Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades

Biochemical Pharmacology

Volumn 56, Issue 3, 1998, Pages 269-277

  Lopez Ilasaca, Marco ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

G proteins; growth factors; MAP kinase; PI 3 kinase; SAPK JNK; tyrosine kinases

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITIDE; PHOSPHOTRANSFERASE; PROTEIN SERINE THREONINE KINASE; TYROSINE KINASE RECEPTOR;

ENZYME ACTIVATION; HUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0031714391     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00059-8     Document Type: Article

References (63)

1. Schlessinger J, Ullrich A. Growth factor signaling by receptor tyrosine kinases. Neuron. 9:1992;383-391.
2. Fantl WJ, Johnson DE, Williams LT. Signaling by receptor tyrosine kinases. Annu Rev Biochem. 62:1993;453-481.
3. Post GR, Brown JH. G protein-coupled receptors and signaling pathways regulating growth responses. FASEB J. 10:1996;741-749.
4. Cano E, Mahadevan LC. Parallel signal processing among mammalian MAPKs. Trends Biochem Sci. 20:1995;117-122.
5. Cohen P. The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Biochem Sci. 7:1997;353-361.
6. Denhardt DT. Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell The potential for multiplex signaling . Biochem J. 318:1996;729-747.
7. Salcini AE, McGlade J, Pelicci G, Nicoletti I, Pawson T, Pelicci PG. Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins. Oncogene. 9:1994;2827-2836.
8. Erpel T, Courtneidge SA. Src family protein tyrosine kinases and cellular signal transduction pathways. Curr Opin Cell Biol. 7:1995;176-182.
9. Watson S, Arkinstall S. The G-Protein Linked Receptor Facts Book. 1994;Academic Press, London.
10. i subfamily of G protein α subunits. Cell. 86:1996;445-452.
11. Neer EJ. Intracellular signaling Turning down G-protein signals . Curr Biol. 7:1997;31-33.
12. Baffy G, Yang L, Raj S, Manning DR, Williamson JR. G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts. J Biol Chem. 269:1994;8483-8487.
13. Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller G, Marmé D, Rapp UR. Protein kinase Cα activates RAF-1 by direct phosphorylation. Nature. 364:1993;249-252.
14. Cook SJ, McCormick F. Kinetic and biochemical correlation between sustained p44ERK1 activation and lysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells. Biochem J. 320:1996;237-245.
15. Faure M, Voyno-Yasenetskaya TA, Bourne HR. cAMP and βγ subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J Biol Chem. 269:1994;7851-7854.
16. Crespo P, Xu N, Simonds WF, Gutkind JS. Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits. Nature. 369:1994;418-420.
17. Lemmon MA, Ferguson KM, Schlessinger J. PH domains Diverse sequences with a common fold recruit signaling molecules to the cell surface . Cell. 85:1996;621-624.
18. Gibson TJ, Hyvonen M, Musacchio A, Saraste M, Birney E. PH domains. Trends Biochem Sci. 19:1994;349-353.
19. van Biesen T, Hawes BE, Luttrell DK, Krueger KM, Touhara K, Porfiri E, Sakaue M, Luttrell LM, Lefkowitz RJ. Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway. Nature. 376:1995;781-784.
20. Daub H, Weiss FU, Wallasch C, Ullrich A. Role of transactivation of the EGF receptor in signaling by G-protein-coupled receptors. Nature. 379:1996;557-560.
21. Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ Science. 275:1997;394-397.
22. ras pathway. J Biol Chem. 269:1994;645-651.
23. Cazaubon SM, Ramos-Morales F, Fischer S, Schweighoffer F, Strosberg AD, Couraud P-O. Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes. J Biol Chem. 269:1994;24805-24809.
24. Ohmichi M, Sawada T, Kanda Y, Koike K, Hirota K, Miyake A, Saltiel AR. Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation. J Biol Chem. 269:1994;3783-3788.
25. Chen Y, Grall D, Salcini AE, Pelicci PG, Pouysségur J, Van Obberghen-Schilling E. Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor. EMBO J. 15:1996;1037-1044.
26. Touhara K, Hawes BE, van Biesen T, Lefkowitz RJ. G protein βγ subunits stimulate phosphorylation of Shc adapter protein. Proc Natl Acad Sci USA. 92:1995;9284-9287.
27. Ptasznik A, Traynor-Kaplan A, Bokoch GM. G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase · Shc adapter protein signaling complexes. J Biol Chem. 270:1995;19969-19973.
28. c-src in vascular smooth muscle cells. Circ Res. 77:1995;1053-1059.
29. Luttrell LM, Hawes BE, van Biesen T, Luttrell DK, Lansing TJ, Lefkowitz RJ. Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gβγ subunit-mediated activation of mitogen-activated protein kinases. J Biol Chem. 271:1996;19443-19450.
30. Langhans-Rajasekaran SA, Wan Y, Huang X-Y. Activation of Tsk and Btk tyrosine kinases by G protein βγ subunits. Proc Natl Acad Sci USA. 92:1995;8601-8605.
31. Rivard N, McKenzie FR, Brondello J-M, Pouysségur J. The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G protein-coupled receptors. J Biol Chem. 270:1995;11017-11024.
32. Li RY, Gaits F, Ragab A, Ragab-Thomas JMF, Chap H. Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein. EMBO J. 14:1995;2519-2526.
33. Zwick E, Daub H, Aoki N, Yamaguchi-Aoki Y, Tinhofer I, Maly K, Ullrich A. Critical role of calcium-dependent epidermal growth factor receptor transactivation in PC12 cell membrane depolarization and bradykinin signaling. J Biol Chem. 272:1997;24767-24770.
34. Clark EA, Brugge JS. Integrins and signal transduction pathways The road taken . Science. 268:1995;233-239.
35. Dikic I, Tokiwa G, Lev S, Courtneidge SA, Schlessinger J. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature. 383:1996;547-550.
36. Tokiwa G, Dikic I, Lev S, Schlessinger J. Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science. 273:1996;792-794.
37. q-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. J Biol Chem. 272:1997;19125-19132.
38. Coso OA, Chiariello M, Yu JC, Teramoto H, Crespo P, Xu N, Miki T, Gutkind JS. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell. 81:1995;1137-1146.
39. Minden A, Lin A, Claret FX, Abo A, Karin M. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell. 81:1995;1147-1157.
40. Coso OA, Teramoto H, Simonds WF, Gutkind JS. Signaling from G protein-coupled receptors to c-Jun kinase involves βγ subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway. J Biol Chem. 271:1996;3963-3966.
41. q/11 subunits. J Biol Chem. 272:1997;27771-27777.
42. 12 to the serum response element and to cellular transformation. Proc Natl Acad Sci USA. 94:1997;10098-10103.
43. Ridley AJ. Rho Theme and variations . Curr Biol. 6:1996;1256-1264.
44. Toker A, Cantley LC. Signaling through the lipid products of phosphoinositide-3-OH kinase. Nature. 387:1997;673-676.
45. Vanhaesebroeck B, Leevers SJ, Panayotou G, Waterfield MD. Phosphoinositide 3-kinases A conserved family of signal transducers . Trends Biochem Sci. 22:1997;267-272.
46. Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD. A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. EMBO J. 14:1995;3339-3348.
47. Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M, Malek D, Stoyanova S, Vanhaesebroeck B, Dhand R, Nürnberg B, Gierschik P, Seedorf K, Hsuan JJ, Waterfield MD, Wetzker R. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science. 269:1995;690-693.
48. Stephens LR, Eguinoa A, Erdjument-Bromage H, Lui M, Cooke F, Coadwell J, Smrcka AS, Thelen M, Cadwallader K, Tempst P, Hawkins PT. The Gβγ sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell. 89:1997;105-114.
49. Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature. 370:1994;527-532.
50. Rubio I, Rodriguez-Viciana P, Downward J, Wetzker R. Interaction of Ras with phosphoinositide 3-kinase γ Biochem J. 326:1997;891-895.
51. Roche S, Koegl M, Courtneidge SA. The phosphatidylinositol 3-kinase α is required for DNA synthesis induced by some, but not all, growth factors. Proc Natl Acad Sci USA. 91:1994;9185-9189.
52. lyn which interact with the effector molecules phospholipase C-γ2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase. Mol Cell Biol. 13:1993;5877-5887.
53. Grand RJ, Turnell AS, Grabham PW. Cellular consequences of thrombin-receptor activation. Biochem J. 313:1996;353-368.
54. Kucera GL, Rittenhouse SE. Human platelets form 3-phosphorylated phosphoinositides in response to α-thrombin, U46619, or GTPγS. J Biol Chem. 265:1990;5345-5348.
55. fyn in human platelets. Mol Cell Biol. 10:1990;3806-3809.
56. Guinebault C, Payrastre B, Sultan C, Mauco G, Breton M, Levy-Toledano S, Plantavid M, Chap H. Tyrosine kinases and phosphoinositide metabolism in thrombin-stimulated human platelets. Biochem J. 292:1993;851-856.
57. 3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins. Cell. 83:1995;821-830.
58. Ferby IM, Waga I, Hoshino M, Kume K, Shimizu T. Wortmannin inhibits mitogen-activated protein kinase activation by platelet-activating factor through a mechanism independent of p85/p110-type phosphatidylinositol 3-kinase. J Biol Chem. 271:1996;11684-11688.
59. 2 activation in CHO cells carrying somatostatin receptor Wortmannin-sensitive pathway to activate mitogen-activated protein kinase . Biochem Biophys Res Commun. 205:1994;18-23.
60. Nishioka N, Hirai S, Mizuno K, Osada S, Suzuki A, Kosaka K, Ohno S. Wortmannin inhibits the activation of MAP kinase following vasopressin V1 receptor stimulation. FEBS Lett. 377:1995;393-398.
61. Hawes BE, Luttrell LM, van Biesen T, Lefkowitz RJ. Phosphatidylinositol 3-kinase is an early intermediate in the Gβγ-mediated mitogen-activated protein kinase signaling pathway. J Biol Chem. 271:1996;12133-12136.
62. Kurosu H, Maehama T, Okada T, Yamamoto T, Hoshino S, Fukui Y, Ui M, Hazeki O, Katada T. Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide. J Biol Chem. 272:1997;24252-24256.
63. i-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc. EMBO J. 16:1997;3097-3105.