Approaches to prophylaxis and therapy

British Medical Bulletin

Volumn 66, Issue , 2003, Pages 281-292

  Dormont, Dominique ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4' IODOESORUBICIN; AMPHOTERICIN B; ANTHRACYCLINE DERIVATIVE; ANTIINFECTIVE AGENT; CELL RECEPTOR; CHLORPROMAZINE; CONGO RED; DAPSONE; DEXTRAN SULFATE; HEPARAN SULFATE; LAMININ RECEPTOR; LIGAND; MEPACRINE; METAL DERIVATIVE; MS 8209; ORGANIC COMPOUND; PEPTIDE DERIVATIVE; PHTHALOCYANINE DERIVATIVE; PLACEBO; POLYAMINE; POLYANION; POLYENE ANTIBIOTIC AGENT; POLYOXOMETALLATE DERIVATIVE; PORPHYRIN DERIVATIVE; PRION PROTEIN; PROLINE; PROTEOGLYCAN; SURAMIN; TETRACYCLINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

BETA SHEET; BIOACCUMULATION; BLOOD BRAIN BARRIER; BRAIN INJURY; CREUTZFELDT JAKOB DISEASE; DEGENERATIVE DISEASE; DIAGNOSTIC TEST; DISEASE CLASSIFICATION; DISEASE MODEL; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG TARGETING; EARLY DIAGNOSIS; EXPERIMENTAL MODEL; GLIOSIS; HISTOPATHOLOGY; HUMAN; IMMUNOMODULATION; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PRION DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; SCREENING TEST; SYMPTOM; TECHNIQUE;

ANIMALS; BRAIN; BRAIN CHEMISTRY; DRUG EVALUATION, PRECLINICAL; HUMANS; IMMUNE SERA; IMMUNE SYSTEM; IMMUNIZATION; MASS SCREENING; MODELS, ANIMAL; NERVOUS SYSTEM; PRION DISEASES; PRIONS; PRPSC PROTEINS; RESEARCH DESIGN;

EID: 0141514766     PISSN: 00071420     EISSN: None     Source Type: Journal    
DOI: 10.1093/bmb/66.1.281     Document Type: Review

References (65)

1. Kimberlin RH, Walker CA. Pathogenesis of experimental scrapie. Ciba Found Symp 1988; 135: 37-62
2. Kimberlin RH, Walker CA. The role of the spleen in the neuroinvasion of scrapie in mice. Virus Res 1989; 12: 201-12
3. Hilton DA, Ghani AC, Conyers L et al. Accumulation of prion protein in tonsil and appendix: review of tissue samples. BMJ 2002; 325: 633-4
4. Hill AF, Butterworth RJ, Jioner S et al. Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples. Lancet 1999; 353: 183-9
5. Bruce ME, McDonnell I, Will RG, Ironside JW. Detection of variant Creutzfeldt-Jakob disease infectivity in extraneural tissues. Lancet 2001; 358: 208-9
6. Kimberlin RH, Walker CA. Pathogenesis of mouse scrapie: effect of route of inoculation on infectivity titres and dose-response curves. J Comp Pathol 1978; 88: 39-47
7. Kimberlin RH. Early events in the pathogenesis of scrapie in mice: biological and biochemical studies. In: Prusiner SB, Hadlow WJ. (eds) Slow Transmissible Diseases of the Nervous System, vol 2. New York: Academic Press, 1979; 33-54
8. Kimberlin RH, Walker CA. Pathogenesis of mouse scrapie: dynamics of agent replication in spleen, spinal cord and brain after infection by different routes. J Comp Pathol 1979; 89: 551-62
9. Aucouturier P, Geissmann F, Damotte D et al. Infected dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie. J Clin Invest 2001; 108: 703-8
10. Brown KL, Stewart K, Ritchie D, Fraser H, Morrison WI, Bruce ME. Follicular dendritic cells in scrapie pathogenesis. Arch Virol Suppl 2000; 16: 13-21
11. Mabbott NA, Mackay F, Minns F, Bruce ME. Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie. Nat Med 2000; 6: 719-20
12. Montrasio F, Frigg H, Glatzel M, Klein MAM, Aguzzi A, Weissmann C. Impaired prion replication in spleen of mice lacking functional follicular dendritic cells. Science 2000; 288: 1257-9
13. Bencsik A, Lezmi S, Hunsmann G, Baron T. Close vicinity of PrP expressing cells (FDC) with noradrenergic fibers in healthy sheep spleen. Dev Immunol 2001; 8: 235-41
14. c expression in the peripheral nervous system is a determinant of prion neuroinvasion. J Gen Virol 2000; 81: 2813-21
15. Follet J, Lemaire-Vieille C, Blanquet-Grossard F et al. PrP expression and replication by Schwann cells: implication in prion spreading. J Virol 2002; 76: 2434-9
16. Beekes M, McBride PA. Early accumulation of pathological PrP in the enteric nervous system and gut-associated lymphoid tissue of hamsters orally infected with scrapie. Neurosci Lett 2000; 278: 181-4
17. Lee DW, Sohn HO, Lim HB et al. Alteration of free radical metabolism in the brain of mice infected with scrapie agent. Free Radic Res 1999; 30: 499-507
18. Kim JI, Choi SI, Kim NH et al. Oxidative stress and neurodegeneration in prion diseases. Ann NY Acad Sci 2001; 928: 182-6
19. Williams AE, van Dam AM, Man-A-Hing WKH, Berkenbosch F, Eikelenboom P, Fraser H. Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice. Brain Res 1994; 654: 200-6
20. Williams AE, Lawson LJ, Perry VH, Fraser H. Characterization of the microglial response in murine scrapie. Neuropathol Appl Neurobiol 1994; 20: 47-55
21. Lehmann S. [The prion protein]. J Soc Biol 2002; 196: 309-12
22. Beringue V, Demoy M, Lasmèzas CI, Gouritin B, Andreux JP, Couvereur P. Role of spleen macrophages in the clearance of scrapie agent at early stages of infection. 13th International Conference on Lymphoid Tissues in Immune Reactions. Geneva, Switzerland, August 1-6, 1999
23. Caughey B, Race RE, Ernst D, Buchmeier MJ, Chesebro B. Prion protein (PrP) biosynthesis in scrapie-infected and uninfected neuroblastoma cells. J Virol 1989; 63: 175-81
24. Kocisko DA, Come JH, Priola SA et al. Cell-free formation of protease-resistant prion protein. Nature 1994; 370: 471-4
25. Saborio GP, Permanne B, Soto C. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 2001; 411: 810-3
26. Scott MR, Supattapone S, Nguyen HO, DeArmond SJ, Prusiner SB. Transgenic models of prion disease. Arch Virol Suppl 2000; 16: 113-24
27. Ehlers B, Diringer H. Dextran sulphate 500 delays and prevents mouse scrapie by impairment of agent replication in spleen. J Gen Virol 1984; 65: 1325-30
28. Kimberlin RH, Walker CA. Suppression of scrapie infection in mice by hetero-polyanion 23, dextran sulfate, and some other polyanions. Antimicrob Agents Chemother 1986; 30: 409-13
29. Dormont D, Yeramian P, Lambert P et al. In vitro and in vivo effects of HPA 23. In: Dormont D, Court LA, Brown P, Kingsbury D. (eds) Unconventional virus diseases of the central nervous system. Fontenay aux Roses: CEA-Diffusion, 1989; 324-8
30. Ladogana A, Casaccia P, Ingrosso L. Sulphate polyanions prolong the incubation period of scrapie-infected hamsters. J Gen Virol 1992; 73: 661-5
31. Manuelidis L, Fritch W, Zaitsev I. Dapsone to delay symptoms in Creutzfeldt-Jakob disease. Lancet 1998; 352: 456
32. Guenther K, Deacon RM, Perry H, Rawlins JNP. Early behavioural changes in scrapie-affected mice and the influence of dapsone. Eur J Neurosci 2001; 14: 401-9
33. Tagliavini F, McArthur RA, Canciani B et al. Effectiveness of anthracycline against experimental prion disease in Syrian hamsters. Science 1997; 276: 1119-22
34. Forloni G, Iussich S, Awan T et al. Tetracyclines affect prion infectivity. Proc Natl Acad Sci USA 2002; 99:10849-54
35. Caughey B, Ernst D, Race R. Congo Red inhibition of scrapie agent replication. J Virol 1993; 67: 6270-2
36. Ingrosso L, Ladogana A, Pocchiari M. Congo Red prolongs the incubation period in scrapie-infected hamsters. J Virol 1995; 69: 506-8
37. Soto C, Kascsak RJ, Saborio GP et al. Reversion of prion protein conformational changes by synthetic beta-sheet breaker peptides. Lancet 2000; 15: 192-7
38. Warner RG, Hundt C, Weiss S, Turnbull JE. Identification of the heparan sulfate binding sites in the cellular prion protein. J Biol Chem 2002; 277: 18421-30
39. Hundt C, Peyrin JM, Häik S et al. Identification of interaction domains of the prion protein with its 37 kDa/67 kDa laminin receptor. EMBO J 2001; 20: 5876-86
40. Priola SA, Raines A, Caughey B. Porphyrin and phthalocyanine antiscrapie compounds. Science 2000; 287: 1503-6
41. Supattapone S, Nguyen HB, Cohen FE, Prusiner SB, Scott MR. Elimination of prions by branched polyamines and implication for therapeutics. Proc Natl Acad Sci USA 1999; 96: 14529-34
42. Supattapone S, Wille H, Uyechi L et al. Branched polyamines cure prion-infected neuroblastoma cells. J Virol 2001; 75: 3453-61
43. Pocchiari M, Schmittinger S, Ladogana A, Masullo C. Effects of amphotericin B in intracerebrally scrapie inoculated hamster. In: CouatLA, Dormont D, Brown P, Kingsbury DT (eds) Unconventional Virus Diseases of the Central Nervous System, vol 1. Fontenay aux roses;CEA-Diffusion, 1986; 314-23
44. Pocchiari M, Casaccia P, Ladogana A. Amphotericin B: a novel class of antiscrapie drugs. J Infect Dis 1989; 160: 795-802
45. Demaimay R, Adjou KT, Beringue V et al. Late treatment with polyene antibiotics can prolong the survival time of scrapie-infected animals. J Virol 1997; 71: 9685-9
46. Demaimay R, Adjou K, Cherifi K, Seman M, Deslys J-P, Dormont D. Molecular pharmacology of an amphotericin-B derivative, MS-8209, in mouse and hamster scrapie. Interdisciplinary World Congress on Antimicrobial and Anticancer Drugs. Genève, April 25-27, 1994
47. res accumulation in Syrian hamsters scrapie. Symposium on Prion and Lentiviral Diseases. Reykjavik, Iceland, August 20-22, 1998
48. Adjou KT, Demaimay R, Lasmèzas C, Deslys JP, Seman M. MS-8209, a new amphotericin B derivative provides enhanced efficacy in delaying hamster scrapie. Antimicrob Agents Chemother 1995; 39: 2810-2
49. res accumulation in the brain of scrapie-infected hamsters. 26th World Veterinary Congress. Lyon, France, Sept 23-26, 1999
50. Beringue V, Lasmèzas CI et al. Inhibiting scrapie neuroinvasion by polyene antibiotic treatment of SCID mice. J Gen Virol 1999; 80: 1873-7
51. Marella M, Lehmann S, Grassi J, Chabry J. Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release. J Biol Chem 2002; 277: 25457-64
52. Korth C, May BCH, Cohen F, Prusiner SB. Acridine and phenothiazine derivatives as pharmcotherapeutics for prion diseases. Proc Natl Acad Sci USA 2001; 98: 9836-41
53. May BC, Fafarman AT, Hong SB et al. Potent inhibition of scrapie prion replication in cultured cells by bis-acridines. Proc Natl Acad Sci USA 2003; 100: 3416-21
54. Milhavet O, Lehmann S. Oxidative stress and the prion protein in transmissible spongiform encephalopathies. Brain Res 2002; 38: 328-39
55. Saez-Valero J, Angeretti N, Forloni G. Caspase-3 activation by beta-amyloid and prion protein peptides is independent from their neurotoxic effect. Neurosci Lett 2000; 293: 207-10
56. Schroder HC, Muller WE. Neuroprotective effect of flupirtine in prion disease. Drugs Today 2002; 38: 49-58
57. Masullo C, Macchi G, Xi YG, Pocchiari M. Failure to ameliorate Creutzfeldt-Jakob disease with amphotericin B therapy. J Infect Dis 1992; 165: 784-5
58. Dormont D, Yeramian P, Lambert P et al. In vitro and in vivo effects of HPA 23. In: Dormont D, Court LA, Brown P, Kingsbury D. (eds) Unconventional virus diseases of the central nervous system. Fontenay aux Roses: CEA-Diffusion, 1989; 324-8
59. Schenk D, Barbour R, Dunn W et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999; 400: 173-7
60. Peretz D, Wiliamson RA, Kaneko K et al. Antibodies inhibit prion propagation and clear cell cultures of prion infectivity. Nature 2001; 412: 739-43
61. Enari E, Flechsig E, Weissmann C. Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody. Proc Natl Acad Sci USA 2001; 98: 9295-9
62. Heppner FL, Mushal C, Arrighi I et al. Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science 2001; 294: 178-82
63. Sigurdsson EM, Sy MS, Li R et al. Anti-prion antibodies for prophylaxis following prion exposure in mice. Neurosci Lett 2003; 336: 185-7
64. White AR, Enever P, Tayebi M et al. Monoclonal antibodies inhibit prion replication and delay the development of prion disease. Nature 2003; 422: 80-3
65. Sethi S, Lipford G, Wagner H, Kretzschmar H. Postexposure prophylaxis against prion disease with a stimulator of innate immunity. Lancet 2002; 360: 229-30