Activated Notch4 inhibits angiogenesis: Role of β1-integrin activation

Molecular and Cellular Biology

Volumn 22, Issue 8, 2002, Pages 2830-2841

  Leong, Kevin G ^a   Hu, Xiaolong ^a   Li, Linheng ^a   Noseda, Michela ^a   Larrivée, Bruno ^a   Hull, Christopher ^a   Hood, Leroy ^a   Wong, Fred ^a   Karsan, Aly ^a  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; NOTCH RECEPTOR; NOTCH4 RECEPTOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CELL FATE; CHORIOALLANTOIS; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM;

ALLANTOIS; ANIMALS; ANTIGENS, CD29; CELL ADHESION; CELL DIVISION; CELL LINE; CELL MOVEMENT; CHICK EMBRYO; CHORION; COLLAGEN; ENDOTHELIUM, VASCULAR; FIBRINOGEN; GENE EXPRESSION; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH;

EID: 0036198525     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.8.2830-2841.2002     Document Type: Article

References (81)

1. HMEC-1: Establishment of an immortalized human microvascular endothelial cell line
2. Notch signaling: Cell fate control and signal integration in development
3. Angiogenesis inhibition
4. In vitro model of angiogenesis using a human endothelium-derived permanent cell line: Contributions of induced gene expression, G-proteins, and integrins
5. Endothelial adhesion molecules in the development of the vascular tree: The garden of forking paths
6. Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines
7. β1 integrin is essential for teratoma growth and angiogenesis
8. Regulation of integrin alpha 5 beta 1 affinity during myogenic differentiation
9. Induction of the angiogenic phenotype by Hox D3
10. Requirement of vascular integrin alpha v beta 3 for angiogenesis
11. Use of the 10-day-old chick embryo model for studying angiogenesis
12. The role of integrins alpha 2 beta 1 and alpha 3 beta 1 in cell-cell and cell-substrate adhesion of human epidermal cells
13. Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor
14. Angiogenesis: Models and modulators
15. Functional partitioning of beta1 integrins revealed by activating and inhibitory mAbs
16. Identification of a role of the vitronectin receptor and protein kinase C in the induction of endothelial cell vascular formation
17. Antibodies to beta 1-integrins cause alterations of aortic vasculogenesis, in vivo
18. A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor
19. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
20. The role of alphav integrins during angiogenesis: Insights into potential mechanisms of action and clinical development
21. TAN-1, the human homologue of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
22. Definition of two angiogenic pathways by distinct alpha v integrins
23. Dissecting the mechanisms of suppressor of hairless function
24. Beta(1) integrin activation inhibits in vitro tube formation: Effects on cell migration, vacuole coalescence and lumen formation
25. Regulation of in vitro capillary tube formation by anti-integrin antibodies
26. Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis
27. Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro
28. Structure/function studies of lin-12/Notch proteins
29. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
30. Expression and function of chicken integrin beta 1 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells
31. Maintenance of somite borders in mice requires the Delta homologue Dll1
32. Integrin affinity modulation
33. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
34. Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity
35. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
36. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
37. The blood vessel wall
38. Endothelial cell death induced by tumor necrosis factor α is inhibited by the Bcl-2 family member, A1
39. Angiopoietin-1 induces sprouting angiogenesis in vitro
40. The intracellular domain of mouse Notch: A constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
41. A monoclonal antibody to beta 1 integrin (CD29) stimulates VLA-dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components
42. Regulation and function of an activation-dependent epitope of the beta 1 integrins in vascular cells after balloon injury in baboon arteries and in vitro
43. Type IV collagen synthesis by cultured human microvascular endothelial cells and its deposition into the subendothelial basement membrane
44. Notch signaling is essential for vascular morphogenesis in mice
45. Cell migration: A physically integrated molecular process
46. Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human Notch4 gene
47. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
48. Quantification of adherent and nonadherent cells cultured in 96-well plates using the supravital stain neutral red
49. Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation
50. Notch as a mediator of cell fate determination in hematopoiesis: Evidence and speculation
51. Differential effects of hepatocyte growth factor isoforms on epithelial and endothelial tubulogenesis
52. A novel, microcarrier-based in vitro assay for rapid and reliable quantification of three-dimensional cell migration and angiogenesis
53. Cell-surface regulation of beta 1-integrin activity on developing retinal neurons
54. Integrin activation by dithiothreitol or Mn2+ induces a ligand-occupied conformation and exposure of a novel NH2-terminal regulatory site on the beta1 integrin chain
55. Physical and biochemical regulation of integrin release during rear detachment of migrating cells
56. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness
57. Del1 induces integrin signaling and angiogenesis by ligation of ανβ3
58. Manipulating angiogenesis: From basic science to the bedside
59. bFGF and tumor angiogenesis - Back in the limelight?
60. Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor
61. Mechanisms of angiogenesis
62. Integrins and vascular extracellular matrix assembly
63. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
64. Factor VIII related antigen as an endothelial cell marker in benign and malignant diseases
65. Angiogenesis promoted by vascular endothelial growth factor: Regulation through alpha1beta1 and alpha2beta1 integrins
66. Skeletal and CNS defects in Presenilin-1-deficient mice
67. Proto-oncogene of int-3, a mouse Notch homologue, is expressed in endothelial cells during early embryogenesis
68. Dll4, a novel Notch ligand expressed in arterial endothelium
69. Endothelial cell attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrins
70. Nuclear access and action of Notch in vivo
71. Identification of a regulatory region of integrin beta 1 subunit using activating and inhibiting antibodies
72. Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium
73. Notch4/Int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
74. Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion
75. Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels
76. Notch signal transduction: A real rip and more
77. Control of beta1 integrin function. Localization of stimulatory epitopes
78. Presenilin 1 is required for Notch1 and D1 expression in the paraxial mesoderm
79. Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
80. An antisense oligonucleotide to the notch ligand jagged enhances fibroblast growth factor-induced angiogenesis in vitro