Endocannabinoids in pain modulation

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 66, Issue 2-3, 2002, Pages 235-242

  Walker, J M ^a   Huang, S M ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID; OPIATE; BIOLOGICAL MARKER; CANNABINOID RECEPTOR; DRUG RECEPTOR; ENDOCANNABINOID; ICOSANOID;

BRAIN; GENETIC ENGINEERING; LIPID TRANSPORT; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; CENTRAL NERVOUS SYSTEM; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALIA;

ANIMALS; BIOLOGICAL MARKERS; BIOLOGICAL TRANSPORT; CANNABINOIDS; CENTRAL NERVOUS SYSTEM; EICOSANOIDS; ENDOCANNABINOIDS; PAIN; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; SIGNAL TRANSDUCTION;

EID: 0036019398     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1054/plef.2001.0361     Document Type: Article

References (68)

1. Determination and characterization of a cannabinoid receptor in rat brain
2. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
3. Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study
4. 1 receptors in rat central nervous system
5. Distribution of neuronal cannabinoid receptor in the adult rat brain: A comparative receptor binding radioautography and in situ hybridization histochemistry
6. Regulation of cannabinoid and mu opioid receptors in rat lumbar spinal cord following neonatal capsaicin treatment
7. Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord
8. Cannabinoid receptors undergo axonal flow in sensory nerves
9. 1 receptor localization in spinal cord and roots, dorsal root ganglion, and peripheral nerve
10. Molecular characterization of a peripheral receptor for cannabinoids
11. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
12. 2: A characterization of expression and adenylate cyclase modulation within the immune system
13. The effects of cannabinoids on the brain
14. The pharmacology of cannabis
15. 35S]GTPgammaS binding in the dorsal horn of the spinal cord of noninflamed and inflamed rats
16. Antipyretic analgesic and anti-inflammatory effects of delta 9-tetrahydrocannabinol in the rat
17. 9-tetrahydrocannabinol in the rat and mouse
18. 9-Nor-9β-hydroxyhexahydrocannabinol a cannabinoid with potent antinociceptive activity: Comparisons with morphine
19. Spinal and supraspinal components of cannabinoid-induced antinociception
20. 2-noradrenergic mechanism
21. The antinociceptive effects of intrathecally administered levonantradol and desacetyllevonantradol in the rat
22. 9-tetrahydrocannabinol THC
23. Analgesic and antiinflammatory activity of constituents of Cannabis sativa L.
24. Pharmacological analysis of levonantradol antinociception in mice
25. Suppression of noxious stimulus-evoked expression of fos-like immunoreactivity in rat spinal cord by a selective cannabinoid agonist
26. The analgesic effects of R(+)-WIN 55,212-2 mesylate a high affinity cannabinoid agonist, in a rat model of neuropathic pain
27. A novel neurotransmitter system involved in the control of motor behavior by the basal ganglia, in neuronal mechanisms for generating locomotor activity
28. Inhibition of noxious stimulus-evoked activity of spinal cord dorsal horn neurons by the cannabinoid WIN55,212-2
29. Cannabinoid modulation of wide dynamic range neurons in the lumbar dorsal horn of the rat by spinally administered WIN55,212-2
30. Intrathecal cannabinoid administration suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in rat spinal cord: Comparison with morphine
31. Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neuron in the lumbar dorsal horn of the rat
32. Suppression of noxious stimulus-evoked activity in the ventral posterolateral nucleus of the thalamus by the cannabinoid WIN55,212-2: Correlation between electrophysiological and antinociceptive effects
33. The cannabinoid WIN55,212-2 inhibits the activity-dependent facilitation of spinal nociceptive responses
34. Antinociceptive actions of WIN55,212-2 following intraventricular administration in rats
35. An examination of the central sites of action of cannabinoid-induced antinociception in the rat
36. Cannabinoid receptor-mediated inhibition of the rat tail-flick reflex after microinjection into the rostral ventromedial medulla
37. Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections
38. Pharmacologic evidence for the modulation of nociception by noradrenergic neurons
39. Cannabinoid receptor activation inhibits GABAergic neurotransmission in rostral ventromedial medulla neurons in vitro
40. Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitro
41. An analgesia circuit activated by cannabinoids
42. Antinociceptive activity of intrathecally administered cannabinoids alone and in combination with morphine in mice
43. SR141716A a cannabinoid receptor antagonist, produces hyperalgesia in untreated mice
44. Antihyperalgesic effects of spinal cannabinoids
45. Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia
46. Pharmacological effects of two active constituents of marihua
47. 1 receptor antagonist, SR141716A, selectively facilitates nociceptive responses of dorsal horn neurones in the rat
48. Cannabinoid-induced presynaptic inhibition of glutamatergic EPSCs in substantia gelatinosa neurons of the rat spinal cord
49. 1 receptors
50. Control of pain initiation by endogenous cannabinoids
51. Identification of the role of endogenous cannabinoids in pain modulation: Strategies and pitfalls
52. Evidence for a role of endogenous cannabinoids in the modulation of acute and tonic pain sensitivity
53. Functional role of high-affinity anadamide transport, as revealed by selective inhibition
54. Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
55. Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
56. Supersensitivity to anandamide and enhanced endogenous cannabinoid signalling in mice lacking fatty acid amide hydrolase
57. Pain modulation by release of the endogenous cannabinoid anandamide
58. Columnar organization in the midbrain periaqueductal gray: Modules for emotional expression
59. Spinomesencephalic tract: Projections from the lumbosacral spinal cord of their rat, cat, and monkey
60. Spinal afferents to functionally distinct periaqueductal gray columns in the rat: An anterograde and retrograde tracing study
61. Long ascending projections to the midbrain from cells of lanima 1 and nucleus of the dorsolateral funiculus of the rat spinal cord
62. Three times as many lamina 1 neurons project to the periaqueductal gray than to the thalamus: A retrograde tracing study in the cat
63. Laminar origins of spinal projection neurons to the periaqueductal gray of the rat
64. Physiology and morphology of the lamina I spinomesencephalic projection
65. Spinal distribution and collateral projections of rat spinomesencephalic tract cells
66. Deep and superficial noxious stimulation increases Fos-like immunoreactivity in different regions of the midbrain periaqueductal grey of the rat
67. Spinal lamina I projection neurons in the rat: Collateral internnervation of parabrachial area and thalamus