Structural features and regulatory properties of the brain glutamate decarboxylases

Neurochemistry International

Volumn 37, Issue 2-3, 2000, Pages 111-119

  Martin, David L ^a,b   Liu, Hongcheng ^a,b   Martin, Sandra B ^a   Wu, Susan J ^a  

^a WADSWORTH CENTER   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Domain; Glutamate decarboxylase; Proteolysis; Structure

Indexed keywords

GLUTAMATE DECARBOXYLASE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN METABOLISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GABAERGIC TRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; SYNAPTIC TRANSMISSION; TARGET CELL; VERTEBRATE;

ANIMALS; BRAIN; CEREBELLUM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUTAMATE DECARBOXYLASE; HYDROLYSIS; IMMUNOBLOTTING; ISOENZYMES; MALE; MASS SPECTROMETRY; MOLECULAR WEIGHT; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; TRYPSIN;

ANIMALIA; VERTEBRATA;

EID: 0034256926     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(00)00014-0     Document Type: Article

References (41)

1. Awapara J., Landua A.J., Fuerst R., Seale B. Free γ-aminobutyric acid in brain. J. Biol. Chem. 187:1950;35-39.
2. Bacq Z.M. Chemical Transmission of Nerve Impulses. 1975;1-106 Pergamon Press, Oxford.
3. Bu D.-F., Erlander M.G., Hitz B.C., Tillakaratne N.J.K., Kaufman D.L., Wagner-McPherson C.B., et al. Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. Proc. Natl. Acad. Sci. USA. 89:1992;2115-2119.
4. Chen C.-H., Wu S.J., Martin D.L. Structural characteristics of brain glutamate decarboxylase in relation to its interaction and activation. Arch. Biochem. Biophys. 349:1998;175-182.
5. 2-terminal domain. J. Cell Biol. 118:1992;309-320.
6. 2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase. J. Biol. Chem. 270:1995;2241-2246.
7. Erlander M.G., Tillakaratne N.J.K., Feldblum S., Patel N., Tobin A.J. Two genes encode distinct glutamate decarboxylases. Neuron. 7:1991;91-100.
8. Esclapez M., Tillakaratne N.J.K., Kaufman D.L., Tobin A.J., Houser C.R. Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms. J. Neurosci. 14:1994;1834-1855.
9. Esclapez M., Tillakaratne N.J.K., Tobin A.J., Houser C.R. Comparative localization of mRNAs encoding two forms of glutamic acid decarboxylase with nonradioactive in situ hybridization methods. J. Comp. Neurol. 331:1993;339-362.
10. Feldblum S., Erlander M.G., Tobin A.J. Different distributions of GAD65 and GAD67 mRNAs suggest that the two glutamate decarboxylases play different functional roles. J. Neurosci. Res. 34:1993;689-706.
11. Gold B.I., Roth R.H. Glutamate decarboxylase activity in striatal slices: characterization of the increase following depolarization. J. Neurochem. 32:1979;883-888.
12. Gold B.I., Simon J.R., Roth R.H. Glutamic acid decarboxylase activity in striatal slices: persistent increase following depolarization. Life Sci. 22:1978;187-194.
13. Hendrickson A.E., Tillakaratne N.J.K., Mehra R.D., Esclapez M., Erickson A., Vician L., Tobin A.J. Differential localization of two glutamic acid decarboxylases (GAD65 and GAD67) in adult monkey visual cortex. J. Comp. Neurol. 343:1994;566-581.
14. Henry S., Tappaz M. Relative enrichment of the lighter 59 kDa form of glutamic acid decarboxylase in nerve endings: an immunoblotting study in the pituitary neurointermediate lobe. Neurosci. Letts. 131:1991;253-256.
15. Itoh M., Uchimura H. Regional differences in cofactor saturation of glutamate decarboxylase (GAD) in discrete brain nuclei of the rat. Effect of repeated administration of haloperidol on GAD activity in substantia nigra. Neurochem. Res. 6:1981;1283-1289.
16. Kaufman D.L., Houser C.R., Tobin A.J. Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J. Neurochem. 56:1991;720-723.
17. Martin D.L. Mammalian brain glutamate decarboxylase. Boulton A.A., Baker G.B., Yu P.H. Neuromethods, Neurotransmitter Enzymes. vol. 5:1986;361-388 Humana Press, New Jersey.
18. 67 associated with specific pools of GABA in the brain? Perspectives on Dev. Neurobiol. 5:1998;119-129.
19. Martin D.L., Martin S.B., Wu S.J., Espina N. Regulatory properties of brain glutamate decarboxylase (GAD): the apoenzyme of GAD is present principally as the smaller of two molecular forms of GAD in brain. J. Neurosci. 11:1991;2725-2731.
20. Martin D.L., Rimvall K. Regulation of γ-aminobutyric acid synthesis in the brain. J. Neurochem. 60:1993;395-407.
21. McPhalen C.A., Vincent M.G., Picot D., Jansonius J.N., Lesk A.M., Chothia C. Domain closure in mitochondrial aspartate aminotransferase. Journal of Molecular Biology. 227:1992;197-213.
22. r 67,000) in the basal ganglia of the rat. J. Comp. Neurol. 318:1992;245-254.
23. Miller L.P., Walters J.R., Eng N., Martin D.L. Glutamate holodecarboxylase levels and the regulation of GABA synthesis. Brain Res. Bull. 5:(Suppl. 2):1980;89-94.
24. Miller L.P., Walters J.R., Martin D.L. Post-mortem changes implicate adenine nucleotides and pyridoxal-5′-phosphate in regulation of brain glutamate decarboxylase. Nature. 266:1977;847-848.
25. Momany C., Ernst S., Ghosh R., Chang N.L., Hackert M.L. Crystallographic structure of a PLP-dependent ornithine decarboxylase from Lactobacillus 30a to 3.0 A resolution. J. Mol. Biol. 252:1995;643-655.
26. Namchuk M., Lindsay L., Turck C.W., Kanaani J., Baekkeskov S. Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha. J. Biol. Chem. 272:1997;1548-1557.
27. Oertel W.H., Schmechel D.E., Tappaz M.L., Kopin I. Production of a specific antiserum to rat brain glutamic acid decarboxylase by injection of an antigen-antibody complex. Neurosci. 6:1981;2689-2700.
28. Qu K., Martin D.L., Lawrence C.E. Motifs and structural fold of the cofactor binding site of human glutamate decarboxylase. Protein Sci. 7:1998;1092-1105.
29. Reetz A., Solimena M., Matteoli M., Folli F., Takei K., DeCamilli P. GABA and pancreatic β-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion. EMBO J. 10:1991;1275-1284.
30. 67 protein is highly sensitive to small increases in intraneuronal gamma-aminobutyric acid levels. J. Neurochem. 62:1994;1375-1381.
31. Roberts E., Frankel S. γ-Aminobutyric acid in brain: its formation from glutamic acid. J. Biol. Chem. 187:1950;55-63.
32. Roberts E., Frankel S. Glutamic acid decarboxylase in brain. J. Biol. Chem. 188:1950;789-795.
33. Sheikh S.N., Martin D.L. Heteromers of glutamate decarboxylase isoforms occur in rat cerebellum. J. Neurochem. 66:1996;2082-2090.
34. Sheikh, S.N., Martin, S.B., Martin, D.L., 1999. Regional distribution and relative amounts of glutamate decarboxylase isoforms in rat and mouse brain. Neurochem. Intl. pp. 3573 - 3580.
35. Shi Y., Veit B., Baekkeskov S. Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65. J. Cell Biol. 124:1994;927-934.
36. Soghomonian J.-J., Martin D.L. Two isoforms of glutamate decarboxylase: why? Trends Pharmacol. Sci. 19:1998;500-505.
37. Solimena M., Aggujaro D., Muntzel C., Dirkx R., Butler M., DeCamilli P., Hayday A. Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region. Proc. Natl. Acad. Sci. USA. 90:1993;3073-3077.
38. Solimena M., Dirkx R. Jr, Radzynski M., Mundigl O., DeCamilli P. A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region. J. Cell Biol. 126:1994;331-341.
39. Udenfriend S. Identification of γ-aminobutyric acid in brain by the isotope derivative method. J. Biol. Chem. 187:1950;65-69.
40. Wingo W.J., Awapara J. Decarboxylation of L-glutamic acid by brain. J. Biol. Chem. 187:1950;267-271.
41. Wood J.G., McLaughlin B.J., Vaughn J.E. Immunocytochemical localization of GAD in electron microscopic preparations of rodent CNS. Roberts E., Chase T.N., Tower D.B. GABA in Nervous System Function. 1976;133-148 Raven Press, New York.