Comparison of pulmonary vascular function and structure in early and established hypoxic pulmonary hypertension in rats

Canadian Journal of Physiology and Pharmacology

Volumn 79, Issue 3, 2001, Pages 227-237

  Jeffery, T K ^a   Wanstall, J C ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Contractile function; Endothelial function; Hypoxic pulmonary hypertension; Pulmonary vasculature; Remodelling

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; ANGIOTENSIN; ANGIOTENSIN I; SEROTONIN; SODIUM CHLORIDE; THROMBOXANE; VASOACTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL FUNCTION; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; HYPERTROPHY; HYPOXIA; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; LUNG LOBE; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VASODILATATION;

EID: 0035074171     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y00-117     Document Type: Article

References (36)

1. 2-adrenoceptors and endothelium-dependent relaxation in canine large arteries
2. Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia
3. Hypoxic exposure time-dependently modulates endothelin-induced contraction of pulmonary artery smooth muscle
4. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
5. Hypoxic remodeling of the rat pulmonary arterial circulation assessed by microdissection
6. Impairment of endothelium-dependent pulmonary artery relaxation in chronic obstructive lung disease
7. Functional effects of 4-aminopyridine (4-AP) on pulmonary and systemic vessels from normoxic control and hypoxic pulmonary hypertensive rats
8. Mechanical properties and reactivity of vessels in isolated perfused lung of chronically hypoxic rats
9. Multiple phenotypically distinct smooth muscle cell populations exist in the adult and developing bovine pulmonary arterial media in vivo
10. Early recovery from hypoxic pulmonary hypertension: A structural and functional study
11. Increased plasma serotonin in primary pulmonary hypertension
12. New findings in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension
13. Phosphodiesterase III and V inhibitors on pulmonary artery from pulmonary hypertensive rats: Differences between early and established pulmonary hypertension
14. Perindopril, an angiotensin converting enzyme inhibitor, in pulmonary hypertensive rats: Comparative effects on pulmonary vascular structure and function
15. Effects of pulmonary hypertension on vasoconstrictor responses to endothelin-1 and sarafotoxin S6C and on inherent tone in rat pulmonary arteries
16. 5-hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats
17. Changes in the renin-angiotensin-aldosterone system in 2 kidney-2 clip Goldblatt hypertensive rats of both sexes submitted to chronic hypobaric hypoxia
18. Impaired nitric oxide-dependent responses and their recovery in hypertensive pulmonary arteries of rats
19. Acetylcholine-induced endothelium-derived contracting factor in hypoxic pulmonary hypertensive rats
20. Endothelin receptors mediating contraction of rat and human pulmonary resistance arteries: Effect of chronic hypoxia in the rat
21. 3H-thymidine by cells of the rat pulmonary arteries and alveolar wall
22. Analysis of repeated-measures designs
23. Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension
24. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats
25. Mechanics of vascular smooth muscle
26. Myosin isoform shifts and decreased reactivity in hypoxia-induced hypertensive pulmonary arterial smooth muscle
27. Altered reactivity of rat pulmonary arterial smooth muscle to vasoactive agents in hypoxia
28. Rat pulmonary circulation after chronic hypoxia: Hemodynamic and structural features
29. The case for treatment of selected patients with primary pulmonary hypertension
30. Selective upregulation of arterial endothelial nitric oxide synthase in pulmonary hypertension
31. Pathogenesis of pulmonary hypertension in the rat model
32. Effect of alveolar pressure on pulmonary artery pressure in chronically hypoxic rats
33. Reduced relaxant potency of nitroprusside on pulmonary artery preparations taken from rats during the development of hypoxic pulmonary hypertension
34. Evidence that nitric oxide from the endothelium attenuates inherent tone in isolated pulmonary arteries from rats with hypoxic pulmonary hypertension
35. Endothelin and 5-hydroxytryptamine on rat pulmonary artery in pulmonary hypertension
36. Responses to vasodilator drugs on pulmonary artery preparations from pulmonary hypertensive rats