Targeting the Mycobacterium tuberculosis 30/32-kDa mycolyl transferase complex as a therapeutic strategy against tuberculosis: Proof of principle by using antisense technology

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 24, 2002, Pages 15614-15619

  Harth, Günter ^a   Horwitz, Marcus A ^a   Tabatadze, David ^b   Zamecnik, Paul C ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Drug design; Inhibition of translation initiation; mRNA secondary structure; Phosphorothioate oligodeoxyribonucleotides

Indexed keywords

ALANINE RACEMASE; ANTISENSE OLIGODEOXYNUCLEOTIDE; GLUTAMATE AMMONIA LIGASE; MYCOLYLTRANSFERASE; PHOSPHOROTHIOIC ACID; TRANSFERASE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BIOTECHNOLOGY; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME INHIBITION; GENE TARGETING; GENETIC CODE; GENETIC TRANSCRIPTION; GROWTH INHIBITION; MOLECULAR WEIGHT; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECONDARY STRUCTURE; SEQUENCE ANALYSIS; TUBERCULOSIS;

ACYLTRANSFERASES; ALANINE RACEMASE; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CARRIER PROTEINS; CELL DIVISION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION, BACTERIAL; GLUTAMATE-AMMONIA LIGASE; MULTIENZYME COMPLEXES; MYCOBACTERIUM TUBERCULOSIS; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; RNA, BACTERIAL; RNA, MESSENGER; THIONUCLEOTIDES; TIME FACTORS; TRANSCRIPTION, GENETIC; TUBERCULOSIS;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 0037180534     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.242612299     Document Type: Article

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