Radiation-induced apoptosis mediated by retinoblastoma protein

Cancer Research

Volumn 58, Issue 15, 1998, Pages 3275-3281

  Bowen, Cai ^a   Spiegel, Sarah ^b   Gelmann, Edward P ^a,b  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOBLASTOMA PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; GAMMA RADIATION; GENE EXPRESSION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; RADIATION INJURY; SIGNAL TRANSDUCTION;

APOPTOSIS; CASPASE 3; CASPASES; CYSTEINE ENDOPEPTIDASES; ENZYME ACTIVATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; ONCOGENE PROTEIN P65(GAG-JUN); PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN KINASES; RETINOBLASTOMA PROTEIN; SERINE ENDOPEPTIDASES; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032146778     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Kerr, J. F. R., Wyllie, A. H., and Currie, A. R. Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br. J. Cancer, 26: 239-257, 1972.
2. Wyllie, A. H., Kerr, J. F. R., and Currie, A. R. Cell death: the significance of apoptosis. Int. Rev. Cytol., 68: 251-306, 1980.
3. Jarvis, W. D., Grant, S., and Kolesnick, R. N. Ceramide and the induction of apoptosis. Clin. Cancer Res., 2: 1-6, 1996.
4. Yarnold, J. Molecular aspects of cellular responses to radiotherapy. Radiother. Oncol., 44: 1-7, 1997.
5. Simonian, P. L., Grillot, D. A., and Nunez, G. Bcl-2 and Bcl-XL can differentially block chemotherapy-induced cell death. Blood, 90: 1208-1216, 1997.
6. Muscarella, D. E., and Bloom, S. E. Involvement of gene-specific DNA damage and apoptosis in the differential toxicity of mitomycin C analogs towards B-lineage versus T-lineage lymphoma cells. Biochem. Pharmacol., 53: 811-822, 1997.
7. Gruber, J., and Greil, R. Apoptosis and therapy of malignant diseases of the hematopoietic system. Int. Arch. Allergy Immunol., 105: 368-373, 1994.
8. Gangemi, R. M., Tiso, M., Marchetti, C., Severi, A. B., and Fabbi, M. Taxol cytotoxicity on human leukemia cell lines is a function of their susceptibility to programmed cell death. Cancer Chemother. Pharmacol., 36: 385-392, 1995.
9. Knudsen, E. S., and Wang, J. Y. Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation. Mol. Cell. Biol., 17: 5771-5783, 1997.
10. Haas-Kogan, D. A., Kogan, S. C., Levi, D., Dazin, P., T'Ang, A., Fung, Y. K., and Israel, M. A. Inhibition of apoptosis by the retinoblastoma gene product. EMBO J., 14: 461-472, 1995.
11. Fan, G., Ma, X., Kren, B. T., and Steer, C. J. The retinoblastoma gene product inhibits TGF-beta1 induced apoptosis in primary rat hepatocytes and human HuH-7 hepatoma cells. Oncogene, 12: 1909-1919, 1996.
12. Morana, S. J., Wolf, C. M., Li, J., Reynolds, J. E., Brown, M. K., and Eastman, A. The involvement of protein phosphatases in the activation of ICE/CED-3 protease intracellular acidification, DNA digestion, and apoptosis. J. Biol. Chem., 271: 18263-18271, 1996.
13. An, B., and Dou, Q. P. Cleavage of retinoblastoma protein during apoptosis: an interleukin 1 beta-converting enzyme-like protease as candidate. Cancer Res., 56: 438-442, 1996.
14. Haupt, Y., Rowan, S., and Oren, M. p53 mediated apoptosis in HeLa cells can be overcome by excess pRB. Oncogene, 10: 1563-1571, 1995.
15. Berry, D. E., Lu, Y., Schmidt, B., Fallon, P. G., O'Connell, C., Hu, S. X., Xu, H. J., and Blanck, G. Retinoblastoma protein inhibits IFN-γ induced apoptosis. Oncogene, 12: 1809-1819, 1996.
16. Phillips, S. M., Barton, C. M., Lee, S. J., Morton, D. G., Wallace D. M., Lemoine, N. R., and Neoptolemos, J. P. Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis. Br. J. Cancer, 70: 1252-1257, 1994.
17. Tricoli, J. V., Gumerlock, P. H., Yao, J. L., Chi, S. G., D'Souza, S. A., Nestok, B. R., and deVereWhite, R. W. Alterations of the retinoblastoma gene in human prostate adenocarcinoma. Genes Chromosomes Cancer, 15: 108-114, 1996.
18. Bookstein, R., Shew, J., Chen, P., Scully, P., and Lee, W. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science (Washington DC), 247: 712-715, 1990.
19. Stone, K. R., Mickey, D. D., Wunderli, H., Mickey, G. H., and Paulson, D. F. Isolation of human prostatic carcinoma cell line (DU-145). J. Natl. Cancer Inst., 21: 274-281, 1978.
20. Berchem, G. J., Bosseler, M., Sugars, L. Y., Voeller, H. J., Zeitlin, S., and Gelmann, E. P. Androgens induce resistance to bcl-2-mediated apoptosis in LNCaP prostate cancer cells. Cancer Res., 55: 735-738, 1995.
21. Ormerod, M. G., Collins, M. K., Rodriguez-Tarduchy, G., and Robertson D. Apoptosis in interleukin-3-dependent haemopoietic cells. J. Immunol. Methods, 153: 57-65, 1992.
22. Chiu, L., Cherwinski, H., Ransom, J., and Dunne, J. F. Flow cytometric ratio analysis of the Hoechst 33342 emission spectrum: multiparametric characterization of apoptotic lymphocytes. J. Immunol. Methods, 189: 157-171, 1996.
23. Kolesnick, R. N., Haimovitz-Friedman, A., and Fuks, Z. The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation. Biochem. Cell Biol., 72: 471-474, 1994.
24. Haimovitz-Friedman, A., Kan, C. C., Ehleiter, D., Persaud, R. S., McLoughlin, M., Fuks, Z., and Kolesnick, R. N. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J. Exp. Med., 180: 525-535, 1994.
25. Spiegel, S., Foster, D., and Kolesnick, R. Signal transduction through lipid second messengers. Curr. Opin. Cell Biol., 8: 159-167, 1996.
26. Oliverio, S., Amendola, A., DiSano, F., Farrace, M. G., Fesus, L., Nemes, Z., Piredda, L., Spineda, A., and Piacentini, M. Tissue transglutaminase-dependent porttranslational modification of the retinoblastoma gene product in promonocytic cells undergoing apoptosis. Mol. Cell. Biol., 17: 6040-6048, 1997.
27. Obeid, L. M., Linardic, C. M., Karoloak, L. A., and Hannun, Y. A. Programmed cell death by ceramide. Science (Washington DC), 259: 1628-1639, 1993.
28. Almasan, A., Yin, Y., Lee, R. E. K., Bradley, A., Li, W., Bertino, J. R., and Wahl, G. M. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc. Natl. Acad. Sci. USA, 92: 5436-5440, 1995.
29. Nicholson, D. W., Ali, A., Thomberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., and Lazebnik, Y. A. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature (Lond.), 376: 37-43, 1995.
30. Tewari, M., Quan, L. T., O'Rourke, K., Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvesen, G. S., and Dixit, V. M. Yama/CPP32 β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell, 81: 801-809, 1995.
31. Duan, H., Chinnaiyan, A. M., Hudson, P. L., Wing, J. P., He, W. W., and Dixit, V. M. ICE-LAP3 a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas-and tumor necrosis factor-induced apoptosis. J. Biol. Chem., 271: 1621-1625, 1996.
32. Orth, K., O'Rourke, K., Salvesen, G. S., and Dixit, V. M. Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases. J. Biol. Chem., 271: 20977-20980, 1996.
33. Weaver, V. M., Lach, B., Walker, P. R., and Sikorska, M. Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes. Biochem. Cell Biol., 71: 488-500, 1993.
34. Yoshida, A., Takauji, R., Inuzuka, M., Ueda, T., and Nakamura, T. Role of serine and ICE-like proteases in induction of apoptosis by etoposide in human leukemia HL-60 cells. Leukemia (Baltimore), 10: 821-824, 1996.
35. Kwo, P., Patel, T., Bronk, S. F., and Gores, G. J. Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes. Am. J. Physiol., 268: G613-G621, 1995.
36. Adjei, P. N., Kaufmann, S. H., Leung, W., Mao, F., and Gores, G. J. Selective induction of apoptosis in Hep 3B cells by topoisomerase 1 inhibitors: evidence for a protease-dependent pathway that does not activate cysteine protease P32. J. Clin. Invest., 98: 2588-2596, 1996.
37. Antoku, K., Liu, Z., and Johnson, D. E. Inhibition of caspase proteases by CrmA enhances the resistance of human leukemic cells to multiple chemotherapeutic agents. Leukemia (Baltimore), 11: 1665-1672, 1997.
38. Chen, Y., Wang, X., Templeton, D., Davis, R. J., and Tan, T. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation. J. Biol. Chem., 271: 31929-31936, 1996.
39. Chen, Y. R., Meyer, C. F., and Tan, T. H. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis. J. Biol. Chem., 271: 631-634, 1996.
40. Verheij, M., Bose, R., Lin, X. H., Yao, B., Jarvis, W. D., Grant, S., Birrer, M. J., Szabo, E., Zon, L. I., Kyriakis, J. M., Haimovitz-Friedman, A., Fuks, Z., and Kolesnick, R. N. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature (Lond.), 380: 75-79, 1996.
41. McConkey, D. J., Goodrich, D., Bucana, C., and Klostergaard, J. The human retino-blastoma gene product suppress ceramide-induced apoptosis in human bladder tumor cells. Oncogene, 13: 1693-1700, 1996.
42. Jin, S., Kharbanda, S., Mayer, B., Kufe, D., and Weaver, D. T. Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit. J. Biol. Chem., 272; 24763-24766, 1997.
43. Yuan, Z. M., Huang, Y., Fan, M. M., Sawyers, C., Kharbanda, S., and Kufe, D. Genotoxic drugs induce interaction of the c-Abl tyrosine kinase and the tumor suppressor protein p53. J. Biol. Chem., 271: 26457-26460, 1996.
44. Dbaibo, G. S., Pushkareva, M. Y., Jayadev, S., Schwarz, J. K., Horowitz, J. M., Obeid, L. M., and Hannun, Y. A. Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc. Natl. Acad. Sci. USA, 92: 1347-1351, 1995.
45. Salvesan, G. S., and Dixit, V. M. Caspases: intracellular signaling by proteolysis. Cell, 91: 443-446, 1997.
46. Algan, O., Stobbe, C. C., Helt, A. M., Hanks, G. E., and Chapman, J. D. Radiation inactivation of human prostate cancer cells: the role of apoptosis. Radiat. Res., 146: 267-275, 1996.
47. Isaacs, W. B., Carter, B. S., and Ewing, C. M. Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles. Cancer Res., 51: 4716-4720, 1991.
48. Carroll, A. G., Voeller, H. J., Winkfield, B., Winstead, G., Wilding, G., and Gelmann, E. P. p53 Mutations in human prostate cancer cell lines and prostate tissues. J. Urol., 147: 216A, 1992.
49. Hardin, J. A., Sherr, D. H., DeMaria, M., and Lopez, P. A. A simple fluorescence method for surface antigen phenotyping of lymphocytes undergoing DNA fragmentation. J. Immunol. Methods, 154: 99-107, 1992.
50. Edsall, L. C., Pirianov, G. G., and Spiegel, S. Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation. J. Neurosci., 17: 6952-6960, 1997.