-
1
-
-
0033569516
-
Pharmacogenomics: Translating functional genomics into rational therapeutics
-
Evans, W.E.; Relling, M.V. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 1999, 286, 487-491.
-
(1999)
Science
, vol.286
, pp. 487-491
-
-
Evans, W.E.1
Relling, M.V.2
-
2
-
-
0035033019
-
Pharmacogenomics: Unlocking the human genome for better therapy
-
McLeod, H.L.; Evans, W.E. Pharmacogenomics: unlocking the human genome for better therapy. Annu. Rev. Pharmacol. Toxicol. 2001, 41, 101-121.
-
(2001)
Annu. Rev. Pharmacol. Toxicol.
, vol.41
, pp. 101-121
-
-
McLeod, H.L.1
Evans, W.E.2
-
3
-
-
0035865322
-
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
-
Sachidanandam, R.; Weissman, D.; Schmidt, S.C.; Kakol, J.M.; Stein, L.D. ; Marth, G.; Sherry, S.; Mullikin, J.C.; Mortimore, B.J.; Willey, D.L.; Hunt, S.E.; Cole, C.G.; Coggill, P.C.; Rice, C.M.; Ning, Z.; Rogers, J.; Bentley, D.R.; Kwok, P.Y.; Mardis, E.R.; Yeh, R.T.; Schultz, B.; Cook, L.; Davenport, R. ; Dante, M.; Fulton, L.; Hillier, L.; Waterston, R.H.; McPherson, J.D.; Gilman, B.; Schaffner, S.; Van Etten, W.J.; Reich, D.; Higgins, J.; Daly, M.J.; Blumenstiel, B.; Baldwin, J.; Stange-Thomann, N.; Zody, M.C.; Linton, L.; Lander, E.S.; Atshuler, D. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 2001, 409, 928-933.
-
(2001)
Nature
, vol.409
, pp. 928-933
-
-
Sachidanandam, R.1
Weissman, D.2
Schmidt, S.C.3
Kakol, J.M.4
Stein, L.D.5
Marth, G.6
Sherry, S.7
Mullikin, J.C.8
Mortimore, B.J.9
Willey, D.L.10
Hunt, S.E.11
Cole, C.G.12
Coggill, P.C.13
Rice, C.M.14
Ning, Z.15
Rogers, J.16
Bentley, D.R.17
Kwok, P.Y.18
Mardis, E.R.19
Yeh, R.T.20
Schultz, B.21
Cook, L.22
Davenport, R.23
Dante, M.24
Fulton, L.25
Hillier, L.26
Waterston, R.H.27
McPherson, J.D.28
Gilman, B.29
Schaffner, S.30
Van Etten, W.J.31
Reich, D.32
Higgins, J.33
Daly, M.J.34
Blumenstiel, B.35
Baldwin, J.36
Stange-Thomann, N.37
Zody, M.C.38
Linton, L.39
Lander, E.S.40
Atshuler, D.41
more..
-
4
-
-
84984932472
-
Exploring the new world of the genome with DNA microarrays
-
Brown, P.O.; Botstein, D. Exploring the new world of the genome with DNA microarrays. Nat. Genet. 1999, 21, 33-37.
-
(1999)
Nat. Genet.
, vol.21
, pp. 33-37
-
-
Brown, P.O.1
Botstein, D.2
-
5
-
-
0034088857
-
A gene expression database for the molecular pharmacology of cancer
-
Scherf, U.; Ross, D.T.; Waltham, M.; Smith, L.H.; Lee, J.K.; Tanabe, L.; Kohn, K.W.; Reinhold, W.C.; Myers, T.G.; Andrews, D.T.; Scudiero, D.A.; Eisen, M.B.; Sausville, E.A.; Pommier, Y.; Botstein, D.; Brown, P.O.; Weinstein, J.N. A gene expression database for the molecular pharmacology of cancer. Nat. Genet. 2000, 24, 236-244.
-
(2000)
Nat. Genet.
, vol.24
, pp. 236-244
-
-
Scherf, U.1
Ross, D.T.2
Waltham, M.3
Smith, L.H.4
Lee, J.K.5
Tanabe, L.6
Kohn, K.W.7
Reinhold, W.C.8
Myers, T.G.9
Andrews, D.T.10
Scudiero, D.A.11
Eisen, M.B.12
Sausville, E.A.13
Pommier, Y.14
Botstein, D.15
Brown, P.O.16
Weinstein, J.N.17
-
6
-
-
0031730097
-
Drug target validation and identification of secondary drug target effects using DNA microarrays
-
Marton, M.J.; DeRisi, J.L.; Bennett, H.A.; Iyer, V.R.; Meyer, M.R.; Roberts, C.J.; Stoughton, R.; Burchard, J.; Slade, D.; Dai, H.; Bassett, D.E., Jr.; Hartwell, L.H.; Brown, P.O.; Friend, S.H. Drug target validation and identification of secondary drug target effects using DNA microarrays. Nat. Med. 1998, 4, 1293-1301.
-
(1998)
Nat. Med.
, vol.4
, pp. 1293-1301
-
-
Marton, M.J.1
DeRisi, J.L.2
Bennett, H.A.3
Iyer, V.R.4
Meyer, M.R.5
Roberts, C.J.6
Stoughton, R.7
Burchard, J.8
Slade, D.9
Dai, H.10
Bassett D.E., Jr.11
Hartwell, L.H.12
Brown, P.O.13
Friend, S.H.14
-
7
-
-
0034680102
-
Molecular portraits of human breast tumours
-
Perou, C.M.; Sorlie, T.; Eisen, M.B.; van de Rijn, M.; Jeffrey, S.S.; Rees, C.A.; Pollack, J.R.; Ross, D.T.; Johnsen, H.; Akslen, L.A.; Fluge, O.; Pergamenschikov, A.; Williams, C.; Zhu, S.X.; Lonning, P.E.; Borresen-Dale, A.L.; Brown, P.O.; Botstein, D. Molecular portraits of human breast tumours. Nature 2000, 406, 747-752.
-
(2000)
Nature
, vol.406
, pp. 747-752
-
-
Perou, C.M.1
Sorlie, T.2
Eisen, M.B.3
Van de Rijn, M.4
Jeffrey, S.S.5
Rees, C.A.6
Pollack, J.R.7
Ross, D.T.8
Johnsen, H.9
Akslen, L.A.10
Fluge, O.11
Pergamenschikov, A.12
Williams, C.13
Zhu, S.X.14
Lonning, P.E.15
Borresen-Dale, A.L.16
Brown, P.O.17
Botstein, D.18
-
8
-
-
0033569406
-
Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
-
Golub, T.R.; Slonim, D.K.; Tamayo, P.; Huard, C.; Gaasenbeek, M.; Mesirov, J.P.; Coller, H.; Loh, M.L.; Downing, J.R.; Caliguiri, M.A.; Bloomfield, C.D.; Lander, E.S. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999, 286, 531-537.
-
(1999)
Science
, vol.286
, pp. 531-537
-
-
Golub, T.R.1
Slonim, D.K.2
Tamayo, P.3
Huard, C.4
Gaasenbeek, M.5
Mesirov, J.P.6
Coller, H.7
Loh, M.L.8
Downing, J.R.9
Caliguiri, M.A.10
Bloomfield, C.D.11
Lander, E.S.12
-
9
-
-
0034598746
-
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
-
Alizadeh, A.A.; Eisen, M.B.; Davis, R.E.; Chi, M.; Lossos, I.S.; Rosenwald, A.; Boldrick, J.C.; Sabet, H.; Tran, T.; Yu, X.; Powell, J.I.; Yang, L.; Marti, G.E.; Moore, T.; Hudson, J., Jr.; Lu, L.; Lewis, D.B.; Tibshirani, R.; Sherlock, G.; Chan, W.C.; Greiner, T.C.; Weisenburger, D.D.; Armitage, J.O. ; Wamke, R.; Levy, R.; Wilson, W.; Grever, M.R.; Byrd, J.C.; Botstein, D.; Brown, P.O.; Staudt, L.M. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000, 403, 503-511.
-
(2000)
Nature
, vol.403
, pp. 503-511
-
-
Alizadeh, A.A.1
Eisen, M.B.2
Davis, R.E.3
Chi, M.4
Lossos, I.S.5
Rosenwald, A.6
Boldrick, J.C.7
Sabet, H.8
Tran, T.9
Yu, X.10
Powell, J.I.11
Yang, L.12
Marti, G.E.13
Moore, T.14
Hudson J., Jr.15
Lu, L.16
Lewis, D.B.17
Tibshirani, R.18
Sherlock, G.19
Chan, W.C.20
Greiner, T.C.21
Weisenburger, D.D.22
Armitage, J.O.23
Wamke, R.24
Levy, R.25
Wilson, W.26
Grever, M.R.27
Byrd, J.C.28
Botstein, D.29
Brown, P.O.30
Staudt, L.M.31
more..
-
10
-
-
0035931947
-
Gene-expression profiles in hereditary breast cancer
-
Hedenfalk, I.; Duggan, D.; Chen, Y.; Radmacher, M.; Bittner, M.; Simon, R.; Meltzer, P.; Gusterson, B.; Esteller, M.; Kallioniemi, O.P.; Wilfond, B.; Borg, A.; Trent, J. Gene-expression profiles in hereditary breast cancer. N. Engl. J. Med. 2001, 344, 539-548.
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 539-548
-
-
Hedenfalk, I.1
Duggan, D.2
Chen, Y.3
Radmacher, M.4
Bittner, M.5
Simon, R.6
Meltzer, P.7
Gusterson, B.8
Esteller, M.9
Kallioniemi, O.P.10
Wilfond, B.11
Borg, A.12
Trent, J.13
-
11
-
-
0035876118
-
Prognostic significance of reverse transcriptase polymerase chain reaction for prostate-specific antigen in men with hormone-refractory prostate cancer
-
Kantoff, P.W.; Halabi, S.; Farmer, D.A.; Hayes, D.F.; Vogelzang, N.A.; Small, E.J. Prognostic significance of reverse transcriptase polymerase chain reaction for prostate-specific antigen in men with hormone-refractory prostate cancer. J. Clin. Oncol. 2001, 15, 3025-3028.
-
(2001)
J. Clin. Oncol.
, vol.15
, pp. 3025-3028
-
-
Kantoff, P.W.1
Halabi, S.2
Farmer, D.A.3
Hayes, D.F.4
Vogelzang, N.A.5
Small, E.J.6
-
12
-
-
0035868665
-
Circulating neuroblastoma cells detected by reverse transcriptase polymerase chain reaction for tyrosine hydroxylase mRNA are an independent poor prognostic indicator in stage 4 neuroblastoma in children over 1 year
-
Burchill, S.A.; Lewis, I.J.; Abrams, K.R.; Riley, R.; Imeson, J.; Pearson, A.D.; Pinkerton, R.; Selby, P. Circulating neuroblastoma cells detected by reverse transcriptase polymerase chain reaction for tyrosine hydroxylase mRNA are an independent poor prognostic indicator in stage 4 neuroblastoma in children over 1 year. J. Clin. Oncol. 2001, 19, 1795-1801.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 1795-1801
-
-
Burchill, S.A.1
Lewis, I.J.2
Abrams, K.R.3
Riley, R.4
Imeson, J.5
Pearson, A.D.6
Pinkerton, R.7
Selby, P.8
-
13
-
-
0034048729
-
Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase
-
Salonga, D.; Danenberg, K.D.; Johnson, M.; Metzger, R.; Groshen, S.; Tsao-Wei, D.D.; Lenz, H.J.; Leichman, C.G.; Leichman, L.; Diasio, R.B.; Danenberg, P.V. Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin. Cancer Res. 2000, 6, 1322-1327.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 1322-1327
-
-
Salonga, D.1
Danenberg, K.D.2
Johnson, M.3
Metzger, R.4
Groshen, S.5
Tsao-Wei, D.D.6
Lenz, H.J.7
Leichman, C.G.8
Leichman, L.9
Diasio, R.B.10
Danenberg, P.V.11
-
14
-
-
0033958277
-
Can dihydropyrimidine dehydrogenase impact 5-fluorouracil-based treatment?
-
Milano, G.; McLeod, H.L. Can dihydropyrimidine dehydrogenase impact 5-fluorouracil-based treatment? Eur. J. Cancer 2000, 36, 37-42.
-
(2000)
Eur. J. Cancer
, vol.36
, pp. 37-42
-
-
Milano, G.1
McLeod, H.L.2
-
15
-
-
0032947479
-
Comparative genomic hybridization and chromosomal instability in solid tumours
-
Rooney, P.H.; Murray, G.I.; Stevenson, D.A.; Haites, N.E.; Cassidy, J.; McLeod, H.L. Comparative genomic hybridization and chromosomal instability in solid tumours. Br. J. Cancer 1999, 80, 862-873.
-
(1999)
Br. J. Cancer
, vol.80
, pp. 862-873
-
-
Rooney, P.H.1
Murray, G.I.2
Stevenson, D.A.3
Haites, N.E.4
Cassidy, J.5
McLeod, H.L.6
-
16
-
-
0032533513
-
Comparative genomic hybridization analysis of chromosomal alterations induced by the development of resistance to thymidylate synthase inhibitors
-
Rooney, P.H.; Stevenson, D.A.; Marsh, S.; Johnston, P.G.; Haites, N.E.; Cassidy, J.; McLeod, H.L. Comparative genomic hybridization analysis of chromosomal alterations induced by the development of resistance to thymidylate synthase inhibitors. Cancer Res. 1998, 58, 5042-5045.
-
(1998)
Cancer Res.
, vol.58
, pp. 5042-5045
-
-
Rooney, P.H.1
Stevenson, D.A.2
Marsh, S.3
Johnston, P.G.4
Haites, N.E.5
Cassidy, J.6
McLeod, H.L.7
-
17
-
-
0032231751
-
Pharmacogenetics of cancer therapy: Getting personal
-
Krynetski, E.Y.; Evans, W.E. Pharmacogenetics of cancer therapy: getting personal. Am. J. Hum. Genet. 1998, 63, 11-16.
-
(1998)
Am. J. Hum. Genet.
, vol.63
, pp. 11-16
-
-
Krynetski, E.Y.1
Evans, W.E.2
-
18
-
-
0034034158
-
Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia
-
McLeod, H.L.; Krynetski, E.; Relling, M.V.; Evans, W.E. Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia. Leukemia 2000, 14, 567-572.
-
(2000)
Leukemia
, vol.14
, pp. 567-572
-
-
McLeod, H.L.1
Krynetski, E.2
Relling, M.V.3
Evans, W.E.4
-
19
-
-
0018822866
-
Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
-
Weinshilboum, R.M.; Sladek, S.L. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am. J. Hum. Genet. 1980, 32, 651-662.
-
(1980)
Am. J. Hum. Genet.
, vol.32
, pp. 651-662
-
-
Weinshilboum, R.M.1
Sladek, S.L.2
-
20
-
-
0028930908
-
Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia
-
McLeod, H.L.; Relling, M.V.; Liu, Q.; Pui, C.-H.; Evans, W.E. Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia. Blood 1995, 85, 1897-1902.
-
(1995)
Blood
, vol.85
, pp. 1897-1902
-
-
McLeod, H.L.1
Relling, M.V.2
Liu, Q.3
Pui, C.-H.4
Evans, W.E.5
-
21
-
-
0027401302
-
Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient
-
Schutz, E.; Gummert, J.; Mohr, F.; Ollerich, M. Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient. Lancet 1993, 341, 436.
-
(1993)
Lancet
, vol.341
, pp. 436
-
-
Schutz, E.1
Gummert, J.2
Mohr, F.3
Ollerich, M.4
-
22
-
-
0027285234
-
Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient
-
McLeod, H.L.; Miller, D.R.; Evans, W.E. Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient. Lancet 1993, 341, 1151.
-
(1993)
Lancet
, vol.341
, pp. 1151
-
-
McLeod, H.L.1
Miller, D.R.2
Evans, W.E.3
-
23
-
-
0028861745
-
A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase
-
Krynetski, E.Y.; Schuetz, J.D.; Galpin, A.J.; Pui, C.-H.; Relling, M.V.; Evans, W.E. A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase. Proc. Natl Acad. Sci. U.S.A. 1995, 92, 949-953.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 949-953
-
-
Krynetski, E.Y.1
Schuetz, J.D.2
Galpin, A.J.3
Pui, C.-H.4
Relling, M.V.5
Evans, W.E.6
-
24
-
-
0029919807
-
Thiopurine S-methyltransferase deficiency: Two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians
-
Tai, H.L.; Krynetski, E.Y.; Yates, C.R.; Loennechen, T.; Fessing, M.Y.; Krynetskaia, N.F.; Evans, W.E. Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians. Am. J. Hum. Genet. 1996, 58, 694-702.
-
(1996)
Am. J. Hum. Genet.
, vol.58
, pp. 694-702
-
-
Tai, H.L.1
Krynetski, E.Y.2
Yates, C.R.3
Loennechen, T.4
Fessing, M.Y.5
Krynetskaia, N.F.6
Evans, W.E.7
-
25
-
-
0031820555
-
Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans
-
Loennechen, T.; Yates, C.R.; Fessing, M.Y.; Relling, M.V.; Krynetski, E.Y.; Evans, W.E. Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans. Clin. Pharmacol. Ther. 1998, 64, 46-51.
-
(1998)
Clin. Pharmacol. Ther.
, vol.64
, pp. 46-51
-
-
Loennechen, T.1
Yates, C.R.2
Fessing, M.Y.3
Relling, M.V.4
Krynetski, E.Y.5
Evans, W.E.6
-
26
-
-
0030986251
-
Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): Mechanisms for the genetic polymorphism of TPMT activity
-
Tai, H.L.; Krynetski, E.Y.; Schuetz, E.G.; Yanishevski, Y.; Evans, W.E. Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity. Proc. Natl Acad. Sci. U.S.A. 1997, 94, 6444-6449.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 6444-6449
-
-
Tai, H.L.1
Krynetski, E.Y.2
Schuetz, E.G.3
Yanishevski, Y.4
Evans, W.E.5
-
27
-
-
0030934850
-
Molecular diagnosis of thiopurine S-methyltransferase deficiency; genetic basis for azathioprine and mercaptopurine intolerance
-
Yates, C.R.; Krynetski, E.Y.; Loennechen, T.; Fessing, M.Y.; Tai, H.L.; Pui, C.H.; Relling, M.V.; Evans, W.E. Molecular diagnosis of thiopurine S-methyltransferase deficiency; genetic basis for azathioprine and mercaptopurine intolerance. Ann. Intern. Med. 1997, 126, 608-614.
-
(1997)
Ann. Intern. Med.
, vol.126
, pp. 608-614
-
-
Yates, C.R.1
Krynetski, E.Y.2
Loennechen, T.3
Fessing, M.Y.4
Tai, H.L.5
Pui, C.H.6
Relling, M.V.7
Evans, W.E.8
-
28
-
-
0032898380
-
Thiopurine methyltransferase alleles in British and Ghanaian populations
-
Ameyaw, M.M.; Collie-Duguid, E.S.; Powrie, R.H.; Ofori-Adjei, D.; McLeod, H.L. Thiopurine methyltransferase alleles in British and Ghanaian populations. Hum. Mol. Genet. 1999, 8, 367-370.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 367-370
-
-
Ameyaw, M.M.1
Collie-Duguid, E.S.2
Powrie, R.H.3
Ofori-Adjei, D.4
McLeod, H.L.5
-
29
-
-
0032898097
-
Polymorphism of the thiopurine S-methyltransferase gene in African Americans
-
Hon, Y.Y.; Fessing, M.Y.; Pui, C.-H.; Relling, M.V.; Krynetski, E.Y.; Evans, W.E. Polymorphism of the thiopurine S-methyltransferase gene in African Americans. Hum. Mol. Genet. 1999, 8, 371-376.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 371-376
-
-
Hon, Y.Y.1
Fessing, M.Y.2
Pui, C.-H.3
Relling, M.V.4
Krynetski, E.Y.5
Evans, W.E.6
-
30
-
-
0032917646
-
The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations
-
Collie-Duguid, E.S.; Pritchard, S.C.; Powrie, R.H.; Sludden, J.; Li, T.; McLeod, H.L. The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations. Pharmacogenetics 1999, 9, 37-42.
-
(1999)
Pharmacogenetics
, vol.9
, pp. 37-42
-
-
Collie-Duguid, E.S.1
Pritchard, S.C.2
Powrie, R.H.3
Sludden, J.4
Li, T.5
McLeod, H.L.6
-
31
-
-
0032532599
-
The relationship between thiopurine methyltrasferase activiy and genotype in blasts from patients with acute leukemia
-
Coulthard, S.A.; Howell, C.; Robson, J.; Hall, A.G. The relationship between thiopurine methyltrasferase activiy and genotype in blasts from patients with acute leukemia. Blood 1998, 92, 2856-2862.
-
(1998)
Blood
, vol.92
, pp. 2856-2862
-
-
Coulthard, S.A.1
Howell, C.2
Robson, J.3
Hall, A.G.4
-
32
-
-
0024451147
-
Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism
-
Lennard, L.; Van Loon, J.A.; Weinshilboum, R.M. Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism. Clin. Pharmacol. Ther. 1989, 46, 149-154.
-
(1989)
Clin. Pharmacol. Ther.
, vol.46
, pp. 149-154
-
-
Lennard, L.1
Van Loon, J.A.2
Weinshilboum, R.M.3
-
33
-
-
0025837127
-
Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia
-
Evans, W.E.; Horner, M.; Chu, Y.Q.; Kalwinsky, D.; Roberts, W.M. Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia. J. Pediatr. 1991, 119, 985-989.
-
(1991)
J. Pediatr.
, vol.119
, pp. 985-989
-
-
Evans, W.E.1
Horner, M.2
Chu, Y.Q.3
Kalwinsky, D.4
Roberts, W.M.5
-
34
-
-
0032212759
-
Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine
-
Black, A.J.; McLeod, H.L.; Capell, H.A.; Powrie, R.H.; Matowe, L.K.; Pritchard, S.C.; Collie-Duguid, E.S.; Reig, D.M. Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine. Ann. Intern. Med. 1998, 129, 716-718.
-
(1998)
Ann. Intern. Med.
, vol.129
, pp. 716-718
-
-
Black, A.J.1
McLeod, H.L.2
Capell, H.A.3
Powrie, R.H.4
Matowe, L.K.5
Pritchard, S.C.6
Collie-Duguid, E.S.7
Reig, D.M.8
-
35
-
-
0033376417
-
Thiopurine methyltransferase genotype and the toxicity of azathioprine in Japanese
-
Ishioka, S. Thiopurine methyltransferase genotype and the toxicity of azathioprine in Japanese. Inter. Med. 1999, 38, 944-947.
-
(1999)
Inter. Med.
, vol.38
, pp. 944-947
-
-
Ishioka, S.1
-
36
-
-
0033486029
-
Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus
-
Relling, M.V.; Hancock, M.L.; Rivera, G.K.; Sandlund, J.T.; Ribeiro, R.C.; Krynetski, E.Y.; Pui, C.H.; Evans, W.E. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. J. Natl Cancer Inst. 1999, 91, 2001-2008.
-
(1999)
J. Natl. Cancer Inst.
, vol.91
, pp. 2001-2008
-
-
Relling, M.V.1
Hancock, M.L.2
Rivera, G.K.3
Sandlund, J.T.4
Ribeiro, R.C.5
Krynetski, E.Y.6
Pui, C.H.7
Evans, W.E.8
-
37
-
-
0031884608
-
Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia
-
Relling, M.V.; Yanishevski, Y.; Nemec, J.; Evans, W.E.; Boyett, J.M.; Behm, F.G.; Pui, C.H. Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia. Leukemia 1998, 12, 346-352.
-
(1998)
Leukemia
, vol.12
, pp. 346-352
-
-
Relling, M.V.1
Yanishevski, Y.2
Nemec, J.3
Evans, W.E.4
Boyett, J.M.5
Behm, F.G.6
Pui, C.H.7
-
38
-
-
0033568538
-
Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells: Relation to thiopurine metabolism
-
Be, J.; Schreder, I.I.; Kristiesson, J.; Madsen, B.; Szumlanski, C.; Weinshilboum, R.; Andersen, J.B.; Schmieglow, K. Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells: relation to thiopurine metabolism. Cancer 1999, 86, 1080-1086.
-
(1999)
Cancer
, vol.86
, pp. 1080-1086
-
-
Be, J.1
Schreder, I.I.2
Kristiesson, J.3
Madsen, B.4
Szumlanski, C.5
Weinshilboum, R.6
Andersen, J.B.7
Schmieglow, K.8
-
39
-
-
0033519986
-
High incidence of secondary brain tumours after radiotherapy and antimetabolites
-
Relling, M.V.; Rubnitz, J.E.; Rivera, G.K.; Boyett, J.M.; Hancock, M.L.; Felix, C.A.; Kun, L.E.; Walter, A.W.; Evans, W.E.; Pui, C.H. High incidence of secondary brain tumours after radiotherapy and antimetabolites. Lancet 1999, 354, 34-39.
-
(1999)
Lancet
, vol.354
, pp. 34-39
-
-
Relling, M.V.1
Rubnitz, J.E.2
Rivera, G.K.3
Boyett, J.M.4
Hancock, M.L.5
Felix, C.A.6
Kun, L.E.7
Walter, A.W.8
Evans, W.E.9
Pui, C.H.10
-
40
-
-
0029622428
-
The pharmacogenetics of codeine hypoalgesia
-
Sindrup, S.H.; Brosen, K. The pharmacogenetics of codeine hypoalgesia. Pharmacogenetics 1995, 5, 335-346.
-
(1995)
Pharmacogenetics
, vol.5
, pp. 335-346
-
-
Sindrup, S.H.1
Brosen, K.2
-
41
-
-
0030471120
-
The hypoalgesic effect of tramadol in relation to CYP2D6
-
Poulsen, L.; Arendt-Nielsen, L.; Brosen, K.; Sindrup, S.H. The hypoalgesic effect of tramadol in relation to CYP2D6. Clin. Pharmacol. Ther. 1996, 60, 636-644.
-
(1996)
Clin. Pharmacol. Ther.
, vol.60
, pp. 636-644
-
-
Poulsen, L.1
Arendt-Nielsen, L.2
Brosen, K.3
Sindrup, S.H.4
-
42
-
-
0032519431
-
Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes
-
Iyer, L.; King, C.D.; Whitington, P.F.; Green, M.D.; Roy, S.K.; Tephly, T.R.; Coffman, B.L.; Ratain, M.J. Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. J. Clin. Investig. 1998, 101, 847-854.
-
(1998)
J. Clin. Investig.
, vol.101
, pp. 847-854
-
-
Iyer, L.1
King, C.D.2
Whitington, P.F.3
Green, M.D.4
Roy, S.K.5
Tephly, T.R.6
Coffman, B.L.7
Ratain, M.J.8
-
43
-
-
0032934383
-
Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism
-
Iyer, L.; Hall, D.; Das, S.; Mortell, M.A.; Ramirez, J.; Kim, S.; Di Rienzo, A.; Ratain, M.J. Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism. Clin. Pharmacol. Ther. 1999, 65, 576-582.
-
(1999)
Clin. Pharmacol. Ther.
, vol.65
, pp. 576-582
-
-
Iyer, L.1
Hall, D.2
Das, S.3
Mortell, M.A.4
Ramirez, J.5
Kim, S.6
Di Rienzo, A.7
Ratain, M.J.8
-
44
-
-
0034671387
-
Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: A pharmacogenetic analysis
-
Ando, Y.; Saka, H.; Ando, M.; Sawa, T.; Muro, K.; Ueoka, H.; Yokovama, A.; Saitoh, S.; Shimokata, K.; Hasegawa, Y. Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis. Cancer Res. 2000, 60, 6921-6926.
-
(2000)
Cancer Res.
, vol.60
, pp. 6921-6926
-
-
Ando, Y.1
Saka, H.2
Ando, M.3
Sawa, T.4
Muro, K.5
Ueoka, H.6
Yokovama, A.7
Saitoh, S.8
Shimokata, K.9
Hasegawa, Y.10
-
45
-
-
0036025450
-
UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity
-
in press
-
Iyer, L.; Das, S.; Janisch, L.; Wen, M.; Ramirez, J.; Karrison, T.; Fleming, G.F.; Vokes, E.E.; Schilsky, R.L.; Ratain, M.J. UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity. Pharmacogenomics J. 2002, 2, in press.
-
(2002)
Pharmacogenomics J.
, vol.2
-
-
Iyer, L.1
Das, S.2
Janisch, L.3
Wen, M.4
Ramirez, J.5
Karrison, T.6
Fleming, G.F.7
Vokes, E.E.8
Schilsky, R.L.9
Ratain, M.J.10
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