The CD8αβ co-receptor on double-positive thymocytes binds with differing affinities to the products of distinct class I MHC loci

European Journal of Immunology

Volumn 31, Issue 9, 2001, Pages 2791-2799

  Moody, Anne Marie ^a   Xiong, Yi ^a   Chang, Hsiu Ching ^a   Reinherz, Ellis L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cell fate; H 2Db; H 2Kb; MHCI 3 domain chimera; Thymic selection

Indexed keywords

CD8 ANTIGEN; COMPLEMENTARY DNA; LYMPHOCYTE ANTIGEN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MONOMER; PEPTIDE; T LYMPHOCYTE RECEPTOR; TETRAMER; CD8ALPHAALPHA ANTIGEN; CD8ALPHABETA ANTIGEN; H 2KB PROTEIN, MOUSE; H-2KB PROTEIN, MOUSE; H2 ANTIGEN; HISTOCOMPATIBILITY ANTIGEN H 2D(B); HISTOCOMPATIBILITY ANTIGEN H-2D(B);

ALLELE; ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CELL MATURATION; CELL SELECTION; CONTROLLED STUDY; GENETIC POLYMORPHISM; MOLECULAR INTERACTION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; T LYMPHOCYTE; THYMOCYTE; THYMUS; ANIMAL; C57BL MOUSE; CD8+ T LYMPHOCYTE; CHEMISTRY; IMMUNOLOGY; METABOLISM; PROTEIN TERTIARY STRUCTURE;

ANIMALS; ANTIGENS, CD8; CD8-POSITIVE T-LYMPHOCYTES; H-2 ANTIGENS; MICE; MICE, INBRED C57BL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANTIGEN, T-CELL; THYMUS GLAND;

EID: 0034741073     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200109)31:9<2791::AID-IMMU2791>3.0.CO;2-X     Document Type: Article

References (29)

1. Structural basis of cell-cell interactions in the immune system
2. Engagement of CD4 and CD8 accessory molecules is required for T cell maturation
3. CD8 is needed for development of cytotoxic T cells but not helper cells
4. Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I α3 domain: CD8 and the T-cell receptor recognize the same class I molecule
5. A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2
6. A second subunit of CD8 is expressed in human T cells
7. Expression of different CD8 isoforms on distinct human lymphocyte subpopulations
8. Cell-cell adhesion mediated by CD8 and MHC class I molecules
9. Crystal structure of the complex between human CD8αα and HLA-A2
10. b
11. T-cell selection
12. CD8 surface levels alter the fate of α/β T cell receptor-expressing thymocytes in transgenic mice
13. The level of CD8 expression can determined the outcome of thymic selection
14. Classical and non-classical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8αα
15. Expression, purification, and functional analysis of murine ectodomain fragments of CD8αα and CD8αβ dimers
16. T cell receptor and coreceptor CD8αα bind peptide-MHC independently and with distinct kinetics
17. A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity
18. Molecular analysis of the antigen receptor of virus-specific cytotoxic T cells and identification of a new Vα family
19. Selective events in T cell development
20. Role of CD8β domains in CD8 coreceptor function: Importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus
21. β2-microglobulin deficient mice lack CD4-8+ cytolytic T cells
22. b knockout mice: Peripheral CD8+ T cell repertoire and anti-lymphocytic choriomeningitis virus cytolytic responses
23. Requirement for CD8-major histocompatibility complex class I interaction in positive and negative of developing T cells
24. Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules
25. b at 2.4Å resolution: Implications for antigen-determinant selection
26. b molecule containing a single viral peptide: Implications for peptide binding and T-cell receptor recognition
27. Phenotypic analysis of antigen-specific T lymphocytes
28. Calculation of protein extinction coefficients from amino acid sequence data
29. A general method for facilitating heterodimeric pairing between two proteins: Application to expression of α and β T-cell receptor extracellular segments