Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase

Journal of Medicinal Chemistry

Volumn 45, Issue 21, 2002, Pages 4669-4678

  Haque, Tasir S ^a   Tadesse, Seifu ^a,b   Marcinkeviciene, Jovita ^a   Rogers, M John ^a,c   Sizemore, Christine ^a,c   Kopcho, Lisa M ^a   Amsler, Karen ^a,d   Ecret, Lisa D ^a   Zhan, Dong Liang ^a   Hobbs, Frank ^a   Slee, Andrew ^a,d   Trainor, George L ^a   Stern, Andrew M ^a   Copeland, Robert A ^a   Combs, Andrew P ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b AMGEN INC   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d Enanta Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DIHYDROOROTATE DEHYDROGENASE; PYRAZOLE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HELICOBACTER PYLORI; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN; REACTION ANALYSIS;

COMBINATORIAL CHEMISTRY TECHNIQUES; ENZYME INHIBITORS; HELICOBACTER PYLORI; HUMANS; OXIDOREDUCTASES; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037057584     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020112w     Document Type: Article

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