FTY 720A mediates reduction of lymphocyte counts in human renal allograft recipients by an apoptosis-independent mechanism

Transplant International

Volumn 13, Issue SUPPL. 1, 2000, Pages

  Bohler T ^a   Waiser, J ^a   Schutz M ^a   Friedrich, M ^a   Schotschel R ^a   Reinhold, S ^a   Schmouder, R ^a,b   Budde, K ^a   Neumayer, H H ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Apoptosis; FTY 720A; Immunosuppression; Lymphopenia; Transplantation

Indexed keywords

DRUG DERIVATIVE; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; PLACEBO; PROPANEDIOL DERIVATIVE; SPHINGOSINE;

APOPTOSIS; ARTICLE; CLINICAL TRIAL; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HUMAN; IMMUNOLOGY; KIDNEY TRANSPLANTATION; LYMPHOCYTE; LYMPHOCYTE COUNT; PHASE 1 CLINICAL TRIAL;

APOPTOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; LYMPHOCYTE COUNT; LYMPHOCYTES; PLACEBOS; PROPYLENE GLYCOLS; SPHINGOSINE;

EID: 0000220111     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2000.tb02048.x     Document Type: Article

References (5)

1. Boehler T, Waiser J, Lichter S, Fritsche L, Budde K, Neumayer H-H (1998) SDZ RAD inhibits lymphocyte proliferation in human renal allograft recipients. Transplant Proc 204: 1854-1857
2. Chiba K, Hoshino Y, Suzuki C, Masubuchi Y, Yanagawa Y, Ohtsuki M, Sasaki S, Fujita T (1996) FTY 720, a novel immunosuppressant possessing unique mechanism I. Prolongation of skin allograft survival and synergistic effect in combination with cyclosporine in rat. Transplant Proc 28: 1056-1059
3. Chiba K, Yanagawa Y, Masubuchi Y, Kataoka H, Kawaguchi T, Ohtsuki M, Hoshino Y (1998) FTY 720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by accelerating of lymphocyte homing in rats. I. FTY 720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. 160: 5037-5044
4. Kiuchi M, Adachi K, Kohara T, Teshima K, Masabuchi Y, Mishina T, Fujita T (1998) S ynthesis and biological evaluation of 2,2-disubstituted 2-aminoethanols: analogues of FTY 720. 6: 101-106
5. Suzuki S, Enosawa S, Kakefuda T, Shinomia T, Amari M, Naoe S, Hoshino Y, Chiba K (1996) A novel immunosuppressant, FTY 720, having a unique mechanism of action induces long-term graft acceptance in rat and dog allotransplantation. Transplantation 61: 200-207