NOTCH4 and the frontal lobe in schizophrenia

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 118 B, Issue 1, 2003, Pages 1-7

  Wassink, Thomas H ^a   Nopoulos, Peggy ^a   Pietila, Jennifer ^a   Crowe, Raymond R ^a   Andreasen, Nancy C ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Association; Brain morphology; Linkage disequilibrium; Magnetic resonance imaging; Wisconsin Card Sort Test (WCST)

Indexed keywords

NOTCH RECEPTOR; CELL SURFACE RECEPTOR; DNA; NOTCH4 PROTEIN, HUMAN; ONCOPROTEIN;

ADULT; ARTICLE; BRAIN DEVELOPMENT; BRAIN SIZE; COGNITION; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FRONTAL LOBE; GENE; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NOTCH4 GENE; PRIORITY JOURNAL; SCHIZOPHRENIA; ALLELE; ANALYSIS OF VARIANCE; GENE FREQUENCY; GENETICS; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; PSYCHOLOGY; TRINUCLEOTIDE REPEAT;

ADULT; ALLELES; ANALYSIS OF VARIANCE; DNA; FEMALE; FRONTAL LOBE; GENE FREQUENCY; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TRINUCLEOTIDE REPEATS;

EID: 0041819531     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.10071     Document Type: Article

References (55)

1. Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J, Lane CR, Schaffner SF, Bolk S, Brewer C, Tuomi T, Gaudet D, Hudson TJ, Daly M, Groop L, Lander ES. 2000. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26:76-80.
2. Andreasen NC. 1997. Linking mind and brain in the study of mental illnesses: A project for a scientific psychopathology. Science 275:1586-1593.
3. Andreasen NC, Cohen G, Harris G, Cizadlo T, Parkkinen J, Rezai K, Swayze VW. 1992a. Image processing for the study of brain structure and function: Problems and programs. J Neuropsychiatry Clin Neurosci 4:125-133.
4. Andreasen NC, Flaum M, Arndt S. 1992b. The comprehensive assessment of symptoms and history (CASH). An instrument for assessing diagnosis and psychopathology. Arch Gen Psychiatry 49:615-623.
5. Andreasen NC, Cizadlo T, Harris G, Swayze Vd, O'Leary DS, Cohen G, Ehrhardt J, Yuh WT. 1993. Voxel processing techniques for the antemortem study of neuroanatomy and neuropathology using magnetic resonance imaging. J Neuropsychiatry Clin Neurosci 5:121-130.
6. Andreasen NC, Flashman L, Flaum M, Arndt S, Swayze Vn, O'Leary DS, Ehrhardt JC, Yuh WT. 1994. Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging. JAMA 272:1763-1769.
7. Andreasen NC, Rajarethinam R, Cizadlo T, Arndt S, Swayze VWn, Flashman LA, O'Leary DS, Ehrhardt JC, Yuh WT. 1996. Automatic atlas-based volume estimation of human brain regions from MR images. J Comput Assist Tomogr 20:98-106.
8. Andrews KL, Mudd JL, Li C, Miner JH. 2002. Quantitative trait loci influence renal disease progression in a mouse model of Alport syndrome. Am J Pathol 160:721-730.
9. Artavanis-Tsakonas S, Rand MD, Lake RJ. 1999. Notch signaling: Cell fate control and signal integration in development. Science 284:770-776.
10. Bartlett PF, Brooker GJ, Faux CH, Dutton R, Murphy M, Turnley A, Kilpatrick TJ. 1998. Regulation of neural stem cell differentiation in the forebrain. Immunol Cell Biol 76:414-418.
11. Bassam BJ, Caetano-Anolles G, Gresshoff PM. 1991. Fast and sensitive silver staining of DNA in polyacrylamide gels. Anal Biochem 196:80-83.
12. Berg EA. 1948. A simple objective test for measuring flexibility in thinking. J Gen Psychol 39:15-22.
13. De Strooper B, Annaert W. 2001. Where Notch and Wnt signaling meet. The presenilin hub. J Cell Biol 152:F17-F20.
14. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR. 2001. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 98:6917-6922.
15. Fan JB, Tang JX, Gu NF, Feng GY, Zou FG, Xing YL, Shi JG, Zhao SM, Zhu SM, Ji LP, Sun WW, Zheng YL, Liu WQ, Breen G, St. Clair D, He L. 2002. A family-based and case-control association study of the NOTCH4 gene and schizophrenia. Mol Psychiatry 7:100-103.
16. Fortini ME. 2001. Notch and presenilin: A proteolytic mechanism emerges. Curr Opin Cell Biol 13:627-634.
17. Givogri MI, Costa RM, Schonmann V, Silva AJ, Campagnoni AT, Bongarzone ER. 2002. Central nervous system myelination in mice with deficient expression of Notch1 receptor. J Neurosci Res 67:309-320.
18. Goldberg TE, Weinberger DR, Berman KF, Pliskin NH, Podd MH. 1987. Further evidence for dementia of the prefrontal type in schizophrenia? A controlled study of teaching the Wisconsin Card Sorting Test. Arch Gen Psychiatry 44:1008-1014.
19. Harris G, Andreasen NC, Cizadlo T, Bailey JM, Bockholt J, Magnotta V, Arndt S. 1999. Improving tissue classification in magnetic resonance imaging: A three-dimensional multispectral discriminant analysis method with automated training class selection. J Comput Assist Tomogr 23:144-154.
20. Hays WL. 1963. Statistics for psychologists. New York: Holt, Rinehart, and Winston. p 532.
21. Hefler LA, Gregg AR. 2002. Inducible and endothelial nitric oxide synthase: Genetic background affects ovulation in mice. Fertil Steril 77:147-151.
22. n polymorphism in the NOTCH4 gene is not associated with schizophrenia in Japanese individuals. BMC Psychiatry 1:1.
23. Joutel A, Tournier-Lasserve E. 1998. Notch signalling pathway and human diseases. Semin Cell Dev Biol 9:619-625.
24. Justice NJ, Jan YN. 2002. Variations on the Notch pathway in neural development. Curr Opin Neurobiol 12:64-70.
25. Lawson GW, Van Winkle LS, Toskala E, Senior RM, Parks WC, Plopper CG. 2002. Mouse strain modulates the role of the ciliated cell in acute tracheobronchial airway injury-distal airways. Am J Pathol 160:315-327.
26. Leong KG, Hu X, Li L, Noseda M, Larrivee B, Hull C, Hood L, Wong F, Karsan A. 2002. Activated Notch4 inhibits angiogenesis: Role of beta 1-integrin activation. Mol Cell Biol 22:2830-2841.
27. Lutolf S, Radtke F, Aguet M, Suter U, Taylor V. 2002. Notch1 is required for neuronal and glial differentiation in the cerebellum. Development 129:373-385.
28. Magnotta VA, Heckel D, Andreasen NC, Cizadlo T, Corson PW, Ehrhardt JC, Yuh WT. 1999. Measurement of brain structures with artificial neural networks: Two- and three-dimensional applications. Radiology 211:781-790.
29. Malhotra AK, Kestler LJ, Mazzanti C, Bates JA, Goldberg T, Goldman D. 2002. A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry 159:652-654.
30. McGinnis RE, Fox H, Yates P, Cameron LA, Barnes MR, Gray IC, Spurr NK, Hurko O, St. Clair D. 2001. Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland. Nat Genet 28:128-129.
31. Meisenzahl EM, Rujescu D, Kirner A, Giegling I, Kathmann N, Leinsinger G, Maag K, Hegerl U, Hahn K, Moller HJ. 2001. Association of an interleukin-1beta genetic polymorphism with altered brain structure in patients with schizophrenia. Am J Psychiatry 158:1316-1319.
32. Miczek KA, de Almeida RM. 2001. Oral drug self-administration in the home cage of mice: Alcohol-heightened aggression and inhibition by the 5-HT1B agonist anpirtoline. Psychopharmacology (Berlin) 157:421-429.
33. Redmond L, Ghosh A. 2001. The role of Notch and Rho GTPase signaling in the control of dendritic development. Curr Opin Neurobiol 11:111-117.
34. Schizophrenia Linkage Collaborative Group for Chromosomes 3, 6, and 8. 1996. Additional support for schizophrenia linkage on chromosomes 6 and 8: A multicenter study. Am J Med Genet 67:580-594.
35. Schwab SG, Albus M, Hallmayer J, Honig S, Borrmann M, Lichtermann D, Ebstein RP, Ackenheil M, Lerer B, Risch N, et al. 1995. Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nat Genet 11:325-327.
36. Sestan N, Artavanis-Tsakonas S, Rakic P. 1999. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science 286:741-746.
37. Sklar P, Schwab SG, Williams NM, Daly M, Schaffner S, Maier W, Albus M, Trixler M, Eichhammer P, Lerer B, Hallmayer J, Norton N, Williams H, Zammit S, Cardno AG, Jones S, McCarthy G, Milanova V, Kirov G, O'Donovan MC, Lander ES, Owen MJ, Wildenauer DB. 2001. Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls. Nat Genet 28:126-128.
38. Spielman RS, McGinnis RE, Ewens WJ. 1993. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516.
39. Straub RE, MacLean CJ, O'Neill FA, Burke J, Murphy B, Duke F, Shinkwin R, Webb BT, Zhang J, Walsh D, et al. 1995. A potential vulnerability locus for schizophrenia on chromosome 6p24-22: Evidence for genetic heterogeneity. Nat Genet 11:287-293.
40. Talairach J, Tournoux P. 1988. Co-planar stereotaxic atlas of the human brain. New York: Theime.
41. Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC, et al. 1995. Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype. Science 269:230-234.
42. Ujike H, Takehisa Y, Takaki M, Tanaka Y, Nakata K, Takeda T, Kodama M, Fujiwara Y, Yamamoto A, Kuroda S. 2001. NOTCH4 gene polymorphism and susceptibility to schizophrenia and schizoaffective disorder. Neurosci Lett 301:41-44.
43. Uyttendaele H, Marazzi G, Wu G, Yan Q, Sassoon D, Kitajewski J. 1996. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development 122:2251-2259.
44. Uyttendaele H, Soriano JV, Montesano R, Kitajewski J. 1998. Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion. Dev Biol 196:204-217.
45. Villa N, Walker L, Lindsell CE, Gasson J, Iruela-Arispe ML, Weinmaster G. 2001. Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels. Mech Dev 108:161-164.
46. Volz HP, Gaser C, Hager F, Rzanny R, Mentzel HJ, Kreitschmann-Andermahr I, Kaiser WA, Sauer H. 1997. Brain activation during cognitive stimulation with the Wisconsin Card Sorting Test - a functional MRI study on healthy volunteers and schizophrenics. Psychiatry Res 75:145-157.
47. Wang S, Barres BA. 2000. Up a notch: Instructing gliogenesis. Neuron 27:197-200.
48. Wang S, Sun CE, Walczak CA, Ziegle JS, Kipps BR, Goldin LR, Diehl SR. 1995. Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nat Genet 10:41-46.
49. Wassink TH, Nelson JJ, Crowe RR, Andreasen NC. 1999. Heritability of BDNF alleles and their effect on brain morphology in schizophrenia. Am J Med Genet 88:724-728.
50. Wassink TH, Crowe RR, Andreasen NC. 2000. Tumor necrosis factor receptor-II: Heritability and effect on brain morphology in schizophrenia. Mol Psychiatry 5:678-682.
51. Wassink TH, Piven J, Vieland VJ, Huang J, Swiderski RE, Pietila J, Braun T, Beck G, Folstein SE, Haines JL, Sheffield VC. 2001. Evidence supporting WNT2 as an autism susceptibility gene. Am J Med Genet 105:406-413.
52. Wechsler D. 1981. Wechsler adult intelligence scale - revised, manual. New York: Psychological Corp.
53. Wei J, Hemmings GP. 2000. The NOTCH4 locus is associated with susceptibility to schizophrenia. Nat Genet 25:376-377.
54. Weinberger DR, Berman KF, Zec RF. 1986. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiatry 43:114-124.
55. Woods RP, Cherry SR, Mazziotta JC. 1992. Rapid automated algorithm for aligning and reslicing PET images. J Comput Assist Tomogr 16:620-633.