Type II tumour necrosis factor-α receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways

Biochemical Journal

Volumn 359, Issue 3, 2001, Pages 525-535

  Jupp, O J ^a   McFarlane, S M ^a   Anderson, H M ^a   Littlejohn, A F ^a   Mohamed, A A A ^a   MacKay, R H ^a   Vandenabeele, P ^a   MacEwan, D J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Apoptosis; Cytokine receptors; Protein kinases phosphatases; Signal transduction

Indexed keywords

CELL CULTURE; CHEMICAL ACTIVATION; CYTOLOGY; TOXICITY;

TUMOUR NECROSIS;

PROTEINS;

CYTOKINE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; RECEPTOR SUBTYPE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

APOPTOSIS; ARTICLE; CELL DEATH; DELETION MUTANT; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE INDUCTION; HUMAN; HUMAN CELL; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION;

ANTIGENS, CD; APOPTOSIS; CELL SEPARATION; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMANS; ISOENZYMES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; RECOMBINANT PROTEINS; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035504199     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3590525     Document Type: Article

References (56)

1. The TNF receptor superfamily of cellular and viral-proteins: Activation, costimulation, and death
2. Tumor necrosis factors in 1998
3. Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level
4. TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis
5. Tumor necrosis factor receptor-mediated signaling pathways
6. Recent advances in the molecular basis of TNF signal transduction
7. 2 Tumor necrosis factor receptors - Structure and function
8. Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells
9. Ligand passing: The 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor
10. The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor
11. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor
12. Functional activities of receptors for tumor necrosis factor-α on human vascular endothelial cells
13. Evidence for exclusive role in signaling of tumor necrosis factor p55 receptor and a potentiating function of p75 receptor on human endothelial cells
14. Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80: Requirement of the TNF receptor-associated factor-2 binding site
15. TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TNFR-associated factor 2 and is specific for TNFR60
16. Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-κB activation, and c-Jun kinase activation
17. Serum levels of tumor necrosis factor-α (TNF-α) and soluble TNF receptors in human immunodeficiency virus type-1 infection - Correlations to clinical, immunological, and virological parameters
18. The tumor necrosis factor ligand and receptor families
19. Stress-activated protein kinases: Activation, regulation and function
20. Human TNF mutants with selective activity on the p55 receptor
21. Human tumor necrosis factor mutants with preferential binding to and activity on either the r55 or r75 receptor
22. 2 levels as a mechanism by which the p70 TNF and p75 NGF receptors enhance apoptosis
23. 11α family of G-proteins family in tumour necrosis factor-α induced apoptotic cell death
24. Cytotoxicity by tumor necrosis factor is mediated by both p55 and p70 receptors
25. The p70 tumor necrosis factor receptor mediates cytotoxicity
26. Tumor necrosis factors cytotoxic activity is signaled by the p55 TNF receptor
27. Tumour necrosis factor is delivered to a mitochondrial receptor
28. Tumor necrosis factor is delivered to mitochondria where a tumor necrosis factor-binding protein is localized
29. Tumor necrosis factor-α mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression
30. Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity
31. TR60 and TR80 tumor necrosis factor (TNB-receptors can independently mediate cytolysis
32. P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death
33. Tumor necrosis factor (TNB receptors in cellular signaling of soluble and membrane-expressed TNF
34. Distinct roles of the two tumor necrosis factor (TNF) receptors in modulating TNF and lymphotoxin α effects
35. 2-adrenoceptor
36. 2-adrenoceptor in transfected neuroblastoma x glioma hybrid cells
37. 2-adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity
38. 2-adrenoceptor by sustained treatment with inverse agonists but not antagonists
39. The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin
40. Activation of p42/p44 mitogen-activated protein kinases (MAPK) and p38 MAPK by tumor necrosis factor (TNF) is mediated through the death domain of the 55-kDa TNF receptor
41. MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis
42. Tumor necrosis factor receptors (TNFR) in mouse fibroblasts deficient in TNFR1 or TNFR2 are signaling competent and activate the mitogen-activated protein kinase pathway with differential kinetics
43. TNF receptor associated factors in cytokine signaling
44. TRAF2 plays a dual role in NF-κB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IκB kinase pathways
45. LPS induced TNF-receptor release in vivo in a murine model
46. Targeted disruption of the mouse caspase-8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
47. Signal transduction by the c-Jun N-terminal kinase (JNK) - From inflammation to development
48. Continuous autotropic signaling by membrane-expressed tumor necrosis factor
49. Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: A role for TNF-R1 activation by endogenous membrane-anchored TNF
50. Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumor necrosis factor (TNF) receptor is mediated by endogenous murine TNF
51. A domain in TNF receptors that mediates figand-independent receptor assembly and signaling
52. Anatomy of TRAF2. Distinct domains for nuclear factor-κB activation and association with tumor necrosis factor signaling proteins
53. Tumor necrosis factor receptor (TNFR)-associated factor 2a (TRAF2a), a TRAF2 splice variant with an extended ring finger domain that inhibits TNFR2-mediated NF-κB activation
54. Dimerization of chimeric erythropoietin 75 kDa tumor necrosis factor (TNF) receptors transduces TNF signals: Necessity for the 75 kDa TNF-receptor transmembrane domain
55. Functional requirement of the 2 TNF receptors for induction of apoptosis in PC60 cells and the role of mitochondria in TNF-induced cytotoxicity
56. Functional-characterization of the human tumor necrosis factor receptor-p75 in a transfected rat/mouse T-cell hybridoma