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Volumn 5, Issue 4, 1999, Pages 399-404

Antagonism of cytotoxic T-lymphocyte activation by soluble CD8

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR; T LYMPHOCYTE RECEPTOR;

EID: 0032903598     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/7398     Document Type: Article
Times cited : (34)

References (54)
  • 1
    • 0024383535 scopus 로고
    • Antigen recognition by class I restricted T lymphocytes
    • Townsend, A. & Bodmer, H. Antigen recognition by class I restricted T lymphocytes. Annu. Rev. Immunol. 7, 601-624 (1989).
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 601-624
    • Townsend, A.1    Bodmer, H.2
  • 2
    • 0021989325 scopus 로고
    • T cells and viral infections
    • Doherty, P.C. T cells and viral infections. Sr. Med. Bull. 41, 7-14 (1985).
    • (1985) Sr. Med. Bull. , vol.41 , pp. 7-14
    • Doherty, P.C.1
  • 3
    • 0024154193 scopus 로고
    • Role of the major histocompatibility complex class I antigens in tumor growth and metastasis
    • Tanaka, K., Yoshioka, T., Bieberich, C. & Jay, C. Role of the major histocompatibility complex class I antigens in tumor growth and metastasis. Annu. Rev. Immunol. 6, 359-380 (1988).
    • (1988) Annu. Rev. Immunol. , vol.6 , pp. 359-380
    • Tanaka, K.1    Yoshioka, T.2    Bieberich, C.3    Jay, C.4
  • 4
    • 0022566875 scopus 로고
    • Effector mechanisms in allograft rejection
    • Mason, D.W. & Morris, P.J. Effector mechanisms in allograft rejection. Annu. Rev. Immunol. 4, 119-145 (1986).
    • (1986) Annu. Rev. Immunol. , vol.4 , pp. 119-145
    • Mason, D.W.1    Morris, P.J.2
  • 5
    • 0025906133 scopus 로고
    • CD8 is needed for development of cytotoxic T cells but not helper T cells
    • Fung Leung, W.P. et al. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65, 443-449 (1991).
    • (1991) Cell , vol.65 , pp. 443-449
    • Fung Leung, W.P.1
  • 6
    • 0027404346 scopus 로고
    • CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny
    • Fung Leung, W.P. et al. CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny. Eur. J. Immunol. 23, 212-216 (1993).
    • (1993) Eur. J. Immunol. , vol.23 , pp. 212-216
    • Fung Leung, W.P.1
  • 7
    • 0026017339 scopus 로고
    • Participation of CD4 coreceptor molecules in T-cell repertoire selection
    • Teh, H.S. et al. Participation of CD4 coreceptor molecules in T-cell repertoire selection. Nature 349, 241-243 (1991).
    • (1991) Nature , vol.349 , pp. 241-243
    • Teh, H.S.1
  • 8
    • 0026632968 scopus 로고
    • Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells
    • Killeen, N., Moriarty, A., Teh, H.S. & Liftman, D.R. Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells. J. Exp. Med. 176, 89-97 (1992).
    • (1992) J. Exp. Med. , vol.176 , pp. 89-97
    • Killeen, N.1    Moriarty, A.2    Teh, H.S.3    Liftman, D.R.4
  • 9
    • 0028468552 scopus 로고
    • The CD8 coreceptor revisited: One chain good, two chains better
    • Zamoyska, R. The CD8 coreceptor revisited: one chain good, two chains better. Immunity 1, 243-246 (1994).
    • (1994) Immunity , vol.1 , pp. 243-246
    • Zamoyska, R.1
  • 10
    • 0025237554 scopus 로고
    • Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs
    • Turner, J.M. et al. Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell 60, 755-765 (1990).
    • (1990) Cell , vol.60 , pp. 755-765
    • Turner, J.M.1
  • 11
    • 0026520993 scopus 로고
    • Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck
    • Van Oers, N.S. et al. Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck. Eur. J. Immunol. 22, 735-743 (1992).
    • (1992) Eur. J. Immunol. , vol.22 , pp. 735-743
    • Van Oers, N.S.1
  • 12
    • 0029845439 scopus 로고    scopus 로고
    • T cell receptor and CD8-dependent tyrosine phosphorylation events in cytotoxic T lymphocytes: Activation of p56lck by CD8 binding to class I protein
    • Anel, A., O'Rourke, A.M., Kleinfeld, A.M. & Mescher, M.F. T cell receptor and CD8-dependent tyrosine phosphorylation events in cytotoxic T lymphocytes: activation of p56lck by CD8 binding to class I protein. Eur. J. Immunol. 26, 2310-2319 (1996).
    • (1996) Eur. J. Immunol. , vol.26 , pp. 2310-2319
    • Anel, A.1    O'Rourke, A.M.2    Kleinfeld, A.M.3    Mescher, M.F.4
  • 13
    • 0032563231 scopus 로고    scopus 로고
    • Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation
    • Kersh, E.N., Shaw, A.S. & Allen, P.M. Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation. Science 281, 572-575 (1998).
    • (1998) Science , vol.281 , pp. 572-575
    • Kersh, E.N.1    Shaw, A.S.2    Allen, P.M.3
  • 14
    • 0027364273 scopus 로고
    • Is CD8 dependence a true reflection of TCR affinity for antigen?
    • Kwan Lim, G.E., Ong, T., Aosai, F., Stauss, H. & Zamoyska, R. Is CD8 dependence a true reflection of TCR affinity for antigen? Int. Immunol. 5, 1219-1228 (1993).
    • (1993) Int. Immunol. , vol.5 , pp. 1219-1228
    • Kwan Lim, G.E.1    Ong, T.2    Aosai, F.3    Stauss, H.4    Zamoyska, R.5
  • 15
    • 0028518843 scopus 로고
    • Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity
    • Yoon, S.T., Dianzani, U., Bottomly, K. & Janeway, C.A., Jr. Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity. Immunity 1, 563-569 (1994).
    • (1994) Immunity , vol.1 , pp. 563-569
    • Yoon, S.T.1    Dianzani, U.2    Bottomly, K.3    Janeway C.A., Jr.4
  • 16
    • 0025924502 scopus 로고
    • Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells
    • Glaichenhaus, N., Shastri, N., Littman, D.R. & Turner, J.M. Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells. Cell 64, 511-520 (1991).
    • (1991) Cell , vol.64 , pp. 511-520
    • Glaichenhaus, N.1    Shastri, N.2    Littman, D.R.3    Turner, J.M.4
  • 17
    • 0025737687 scopus 로고
    • Phosphorylation of murine CD8 alpha is not essential for responses of T cell hybridomas to antigen
    • Williams, O., Vukmanovic, S. & Zamoyska, R. Phosphorylation of murine CD8 alpha is not essential for responses of T cell hybridomas to antigen. Int. Immunol. 3, 785-792 (1991).
    • (1991) Int. Immunol. , vol.3 , pp. 785-792
    • Williams, O.1    Vukmanovic, S.2    Zamoyska, R.3
  • 18
    • 0026742129 scopus 로고
    • Cytotoxic T-lymphocyte activation involves a cascade of signalling and adhesion events
    • O'Rourke, A.M. & Mescher, M.F. Cytotoxic T-lymphocyte activation involves a cascade of signalling and adhesion events. Nature 358, 253-255 (1992).
    • (1992) Nature , vol.358 , pp. 253-255
    • O'Rourke, A.M.1    Mescher, M.F.2
  • 19
    • 0027501143 scopus 로고
    • Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association
    • Chan, I.T. et al. Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association. Science 261, 1581-1584 (1993).
    • (1993) Science , vol.261 , pp. 1581-1584
    • Chan, I.T.1
  • 21
    • 0025299647 scopus 로고
    • Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling
    • O'Rourke, A.M., Rogers, J. & Mescher, M.F. Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling. Nature 346, 187-189 (1990).
    • (1990) Nature , vol.346 , pp. 187-189
    • O'Rourke, A.M.1    Rogers, J.2    Mescher, M.F.3
  • 22
    • 0025366452 scopus 로고
    • A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2
    • Salter, R.D. et al. A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2. Nature 345, 41-46 (1990).
    • (1990) Nature , vol.345 , pp. 41-46
    • Salter, R.D.1
  • 23
    • 0025208391 scopus 로고
    • Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule
    • Connolly, J.M., Hansen, T.H., Ingold, A.L. & Potter, T.A. Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule. Proc. Natl. Acad. Sci. USA 87, 2137-2141 (1990).
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 2137-2141
    • Connolly, J.M.1    Hansen, T.H.2    Ingold, A.L.3    Potter, T.A.4
  • 24
    • 0028797801 scopus 로고
    • CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes
    • Luescher, I.F. et al. CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes. Nature 373, 353-356 (1995).
    • (1995) Nature , vol.373 , pp. 353-356
    • Luescher, I.F.1
  • 25
    • 0029807351 scopus 로고    scopus 로고
    • CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes
    • Garcia, K.C. et al. CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. Nature 384, 577-581 (1996).
    • (1996) Nature , vol.384 , pp. 577-581
    • Garcia, K.C.1
  • 26
    • 0030926140 scopus 로고    scopus 로고
    • Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2
    • Gao, G.F. et al. Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. Nature 387, 630-634 (1997).
    • (1997) Nature , vol.387 , pp. 630-634
    • Gao, G.F.1
  • 27
    • 0029855347 scopus 로고    scopus 로고
    • Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
    • Garboczi, D.N. et al. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384, 134-141 (1996).
    • (1996) Nature , vol.384 , pp. 134-141
    • Garboczi, D.N.1
  • 28
    • 0033082128 scopus 로고    scopus 로고
    • T cell receptor and coreceptor CD8αα bind peptide-MHC independently and with distinct kinetics
    • Wyer, J.R. et al. T Cell Receptor and Coreceptor CD8αα Bind Peptide-MHC Independently and with Distinct Kinetics. Immunity 10, 219-225 (1999).
    • (1999) Immunity , vol.10 , pp. 219-225
    • Wyer, J.R.1
  • 29
    • 0027205194 scopus 로고
    • Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells
    • Jameson, S.C., Carbone, F.R. & Bevan, M.J. Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J. Exp. Med. 177, 1541-1550 (1993).
    • (1993) J. Exp. Med. , vol.177 , pp. 1541-1550
    • Jameson, S.C.1    Carbone, F.R.2    Bevan, M.J.3
  • 30
    • 0026503161 scopus 로고
    • Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor
    • De Magistris, M.T. et al. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell 68, 625-634 (1992).
    • (1992) Cell , vol.68 , pp. 625-634
    • De Magistris, M.T.1
  • 31
    • 0031659446 scopus 로고    scopus 로고
    • The influence of antigenic variation on cytotoxic T lymphocyte responses in HIV-1 infection
    • Price, D.A. et al. The influence of antigenic variation on cytotoxic T lymphocyte responses in HIV-1 infection. J. Mol. Med. 76, 699-708 (1998).
    • (1998) J. Mol. Med. , vol.76 , pp. 699-708
    • Price, D.A.1
  • 32
    • 0030869489 scopus 로고    scopus 로고
    • Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides
    • Sewell, A.K., Harcourt, G.C., Goulder, P.J., Price, D.A. & Phillips, R.E. Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides. Eur. J. Immunol. 27, 2323-2329 (1997).
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2323-2329
    • Sewell, A.K.1    Harcourt, G.C.2    Goulder, P.J.3    Price, D.A.4    Phillips, R.E.5
  • 33
    • 0028360076 scopus 로고
    • Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells
    • Bertoletti, A. et al. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 369, 407-410 (1994).
    • (1994) Nature , vol.369 , pp. 407-410
    • Bertoletti, A.1
  • 34
    • 0028261060 scopus 로고
    • Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants
    • Klenerman, P. et al. Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants. Nature 369, 403-407 (1994).
    • (1994) Nature , vol.369 , pp. 403-407
    • Klenerman, P.1
  • 35
    • 0028761258 scopus 로고
    • Promethean viruses?
    • Allen, P.M. & Zinkernagel, R.M. Promethean viruses? Nature 369, 355-356 (1994).
    • (1994) Nature , vol.369 , pp. 355-356
    • Allen, P.M.1    Zinkernagel, R.M.2
  • 36
    • 0030954195 scopus 로고    scopus 로고
    • Altered hapten ligands antagonize trinitrophenyl-specific cytotoxic T cells and block internalization of hapten-specific receptors
    • Preckel, T., Grimm, R., Martin, S. & Weltzien, H.U. Altered hapten ligands antagonize trinitrophenyl-specific cytotoxic T cells and block internalization of hapten-specific receptors. J. Exp. Med. 185, 1803-1813 (1997).
    • (1997) J. Exp. Med. , vol.185 , pp. 1803-1813
    • Preckel, T.1    Grimm, R.2    Martin, S.3    Weltzien, H.U.4
  • 37
    • 0032516035 scopus 로고    scopus 로고
    • Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade
    • Purbhoo, M.A. et al. Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade. Proc. Natl. Acad. Sci. USA 95, 4527-4532 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 4527-4532
    • Purbhoo, M.A.1
  • 38
    • 0030057218 scopus 로고    scopus 로고
    • T cell activation determined by T cell receptor number and tunable thresholds
    • Viola, A. & Lanzavecchia, A. T cell activation determined by T cell receptor number and tunable thresholds. Science 273, 104-106 (1996).
    • (1996) Science , vol.273 , pp. 104-106
    • Viola, A.1    Lanzavecchia, A.2
  • 40
    • 0003104975 scopus 로고    scopus 로고
    • A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists
    • Lyons, D.S. et al. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 5, 53-61 (1996).
    • (1996) Immunity , vol.5 , pp. 53-61
    • Lyons, D.S.1
  • 41
    • 0031020465 scopus 로고    scopus 로고
    • Effects of epitope modification on T cell receptor-ligand binding and antigen recognition by seven H-2Kd-restricted cytotoxic T lymphocyte clones specific for a photoreactive peptide derivative
    • Kessler, B.M., Bassanini, P., Cerottini, J.C. & Luescher, I.F. Effects of epitope modification on T cell receptor-ligand binding and antigen recognition by seven H-2Kd-restricted cytotoxic T lymphocyte clones specific for a photoreactive peptide derivative. J. Exp. Med. 185, 629-640 (1997).
    • (1997) J. Exp. Med. , vol.185 , pp. 629-640
    • Kessler, B.M.1    Bassanini, P.2    Cerottini, J.C.3    Luescher, I.F.4
  • 42
    • 0030863079 scopus 로고    scopus 로고
    • CD4 augments the response of a T cell to agonist but not to antagonist ligands
    • Hampl, J., Chien, Y.H. & Davis, M.M. CD4 augments the response of a T cell to agonist but not to antagonist ligands. Immunity 7, 379-385 (1997).
    • (1997) Immunity , vol.7 , pp. 379-385
    • Hampl, J.1    Chien, Y.H.2    Davis, M.M.3
  • 43
    • 17344362313 scopus 로고    scopus 로고
    • Ligand recognition by alphabeta T cell receptors
    • Davis, M.M. et al. Ligand recognition by alphabeta T cell receptors. Annu. Rev. Immunol. 16, 523-544 (1998).
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 523-544
    • Davis, M.M.1
  • 44
    • 0032192469 scopus 로고    scopus 로고
    • Initiation of signal transduction through the T cell receptor requires the peptide multivalent engagement of MHC ligands
    • Boniface, J.J. et al. Initiation of signal transduction through the T cell receptor requires the peptide multivalent engagement of MHC ligands. Immunity 9, 459-466 (1998).
    • (1998) Immunity , vol.9 , pp. 459-466
    • Boniface, J.J.1
  • 45
    • 0031889939 scopus 로고    scopus 로고
    • A structure-based approach to designing synthetic CD8alfa peptides that can inhibit cytotoxic T-lymphocyte reponses
    • Choksi, S., Jameson, B.A. & Korngold, R. A structure-based approach to designing synthetic CD8alfa peptides that can inhibit cytotoxic T-lymphocyte reponses. Nature Med. 4, 309-314 (1998).
    • (1998) Nature Med. , vol.4 , pp. 309-314
    • Choksi, S.1    Jameson, B.A.2    Korngold, R.3
  • 46
    • 0024505227 scopus 로고
    • A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing
    • Giblin, P., Ledbetter, J.A. & Kavathas, P. A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing. Proc. Natl. Acad. Sci. USA 86, 998-1002 (1989).
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 998-1002
    • Giblin, P.1    Ledbetter, J.A.2    Kavathas, P.3
  • 47
    • 0024426761 scopus 로고
    • Plasma levels of soluble CD8 antigen and interleukin-2 receptor antigen in patients with hairy cell leukemia, relationship with splenectomy and with clinical response to therapy
    • Ho, A.D. et al. Plasma levels of soluble CD8 antigen and interleukin-2 receptor antigen in patients with hairy cell leukemia, relationship with splenectomy and with clinical response to therapy. Leukemia 3, 718-723 (1989).
    • (1989) Leukemia , vol.3 , pp. 718-723
    • Ho, A.D.1
  • 48
    • 0025172716 scopus 로고
    • Soluble interleukin-2 receptor and soluble CD8 antigen in active rheumatoid arthritis
    • Zielinski, C.C., Pesau, B. & Muller, C. Soluble interleukin-2 receptor and soluble CD8 antigen in active rheumatoid arthritis. Clin. Immunol. Immunopathol. 57, 74-82 (1990).
    • (1990) Clin. Immunol. Immunopathol. , vol.57 , pp. 74-82
    • Zielinski, C.C.1    Pesau, B.2    Muller, C.3
  • 49
    • 0025735849 scopus 로고
    • Soluble CD8 levels in the CSF and serum of patients with multiple sclerosis
    • Maimone, D. & Reder, A.T. Soluble CD8 levels in the CSF and serum of patients with multiple sclerosis. Neurology 41, 851-854 (1991).
    • (1991) Neurology , vol.41 , pp. 851-854
    • Maimone, D.1    Reder, A.T.2
  • 50
    • 0028327539 scopus 로고
    • Elevated in vivo and in vitro secretion of CD8-alpha molecules in patients with systemic lupus erythematosus
    • Linker Israeli, M. et al. Elevated in vivo and in vitro secretion of CD8-alpha molecules in patients with systemic lupus erythematosus. J. Immunol. 152, 3158-3167 (1994).
    • (1994) J. Immunol. , vol.152 , pp. 3158-3167
    • Linker Israeli, M.1
  • 51
    • 0024596210 scopus 로고
    • Increased levels of soluble CD8 molecule in the serum of patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related disorders
    • Agostini, C. et al. Increased levels of soluble CD8 molecule in the serum of patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related disorders. Clin. Immunol. Immunopathol. 50, 146-153 (1989).
    • (1989) Clin. Immunol. Immunopathol. , vol.50 , pp. 146-153
    • Agostini, C.1
  • 52
    • 0018866878 scopus 로고
    • The differentiation and function of human T lymphocytes
    • Reinherz, E.L. & Schlossman, S.F. The differentiation and function of human T lymphocytes. Cell 19, 821-827 (1980).
    • (1980) Cell , vol.19 , pp. 821-827
    • Reinherz, E.L.1    Schlossman, S.F.2
  • 53
    • 0032510455 scopus 로고    scopus 로고
    • Antigen specific release of beta-chemokines by anti-HIV1 cytotoxic T lymphocytes
    • Price, D.A. et al. Antigen specific release of beta-chemokines by anti-HIV1 cytotoxic T lymphocytes. Curr. Biol. 8, 355-358 (1998).
    • (1998) Curr. Biol. , vol.8 , pp. 355-358
    • Price, D.A.1
  • 54
    • 0026613778 scopus 로고
    • Reprogramming the immune system for peripheral tolerance with CD4 and CD8 monoclonal antibodies
    • Cobbold, S.P., Qin, S., Leong, L.Y., Martin, C. & Waldmann, H. Reprogramming the immune system for peripheral tolerance with CD4 and CD8 monoclonal antibodies. Immunol. Rev. 129, 165-201 (1992).
    • (1992) Immunol. Rev. , vol.129 , pp. 165-201
    • Cobbold, S.P.1    Qin, S.2    Leong, L.Y.3    Martin, C.4    Waldmann, H.5


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