메뉴 건너뛰기




Volumn 15, Issue 4, 2003, Pages 474-481

Modulation of developmental signals by endocytosis: Different means and many ends

Author keywords

[No Author keywords available]

Indexed keywords

MORPHOGEN; NOTCH RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 0042767664     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(03)00072-3     Document Type: Review
Times cited : (50)

References (46)
  • 1
    • 0036341207 scopus 로고    scopus 로고
    • Signal transduction and endocytosis: Close encounters of many kinds
    • Sorkin A., Von Zastrow M. Signal transduction and endocytosis: close encounters of many kinds. Nat Rev Mol Cell Biol. 3:2002;600-614.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 600-614
    • Sorkin, A.1    Von Zastrow, M.2
  • 2
    • 0032524325 scopus 로고    scopus 로고
    • Nuclear access and action of notch in vivo
    • Struhl G., Adachi A. Nuclear access and action of notch in vivo. Cell. 93:1998;649-660.
    • (1998) Cell , vol.93 , pp. 649-660
    • Struhl, G.1    Adachi, A.2
  • 3
    • 0032574993 scopus 로고    scopus 로고
    • Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
    • Schroeter E.H., Kisslinger J.A., Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature. 393:1998;382-386.
    • (1998) Nature , vol.393 , pp. 382-386
    • Schroeter, E.H.1    Kisslinger, J.A.2    Kopan, R.3
  • 4
    • 0033867521 scopus 로고    scopus 로고
    • A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
    • Mumm J.S., Schroeter E.H., Saxena M.T., Griesemer A., Tian X., Pan D.J., Ray W.J., Kopan R. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol Cell. 5:2000;197-206.
    • (2000) Mol Cell , vol.5 , pp. 197-206
    • Mumm, J.S.1    Schroeter, E.H.2    Saxena, M.T.3    Griesemer, A.4    Tian, X.5    Pan, D.J.6    Ray, W.J.7    Kopan, R.8
  • 5
    • 0034051852 scopus 로고    scopus 로고
    • Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
    • Parks A.L., Klueg K.M., Stout J.R., Muskavitch M.A. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development. 127:2000;1373-1385.
    • (2000) Development , vol.127 , pp. 1373-1385
    • Parks, A.L.1    Klueg, K.M.2    Stout, J.R.3    Muskavitch, M.A.4
  • 6
    • 0035650895 scopus 로고    scopus 로고
    • Xenopus Neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling
    • Deblandre G.A., Lai E.C., Kintner C. Xenopus Neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling. Dev Cell. 1:2001;795-806.
    • (2001) Dev Cell , vol.1 , pp. 795-806
    • Deblandre, G.A.1    Lai, E.C.2    Kintner, C.3
  • 7
    • 0035975961 scopus 로고    scopus 로고
    • Neuralized functions as an E3 ubiquitin ligase during Drosophila development
    • Yeh E., Dermer M., Commisso C., Zhou L., McGlade C.J., Boulianne G.L. Neuralized functions as an E3 ubiquitin ligase during Drosophila development. Curr Biol. 11:2001;1675-1679.
    • (2001) Curr Biol , vol.11 , pp. 1675-1679
    • Yeh, E.1    Dermer, M.2    Commisso, C.3    Zhou, L.4    McGlade, C.J.5    Boulianne, G.L.6
  • 8
    • 0035651380 scopus 로고    scopus 로고
    • Drosophila Neuralized is a ubiquitin ligase that promotes the internalization and degradation of Delta
    • This study shows that Neuralized activates Notch signalling by promoting Delta internalisation and degradation. Internalisation of Delta is accelerated by the overexpression of Neuralized in wing discs and this requires Neuralized to have intact ubiquitin ligase activity. Moreover, Neuralized and Delta form a complex, as shown by immunoprecipitation experiments.
    • Lai E.C., Deblandre G.A., Kintner C., Rubin G.M. Drosophila Neuralized is a ubiquitin ligase that promotes the internalization and degradation of Delta. Dev Cell. 1:2001;783-794 This study shows that Neuralized activates Notch signalling by promoting Delta internalisation and degradation. Internalisation of Delta is accelerated by the overexpression of Neuralized in wing discs and this requires Neuralized to have intact ubiquitin ligase activity. Moreover, Neuralized and Delta form a complex, as shown by immunoprecipitation experiments.
    • (2001) Dev Cell , vol.1 , pp. 783-794
    • Lai, E.C.1    Deblandre, G.A.2    Kintner, C.3    Rubin, G.M.4
  • 10
    • 0037238008 scopus 로고    scopus 로고
    • Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta
    • The authors identify Mind Bomb as an essential positive regulator of Notch signalling in zebrafish. They show that Mind Bomb is a ubiquitin ligase that promotes Delta ubiquitination and endocytosis. They also show that in frame addition of Ubiquitin to a trafficking-impaired form of Delta rescues trafficking and function, highlighting the importance of endocytosis and ubiquitination in signalling.
    • Itoh M., Kim C.H., Palardy G., Oda T., Jiang Y.J., Maust D., Yeo S.Y., Lorick K., Wright G.J., Ariza-McNaughton L.et al. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev Cell. 4:2003;67-82 The authors identify Mind Bomb as an essential positive regulator of Notch signalling in zebrafish. They show that Mind Bomb is a ubiquitin ligase that promotes Delta ubiquitination and endocytosis. They also show that in frame addition of Ubiquitin to a trafficking-impaired form of Delta rescues trafficking and function, highlighting the importance of endocytosis and ubiquitination in signalling.
    • (2003) Dev Cell , vol.4 , pp. 67-82
    • Itoh, M.1    Kim, C.H.2    Palardy, G.3    Oda, T.4    Jiang, Y.J.5    Maust, D.6    Yeo, S.Y.7    Lorick, K.8    Wright, G.J.9    Ariza-McNaughton, L.10
  • 11
    • 0031012155 scopus 로고    scopus 로고
    • Regulation of neuronal diversity in the Xenopus retina by Delta signalling
    • Dorsky R.I., Chang W.S., Rapaport D.H., Harris W.A. Regulation of neuronal diversity in the Xenopus retina by Delta signalling. Nature. 385:1997;67-70.
    • (1997) Nature , vol.385 , pp. 67-70
    • Dorsky, R.I.1    Chang, W.S.2    Rapaport, D.H.3    Harris, W.A.4
  • 12
    • 0031240003 scopus 로고    scopus 로고
    • Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina
    • Henrique D., Hirsinger E., Adam J., Le Roux I., Pourquie O., Ish-Horowicz D., Lewis J. Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina. Curr Biol. 7:1997;661-670.
    • (1997) Curr Biol , vol.7 , pp. 661-670
    • Henrique, D.1    Hirsinger, E.2    Adam, J.3    Le Roux, I.4    Pourquie, O.5    Ish-Horowicz, D.6    Lewis, J.7
  • 13
    • 0037069661 scopus 로고    scopus 로고
    • Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans
    • Shaye D.D., Greenwald I. Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans. Nature. 420:2002;686-690.
    • (2002) Nature , vol.420 , pp. 686-690
    • Shaye, D.D.1    Greenwald, I.2
  • 14
    • 0031788431 scopus 로고    scopus 로고
    • Genetic characterization of the Drosophila melanogaster suppressor of deltex gene: A regulator of notch signaling
    • Fostier M., Evans D.A., Artavanis-Tsakonas S., Baron M. Genetic characterization of the Drosophila melanogaster suppressor of deltex gene: a regulator of notch signaling. Genetics. 150:1998;1477-1485.
    • (1998) Genetics , vol.150 , pp. 1477-1485
    • Fostier, M.1    Evans, D.A.2    Artavanis-Tsakonas, S.3    Baron, M.4
  • 15
    • 0033051919 scopus 로고    scopus 로고
    • The Drosophila melanogaster suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase
    • Cornell M., Evans D.A., Mann R., Fostier M., Flasza M., Monthatong M., Artavanis-Tsakonas S., Baron M. The Drosophila melanogaster suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase. Genetics. 152:1999;567-576.
    • (1999) Genetics , vol.152 , pp. 567-576
    • Cornell, M.1    Evans, D.A.2    Mann, R.3    Fostier, M.4    Flasza, M.5    Monthatong, M.6    Artavanis-Tsakonas, S.7    Baron, M.8
  • 17
    • 0030199973 scopus 로고    scopus 로고
    • Control of daughter cell fates during asymmetric division: Interaction of Numb and Notch
    • Guo M., Jan L.Y., Jan Y.N. Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron. 17:1996;27-41.
    • (1996) Neuron , vol.17 , pp. 27-41
    • Guo, M.1    Jan, L.Y.2    Jan, Y.N.3
  • 18
    • 0027947609 scopus 로고
    • Asymmetric distribution of Numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells
    • Rhyu M.S., Jan L.Y., Jan Y.N. Asymmetric distribution of Numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell. 76:1994;477-491.
    • (1994) Cell , vol.76 , pp. 477-491
    • Rhyu, M.S.1    Jan, L.Y.2    Jan, Y.N.3
  • 20
    • 0036696444 scopus 로고    scopus 로고
    • The endocytic protein alpha-adaptin is required for Numb-mediated asymmetric cell division in Drosophila
    • This study provides valuable insight into the mechanism of asymmetric cell division. The authors show that α-adaptin acts downstream of Numb in this process. They also show that, as a result of its interaction with Numb, α-adaptin is asymmetrically localised in asymmetrically dividing cells.
    • Berdnik D., Torok T., Gonzalez-Gaitan M., Knoblich J.A. The endocytic protein alpha-adaptin is required for Numb-mediated asymmetric cell division in Drosophila. Dev Cell. 3:2002;221-231 This study provides valuable insight into the mechanism of asymmetric cell division. The authors show that α-adaptin acts downstream of Numb in this process. They also show that, as a result of its interaction with Numb, α-adaptin is asymmetrically localised in asymmetrically dividing cells.
    • (2002) Dev Cell , vol.3 , pp. 221-231
    • Berdnik, D.1    Torok, T.2    Gonzalez-Gaitan, M.3    Knoblich, J.A.4
  • 21
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • Ingham P.W., McMahon A.P. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15:2001;3059-3087.
    • (2001) Genes Dev , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 23
    • 0035901616 scopus 로고    scopus 로고
    • The sterol-sensing domain of Patched protein seems to control smoothened activity through Patched vesicular trafficking
    • Martin V., Carrillo G., Torroja C., Guerrero I. The sterol-sensing domain of Patched protein seems to control smoothened activity through Patched vesicular trafficking. Curr Biol. 11:2001;601-607.
    • (2001) Curr Biol , vol.11 , pp. 601-607
    • Martin, V.1    Carrillo, G.2    Torroja, C.3    Guerrero, I.4
  • 24
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing Hedgehog
    • Chen Y., Struhl G. Dual roles for patched in sequestering and transducing Hedgehog. Cell. 87:1996;553-563.
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 25
    • 0034682719 scopus 로고    scopus 로고
    • Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
    • Denef N., Neubuser D., Perez L., Cohen S.M. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell. 102:2000;521-531.
    • (2000) Cell , vol.102 , pp. 521-531
    • Denef, N.1    Neubuser, D.2    Perez, L.3    Cohen, S.M.4
  • 26
    • 0033635292 scopus 로고    scopus 로고
    • Post-transcriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system
    • Alcedo J., Zou Y., Noll M. Post-transcriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system. Mol Cell. 6:2000;457-465.
    • (2000) Mol Cell , vol.6 , pp. 457-465
    • Alcedo, J.1    Zou, Y.2    Noll, M.3
  • 27
    • 0037172658 scopus 로고    scopus 로고
    • Sonic Hedgehog induces the segregation of patched and smoothened in endosomes
    • The authors show that late endosomal sorting is essential for Sonic Hedgehog signalling, and that, following stimulation by Sonic Hedgehog, Patched and Smoothened are segregated in different membrane compartments.
    • Incardona J.P., Gruenberg J., Roelink H. Sonic Hedgehog induces the segregation of patched and smoothened in endosomes. Curr Biol. 12:2002;983-995 The authors show that late endosomal sorting is essential for Sonic Hedgehog signalling, and that, following stimulation by Sonic Hedgehog, Patched and Smoothened are segregated in different membrane compartments.
    • (2002) Curr Biol , vol.12 , pp. 983-995
    • Incardona, J.P.1    Gruenberg, J.2    Roelink, H.3
  • 29
    • 0009603803 scopus 로고    scopus 로고
    • Sonic Hedgehog signaling by the Patched-Smoothened receptor complex
    • Murone M., Rosenthal A., de Sauvage F.J. Sonic Hedgehog signaling by the Patched-Smoothened receptor complex. Curr Biol. 9:1999;76-84.
    • (1999) Curr Biol , vol.9 , pp. 76-84
    • Murone, M.1    Rosenthal, A.2    De Sauvage, F.J.3
  • 30
    • 0037158748 scopus 로고    scopus 로고
    • Patched acts catalytically to suppress the activity of Smoothened
    • This work provides fundamental information on how Patched represses Smoothened activity. Because Patched efficiently inhibits a 50 fold molar excess of Smoothened, the previously accepted model of stoichiometric inhibition is dismissed.
    • Taipale J., Cooper M.K., Maiti T., Beachy P.A. Patched acts catalytically to suppress the activity of Smoothened. Nature. 418:2002;892-897 This work provides fundamental information on how Patched represses Smoothened activity. Because Patched efficiently inhibits a 50 fold molar excess of Smoothened, the previously accepted model of stoichiometric inhibition is dismissed.
    • (2002) Nature , vol.418 , pp. 892-897
    • Taipale, J.1    Cooper, M.K.2    Maiti, T.3    Beachy, P.A.4
  • 31
    • 0035901572 scopus 로고    scopus 로고
    • Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in smoothened regulation
    • Strutt H., Thomas C., Nakano Y., Stark D., Neave B., Taylor A.M., Ingham P.W. Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in smoothened regulation. Curr Biol. 11:2001;608-613.
    • (2001) Curr Biol , vol.11 , pp. 608-613
    • Strutt, H.1    Thomas, C.2    Nakano, Y.3    Stark, D.4    Neave, B.5    Taylor, A.M.6    Ingham, P.W.7
  • 32
    • 0037032812 scopus 로고    scopus 로고
    • Molecular mechanisms of axon guidance
    • Dickson B.J. Molecular mechanisms of axon guidance. Science. 298:2002;1959-1964.
    • (2002) Science , vol.298 , pp. 1959-1964
    • Dickson, B.J.1
  • 33
    • 0036684011 scopus 로고    scopus 로고
    • Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the Roundabout receptor
    • This article suggests that Commissureless acts on Roundabout by sequestering it away from the plasma membrane, into an endocytic compartment. It also shows that the ubiquitinating ligase Nedd-4 binds to, and ubiquitinates, Commissureless.
    • Myat A., Henry P., McCabe V., Flintoft L., Rotin D., Tear G. Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the Roundabout receptor. Neuron. 35:2002;447-459 This article suggests that Commissureless acts on Roundabout by sequestering it away from the plasma membrane, into an endocytic compartment. It also shows that the ubiquitinating ligase Nedd-4 binds to, and ubiquitinates, Commissureless.
    • (2002) Neuron , vol.35 , pp. 447-459
    • Myat, A.1    Henry, P.2    McCabe, V.3    Flintoft, L.4    Rotin, D.5    Tear, G.6
  • 34
    • 0037162692 scopus 로고    scopus 로고
    • Comm sorts Robo to control axon guidance at the Drosophila midline
    • Using cell transplantation experiments, the authors show that commissureless is specifically required in contralateral neurons, where it downregulates Roundabout. They also provide evidence that, in the presence of Commissureless, Roundabout does not reach the plasma membrane and is delivered to the endosomes.
    • Keleman K., Rajagopalan S., Cleppien D., Teis D., Paiha K., Huber L.A., Technau G.M., Dickson B.J. Comm sorts Robo to control axon guidance at the Drosophila midline. Cell. 110:2002;415-427 Using cell transplantation experiments, the authors show that commissureless is specifically required in contralateral neurons, where it downregulates Roundabout. They also provide evidence that, in the presence of Commissureless, Roundabout does not reach the plasma membrane and is delivered to the endosomes.
    • (2002) Cell , vol.110 , pp. 415-427
    • Keleman, K.1    Rajagopalan, S.2    Cleppien, D.3    Teis, D.4    Paiha, K.5    Huber, L.A.6    Technau, G.M.7    Dickson, B.J.8
  • 35
    • 0035368514 scopus 로고    scopus 로고
    • Regulated endocytic routing modulates Wingless signaling in Drosophila embryos
    • Dubois L., Lecourtois M., Alexandre C., Hirst E., Vincent J.P. Regulated endocytic routing modulates Wingless signaling in Drosophila embryos. Cell. 105:2001;613-624.
    • (2001) Cell , vol.105 , pp. 613-624
    • Dubois, L.1    Lecourtois, M.2    Alexandre, C.3    Hirst, E.4    Vincent, J.P.5
  • 36
    • 0036272313 scopus 로고    scopus 로고
    • Internalization-dependent and -independent requirements for transforming growth factor beta receptor signaling via the Smad pathway
    • This article shows that treatments that inhibit internalisation of a transforming growth factor β receptor also inhibit signalling.
    • Penheiter S.G., Mitchell H., Garamszegi N., Edens M., Dore J.J. Jr., Leof E.B. Internalization-dependent and -independent requirements for transforming growth factor beta receptor signaling via the Smad pathway. Mol Cell Biol. 22:2002;4750-4759 This article shows that treatments that inhibit internalisation of a transforming growth factor β receptor also inhibit signalling.
    • (2002) Mol Cell Biol , vol.22 , pp. 4750-4759
    • Penheiter, S.G.1    Mitchell, H.2    Garamszegi, N.3    Edens, M.4    Dore J.J., Jr.5    Leof, E.B.6
  • 37
    • 0037144841 scopus 로고    scopus 로고
    • TGF beta receptor internalization into EEA1-enriched early endosomes: Role in signaling to Smad2
    • This article also shows that treatments that inhibit internalisation of a transforming growth factor β receptor block signalling. Moreover evidence is provided that endosomal localisation of SARA is essential for signalling.
    • Hayes S., Chawla A., Corvera S. TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. J Cell Biol. 158:2002;1239-1249 This article also shows that treatments that inhibit internalisation of a transforming growth factor β receptor block signalling. Moreover evidence is provided that endosomal localisation of SARA is essential for signalling.
    • (2002) J Cell Biol , vol.158 , pp. 1239-1249
    • Hayes, S.1    Chawla, A.2    Corvera, S.3
  • 38
  • 39
    • 0037168108 scopus 로고    scopus 로고
    • Unrestricted synaptic growth in Spinster - A late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation
    • Sweeney S.T., Davis G.W. Unrestricted synaptic growth in Spinster - a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation. Neuron. 36:2002;403-416.
    • (2002) Neuron , vol.36 , pp. 403-416
    • Sweeney, S.T.1    Davis, G.W.2
  • 40
    • 0030671306 scopus 로고    scopus 로고
    • Production of a Dpp activity gradient in the early Drosophila embryo through the opposing actions of the Sog and TLD proteins
    • Marques G., Musacchio M., Shimell M.J., Wunnenberg-Stapleton K., Cho K.W., O'Connor M.B. Production of a Dpp activity gradient in the early Drosophila embryo through the opposing actions of the Sog and TLD proteins. Cell. 91:1997;417-426.
    • (1997) Cell , vol.91 , pp. 417-426
    • Marques, G.1    Musacchio, M.2    Shimell, M.J.3    Wunnenberg-Stapleton, K.4    Cho, K.W.5    O'Connor, M.B.6
  • 41
    • 0036007119 scopus 로고    scopus 로고
    • Creation of a Sog morphogen gradient in the Drosophila embryo
    • Srinivasan S., Rashka K.E., Bier E. Creation of a Sog morphogen gradient in the Drosophila embryo. Dev Cell. 2:2002;91-101.
    • (2002) Dev Cell , vol.2 , pp. 91-101
    • Srinivasan, S.1    Rashka, K.E.2    Bier, E.3
  • 42
    • 0034704824 scopus 로고    scopus 로고
    • Wingless gradient formation in the Drosophila wing
    • Strigini M., Cohen S.M. Wingless gradient formation in the Drosophila wing. Curr Biol. 10:2000;293-300.
    • (2000) Curr Biol , vol.10 , pp. 293-300
    • Strigini, M.1    Cohen, S.M.2
  • 43
    • 0033636094 scopus 로고    scopus 로고
    • Dpp gradient formation in the Drosophila wing imaginal disc
    • Teleman A.A., Cohen S.M. Dpp gradient formation in the Drosophila wing imaginal disc. Cell. 103:2000;971-980.
    • (2000) Cell , vol.103 , pp. 971-980
    • Teleman, A.A.1    Cohen, S.M.2
  • 44
    • 0036080430 scopus 로고    scopus 로고
    • Do morphogen gradients arise by diffusion?
    • Lander A.D., Nie Q., Wan F.Y. Do morphogen gradients arise by diffusion? Dev Cell. 2:2002;785-796.
    • (2002) Dev Cell , vol.2 , pp. 785-796
    • Lander, A.D.1    Nie, Q.2    Wan, F.Y.3
  • 45
    • 0037663379 scopus 로고    scopus 로고
    • Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain
    • published online 7 April 2003, DOI 10.1074/jbc.M302827200.
    • McGill MA, McGlade CJ: Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem, published online 7 April 2003, DOI 10.1074/jbc.M302827200.
    • J Biol Chem
    • McGill, M.A.1    McGlade, C.J.2
  • 46
    • 0037598870 scopus 로고    scopus 로고
    • Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover
    • Di Guglielmo G.M., Le Roy C., Goodfellow A.F., Wrana J.L. Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat Cell Biol. 5:2003;410-421.
    • (2003) Nat Cell Biol , vol.5 , pp. 410-421
    • Di Guglielmo, G.M.1    Le Roy, C.2    Goodfellow, A.F.3    Wrana, J.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.