A Growing Family of Receptor Genes for Lysophosphatidic Acid (LPA) and other Lysophospholipids (LPs)

Cell Biochemistry and Biophysics

Volumn 30, Issue 2, 1999, Pages 213-242

  Chun, Jerold ^a,b   Contos, James J A ^a,c   Munroe, Donald ^d  

^a San Diego   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NPS Pharmaceutical Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; G PROTEIN COUPLED RECEPTOR; IMMEDIATE EARLY PROTEIN; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHOLIPID; LYSOPHOSPHOLIPID RECEPTOR; MESSENGER RNA; SERINE PROTEINASE; SITE 1 PROTEASE; SITE-1 PROTEASE;

BIOLOGICAL MODEL; BRAIN CORTEX; CHROMOSOME 4; CHROMOSOME MAP; GENETICS; HISTOLOGY; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYLOGENY; PHYSIOLOGY; REVIEW; TISSUE DISTRIBUTION;

BASE SEQUENCE; CEREBRAL CORTEX; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 4; HUMANS; IMMEDIATE-EARLY PROTEINS; LYSOPHOSPHOLIPIDS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PHYLOGENY; PROPROTEIN CONVERTASES; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LYSOPHOSPHATIDIC ACID; RECEPTORS, LYSOPHOSPHOLIPID; RNA, MESSENGER; SERINE ENDOPEPTIDASES; TISSUE DISTRIBUTION;

EID: 0032609751     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02738068     Document Type: Article

References (75)

1. Hecht, J. H., Weiner, J. A., Post, S. R., and Chun, J. (1996) Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex, J. Cell Biol. 135(4), 1071-1083.
2. Durieux, M. E., and Lynch, K. R. (1993) Signalling properties of lysophosphatidic acid, Trends Pharmacol. Sci. 14(6), 249-254.
3. Gaits, F., Fourcade, O., Le Balle, F., Gueguen, G., Gaig, B., Gassama-Diagne, A., Fauvel, J., Salles, J. P., Mauco, G., Simon, M. F., and Chap, H. (1997) Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis, FEBS Lett. 410(1), 54-58.
4. Moolenaar, W. H. (1995a) Lysophosphatidic acid signalling, Curr. Opin. Cell Biol. 7(2), 203-210.
5. Moolenaar, W. H. (1995b) Lysophosphatidic acid, a multifunctional phospholipid messenger, J. Biol. Chem. 270(22), 12,949-12,952.
6. Moolenaar, W. H., Jalink, K., and van Corven, E. J. (1992) Lysophosphatidic acid: a bioactive phospholipid with growth factor-like properties, Rev. Physiol. Biochem. Pharmacol. 119, 47-65.
7. Moolenaar, W. H., Kranenburg, O., Postma, F. R., and Zondag, G. C. (1997) Lysophosphatidic acid: G-protein signalling and cellular responses, Curr. Opin. Cell Biol. 9(2), 168-173.
8. Cuvillier, O., Pirianov, G., Kleuser, B., Vanek, P. G., Coso, O. A., Gutkind, S., and Spiegel, S. (1996) Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate, Nature 381(6585), 800-8003.
9. Edsall, L. C., Pirianov, G. G., and Spiegel, S. (1997) Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation, J. Neurosci. 17(18), 6952-6960.
10. Spiegel, S., and Merrill, A. H., Jr. (1996) Sphingolipid metabolism and cell growth regulation, Faseb. J. 10(12), 1388-1397.
11. Simon, M. F., Chap, H., and Douste-Blazy, L. (1982) Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: a new group of phospholipid mediators?, Biochem Biophys Res Commun 108(4), 1743-1750.
12. Sugiura, T., Tokumura, A., Gregory, L., Nouchi, T., Weintraub, S. T., and Hanahan, D. J. (1994) Biochemical characterization of the interaction of lipid phosphoric acids with human platelets: comparison with platelet activating factor, Arch. Biochem. Biophys. 311(2), 358-368.
13. Boulder Committee (1970) Embryonic vertebrate central nervous system: revised terminology., Anat. Rec. 166, 257-261.
14. Erickson, J. R., Wu, J. J., Goddard, J. G., Tigyi, G., Kawanishi, K., Tomei, L. D., and Kiefer, M. C. (1998) Edg-2/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid, J. Biol. Chem. 273(3), 1506-1510.
15. Fukushima, N., Kimura, Y., and Chun, J. (1998) A single receptor encoded by vzg-1/lpA1/edg-2 couples to G-proteins and mediates multiple cellular responses to lysophosphatidic acid (LPA)., Proc. Natl. Acad. Sci. USA. 95(11), 6151-6156.
16. Lee, M.-J., Van Brocklyn, J. R., Thangada, S., Liu, C. H., Hand, A. R., Menzeleev, R., Spiegel, S., and Hla, T. (1998) Sphingosine-1-Phosphate as a ligand for the G-protein coupled receptor EDG-1, Science 279, 1552-1555.
17. Zondag, G. C. M., Postma, F. R., van Etten, I., Verlaan, I., and Moolenaar, W. H. (1998) Sphingosine 1-phosphate singalling through the G-protein-coupled receptor Edg-1, Biochem. J. 330, 605-609.
18. Angevine, J., Jr., Bodian, D., Coulombre, A., Edds, M., Jr., Hamburger, V., Jacobson, M., Lyser, K., Prestige, M., Sidman, R., Varon, S., and Weiss, P. (1970) Embryonic vertebrate central nervous system: revised terminology, Anat. Rec. 166, 257-262.
19. Angevine, J. B., and Sidman, R. L. (1961) Autoradiographic study of cell migration during histogenesis of cerebral cortex in the mouse, Nature 192, 766-768.
20. Caviness, V. S., Jr., Takahashi, T., and Nowakowski, R. S. (1995) Numbers, time and neocortical neuronogenesis: a general developmental and evolutionary model, Trends Neurosci. 18(9), 379-383.
21. Rakic, P., Stensas, L., Sayre, E., and Sidman, R. (1974) Computer-aided three-dimensional reconstruction and quantitative analysis of cells from serial electron microscopic montages of foetal monkey brain., Nature 250(461), 31-34.
22. Sidman, R., Miale, I., and Feder, N. (1959) Cell proliferation and migration in the primitive ependymal zone; an autoradiographic study of histogenesis in the nervous system, Exp. Neurol. 1, 322-333.
23. Weiner, J. A., and Chun, J. (1997b) Png-1, a nervous system-specific zinc finger gene, identifies regions containing postmitotic neurons during mammalian embryonic development, J. Comp. Neurol. 381, 130-142.
24. Blaschke, A. J., Staley, K., and Chun, J. (1996) Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex, Development 122(4), 1165-1174.
25. Blaschke, A. J., Weiner, J. A., and Chun, J. (1998) Programmed cell death is a universal feature of neuroproliferative regions throughout the developing CNS, J. Comp. Neurol. 396(1), 39-50.
26. Chun, J., and Blaschke, A. J. (1997) Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR, in: Current Protocols in Neuroscience (J. N. e. a. Crawley, ed.) John Wiley and Sons, Inc., New York, pp. 3.8.1-3.8.19.
27. Staley, K., Blaschke, A. J., and Chun, J. J. M. (1997) Apoptotic DNA fragmentation is detected by a semi-quantitative ligation-mediated PCR of blunt DNA Ends, Cell Death and Diff. 4, 66-75.
28. Sauer, F. C. (1935) Mitosis in the neural tube, J Comp Neurol 62, 377-405.
29. Seymour, R. M., and Berry, M. (1975) Scanning and transmission electron microscope studies of interkinetic nuclear migration in the cerebral vesicles of the rat, J. Comp. Neurol. 160(1), 105-125.
30. Augusti-Tocco, G., and Sato, G. (1969) Establishment of functional clonal lines of neurons from mouse neuroblastoma, Proc. Natl. Acad. Sci. USA. 64, 312-315.
31. Klee, W. A., and Nirenberg, M. (1974) A neuroblastoma times glioma hybrid cell line with morphine receptors, Proc. Natl. Acad. Sci. USA 71, 3473-3477.
32. Greene, L. A. (1978) Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium, J. Cell Biol. 78(3), 747-755.
33. Greene, L. A., and Tischler, A. S. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor, Proc. Natl. Acad. Sci. USA 73(7), 2424-2428.
34. Chun, J., and Jaenisch, R. (1996) Clonal cell lines produced by infection of neocortical neuroblasts using multiple oncogenes transduced by retroviruses, Mol. Cell Neurosci. 7(4), 304-321.
35. Weiner, J. A., and Chun, J. (1997a) Maternally derived immunoglobulin light chain is present in the fetal mammalian CNS, J. Neursci. 17(9), 3148-3156.
36. Buck, L., and Axel, R. (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition, Cell 65(1), 175-187.
37. Libert, F., Parmentier, M., Lefort, A., Dinsart, C., Van Sande, J., Maenhaut, C., Simons, M. J., Dumont, J. E., and Vassart, G. (1989) Selective amplification and cloning of four new members of the G protein-coupled receptor family. Science 244(4904), 569-572.
38. Gensburger, C., Labourdette, G., and Sensenbrenner, M. (1987) Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro, FEBS Lett 217(1), 1-5.
39. Ghosh, A., and Greenberg, M. E. (1995) Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis, Neuron 15(1), 89-103.
40. Kilpatrick, T. J., and Bartlett, P. F. (1993) Cloning and growth of multipotential neural precursors: requirements for proliferation and differentiation, Neuron 10, 255-265.
41. Temple, S., and Qian, X. (1995) bFGF, neurotrophins, and the control or cortical neurogenesis, Neuron 15(2), 249-252.
42. Temple, S., and Davis, A. A. (1994) Isolated rat cortical progenitor cells are maintained in division in vitro by membrane-associated factors, Development 120(4), 999-1008.
43. An, S., Dickens, M. A., Bleu, T., Hallmark, O. G., and Goetzl, E. J. (1997b) Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid, Biochem. Biophys. Res. Commun. 231(3), 619-622.
44. Macrae, A. D., Premont, R. T., Jaber, M., Peterson, A. S., and Lefkowitz, R. J. (1996) Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain, Brain Res. Mol. Brain Res. 42(2), 245-254.
45. Liu, C. H., and Hla, T. (1997) The mouse gene for the inducible G-protein-coupled receptor edg-1, Genomics 43(1), 15-24.
46. Hla, T., and Maciag, T. (1990) An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors., J. Biol. Chem. 265(16), 9308-9313.
47. Lee, M. J., Evans, M., and Hla, T. (1996) The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway, J. Biol. Chem. 271(19), 11,272-11,279.
48. Hla, T., Jackson, A. Q., Appleby, S. B., and Maciag, T. (1995) Characterization of edg-2, a human homologue of the Xenopus maternal transcript GlO from endothelial cells, Biochim. Biophys. Acta. 1260(2), 227-229.
49. Hla, T., Zimrin, A. B., Evans, M., Ballas, K., and Maciag, T. (1997) The immediate-early gene product MAD-3/EDG-3/IkappaB alpha is an endogenous modulator of fibroblast growth factor-1 (FGF-1) dependent human endothelial cell growth, FEBS Lett. 414(2), 419-424.
50. Stella, N., Schweitzer, P., and Piomelli, D. (1997) A second endogenous cannabinoid that modulates long-term potentiation, Nature 388(6644), 773-778.
51. Lado, D. C., Browe, C. S., Gaskin, A. A., Borden, J. M., and MacLennan, A. J. (1994) Cloning of the rat edg-1 immediate-early gene: expression pattern suggests diverse functions, Gene 149(2), 331-336.
52. MacLennan, A. J., Browe, C. S., Gaskin, A. A., Lado, D. C., and Shaw, G. (1994) Cloning and characterization of a putative G-protein coupled receptor potentially involved in development, Mol. Cell Neurosci. 5(3), 201-209.
53. Masana, M. I., Brown, R. C., Pu, H., Gurney, M. E., and Dubocovich, M. L. (1995) Cloning and characterization of a new member of the G-protein coupled receptor EDG family, Receptors Channels 3(4), 255-262.
54. Okazaki, H., Ishizaka, N., Sakurai, T., Kurokawa, K., Goto, K., Kumada, M., and Takuwa, Y. (1993) Molecular cloning of a novel putative G protein-coupled receptor expressed in the cardiovascular system, Biochem. Biophys. Res. Commun. 190(3), 1104-1109.
55. Wilkie, T. M., Chen, Y., Gilbert, D. J., Moore, K. J., Yu, L., Simon, M. I., Copeland, N. G., and Jenkins, N. A. (1993) Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors, Genomics 18(2), 175-184.
56. Yamaguchi, F., Tokuda, M., Hatase, O., and Brenner, S. (1996) Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9, Biochem. Biophys. Res. Commun. 227(2), 608-614.
57. Abood, M. E., Ditto, K. E., Noel, M. A., Showalter, V. M., and Tao, Q. (1997) Isolation and expression of a mouse CB1 cannabinoid receptor gene. Comparison of binding properties with those of native CB1 receptors in mouse brain and N18TG2 neuroblastoma cells, Biochem. Pharmacol. 53(2), 207-214.
58. Mechoulam, R., Ben Shabat, S., Hanus, L., Fride, E., Vogel, Z., Bayewitch, M., and Sulcova, A. E. (1996) Endogenous cannabinoid ligands - chemical and biological studies, J. Lipid Mediat. Cell Signal 14(1-3), 45-49.
59. Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., and et al. (1995) Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors, Biochem. Pharmacol. 50(1), 83-90.
60. Yatomi, Y., Yamamura, S., Ruan, F., and Igarashi, Y. (1997) Sphingosine 1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid, J. Biol. Chem. 272(8), 5291-5297.
61. Postma, F. R., Jalink, K., Hengeveld, T., and Moolenaar, W. H. (1996) Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor, Embo. J. 15(10), 2388-2392.
62. An, S., Bleu, T., Huang, W., Hallmark, O. G., Coughlin, S. R., and Goetzl, E. J. (1997a) Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids, FEBS Lett. 417(3), 279-282.
63. Hooks, S. B., Ragan, S. P., Hopper, D. W., Hönemann, C. W., Durieux, M. E., Macdonald, T. L., and Lynch, K. R. (1998) Characterization of a receptor subtype-selective lysophosphatidic acid mimetic, Mol. Pharmacol. 53(2), 188-194.
64. Guo, Z., Liliom, K., Fischer, D. J., Bathurst, I. C., Tomei, L. D., Kiefer, M. C., and Tigyi, G. (1996) Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes, Proc. Natl. Acad. Sci. USA 93(25), 14,367-14,372.
65. Tokumura, A., Fukuzawa, K., and Tsukatani, H. (1978) Effects of synthetic and natural lysophosphatidic acids on the arterial blood pressure of different animal species, Lipids 13(8), 572-574.
66. Tokumura, A., Fukuzawa, K., Yamada, S., and Tsukatani, H. (1980) Stimulatory effect of lysophosphatidic acids on uterine smooth muscles of non-pregant rats, Arch. Int. Pharmacodyn. Ther. 245(1), 74-83.
67. Higgins, D. G., Thompson, J. D., and Gibson, T. J. (1996) Using CLUSTAL for multiple sequence alignments, Methods Enzymol. 266, 383-402.
68. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice, Nucleic Acids Res. 22(22), 4673-4680.
69. Feng, D. F., and Doolittle, R. F. (1996) Progressive alignment of amino acid sequences and construction of phylogenetic trees from them, Methods Enzymol. 266, 368-382.
70. Chun, J. (1999) Lysophospholipid receptors: Implications for Neural Signaling. Crit. Rev. Neurobiol. in press.
71. Dubin, A. E., Bahnson, T., Weiner, J. A., Fukushima, N., and Chun, J. (1999) Lysophosphatidic acid (LPA) stimulates neurotransmitter-like conductance changes that precede GABA and L-Glutamate in early, presumptive cortical neuroblasts. J. Neurosci. 19, 1371-1381.
72. A1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. J. Comp. Neurol.. 398, 587-598.
73. A1/vzg-1/Gpcr26. Genomics 51(3), 364-378.
74. Lee, M. J., Thangada, S., Liu, C. H., Thompson, B. D., and Hla, T. (1998) Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. J. Biol. Chem. 273(34), 22,105-22,112.
75. Zhang, G., Contos, J. J. A., Weiner, J. A., Fukushima, N., and Chun, J. (1999) Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene 227, 89-99.