Ablation of p21waf1cip1 expression enhances the capacity of p53-deficient human tumor cells to repair UVB-induced DNA damage

Cancer Research

Volumn 61, Issue 9, 2001, Pages 3781-3786

  Therrien, Jean Philippe ^a   Loignon, Martin ^b   Drouin, Régen ^a   Drobetsky, Elliot A ^b  

^a UNIVERSITÉ LAVAL   (Canada)

^b MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; CYCLOBUTANE; PROTEIN C JUN; PROTEIN P21; PROTEIN P53; PYRIMIDINE DIMER;

ADENOCARCINOMA; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL STRAIN; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EXCISION REPAIR; GENE EXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION MUTAGENESIS; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; ULTRAVIOLET B RADIATION;

ADENOCARCINOMA; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA DAMAGE; DNA REPAIR; DNA, NEOPLASM; GENES, JUN; HUMANS; POLYMERASE CHAIN REACTION; PYRIMIDINE DIMERS; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 0035328786     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma
2. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers
3. DNA repair protects against cutaneous and internal neoplasia: Evidence from xeroderma pigmentosum
4. Molecular mechanism of nucleotide excision repair
5. Human cells compromised for p53 function exhibit defective global and transcription-coupled nucleotide excision repair, whereas cells compromised for pRb function are defective only in global repair
6. Decreased DNA repair efficiency by loss or disruption of p53 function preferentially affects removal of cyclobutane pyrimidine dimers from non-transcribed strand and slow repair sites in transcribed strand
7. Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts
8. Human fibroblasts expressing the human papillomavirus E6 gene are deficient in global genomic nucleotide excision repair and sensitive to ultraviolet irradiation
9. Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance
10. Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair
11. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
12. Wild-type human p53 transactivates the human proliferating cell nuclear antigen promoter
13. Inhibition of DNA replication factor RPA by p53
14. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen
15. p53 modulation of TFIIH-associated nucleotide excision repair activity
16. p53-dependent G1 arrest involves pRb-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein
17. Proliferating cell nuclear antigen is required for DNA excision repair
18. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
19. Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair
20. Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
21. Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21
22. The C-terminal domain of p21 inhibits nucleotide excision repair in vitro and in vivo
23. Repair defect in p21 waf1/cip1-/-human cancer cells
24. Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells
25. p53-mediated DNA repair responses to UV radiation: Studies of mouse cells lacking p53, p21, and/or gadd45 genes
26. Sunlight and sunburn in human skin cancer: P53, apoptosis, and tumor promotion
27. Genetic determinants of p53-induced apoptosis and growth arrest
28. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
29. Ligation-mediated PCR for analysis of UV damage
30. DNA repair domains within a human gene: Selective repair of sequences near the transcription initiation site
31. Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer
32. Waf1/cip1 is induced in p53-mediated G1 arrest and apoptosis
33. Expression of p21waf1/cip1 is heterogeneous and unrelated to proliferation index in human ovarian carcinoma
34. p53 expression overcomes p21waf1/cip1-mediated G1 arrest and induces apoptosis in human cancer cells
35. A p53-independent pathway for induction of p21waf1cip1 and concomitant G1 arrest in UV-irradiated human skin fibroblasts
36. UV induces p21waf1/cip1 protein in keratinocytes without p53
37. UV radiation is a transcriptional inducer of p21(cip1/waf1) cyclin-kinase inhibitor in a p53-independent manner
38. Inhibition of RNA polymerase II as a trigger for the p53 response
39. Persistent DNA damage induced by ultraviolet light inhibits p21waf1 and bax expression: Implications for DNA repair. UV sensitivity and the induction of apoptosis
40. Blockage of RNA polymerase as a possible trigger for UV light-induced apoptosis
41. Mutations of GTBP in genetically unstable cells
42. Transcription-coupled repair deficiency and mutations in human mismatch repair genes
43. Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2, in transcription-coupled repair
44. Polymorphisms and probable lack of mutation in the waf1/cip1 gene in colorectal cancer
45. Absence of waf1 mutations in a variety of human malignancies
46. Molecular analysis of the cip1/waf1 (p21) gene in diverse types of human tumors