Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures

Neurology

Volumn 56, Issue 6, 2001, Pages 709-715

  Petroff, Ognen A C ^a   Hyder, Fahmeed ^b   Rothman, Douglas L ^b   Mattson, Richard H ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; HOMOCARNOSINE; LAMOTRIGINE; PYROGLUTAMIC ACID; VALPROIC ACID;

ADULT; ARTICLE; CLINICAL ARTICLE; COMPLEX PARTIAL SEIZURE; DISEASE CONTROL; FEMALE; HUMAN; IN VIVO STUDY; MALE; MYOCLONUS EPILEPSY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEIZURE; VISUAL CORTEX;

EID: 0035957297     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.56.6.709     Document Type: Article

References (60)

1. Epilepsy and gamma-aminobutyric acid-mediated inhibition
2. Glutamate, GABA, and epilepsy
3. Neocortical neuronal diversity: Chemical heterogeneity revealed by colocalization studies of classical neurotransmitters, neuropeptides, calcium-binding proteins, and cell surface molecules
4. Inherited disorders of GABA metabolism
5. Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy
6. Altered GABA-mediated synaptic transmission in human epilepsy
7. Vigabatrin increases human brain homocarnosine and improves seizure control
8. Measuring human brain GABA in vivo: Effects of GABA-transaminase inhibition with vigabatrin
9. Low brain GABA level is associated with poor seizure control
10. New NMR measurements in epilepsy. Measuring brain GABA in patients with complex partial seizures
11. GABA levels in the brain: A target for new antiepileptic drugs
12. Carrier-mediated GABA release activates GABA receptors on hippocampal neurons
13. New antiepileptic drugs: Comparison of key clinical trials
14. Management of epilepsy in adolescents and adults
15. Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy
16. Acute effects of vigabatrin on brain GABA and homocarnosine in patients with complex partial seizures
17. Functional imaging in the epilepsies: Proton MRS: GABA & glutamate
18. Homocarnosinosis: Increased content of homocarnosine and deficiency of homocarnosinase in brain
19. Regional distribution of homocarnosine, homocarnosine-carnosine synthetase, and homocarnosinase in human brain
20. Localization of a novel pathway for the liberation of GABA in human CNS
21. Regional distribution of amino acids in human brain obtained at autopsy
22. Artifactual increases in the concentration of free GABA in samples of human cerebrospinal fluid are due to degradation of homocarnosine
23. Cerebrospinal fluid GABA and seizure control with vigabatrin
24. Increased homocarnosine is associated with improved seizure control
25. Effects of 2-pyrrolidone on the concentration of GABA in rat tissue
26. On the role of GABA in vertebrate polyamine metabolism
27. 2-Pyrrolidinone in human cerebrospinal fluid: A major constituent of total gamma-aminobutyric acid
28. 1H NMR measurements of 2-pyrrolidinone in human brain in vivo
29. Effects of gabapentin on brain GABA, homocarnosine, and pyrrolidinone in epilepsy
30. Levetiracetam for partial seizures: Results of a double-blind, randomized clinical trial
31. A comparison of valproate with carbamazepine for the treatment of partial seizures and secondarily generalized tonic clonic seizures in adults
32. Lamotrigine
33. Myoclonus and epilepsy in childhood: A review of treatment with valproate, ethosuximide, lamotrigine and zonisamide
34. Role of vigabatrin and lamotrigine in treatment of childhood epileptic syndromes
35. Valproate: A reappraisal of its pharmacodynamic properties and mechanisms of action
36. Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine, and GABA in patients with refractory complex partial seizures
37. Lamotrigine mechanisms of action
38. Analysis of CSF amino acids in young patients with generalized refractory epilepsy during an add-on study with lamotrigine
39. Acute and chronic alterations in human cerebral GABA levels in response to topiramate, lamotrigine, and gabapentin
40. Brain homocarnosine levels correlate with seizure control in patients with juvenile myoclonic epilepsy or complex partial seizures taking valproate or lamotrigine
41. Juvenile myoclonic epilepsy. A review
42. Juvenile myoclonic epilepsy
43. Improvements on an in vivo automated shimming method (FASTERMAP)
44. 1H NMR measurements of GABA levels in human brain in vivo
45. Homocarnosine and the measurement of neuronal pH in patients with epilepsy
46. Reflex seizures induced by intermittent light stimulation
47. Transcranial magnetic stimulation: Its current role in epilepsy research
48. Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans
49. EEG, drug effects, and central nervous system poisoning
50. Photosensitive epilepsy in man and the baboon
51. The photosensitive epilepsies of the baboon: A model of generalized reflex epilepsy
52. Cerebrospinal fluid amino acid and monoamine metabolite levels of Papio papio: Correlation with photosensitivity
53. A comparison of the acute effect of single doses of vigabatrin and sodium valproate on photosensitivity in epileptic patients
54. Preliminary evidence of reduced cortical GABA levels in localized 1-H-MR spectra of alcohol-dependent and hepatic encephalopathy patients
55. Enhanced excitability of the human visual cortex induced by short-term light deprivation
56. Carnosine modulates zinc and copper effects on amino acid receptors and synaptic transmission
57. Regulation of excitability in the epileptic human dentate gyrus
58. Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc
59. Zinc-induced collapse of augmented inhibition by GABA in temporal lobe epilepsy model