Complete mapping of a novel HLA A*6801-restricted HIV-1 Tat epitope directly ex vivo with a rapid modified enzyme-linked immunospot assay

AIDS

Volumn 16, Issue 9, 2002, Pages 1285-1287

  Oxenius, Annette ^a   Jakobsen, Bent K ^a   Easterbrook, Philippa J ^a   Boulter, Jonathan M ^a   Tun, Tin ^a   Waters, Anele ^a   Agudelo, Juliet ^a   Barnardo, Martin ^a   Phillips, Rodney E ^a   Price, David A ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CD8 ANTIGEN; EPITOPE; HLA A ANTIGEN; HLA ANTIGEN CLASS 1; MONOMER; PEPTIDE; TRANSACTIVATOR PROTEIN;

ANALYTIC METHOD; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR RECOGNITION; MOLECULAR STABILITY; PRIORITY JOURNAL; CHEMISTRY; IMMUNOLOGY; METHODOLOGY;

ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; GENE PRODUCTS, TAT; HIV-1; HLA-A ANTIGENS; HUMAN; SUPPORT, NON-U.S. GOV'T; HUMANS;

EID: 0037076717     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200206140-00012     Document Type: Article

References (13)

1. Cytotoxic T lymphocyte responses to human immunodeficiency virus: Control and escape
2. The evolving field of HIV CTL epitope mapping: New approaches to the identification of novel epitopes
3. Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: Rapid characterization of CTL responses by enzyme-linked immunospot assay
4. Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by Elispot and intracellular cytokine staining assays
5. Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent
6. Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia
7. Human immunodeficiency virus type 1 Rev- and Tat-specific cytotoxic T lymphocyte frequencies inversely correlate with rapid progression to AIDS
8. The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals
9. Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle
10. Extensive alanine substitutions increase binding affinity of an influenza nucleoprotein peptide to HLA-Aw68 and do not abrogate peptide- specific CTL recognition
11. Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8
12. Control of viral replication and disease onset in cynomolgus monkeys by HIV-1 TAT vaccine