An algorithm-directed two-component library synthesized via solid-phase methodology yielding potent and orally bioavailable p38 MAP kinase inhibitors

Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2002, Pages 2173-2184

  McKenna, Jeffrey M ^a   Halley, Frank ^a   Souness, John E ^a   McLay, Iain M ^a   Pickett, Stephen D ^a   Collis, Alan J ^a   Page, Kenneth ^a   Ahmed, Imtiaz ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (5 METHYL 5 MORPHOLINOCARBONYL 1,3 DIOXAN 2 YL) 5 (4 PYRIDINYL)IMIDAZOLE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ALGORITHM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; ISOMER; MONTE CARLO METHOD; NONHUMAN; PAW EDEMA; RAT; SOLID PHASE EXTRACTION;

ADMINISTRATION, ORAL; ALGORITHMS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CELL LINE; COMBINATORIAL CHEMISTRY TECHNIQUES; DIOXANES; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; MONTE CARLO METHOD; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PIPERAZINES; PYRIMIDINES; RATS; RATS, INBRED LEW; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037161596     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011132l     Document Type: Article

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