Central nervous system cell transplantation: A novel therapy for storage diseases?

Current Opinion in Neurology

Volumn 9, Issue 2, 1996, Pages 126-136

  Snyder, Evan Y ^a   Wolfe, John H ^b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; CELL DIFFERENTIATION; CELL REGENERATION; CELL TRANSPLANTATION; CENTRAL NERVOUS SYSTEM; DEGENERATIVE DISEASE; GENE TRANSFER; HUMAN; MONKEY; MOUSE; MUCOPOLYSACCHARIDOSIS TYPE 7; NONHUMAN; RAT; SHORT SURVEY; STEM CELL; STORAGE DISEASE;

EID: 0029885565     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019052-199604000-00013     Document Type: Short Survey

References (103)

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56. •] this paper suggests that neural progenitors, propagated by a variety of techniques and from a variety of CNS regions, behave intriguingly similarly.
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63. ••].
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90. •] describe new mouse models of genetic neurodegenerative lysosomal storage diseases which may be useful for testing experimental therapies, including neural progenitor and stem cell transplantation.
91. •].
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96. •] describe an intriguing mouse model which is the 'cellular' equivalent of a gene knockout. Neurons of a particular type and particular location in adult rodent neocortex are targeted to degenerate by apopotic mechanisms, while other cell types and structures remain intact. This degeneration appears to create a microenvironment which may actually recapitulate certain embryonic developmental signals. This model provides an opportunity for studying the effects apoptosis might have in influencing the migration and differentiation of neural progenitors, perhaps to therapeutic ends. This possibility was explored in preliminary form in an abstract [72].
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