Combinatorial synthesis of 3-(Amidoalkyl) and 3-(Aminoalkyl)-2-arylindole derivatives: Discovery of potent ligands for a variety of G-protein coupled receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 1, 2002, Pages 93-96

  Willoughby, Christopher A ^a   Hutchins, Steven M ^a   Rosauer, Keith G ^a   Dhar, Madhumeeta J ^a   Chapman, Kevin T ^a   Chicchi, Gary G ^a   Sadowski, Sharon ^a   Weinberg, David H ^a   Patel, Smita ^b   Malkowitz, Lorraine ^a   Di Salvo, Jerry ^a   Pacholok, Stephen G ^a   Cheng, Kang ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; G PROTEIN COUPLED RECEPTOR; INDOLE DERIVATIVE; LIGAND; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y5 RECEPTOR; SEROTONIN RECEPTOR; TACHYKININ RECEPTOR;

ARTICLE; COMBINATORIAL CHEMISTRY; CYCLIZATION; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; LIGAND BINDING; RECEPTOR BINDING;

AMIDES; AMINES; BINDING, COMPETITIVE; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG EVALUATION, PRECLINICAL; GTP-BINDING PROTEINS; HUMANS; INDOLES; LIGANDS; RECEPTORS, CELL SURFACE; RECEPTORS, CHEMOKINE; RECEPTORS, SEROTONIN; RECEPTORS, TACHYKININ; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18244382828     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00665-5     Document Type: Article

References (18)