multiple pertussis toxin-sensitive G-proteins can couple receptors to GIRK channels in rat sympathetic neurons when expressed heterologously, but only native Giproteins do so in situ. Eur J Neurosci 14:283-292
15. Gilman AG (1987) G proteins: transducers of receptor-generated signals. Annu Rev Biochem 56:615-649
16. Gingrich JA, Caron MG (1993) Recent advances in the molecular biology of dopamine receptors. Annu Rev Neurosci 16:299-321
17. Giros B, Sokoloff P, Martres MP, Riou JF, Emorine LJ, Schwartz JC (1989) Alternative splicing directs the expression of two D2 dopamine receptor isoforms. Nature 342:923-926
18. Gregerson KA, Flagg TP, O'Neill TJ, Anderson M, Lauring O, Horel JS, Welling PA (2001) Identification of G protein-coupled, inward rectifier potassium channel gene products from the rat anterior pituitary gland. Endocrinology 142:2820-2832
19. Greif GJ, Lin YJ, Liu JC, Freedman JE (1995) Dopamine-modulated potassium channels on rat striatal neurons: specific activation and cellular expression. J Neurosci 15:4533-4544
20. + channels. Pflugers Arch 441:544-550
21. Haber SN, Fudge JL (1997) The primate substantia nigra and VTA: integrative circuitry and function. Crit Rev Neurobiol 11:323-342
22. Hille B (1994) Modulation of ion-channel function by G-protein-coupled receptors. Trends Neurosci 17:531-536
23. Holmes C, Smith H, Ganderton R, Arranz M, Collier D, Powell J, Lovestone S (2001) Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation. J Neurol Neurosurg Psychiatry 71:777-779
24. Hori H, Ohmori O, Shinkai T, Kojima H, Nakamura J (2001) Association between three functional polymorphisms of dopamine D2 receptor gene and tardive dyskinesia in schizophrenia. Am J Med Genet 105:774-778
25. Huff RM (1996) Signal transduction pathways modulated by the D2 subfamily of dopamine receptors. Cell Signal 8:453-459
26. Jentsch TJ (2000) Neuronal KCNQ potassium channels: physiology and role in disease. Nat Rev Neurosci 1:21-30
27. Jespersen T, Grunnet M, Angelo K, Klaerke DA, Olesen SP (2002) Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes. Biotechniques 32:536-538, 540
28. Kapur S, Remington G (2001) Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia. Annu Rev Med 52:503-517
29. Kebabian JW, Calne DB (1979) Multiple receptors for dopamine. Nature 277:93-96
30. Khan ZU, Mrzljak L, Gutierrez A, Calle A de la, GoldmanRakic PS (1998) Prominence of the dopamine D2 short isoform in dopaminergic pathways. Proc Natl Acad Sci USA 95:7731-7736
31. + channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway. Proc Natl Acad Sci USA 97:4333-4338
32. Kubisch C, Schroeder BC, Friedrich T, Lutjohann B, el Amraoui A, Marlin S, Petit C, Jentsch TJ (1999) KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell 96:437-446
33. Kuzhikandathil EV, Yu W, Oxford GS (1998) Human dopamine D3 and D2L receptors couple to inward rectifier potassium channels in mammalian cell lines. Mol Cell Neurosci 12:390-402
34. Lachowicz JE, Sibley DR (1997) Molecular characteristics of mammalian dopamine receptors. Pharmacol Toxicol 81:105-113
35. Lamas JA (1999) The role of calcium in M-current inhibition by muscarinic agonists in rat sympathetic neurons. Neuroreport 10:2395-2400
36. Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, Steinmeyer K (2000) Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity. J Biol Chem 275:22395-22400
37. Lin YJ, Greif GJ, Freedman JE (1996) Permeation and block of dopamine-modulated potassium channels on rat striatal neurons by cesium and barium ions. J Neurophysiol 76:1413-1422
38. Liu LX, Monsma FJ Jr, Sibley DR, Chiodo LA (1996) D2L, D2S, and D3 dopamine receptors stably transfected into NG108-15 cells couple to a voltage-dependent potassium current via distinct G protein mechanisms. Synapse 24:156-164
39. Maroon NV (1997) Control of M-current. Annu Rev Physiol 59:483-504
40. Meves H, Schwarz JR, Wulfsen I (1999) Separation of M-like current and ERG current in NG108-15 cells. Br J Pharmacol 127:1213-1223
41. Moore SD, Madamba SG, Joels M, Siggins GR (1988) Somatostatin augments the M-current in hippocampal neurons. Science 239:278-280
42. Noda M, Obana M, Akaike N (1998) Inhibition of M-type K+ current by linopirdine, a neurotransmitter-release enhancer, in NG108-15 neuronal cells and rat cerebral neurons in culture. Brain Res 794:274-280
43. O'Neill C, Wiehager B, Fowler CJ, Ravid R, Winblad B, Cowburn RF (1994) Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain. Brain Res 636:193-201
44. Okada F, Tokumitsu Y, Takahashi N, Crow TJ, Roberts GW (1994) Reduced concentrations of the alpha-subunit of GTP-binding protein Go in schizophrenic brain. J Neural Transm Gen Sect 95:95-104
45. Ozawa H, Saito T, Hatta S, Hashimoto E, Froelich L, Ohshika H, Takahata N, Riederer P (1994) Reduced sensitivity to ethanol of Gs alpha and Gi/o alpha in the cerebral cortex of alcoholic patients. Alcohol Alcohol 29 Suppl 1:93-97
46. Pickel VM, Chan J, Nirenberg MJ (2002) Region-specific targeting of dopamine D2-receptors and somatodendritic vesicular monoamine transporter 2 (VMAT2) within ventral tegmental area subdivisions. Synapse 45:113-124
47. Rehman HU, Masson EA (2001) Neuroendocrinology of ageing. Age Ageing 30:279-287
48. Rivera A, Cuellar B, Giron FJ, Grandy DK, Calle A de la, Moratalla R (2002) Dopamine D4 receptors are heterogeneously distributed in the striosomes/matrix compartments of the striatum. J Neurochem 80:219-229
49. Robbins J (2001) KCNQ potassium channels: physiology, pathophysiology, and pharmacology. Pharmacol Ther 90:1-19
50. Sakai Y, Sekiguchi M, Okamoto K, Kuwano R, Takahashi Y (1990) Dopamine receptors expressed in the Xenopus oocytes injected with bovine striatal mRNA. Brain Res Mol Brain Res 7:183-187
51. Ks potassium channel. Nature 384:80-83
52. + channels causes epilepsy. Nature 396:687-690
53. Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ (2000) KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. J Biol Chem 275:24089-24095
54. Schroeder BC, Waldegger S, Fehr S, Bleich M, Warth R, Greger R, Jentsch TJ (2000) A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403:196-199
55. Seeman P, Tol HH van (1994) Dopamine receptor pharmacology. Trends Pharmacol Sci 15:264-270
56. Shah M, Mistry M, Marsh SJ, Brown DA, Delmas P (2002) Molecular correlates of the M-current in cultured rat hippocampal neurons. J Physiol (Lond) 544:29-37
57. Simon MI, Strathmann MP, Gautam N (1991) Diversity of G proteins in signal transduction. Science 252:802-808
58. Sims SM, Singer JJ, Walsh JV Jr (1988) Antagonistic adrenergic-muscarinic regulation of M current in smooth muscle cells. Science 239:190-193
59. Skaaning JB, Levavi-Sivan B, Fishburn CS, Fuchs S (1997) Functional expression of the murine D2, D3, and D4 dopamine receptors in Xenopus laevis oocytes. FEBS Lett 420:191-195
60. Sogaard R, Ljungstrom T, Pedersen KA, Olesen SP, Jensen BS (2001) KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology. Am J Physiol 280:C859-C866
61. Stoof JC, Kebabian JW (1984) Two dopamine receptors: biochemistry, physiology and pharmacology. Life Sci 35:2281-2296
62. Suh B, Hille B (2002) Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis. Neuron 35:507-520
63. Sumikawa K, Parker I, Miledi R (1984) Messenger RNA from rat brain induces noradrenaline and dopamine receptors in Xenopus oocytes. Proc R Soc Lond B Biol Sci 223:255-260
64. Tinel N, Lauritzen I, Chouabe C, Lazdunski M, Borsotto M (1998) The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3. FEBS Lett 438:171-176
65. + channel in acutely dissociated rat substantia nigra neurones. Neuropharmacology 39:191-201
66. Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D (1998) KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282:1890-1893
67. Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, VanRaay TJ, Shen J, Timothy KW, Vincent GM, de Jager T, Schwartz PJ, Toubin JA, Moss AJ, Atkinson DL, Landes M, Connors TD, Keating MT (1996) Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias, Nat Genet 12:17-23
68. Wemer P, Hussy N, Buell G, Jones KA, North RA (1996) D2, D3, and D4 dopamine receptors couple to G protein-regulated potassium channels in Xenopus oocytes. Mol Pharmacol 49:656-661
69. Wise A, Gearing K, Rees S (2002) Target validation of G-protein coupled receptors. Drug Discov Today 7:235-246
70. Womble MD, Moises HC (1992) Muscarinic inhibition of M-current and a potassium leak conductance in neurones of the rat basolateral amygdala. J Physiol (Lond) 457:93-114
71. o subtype of G proteins in SH-SY5Y cells. Br J Pharmacol 128:1181-1188