A combinatorial library of indinavir analogues and its in vitro and in vivo studies

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 4, 2002, Pages 529-532

  Cheng, Yuan ^a   Rano, Thomas A ^a   Huening, Tracy T ^a   Zhang, Fengqi ^a   Lu, Zhijian ^a   Schleif, William A ^a   Gabryelski, Lori ^a   Olsen, David B ^a   Stahlhut, Mark ^a   Kuo, Lawrence C ^a   Lin, Jiunn H ^a   Xu, Xin ^a   Jin, Lixia ^a   Olah, Timothy V ^a   McLoughlin, Debra A ^a   King, Rick C ^a   Chapman, Kevin T ^a   Tata, James R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDINAVIR DERIVATIVE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS ENZYME; DRUG DERIVATIVE; INDINAVIR;

AREA UNDER THE CURVE; ARTICLE; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; DOG; DRUG ACTIVITY; DRUG HALF LIFE; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PROTEINASE INHIBITION; WILD TYPE; ANIMAL; CELL CULTURE; DRUG EFFECT; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; IC 50; METABOLIC CLEARANCE RATE; MUTATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CANIS FAMILIARIS; HUMAN IMMUNODEFICIENCY VIRUS 1;

ANIMALS; AREA UNDER CURVE; COMBINATORIAL CHEMISTRY TECHNIQUES; DOGS; DRUG EVALUATION, PRECLINICAL; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; INDINAVIR; INHIBITORY CONCENTRATION 50; METABOLIC CLEARANCE RATE; MUTATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 18244364639     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00824-1     Document Type: Article

References (20)