Magnetic resonance spectroscopy of neurotransmitters in human brain

Annals of Neurology

Volumn 54, Issue SUPPL. 6, 2003, Pages

  Novotny Jr , Edward J ^a   Fulbright, Robert K ^a   Pearl, Phillip L ^b   Gibson, K Michael ^c   Rothman, Douglas L ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; AMINO ACID RECEPTOR AFFECTING AGENT; GLUTAMATE RECEPTOR; GLUTAMIC ACID; GLUTAMINE; GLYCINE; NEUROTRANSMITTER;

BIOSYNTHESIS; BRAIN LEVEL; BRAIN MAPPING; BRAIN METABOLISM; BRAIN REGION; CONFERENCE PAPER; DIAGNOSTIC IMAGING; HUMAN; IMAGE ANALYSIS; ISOTOPE LABELING; MAGNETIC FIELD; MEASUREMENT; NEUROLOGIC DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEDIATRIC NEUROTRANSMITTER DISORDER; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TECHNIQUE; TURNOVER TIME;

BRAIN CHEMISTRY; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; GLYCINE; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; NEUROTRANSMITTER AGENTS;

EID: 0042868561     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.10697     Document Type: Conference Paper

References (50)

1. Rothman DL, Behar KL, Hetherington HP, Shulman RG. Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo. Proc Natl Acad Sci USA 1984;81:6330-6334.
2. Rothman DL, Hyder F, Sibson NR, et al. In vivo magnetic resonance spectroscopy studies of the glutamate and gaba neurotransmitter cycles and functional neuroenergetics. In: Davis KL, Charney DS, Coyle JT, Nemeroff C, eds. Neuropsychopharmacology: The Fifth Generation of Progress. Philadelphia: Lippincott, 2002:315-342.
3. Madden DR. The structure and function of glutamate receptor ion channels. Nat Rev Neurosci 2002;3:91-101.
4. Hermans E, Challiss RA. Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors. Biochem J 2001;359:465-484.
5. Danbolt NC, Chaudhry FA, Dehnes Y, et al. Properties and localization of glutamate transporters. Prog Brain Res 1998;116:23-43.
6. Danbolt NC. Glutamate uptake. Prog Neurobiol 2001;65:1-105.
7. Rothstein JD. Excitotoxicity hypothesis. Neurology 1996;47: S19-S25; discussion, S26.
8. Bergles DE, Diamond JS, Jahr CE. Clearance of glutamate inside the synapse and beyond. Curr Opin Neurobiol 1999;9:293-298.
9. Rothman DL, Hanstock CC, Petroff OA, et al. Localized 1H NMR spectra of glutamate in the human brain. Magn Reson Med 1992;25:94-106.
10. Pan JW, Mason GF, Pohost GM, Hetherington HP. Spectroscopic imaging of human brain glutamate by water-suppressed J-refocused coherence transfer at 4.1 T. Magn Reson Med 1996;36:7-12.
11. Pouwels PJ, Brockmann K, Kruse B, et al. Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS. Pediatric Res 1999;46:474-485.
12. Novotny E, Ashwal S, Shevell M. Proton magnetic resonance spectroscopy: an emerging technology in pediatric neurology research. Pediatr Res 1998;44:1-10.
13. Pan JW, Lane JB, Hetherington H, Percy AK. Rett syndrome: 1H spectroscopic imaging at 4.1 Tesla. J Child Neurol 1999;14:524-528.
14. Gruetter R, Novotny EJ, Boulware SD, et al. Localized 13C NMR spectroscopy in the human brain of amino acid labeling from D-[1-13C]glucose. J Neurochem 1994;63:1377-1385.
15. Mason GF, Gruetter R, Rothman DL, et al. Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR. J Cereb Blood Flow Metab 1995;15:12-25.
16. Lebon V, Petersen KF, Cline GW, et al. Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism. J Neurosci 2002;22:1523-1531.
17. Bluml S, Moreno A, Hwang JH, Ross BD. 1-(13)C glucose magnetic resonance spectroscopy of pediatric and adult brain disorders. NMR Biomed 2001;14:19-32.
18. Nicholls D, Attwell D. The release and uptake of excitatory amino acids. Trends Pharmacol Sci 1990;11:462-468.
19. Sibson NR, Dhankhar A, Mason GF, et al. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc Natl Acad Sci USA 1998;95:316-321.
20. Sokoloff L. Measurement of local cerebral glucose utilization and its relation to local functional activity in the brain. Adv Exp Med Biol 1991;291:21-42.
21. Attwell D, Laughlin SB. An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab 2001;21:1133-1145.
22. Magistretti PJ, Pellerin L, Rothman DL, Shulman RG. Energy on demand. Science 1999;283:496-497.
23. Pellerin L, Magistretti P. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci USA 1994;91:10625-10629.
24. Rothman DL, Howseman AM, Graham GD, et al. Localized proton NMR observation of [3-13C]lactate in stroke after [1-13C]glucose infusion. Magn Reson Med 1991;21:302-307.
25. Verleysdonk S, Martin H, Willker W, et al. Rapid uptake and degradation of glycine by astroglial cells in culture: synthesis and release of serine and lactate. Glia 1999;27:239-248.
26. Le Novere N, Changeux JP. The ligand gated ion channel database. Nucleic Acids Res 1999;27:340-342.
27. Belachew S, Malgrange B, Rigo JM, et al. Glycine triggers an intracellular calcium influx in oligodendrocyte progenitor cells which is mediated by the activation of both the ionotropic glycine receptor and Na+-dependent transporters. Eur J Neurosci 2000;12:1924-1930.
28. Gadea A, Lopez-Colome AM. Glial transporters for glutamate, glycine, and GABA III. Glycine transporters. J Neurosci Res 2001;64:218-222.
29. Moss SJ, Smart TG. Constructing inhibitory synapses. Nat Rev Neurosci 2001;2:240-250.
30. Heindel W, Kugel H, Roth B. Noninvasive detection of increased glycine content by proton MR spectroscopy in the brains of two infants with nonketotic hyperglycinemia. Am J Neuroradiol 1993;14:629-635.
31. Ment LR, Bada HS, Barnes P, et al. Practice parameter: neuroimaging of the neonate: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 2002;58:1726-1738.
32. Martin DL, Liu H, Martin SB, Wu SJ. Structural features and regulatory properties of the brain glutamate decarboxylases. Neurochem Int 2000;37:111-119.
33. Martin DL. Short-term control of GABA synthesis in brain. Prog Biophys Mol Biol 1993;60:17-28.
34. Wu Y, Wang W, Richerson GB. GABA transaminase inhibition induces spontaneous and enhances depolarization-evoked GABA efflux via reversal of the GABA transporter. J Neurosci 2001;21:2630-2639.
35. Sieghart W. Unraveling the function of GABA(A) receptor subtypes. Trends Pharmacol Sci 2000;21:411-413.
36. Bettler B, Kaupmann K, Bowery N. GABAB receptors: drugs meet clones. Curr Opin Neurobiol 1998;8:345-350.
37. Borden LA. GABA transporter heterogeneity: pharmacology and cellular localization. Neurochemistry Int 1996;29:335-356.
38. Martin DL, Rimvall K. Regulation of gamma-aminobutyric acid synthesis in the brain. J Neurochem 1993;60:395-407.
39. Rothman DL, Petroff OA, Behar KL, Mattson RH. Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo. Proc Natl Acad Sci USA 1993;90:5662-5666.
40. Petroff OA, Rothman DL, Behar KL, Mattson RH. Low brain GABA level is associated with poor seizure control. Ann Neurol 1996;40:908-911.
41. Novotny EJ Jr, Hyder F, Shevell M, Rothman DL. GABA changes with vigabatrin in the developing human brain. Epilepsia 1999;40:462-466.
42. Behar KL, Rothman DL, Petersen KF, et al. Preliminary evidence of low cortical GABA levels in localized 1H-MR spectra of alcohol-dependent and hepatic encephalopathy patients. Am J Psychiatry 1999;156:952-954.
43. Goddard AW, Mason GF, Almai A, et al. Reductions in occipital cortex GABA levels in panic disorder detected with 1H-magnetic resonance spectroscopy. Arch Gen Psychiatry 2001;58:556-561.
44. Jakobs C, Jaeken J, Gibson KM. Inherited disorders of GABA metabolism. J Inherit Metab Dis 1993;16:704-715.
45. Novotny EJ, de Graaf RA, Mason GF, et al. Brain GABA in SSADH deficiency. Abstracts of International Society of Magnetic Resonance in Medicine Eleventh Scientific Meeting; Toronto, Ontario, Canada, 2003.
46. Rothman DL, Behar KL, Prichard JW, Petroff OA. Homocarnosine and the measurement of neuronal pH in patients with epilepsy. Magn Reson Med 1997;38:924-929.
47. Petroff OA, Hyder F, Rothman DL, Mattson RH. Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures. Neurology 2001;56:709-715.
48. Novotny EJ Jr, Avison MJ, Herschkowitz N, et al. In vivo measurement of phenylalanine in human brain by proton nuclear magnetic resonance spectroscopy. Pediatr Res 1995;37:244-249.
49. de Graaf RA, Pan JW, Telang F, et al. Differentiation of glucose transport in human brain gray and white matter. J Cereb Blood Flow Metab 2001;21:483-492.
50. Tkac I, Andersen P, Adriany G, et al. In vivo 1H NMR spectroscopy of the human brain at 7 T. Magn Reson Med 2001;46:451-456.