Treatment of hypoxic-ischemic brain injury in newborn rats with TPCK 3 h after hypoxia decreases caspase-9 activation and improves neuropathologic outcome

Developmental Neuroscience

Volumn 25, Issue 1, 2003, Pages 34-40

  Feng, Yangzheng ^a   LeBlanc, Michael H ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; bax; bcl 2; Caspase 3; Chloromethyl ketone; Cytochrome c; Serine protease; Stroke

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; OXYGEN; PROTEIN BAX; PROTEIN BCL 2; TOSYLPHENYLALANYL CHLOROMETHYL KETONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; CAROTID ARTERY LIGATION; CONTROLLED STUDY; CYTOSOL; DISEASE SEVERITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; FLUORESCENCE; HEMISPHERE; HYPOXIA; MALE; NEUROPATHOLOGY; NEUROPROTECTION; NEWBORN PERIOD; NONHUMAN; OPTICAL DENSITY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; TREATMENT OUTCOME; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; BRAIN; CASPASE 9; CASPASES; CYTOCHROME C GROUP; CYTOSOL; DRUG ADMINISTRATION SCHEDULE; ENZYME ACTIVATION; HYPOXIA-ISCHEMIA, BRAIN; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SERINE PROTEINASE INHIBITORS; TOSYLPHENYLALANYL CHLOROMETHYL KETONE;

EID: 0042164862     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000071466     Document Type: Article

References (38)

1. Sulston JE, Schierenberg E, White JG, Thomson JN: The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol 1983;100:64-119.
2. Ramachandra S, Studzinski GP: Morphological and biochemical criteria of apoptosis; in Studzinski GP (ed): Cell Growth and Apoptosis. Oxford, Oxford University Press, 1995, pp 120-142.
3. Fearnhead HO, MacFarlane M, Dinsdale D, Cohen GM: DNA degradation and proteolysis in thymocyte apoptosis. Toxicol Lett 1995;82/83:135-141.
4. Higuchi M, Singh S, Chan H, Aggarwal BB: Protease inhibitors differentially regulate tumor necrosis factor-induced apoptosis, nuclear factor-κB activation, cytotoxicity, and differentiation. Blood 1995;86:2248-2256.
5. Dong Z, Saikumar P, Weinberg J M, Venkatachalam MA: Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death: Involvement of serine but not cysteine proteases. Am J Pathol 1997;151:1205-1213.
6. Mansat V, Bettaîeb A, Levade T, Laurent G, Jaffrézou JP: Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin. FASEB J 1997;11:695-702.
7. Takauji AY, Inuzuka M, Ueda T, Nakamura T: Role of serine and ICE-like proteases in induction of apoptosis by etoposide in human leukemia HL-60 cells. Leukemia 1996;10:821-824.
8. Schoellmann G, Shaw E: Direct evidence for the presence of histidine in the active center of chymotrypsin. Biochemistry 1963;2:252-255.
9. Griscavage JM, Wilk S, Ignarro LJ: Serine and cysteine proteinase inhibitors prevent nitric oxide production by activated macrophages by interfering with transcription of the inducible NO synthase gene. Biochem Biophys Res Commun 1995;215:721-729.
10. Ruetten H, Thiemermann C: Effect of calpain inhibitor 1, an inhibitor of the proteolysis of IκB, on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat. Br J Pharmacol 1997;121:695-704.
11. Tamatani M, Che CH, Matsuzaki H, Ogawa S, Okado H, Miyake S, Mizuno T, Tohyama M: Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NF-κB activation in primary hippocampal neurons. J Biol Chem 1999;274:8531-8538.
12. Susin SA, Zamzami N, Castedo M, Daugas E, Wang HG, Geley S, Fassy F, Reed JC, Kroemer G: The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95 and ceramide-induced apoptosis. J Exp Med 1997;186:25-37.
13. Noshita N, Sugawara T, Fujimura M, Morita-Fujimura Y, Chan PH: Manganese superoxide dismutase affects cytochrome c release and caspase-9 activation after transient focal ischemia in mice. J Cereb Blood Flow Metab 2001;21:557-567.
14. Dong Z, Saikumar P, Patel Y, Weinberg JM, Venkatachalam MA: Serine protease inhibitors suppress cytochrome c-mediated caspase-9 activation and apoptosis during hypoxia-reoxygenation. Biochem J 2000;347:669-677.
15. Slee EA, Hart MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang HG, Reed JC, Nicholson DW, Alnemri ES, Green DR, Martin SJ: Ordering of the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 1999;144:281-292.
16. Rice JE 3rd, Vannucci RC, Brierley JB: The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 1981;9:131-141.
17. Cheng Y, Deshmukh M, D'Costa A, Demaro JA, Gidday JM, Shah A, Sun Y, Jacquin MF, Johnson EM Jr, Holtzman DM: Capase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury. J Clin Invest 1998;9:1992-1999.
18. Palmer C, Vannucci R C, Towfighi J: Reduction of perinatal hypoxic-ischemic brain damage with allopurinol. Pediatr Res 1990;27:332-336.
19. LeBlanc MH, Feng YZ, Fratkin JD: TPCK pre-treatment reduces hypoxic ischemic brain injury in the newborn rat. Eur J Pharm Sci 2000;390:249-256.
20. Trescher WH, Ishiwa S, Johnston MV: Brief post-hypoxic-ischemic hypothermia markedly delays neonatal brain injury. Brain Dev 1997;19:326-338.
21. Northington FJ, Ferriero DM, Martin LJ: Neurodegeneration in the thalamus following neonatal hypoxia-ischemia is programmed cell death. Dev Neurosci 2001;23:186-191.
22. Fujimura M, Morita-Fujimura Y, Kawase M, Copin JC, Calagui B, Epstein CJ, Chan PH: Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome c and subsequent DNA fragmentation after permanent focal ischemia in mice. J Neurosci 1999;19:3414-3422.
23. Almli CR, Levy TJ, Han BH, Shah AR, Gidday JM, Holzman DM: BDNF protects against spacial memory deficits following hypoxia-ischemia. Exp Neurol 2000;166:99-114.
24. Shah GM, Poirier D, Duchaine C, Brochu G, Desnoyers S, Lagueux J, Verreault A, Hoflack JC, Kirkland JB, Poirier GG: Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo. Anal Biochem 1995;227:1-13.
25. Bradford MM: A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 1976;72:248-254.
26. Chen J, Graham SH, Nakayama N, Zhu RL, Jin K, Stetler RA, Simon RP: Apoptosis repressor genes Bcl-2 and Bcl-x-long are expressed in the rat brain following global ischemia. J Cereb Blood Flow Metab 1997;17:2-10.
27. Cai Z, Xiao F, Fratkin JD, Rhodes PG: Protection of neonatal rat brain from hypoxic-ischemia by LY379268, a Group II metabotrophic glutamate receptor agonist. Neuroreport 1999;10:3927-3931.
28. Hara A, Niwa M, Nakashima M, Iwai T, Uematsu T, Yoshimi N, Mori H: Protective effect of apoptosis-inhibitory agent, N-tosyl-L-phenylalanyl chloromethyl ketone against ischemia-induced hippocampal neuronal damage. J Cereb Blood Flow Metab 1998;17:819-823.
29. Feng YZ, LeBlanc MH: N-tosyl-L-phenylalanyl-chloromethyl ketone eliminates the increase in caspase-3 and bcl-2 caused by brain injury in the newborn rat. Phamacology 2002;66:115-119.
30. Pahan K, Sheikh FG, Khan M, Nambboodiri AMS, Singh I: Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes. J Biol Chem 1998;273:2591-2600
31. Mattson MP, Culmsee C, Yu Z, Camandola S: Roles of nuclear factor κB in neuronal survival and plasticity. J Neurochem 2000;74:443-456.
32. Banasiak KJ, Cronin T, Haddad GG: bcl-2 prolongs neuronal survival during hypoxia-induced apoptosis. Brain Res Mol Brain Res 1999;72:214-225.
33. Clark RSB, Kochanek PM, Chen M, Watkins SC, Marion DW, Chen J, Hamilton RL, Loeffert JE, Graham SH: Increases in Bcl-2 and cleavage of caspase-1 and caspase-3 in human brain after head injury. FASEB J 1999;13:813-821.
34. Grandgirard D, Studer E, Monney L, Belser T, Fellay I, Borner C, Michel MR: Alphaviruses induce apoptosis in Bcl-2-overexpression cells: Evidence for a caspase-mediated, proteolytic inactivation of Bcl-2. EMBO J 1998;17:1268-1278.
35. Tomicic MT, Thust R, Kaina B: Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: Critical role of DNA breaks, Bcl-2 decline and caspase-9 activation. Oncogene 2002;21:2141-2153.
36. Kirsch DG, Doseff A, Chau BN, Lim DS, de Souza-Pinto NC, Hansford R, Kastan MB, Lazebnik YA, Hardwick JM: Caspase-3-dependent cleavage of bcl-2 promotes release of cytochrome c. J Biol Chem 1999;274:21155-21161.
37. Fadeel B, Hassan Z, Hellsrom-Lindberg E, Henter JI, Orrenius S, Zhivotovsky B: Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human leukemia cells. Leukemia 1999;13:719-728.
38. Kuida K: Caspase-9. Int J Biochem Cell Biol 2000;32:121-124.