BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia

Experimental Neurology

Volumn 166, Issue 1, 2000, Pages 99-114

  Almli, C Robert ^a   Levy, Todd J ^a   Han, Byung Hee ^a   Shah, Aarti R ^a   Gidday, Jeffrey M ^a   Holtzman, David M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain derived neurotrophic factor (BDNF); CA1 neurons; Cortex; Hippocampus; Hypoxia ischemia; Place navigation; Spatial memory; Striatum; Water maze

Indexed keywords

BRAIN DERIVED GROWTH FACTOR;

AMNESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; DRUG MECHANISM; MAZE TEST; NEUROPROTECTION; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; SPATIAL MEMORY;

EID: 0033762841     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7492     Document Type: Article

References (75)

1. Neonatal cerebral blood flow (PET) and childhood relational memory performance
2. Neonatal hippocampal damage in rats: Long-term spatial memory deficits and associations with magnitude of hippocampal damage
3. Hippocampus forum: Is the hippocampal formation preferentially involved in spatial behavior?
4. Neurobehavioral deficit due to ischemic brain damage limited to half of the CA1 sector of the hippocampus
5. The development of interlimb co-ordination during swimming in postnatal rats
6. Global ischemia and behavioral deficits
7. Correlation between hippocampal neuronal damage and spatial learning deficit due to global ischemia
8. Global ischemic neuronal damage relates to behavioral deficits: A pharmacological approach
9. Sensorimotor function and neuropathology five to six weeks after hypoxiaischemia in seven-day-old rats
10. Early-life malnutrition selectively retards the development of distal- but not proximalcue navigation
11. Variability as a characteristic of immature motor systems. An electromyographic study of swimming in the newborn rat
12. Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury
13. Marked age-dependent neuroprotection by BDNF against neonatal hypoxic-ischemic brain injury
14. Caudate nucleus and memory for egocentric localization
15. Neonatal anoxia induces transitory hyperactivity, permanent spatial memory deficits and CA1 cell density reduction in developing rats
16. Carboxyfullerenes as neuroprotective agents
17. Hippocampal representation in spatial learning
18. Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family
19. Place navigation in rats with unilateral tetrodotoxin inactivation of the dorsal hippocampus: I Place but not procedural learning can be lateralized to one hippocampus
20. Evidence of nuclear DNA fragmentation following hypoxia-ischemia in the infant j rat brain, and transient forebrain ischemia in the adult gerbil
21. Neonatal mice lacking neuronal nitric oxide synthase are less vulnerable to hypoxic-ischemic injury
22. Reduction in cerebral ischemic injury in the newborn rat by potentiation of endogenous adenosine
23. Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat
24. Protective effects of brain hypothermia on behavior and histopathology following global cerebral ischemia in rats
25. Activation of NMDA receptors increases brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampai formation
26. DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat
27. Nerve growth factor protects the neonatal brain against hypoxic-ischemic injury
28. Long-term effects of neonatal ischemic-hypoxic brain injury on sensorimotor and locomotor tasks in rats
29. Neurotransmitter alterations in a model of perinatal hypoxic-ischemic brain injury
30. Distribution of brain-derived neurotrophic factor in rats and its changes with development in the brain
31. The trkB tyrosine kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain
32. Regulated neurotrophin receptor responsiveness during neuronal migration and early differentiation
33. Evidence for anatomical but not functional asymmetry in the hemidecorticate rat
34. A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats
35. Induction of brain derived neurotrophic factor mRNA by seizures in neonatal and juvenile rat brain
36. Anoxic-ischemic encephalopathy in rats
37. Learning deficit in BDNF mutant mice
38. NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression
39. MK-801 protects the neonatal brain from hypoxic-ischemic damage
40. Increased production of the trkB protein tyrosine kinase receptor after brain insults
41. Intact spatial learning and memory in transgenic mice with reduced BDNF
42. Spatial localization does not require the presence of local cues
43. Place navigation in rats with hippocampal lesions
44. Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions
45. Comparison of effects of global ischaemia on spatial learning in the standard and radial water maze: Relationship of hippocampal damage to performance
46. Global ischaemia: Hippocampal pathology and spatial deficits in the water maze
47. Relation of spatial learning of rats in the Morris water maze task to the number of viable CA1 neurons following four-vessel occlusion
48. Potential new therapies for perinatal cerebral hypoxia-ischemia
49. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice
50. Widespread expression of BDNF but not NT-3 by target areas of basal forebrain cholinergic neurons
51. Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia
52. Temporal profile of neuronal damage in a model of transient forebrain ischemia
53. Right-hippocampal contralateral-hand effect in the recall of spatial location in the actual modality
54. Three cases of enduring memory impairment after bilateral damage limited to the hippocampal formation
55. The influence of immaturity on hypoxic-ischemic brain damage in the rat
56. The relationship of structural ischemic brain damage to Neurobehavioral deficit: The effect of postischemic MK-801
57. Higher neonatal cerebral blood flow correlates with worse childhood neurological outcome
58. Selective vulnerability of the hippocampus in brain ischemia
59. Nuclear condensation and fragmentation following cerebral hypoxia-ischemia occurs more frequently in immature than older rats
60. A behavioral analysis of spatial localization following electrolytic, kainate- or colchicine-induced damage to the hippocampal formation in the rat
61. Neuropathology of remote hypoxic-ischemic damage in the immature rat
62. Temporal evolution of neuropathologic changes in an immature rat model of cerebral hypoxia: A light microscopic study
63. Brief post-hypoxic hypothermia markedly delays neonatal brain injury
64. Unilateral hippocampal ablation at birth causes a reduction in contralateral LTP
65. Dissociation of motor hyperactivity and spatial memory deficits by selective hippocampal lesions in the neonatal rat
66. Unilateral hippocampal lesions in newborn and adult rats: Effects on spatial memory and BDNF gene expression
67. Experimental biology of cerebral hypoxia-ischemia: Relation to perinatal brain damage
68. Measuring the accentuation of the brain damage that arises from perinatal cerebral hypoxia-ischemia
69. Differential effects of early hippocampal pathology on episodic and semantic memory
70. Behavioral performance of rats following neonatal hypoxia-ischemia
71. Human amnesia and the medial temporal region: Enduring memory impairment following a bilateral lesion limited to Field CA1 of the hippocampus
72. Enduring memory impairment in monkeys after ischemic damage to the hippocampus