메뉴 건너뛰기




Volumn 19, Issue 2, 1997, Pages 245-256

DNA vaccines: Safety and efficacy issues

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE;

EID: 0030662578     PISSN: 03444325     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00870272     Document Type: Review
Times cited : (82)

References (56)
  • 1
    • 0003407417 scopus 로고    scopus 로고
    • Obtain from: Office of Communication, Training and Manufacturers Assistance (HFM-10) Center for Biologics Evaluation and Research. FDA, Bethesda
    • Points to consider on Plasmid DNA Vaccines for Preventive Infectious Disease Indications (1996) Obtain from: Office of Communication, Training and Manufacturers Assistance (HFM-10) Center for Biologics Evaluation and Research. FDA, Bethesda
    • (1996) Points to Consider on Plasmid DNA Vaccines for Preventive Infectious Disease Indications
  • 2
    • 0023765856 scopus 로고
    • Age-related decline in the lethal hit but not the binding stage of cytotoxic T cell activity in mice
    • Bloom HT, Kubota LF, Kawakami K (1988) Age-related decline in the lethal hit but not the binding stage of cytotoxic T cell activity in mice. Cell Immunol 114:440
    • (1988) Cell Immunol , vol.114 , pp. 440
    • Bloom, H.T.1    Kubota, L.F.2    Kawakami, K.3
  • 3
    • 0002549618 scopus 로고
    • Epidemiologi, and statistical characteristics of this United States elderly population
    • Finch CE, Schneider FL (eds) Van Nostrand Reinhold, New York
    • Broody JA, Brock DB (1985) In: Finch CE, Schneider FL (eds) Handbook of the biology of aging, 2nd edn. Epidemiologi, and statistical characteristics of this United States elderly population. Van Nostrand Reinhold, New York, pp 3-20
    • (1985) Handbook of the Biology of Aging, 2nd Edn. , pp. 3-20
    • Broody, J.A.1    Brock, D.B.2
  • 5
    • 0027214439 scopus 로고
    • Bovine herpesvirus 1: Immune responses in mice and cattle injected with plasmid DNA
    • Cox GJ, Zamb TJ, Babiuk LA (1993) Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA. J Virol 67:5664
    • (1993) J Virol , vol.67 , pp. 5664
    • Cox, G.J.1    Zamb, T.J.2    Babiuk, L.A.3
  • 6
    • 0018872434 scopus 로고
    • Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus
    • Ebling FM, Hahn BH (1980) Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus. Arthritis Rheum 23:392
    • (1980) Arthritis Rheum , vol.23 , pp. 392
    • Ebling, F.M.1    Hahn, B.H.2
  • 7
    • 0020519752 scopus 로고
    • Diminished T cell response to influenza virus in aged mice
    • Effros RB, Walford RL (1983) Diminished T cell response to influenza virus in aged mice. Immunology 49:387
    • (1983) Immunology , vol.49 , pp. 387
    • Effros, R.B.1    Walford, R.L.2
  • 8
    • 0021680290 scopus 로고
    • The effect of age on the antigen-presenting mechanism in limiting dilution precursor cell frequency analysis
    • Effros RB, Walford RL (1984) The effect of age on the antigen-presenting mechanism in limiting dilution precursor cell frequency analysis. Cell Immunol 88:531
    • (1984) Cell Immunol , vol.88 , pp. 531
    • Effros, R.B.1    Walford, R.L.2
  • 11
    • 0028957214 scopus 로고
    • Induction of cross-reactive anti-dsDNA antibodies in preautoimniune NZB/NZW mice by immunization with bacterial DNA
    • Gilkeson GS, Pippen AM, Pisetsky DS (1995) Induction of cross-reactive anti-dsDNA antibodies in preautoimniune NZB/NZW mice by immunization with bacterial DNA. J Clin Invest 95:1398
    • (1995) J Clin Invest , vol.95 , pp. 1398
    • Gilkeson, G.S.1    Pippen, A.M.2    Pisetsky, D.S.3
  • 12
    • 0029867033 scopus 로고    scopus 로고
    • Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of IL-10: IFN-gamma secreting cells in the peripheral blood
    • Hagiwara E, Gourley M, Lee S, Klinman DM (1996) Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of IL-10: IFN-gamma secreting cells in the peripheral blood. Arthritis Rheum 39:379
    • (1996) Arthritis Rheum , vol.39 , pp. 379
    • Hagiwara, E.1    Gourley, M.2    Lee, S.3    Klinman, D.M.4
  • 13
    • 0030028722 scopus 로고    scopus 로고
    • Bacterial DNA induces murine interferon-gamma production by stimulation of IL-12 and tumor necrosis factor-alpha
    • Halpern MD, Kurlander RJ, Pisetsky DS (1996) Bacterial DNA induces murine interferon-gamma production by stimulation of IL-12 and tumor necrosis factor-alpha. Cell Immunol 167:72
    • (1996) Cell Immunol , vol.167 , pp. 72
    • Halpern, M.D.1    Kurlander, R.J.2    Pisetsky, D.S.3
  • 15
    • 0026801986 scopus 로고
    • Pore-forming protein in individual CTL. The effect of senescence provides a probe for understanding the lytic mechanism
    • Horvath JA, Mostowski HS, Okumura K, Bloom ET (1992) Pore-forming protein in individual CTL. The effect of senescence provides a probe for understanding the lytic mechanism. Eur J Immunol 22:2649
    • (1992) Eur J Immunol , vol.22 , pp. 2649
    • Horvath, J.A.1    Mostowski, H.S.2    Okumura, K.3    Bloom, E.T.4
  • 16
    • 0015382576 scopus 로고
    • The mechanism of antigenic stimulation of primary and secondary clonal precursor cells
    • Klinman NR (1972) The mechanism of antigenic stimulation of primary and secondary clonal precursor cells. J Exp Med 136:241
    • (1972) J Exp Med , vol.136 , pp. 241
    • Klinman, N.R.1
  • 17
    • 0025028745 scopus 로고
    • Polyclonal B cell activation in lupus-prone mice precedes and predicts the development of autoimmune disease
    • Klinman DM (1990) Polyclonal B cell activation in lupus-prone mice precedes and predicts the development of autoimmune disease. J Clin Invest 86:1249
    • (1990) J Clin Invest , vol.86 , pp. 1249
    • Klinman, D.M.1
  • 18
    • 0026701238 scopus 로고
    • Analysis of B lymphocytes cross-reactivity at the single cell level
    • Klinman DM (1992) Analysis of B lymphocytes cross-reactivity at the single cell level. J Immunol Methods 152:217
    • (1992) J Immunol Methods , vol.152 , pp. 217
    • Klinman, D.M.1
  • 19
    • 0023204355 scopus 로고
    • Systemic autoimmune disease arises from polyclonal B cell activation
    • Klinman DM, Steinberg AD (1987) Systemic autoimmune disease arises from polyclonal B cell activation. J Exp Med 165:1755
    • (1987) J Exp Med , vol.165 , pp. 1755
    • Klinman, D.M.1    Steinberg, A.D.2
  • 21
    • 0026066263 scopus 로고
    • Quantitation of IgG and IgM secreting B cells in the peripheral blood of patients with systemic lupus erythematosus
    • Klinman DM, Shirai A, Ishigatsubo Y, Conover J, Steinberg AD (1991) Quantitation of IgG and IgM secreting B cells in the peripheral blood of patients with systemic lupus erythematosus. Arthritis Rheum 34:1404
    • (1991) Arthritis Rheum , vol.34 , pp. 1404
    • Klinman, D.M.1    Shirai, A.2    Ishigatsubo, Y.3    Conover, J.4    Steinberg, A.D.5
  • 22
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFN-γ
    • Klinman DM, Yi A, Beaucage SL, Conover J, Krieg AM (1996) CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFN-γ. Proc Natl Acad Sci USA 93:2879
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2879
    • Klinman, D.M.1    Yi, A.2    Beaucage, S.L.3    Conover, J.4    Krieg, A.M.5
  • 23
    • 0031569601 scopus 로고    scopus 로고
    • Contribution of CpG motifs to the immunogenicity of DNA vaccines
    • Klinman DM, Yamshchikov G, Ishigatsubo Y (1997) Contribution of CpG motifs to the immunogenicity of DNA vaccines. J Immunol 158:3635
    • (1997) J Immunol , vol.158 , pp. 3635
    • Klinman, D.M.1    Yamshchikov, G.2    Ishigatsubo, Y.3
  • 25
    • 0025290641 scopus 로고
    • Polymorphism of age-related changes in interleukin production: Differential changes of T helper subpopulations, synthesizing IL-2, IL-3, and IL-4
    • Kubo M, Cinader B (1990) Polymorphism of age-related changes in interleukin production: differential changes of T helper subpopulations, synthesizing IL-2, IL-3, and IL-4. Eur J Immunol 20:1289
    • (1990) Eur J Immunol , vol.20 , pp. 1289
    • Kubo, M.1    Cinader, B.2
  • 26
    • 0014259755 scopus 로고
    • Pathogenesis of the glomerulonephritis of NZB/W mice
    • Lambert PH, Dixon FJ (1968) Pathogenesis of the glomerulonephritis of NZB/W mice. J Exp Med 127:507
    • (1968) J Exp Med , vol.127 , pp. 507
    • Lambert, P.H.1    Dixon, F.J.2
  • 27
    • 0025340285 scopus 로고
    • Changes in lymphocyte subsets and immune competence in very advanced age
    • Lehtonen L, Eskola J, Vainio O, Lehtonen A (1990) Changes in lymphocyte subsets and immune competence in very advanced age. J Gerontol 45:M108
    • (1990) J Gerontol , vol.45
    • Lehtonen, L.1    Eskola, J.2    Vainio, O.3    Lehtonen, A.4
  • 30
    • 0028568370 scopus 로고
    • Activation and 'deletion' of self-reactive mature and immature T cells during ontogeny of Mls-1a: Implications for neonatal tolerance induction
    • Marodon G, Rocha B (1995) Activation and 'deletion' of self-reactive mature and immature T cells during ontogeny of Mls-1a: implications for neonatal tolerance induction. Int Immunol 6:1899
    • (1995) Int Immunol , vol.6 , pp. 1899
    • Marodon, G.1    Rocha, B.2
  • 31
    • 0024497811 scopus 로고
    • The cell biology of aging: Immunologie models
    • Miller RA (1989) The cell biology of aging: immunologie models. J Gerontol 44:B4
    • (1989) J Gerontol , vol.44
    • Miller, R.A.1
  • 32
    • 0029157095 scopus 로고
    • Complexity of the cytokine and antibody response elicited by immunizing mice with Plasmodium yoelii circumsporozoite protein plasmid DNA
    • Mor G, Klinman DM, Shapiro S, Hagiwara E, Sedegah M, Norman JA, Hoffman SL, Steinberg AD (1995) Complexity of the cytokine and antibody response elicited by immunizing mice with Plasmodium yoelii circumsporozoite protein plasmid DNA. J Immunol 155:2039
    • (1995) J Immunol , vol.155 , pp. 2039
    • Mor, G.1    Klinman, D.M.2    Shapiro, S.3    Hagiwara, E.4    Sedegah, M.5    Norman, J.A.6    Hoffman, S.L.7    Steinberg, A.D.8
  • 34
    • 0031568098 scopus 로고    scopus 로고
    • T cell derived IL-4 and dendritic cell-derived IL-12 regulate the lymphokine-producing phenotype of alloantigen primed naive human CD4 T cells
    • Oshima T, Delespesse G (1997) T cell derived IL-4 and dendritic cell-derived IL-12 regulate the lymphokine-producing phenotype of alloantigen primed naive human CD4 T cells. J Immunol 158:629
    • (1997) J Immunol , vol.158 , pp. 629
    • Oshima, T.1    Delespesse, G.2
  • 36
    • 0014690947 scopus 로고
    • Measurement of serum anti-DNA binding activity in systemic lupus erythematosus
    • Pincus T, Schur PH, Rose JA, Decker JL, Talal N (1970) Measurement of serum anti-DNA binding activity in systemic lupus erythematosus. N Engl J Med 281:701
    • (1970) N Engl J Med , vol.281 , pp. 701
    • Pincus, T.1    Schur, P.H.2    Rose, J.A.3    Decker, J.L.4    Talal, N.5
  • 40
    • 0030012251 scopus 로고    scopus 로고
    • Induction of protective CTL responses in newborn mice by a murine retrovirus
    • Sarzotti M, Robbins DS, Hoffman PM (1996) Induction of protective CTL responses in newborn mice by a murine retrovirus. Science 271:1726
    • (1996) Science , vol.271 , pp. 1726
    • Sarzotti, M.1    Robbins, D.S.2    Hoffman, P.M.3
  • 41
    • 8944253295 scopus 로고    scopus 로고
    • Non-coding bacterial DNA sequences necessary for effective intradermal gene immunization
    • Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen M, Carson DA, Raz E (1996) Non-coding bacterial DNA sequences necessary for effective intradermal gene immunization. Science 273:352
    • (1996) Science , vol.273 , pp. 352
    • Sato, Y.1    Roman, M.2    Tighe, H.3    Lee, D.4    Corr, M.5    Nguyen, M.6    Carson, D.A.7    Raz, E.8
  • 42
    • 0018833714 scopus 로고
    • Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice
    • Scollary RGE, Butcher EC, Weissman IL (1980) Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur J Immunol 10:210
    • (1980) Eur J Immunol , vol.10 , pp. 210
    • Scollary, R.G.E.1    Butcher, E.C.2    Weissman, I.L.3
  • 43
    • 0028077102 scopus 로고
    • Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein
    • Sedegah M, Hedstrom R, Hobart P, Hoffman SL (1994) Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc Natl Acad Sci USA 91:9866
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9866
    • Sedegah, M.1    Hedstrom, R.2    Hobart, P.3    Hoffman, S.L.4
  • 44
    • 0027154653 scopus 로고
    • Detection and quantitation of cells secreting IL-6 under physiological conditions in BALB/c mice
    • Shirai A, Holmes K, Klinman DM (1993) Detection and quantitation of cells secreting IL-6 under physiological conditions in BALB/c mice. J Immunol 150:793
    • (1993) J Immunol , vol.150 , pp. 793
    • Shirai, A.1    Holmes, K.2    Klinman, D.M.3
  • 45
    • 0027933708 scopus 로고
    • Individual cells simultaneously produce both IL-4 and IL-6 under physiologic conditions in vivo
    • Shirai A, Sierra V, Kelly CI, Klinman DM (1994) Individual cells simultaneously produce both IL-4 and IL-6 under physiologic conditions in vivo. Cytokine 6:329
    • (1994) Cytokine , vol.6 , pp. 329
    • Shirai, A.1    Sierra, V.2    Kelly, C.I.3    Klinman, D.M.4
  • 46
    • 0001898834 scopus 로고    scopus 로고
    • Ontogeny of the immune response: A perspective
    • Cooper MD (ed) Raven Press, New York
    • Silverstein AM (1997) Ontogeny of the immune response: a perspective. In: Cooper MD (ed) Development of Host Defenses. Raven Press, New York, pp 1-10
    • (1997) Development of Host Defenses , pp. 1-10
    • Silverstein, A.M.1
  • 47
    • 0016803154 scopus 로고
    • The ontogeny of antigen-specific T cells
    • Silverstein AM, Segal S (1975) The ontogeny of antigen-specific T cells. J Exp Med 142:802
    • (1975) J Exp Med , vol.142 , pp. 802
    • Silverstein, A.M.1    Segal, S.2
  • 48
  • 49
    • 0014047736 scopus 로고
    • Developmental aspects of immunity
    • Sterzl J, Silverstein AM. (1967) Developmental aspects of immunity. Adv Immunol 6:337
    • (1967) Adv Immunol , vol.6 , pp. 337
    • Sterzl, J.1    Silverstein, A.M.2
  • 50
    • 0017177352 scopus 로고
    • Changes in immunoglobulin class and subclass of anti-DNA antibodies Io DNA and RNA. II. Sequential switch from IgM to IgG in NZB/W F1 mice
    • Steward MW, Hay FC (1976) Changes in immunoglobulin class and subclass of anti-DNA antibodies Io DNA and RNA. II. Sequential switch from IgM to IgG in NZB/W F1 mice. Clin Exp Immunol 26:363
    • (1976) Clin Exp Immunol , vol.26 , pp. 363
    • Steward, M.W.1    Hay, F.C.2
  • 51
    • 0026579897 scopus 로고
    • Genetic immunization is a simple method for eliciting an im-mune response
    • Tang D, DeVit M, Johnston SA (1992) Genetic immunization is a simple method for eliciting an im-mune response. Nature 356:152
    • (1992) Nature , vol.356 , pp. 152
    • Tang, D.1    DeVit, M.2    Johnston, S.A.3
  • 53
    • 0024325071 scopus 로고
    • The cellular and subcellular bases of immunosenescence
    • Thoman ML, Weigle WO (1989) The cellular and subcellular bases of immunosenescence. Adv Immunol 46:221
    • (1989) Adv Immunol , vol.46 , pp. 221
    • Thoman, M.L.1    Weigle, W.O.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.