KCNQ4 channels expressed in mammalian cells: Functional characteristics and pharmacology

American Journal of Physiology - Cell Physiology

Volumn 280, Issue 4 49-4, 2001, Pages

  Søgaard, Rikke ^a   Ljungstrøm, Trine ^a   Pedersen, Kamilla Angelo ^a   Olesen, Søren Peter ^a,b   Skaaning Jensen, B O ^a,b,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NEUROSEARCH A S   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Bepridil; Linopirdine; M current; XE 991

Indexed keywords

ANTIARRHYTHMIC AGENT; BEPRIDIL; CLOFILIUM; LINOPIRDINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

ARTICLE; GENE EXPRESSION; HUMAN; HUMAN CELL; MAMMAL CELL; MEMBRANE CURRENT; MEMBRANE POTENTIAL; MEMBRANE STEADY POTENTIAL; PATCH CLAMP; PRIORITY JOURNAL;

MAMMALIA;

EID: 2142661025     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2001.280.4.c859     Document Type: Article

References (14)

1. Aiken SP, Lampe BJ, Murphy PA, and Brown BS. Reduction of spike frequency adaptation and blockade of M current in rat CA1 pyramidal neurones by linopirdine (DuP 996), a neurotransmitter release enhancer. Er J Pharmacol 115: 1163-1168, 1995.
2. Bezanilla F and Stefani E. Gating currents. Methods Enzymol 293: 331-352, 1998.
3. Biervert C, Schroeder BC, Kubisch C, Berkovic SF, Propping P, Jentsch TJ, and Steinlein OK. A potassium channel mutation in neonatal human epilepsy. Science 279: 403-406, 1998.
4. Brown DA. Ion Channels (3rd ed.), edited by Narahashi T. New York: Plenum, 1988, vol. 1, p. 55-94.
5. Brown DA, Constanti A, and Adams PR. Slow cholinergic and peptidergic transmission in sympathetic ganglia. Fed Proc 40: 2625-2630, 1981.
6. Charlier C, Singh NA, Ryan SG, Lewis TB, Reus BE, Leach RJ, and Leppert M. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat Genet 18: 53-55, 1998.
7. + channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias. EMBO J 16: 5472-5479, 1997.
8. Coucke PJ, Van Hauwe P, Kelley PM, Kunst H, Schatteman I, Van Velzen D, Meyers J, Ensink RJ, Verstreken M, Declau F, Marres H, Kastury K, Bhasin S, McGuirt WT, Smith RJ, Cremers CW, Van de Heyning P, Willems PJ, Smith SD, and Van Camp G. Mutations in the KCNQ4 gene are responsible for autosomal dominant deafness in four DFNA2 families. Hum Mol Genet 8: 1321-1328, 1999.
9. Hille B. Ionic Channels of Excitable Membranes (2nd ed.). Sunderland, MA: Sinauer, 1992.
10. + channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway. Proc Natl Acad Sci USA 97: 4333-4338, 2000.
11. Kohler M, Hirschberg B, Bond CT, Kinzie JM, Marrion NV, Maylie J, and Adelman JP. Small-conductance, calcium-activated potassium channels from mammalian brain. Science 273: 1709-1714, 1996.
12. Kubisch C, Schroeder BC, Friedrich T, Lutjohann B, El-Amraoui A, Marlin S, Petit C, and Jentsch TJ. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell 96: 437-446, 1999.
13. 2+-dependent phosphorylation in rod photoreceptors. Am J Physiol Cell Physiol 272: C1844-C1853, 1997.
14. Marrion NV. Selective reduction of one mode of M-channel gating by muscarine in sympathetic neurons. Neuron 11: 77-84, 1993.