Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide

Biochemistry

Volumn 42, Issue 30, 2003, Pages 9041-9049

  Kozak, Kevin R ^a   Prusakiewicz, Jeffery J ^a   Rowlinson, Scott W ^a,b   Prudhomme, Daniel R ^a   Marnett, Lawrence J ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; HYDROPHOBICITY; METABOLISM;

LIGANDS;

BIOCHEMISTRY;

2 ARACHIDONOYLGLYCEROL; AMINO ACID; ANANDAMIDE; ARACHIDONIC ACID; ARGININE; CANNABINOID; CANNABINOID RECEPTOR; CARBOXYLIC ACID; CYCLOOXYGENASE 2; HYDROGEN; HYDROXYL GROUP; ISOENZYME; LEUCINE; LIGAND; PROSTAGLANDIN H2; TYROSINE;

ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; FATTY ACID SYNTHESIS; GENETIC CONSERVATION; HYDROPHOBICITY; MUTATIONAL ANALYSIS; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SITE DIRECTED MUTAGENESIS;

ACETYLATION; AMINO ACIDS; ANIMALS; ARACHIDONIC ACIDS; BINDING SITES; CANNABINOIDS; CATALYSIS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENDOCANNABINOIDS; FATTY ACIDS, UNSATURATED; HYDROPHOBICITY; HYDROXYEICOSATETRAENOIC ACIDS; ISOENZYMES; MALE; MEMBRANE PROTEINS; METHIONINE; MICE; MUTAGENESIS, SITE-DIRECTED; OXYGEN; POLYUNSATURATED ALKAMIDES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SERINE; SHEEP; SUBSTRATE SPECIFICITY; TYROSINE;

ANIMALIA;

EID: 0041664897     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034471k     Document Type: Article

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