메뉴 건너뛰기




Volumn 58, Issue , 2003, Pages 131-153

Role of Defective Apoptosis in Type 1 Diabetes and Other Autoimmune Diseases

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; FAS ANTIGEN; FAS LIGAND; GRANULOCYTE COLONY STIMULATING FACTOR; HLA ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEASOME; PROTEIN LMP2; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN; UNCLASSIFIED DRUG; CYSTEINE PROTEINASE; LMP 2 PROTEIN; LMP-2 PROTEIN; MULTIENZYME COMPLEX;

EID: 0041307005     PISSN: 00799963     EISSN: None     Source Type: Journal    
DOI: 10.1210/rp.58.1.131     Document Type: Review
Times cited : (36)

References (118)
  • 3
    • 0025085992 scopus 로고
    • Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules
    • Allen RD, Marshall JD, Roths JB, Sidman CL 1990 Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules. J Exp Med 172:1367-1375
    • (1990) J Exp Med , vol.172 , pp. 1367-1375
    • Allen, R.D.1    Marshall, J.D.2    Roths, J.B.3    Sidman, C.L.4
  • 5
    • 0033001488 scopus 로고    scopus 로고
    • The NOD mouse model of type I diabetes: As good as it gets?
    • Atkinson MA, Leiter EH 1999 The NOD mouse model of type I diabetes: as good as it gets? Nat Med 5:601-604
    • (1999) Nat Med , vol.5 , pp. 601-604
    • Atkinson, M.A.1    Leiter, E.H.2
  • 6
    • 0030271387 scopus 로고    scopus 로고
    • NF-κB: Ten years after
    • Baeuerle PA, Baltimore D 1996 NF-κB: ten years after. Cell 87:13-20
    • (1996) Cell , vol.87 , pp. 13-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 7
    • 0000879672 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • Baldwin AS 1996 The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 12:141-179
    • (1996) Annu Rev Immunol , vol.12 , pp. 141-179
    • Baldwin, A.S.1
  • 9
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-κB in preventing TNF-α-induced cell death
    • Beg AA, Baltimore D 1996 An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274:782-784
    • (1996) Science , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 10
    • 0029059060 scopus 로고
    • Embryonic lethality and liver degeneration in mice lacking the relA component of NF-κB
    • Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D 1995 Embryonic lethality and liver degeneration in mice lacking the relA component of NF-κB. Nature 376:167-170
    • (1995) Nature , vol.376 , pp. 167-170
    • Beg, A.A.1    Sha, W.C.2    Bronson, R.T.3    Ghosh, S.4    Baltimore, D.5
  • 11
    • 0028500190 scopus 로고
    • Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins
    • Belich MP, Glynne RJ, Senger G, Sheer D, Trowsdale J 1994 Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins. Curr Biol 4:769-776
    • (1994) Curr Biol , vol.4 , pp. 769-776
    • Belich, M.P.1    Glynne, R.J.2    Senger, G.3    Sheer, D.4    Trowsdale, J.5
  • 12
    • 0033611544 scopus 로고    scopus 로고
    • TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105
    • Belich MP, Salmeron A, Johnston LH, Ley SC 1999 TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105. Nature 397:363-368
    • (1999) Nature , vol.397 , pp. 363-368
    • Belich, M.P.1    Salmeron, A.2    Johnston, L.H.3    Ley, S.C.4
  • 13
    • 0024276882 scopus 로고
    • The same inducible nuclear protein regulates mitogen activation of both the interleukin-2 receptor-α gene and type 1 HIV
    • Bohnline E, Lowenthal JW, Siekevitz M, Franza BR, Greene WC 1988 The same inducible nuclear protein regulates mitogen activation of both the interleukin-2 receptor-α gene and type 1 HIV. Cell 53:827-836
    • (1988) Cell , vol.53 , pp. 827-836
    • Bohnline, E.1    Lowenthal, J.W.2    Siekevitz, M.3    Franza, B.R.4    Greene, W.C.5
  • 15
    • 0032498962 scopus 로고    scopus 로고
    • Inhibition of NF-κB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis
    • Bushdid PB, Brantley DM, Yull FE, Blaeuer GL, Hoffman LH, Niswander L, Kerr LD 1998 Inhibition of NF-κB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Nature 392:615-618
    • (1998) Nature , vol.392 , pp. 615-618
    • Bushdid, P.B.1    Brantley, D.M.2    Yull, F.E.3    Blaeuer, G.L.4    Hoffman, L.H.5    Niswander, L.6    Kerr, L.D.7
  • 16
    • 0031985287 scopus 로고    scopus 로고
    • Nuclear factor (NF)-κB2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses
    • Caamano JH, Rizzo CA, Durham SK, Barton DS, Raventos-Suarez C, Snapper CM, Bravo R 1998 Nuclear factor (NF)-κB2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses. J Exp Med 187:185-196
    • (1998) J Exp Med , vol.187 , pp. 185-196
    • Caamano, J.H.1    Rizzo, C.A.2    Durham, S.K.3    Barton, D.S.4    Raventos-Suarez, C.5    Snapper, C.M.6    Bravo, R.7
  • 18
    • 0032502709 scopus 로고    scopus 로고
    • Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor κB1
    • Coux O, Goldberg AL 1998 Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor κB1. J Biol Chem 273:8820-8828
    • (1998) J Biol Chem , vol.273 , pp. 8820-8828
    • Coux, O.1    Goldberg, A.L.2
  • 19
    • 0030016595 scopus 로고    scopus 로고
    • Structure and functions of the 20S and 26S proteasomes
    • Coux O, Tanaka K, Goldberg AL 1996 Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem 65:801-847
    • (1996) Annu Rev Biochem , vol.65 , pp. 801-847
    • Coux, O.1    Tanaka, K.2    Goldberg, A.L.3
  • 21
    • 0024580741 scopus 로고
    • Functionally distinct NF-κB binding sites in the immunoglobulin κ and IL-2 receptor α chain genes
    • Cross SL, Halden NF, Lenardo M, Leonard WJ 1989 Functionally distinct NF-κB binding sites in the immunoglobulin κ and IL-2 receptor α chain genes. Science 244:466-468
    • (1989) Science , vol.244 , pp. 466-468
    • Cross, S.L.1    Halden, N.F.2    Lenardo, M.3    Leonard, W.J.4
  • 22
    • 0031423760 scopus 로고    scopus 로고
    • The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD
    • Delovitch TL, Singh B 1997 The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD [published erratum appears in Immunity 1998;8:531]. Immunity 7:727-738
    • (1997) Immunity , vol.7 , pp. 727-738
    • Delovitch, T.L.1    Singh, B.2
  • 23
    • 0032076171 scopus 로고    scopus 로고
    • published erratum
    • Delovitch TL, Singh B 1997 The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD [published erratum appears in Immunity 1998;8:531]. Immunity 7:727-738
    • (1998) Immunity , vol.8 , pp. 531
  • 24
    • 0029913381 scopus 로고    scopus 로고
    • Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production
    • Desai-Mehta A, Lu L, Ramsey-Goldman R, Datta SK 1996 Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production. J Clin Invest 97:2063-2073
    • (1996) J Clin Invest , vol.97 , pp. 2063-2073
    • Desai-Mehta, A.1    Lu, L.2    Ramsey-Goldman, R.3    Datta, S.K.4
  • 25
    • 0029802697 scopus 로고    scopus 로고
    • Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity
    • Drappa J, Vaishnaw AK, Sullivan KE, Chu JL, Elkon KB 1996 Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity [see comments]. N Engl J Med 335:1643-1649
    • (1996) N Engl J Med , vol.335 , pp. 1643-1649
    • Drappa, J.1    Vaishnaw, A.K.2    Sullivan, K.E.3    Chu, J.L.4    Elkon, K.B.5
  • 26
    • 0028330345 scopus 로고
    • Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus
    • Emlen W, Niebur J, Kadera R 1994 Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol 152:3685-3692.
    • (1994) J Immunol , vol.152 , pp. 3685-3692
    • Emlen, W.1    Niebur, J.2    Kadera, R.3
  • 27
    • 0026066613 scopus 로고
    • Generation of p50 subunit of NF-κB by processing of p 105 through an ATP-dependent pathway
    • Fan CM, Maniatis T 1991 Generation of p50 subunit of NF-κB by processing of p 105 through an ATP-dependent pathway. Nature 354:395-398
    • (1991) Nature , vol.354 , pp. 395-398
    • Fan, C.M.1    Maniatis, T.2
  • 28
    • 0024429737 scopus 로고
    • Abnormal T lymphocyte subsets in type I diabetes mellitus: Analysis with anti-2H4 and anti-4B4 antibodies
    • Faustman D, Eisenbarth G, Daley J, Breitmeyer J 1989 Abnormal T lymphocyte subsets in type I diabetes mellitus: analysis with anti-2H4 and anti-4B4 antibodies. Diabetes 38:1462-1468
    • (1989) Diabetes , vol.38 , pp. 1462-1468
    • Faustman, D.1    Eisenbarth, G.2    Daley, J.3    Breitmeyer, J.4
  • 29
    • 0026321504 scopus 로고
    • Linkage of faulty major histocompatibility complex class I to autoimmune diabetes
    • Faustman D, Li X, Lin HY, Fu Y, Eisenbarth G, Avruch J, Guo J 1991 Linkage of faulty major histocompatibility complex class I to autoimmune diabetes. Science 254:1756-1761
    • (1991) Science , vol.254 , pp. 1756-1761
    • Faustman, D.1    Li, X.2    Lin, H.Y.3    Fu, Y.4    Eisenbarth, G.5    Avruch, J.6    Guo, J.7
  • 30
    • 0023374546 scopus 로고
    • The pathogenesis of beta cell destruction in type I (insulin-dependent) diabetes mellitus
    • Foulis AK 1987 The pathogenesis of beta cell destruction in type I (insulin-dependent) diabetes mellitus. J Pathol 152:141-148
    • (1987) J Pathol , vol.152 , pp. 141-148
    • Foulis, A.K.1
  • 32
    • 0031975908 scopus 로고    scopus 로고
    • Rejection of allogeneic and syngeneic but not MHC class I-deficient tumor grafts by MHC class I-deficient mice
    • Freland S, Chambers BJ, Andersson M, Van Kaer L, Ljunggren HG 1998 Rejection of allogeneic and syngeneic but not MHC class I-deficient tumor grafts by MHC class I-deficient mice. J Immunol 160:572-579
    • (1998) J Immunol , vol.160 , pp. 572-579
    • Freland, S.1    Chambers, B.J.2    Andersson, M.3    Van Kaer, L.4    Ljunggren, H.G.5
  • 33
    • 0026595367 scopus 로고
    • Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits
    • Fruh K, Yang Y, Arnold D, Chambers J, Wu L, Waters JB, Spies T, Peterson PA 1992 Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits. J Biol Chem 267:22131-22140
    • (1992) J Biol Chem , vol.267 , pp. 22131-22140
    • Fruh, K.1    Yang, Y.2    Arnold, D.3    Chambers, J.4    Wu, L.5    Waters, J.B.6    Spies, T.7    Peterson, P.A.8
  • 34
    • 0027325037 scopus 로고
    • Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity
    • Fu Y, Nathan DM, Li F, Li X, Faustman DL 1993 Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity. J Clin Invest 9 1:2301-2307
    • (1993) J Clin Invest , vol.91 , pp. 2301-2307
    • Fu, Y.1    Nathan, D.M.2    Li, F.3    Li, X.4    Faustman, D.L.5
  • 35
    • 0030037846 scopus 로고    scopus 로고
    • Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-γ-induced subunits LMP2 and LMP7
    • Gaczynska M, Goldberg AL, Tanaka K, Hendil KB, Rock KL 1996 Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-γ-induced subunits LMP2 and LMP7. J Biol Chem 27 1:17275-17280
    • (1996) J Biol Chem , vol.271 , pp. 17275-17280
    • Gaczynska, M.1    Goldberg, A.L.2    Tanaka, K.3    Hendil, K.B.4    Rock, K.L.5
  • 36
    • 0025266685 scopus 로고
    • Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB
    • Ghosh S, Baltimore D 1990 Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB. Nature 344:678-682
    • (1990) Nature , vol.344 , pp. 678-682
    • Ghosh, S.1    Baltimore, D.2
  • 37
    • 0028091278 scopus 로고
    • + T cell repertoire in β-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I
    • + T cell repertoire in β-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I. J Exp Med 179:661-672
    • (1994) J Exp Med , vol.179 , pp. 661-672
    • Glas, R.1    Ohlen, C.2    Hoglund, P.3    Karre, K.4
  • 38
    • 0029071646 scopus 로고
    • Functions of the proteasome: The lysis at the end of the tunnel
    • Goldberg AL 1995 Functions of the proteasome: the lysis at the end of the tunnel [see comment], Science 268:522-523
    • (1995) Science , vol.268 , pp. 522-523
    • Goldberg, A.L.1
  • 41
    • 0033499621 scopus 로고    scopus 로고
    • NOD mice are defective in proteasome production and activation of NF-κB
    • Hayashi T, Faustman D 1999 NOD mice are defective in proteasome production and activation of NF-κB. Mol Cell Biol 19:8646-8659
    • (1999) Mol Cell Biol , vol.19 , pp. 8646-8659
    • Hayashi, T.1    Faustman, D.2
  • 42
    • 0034681387 scopus 로고    scopus 로고
    • Essential role of HLA-encoded proteasome subunits in NF-κB activation and prevention of TNF-α-induced apoptosis
    • Hayashi T, Faustman D 2000 Essential role of HLA-encoded proteasome subunits in NF-κB activation and prevention of TNF-α-induced apoptosis. J Biol Chem 275:5238-5247
    • (2000) J Biol Chem , vol.275 , pp. 5238-5247
    • Hayashi, T.1    Faustman, D.2
  • 43
    • 0027369661 scopus 로고
    • Identification of a new serine kinase that activates NFκB by direct phosphorylation
    • Hayashi T, Sekine T, Okamoto T 1993a Identification of a new serine kinase that activates NFκB by direct phosphorylation. J Biol Chem 268:26790-26795
    • (1993) J Biol Chem , vol.268 , pp. 26790-26795
    • Hayashi, T.1    Sekine, T.2    Okamoto, T.3
  • 44
    • 0027217531 scopus 로고
    • Oxireductive regulation of nuclear factor κB, involvement of a cellular reducing catalyst thioredoxin
    • Hayashi T, Ueno Y, Okamoto T 1993b Oxireductive regulation of nuclear factor κB, involvement of a cellular reducing catalyst thioredoxin. J Biol Chem 268:11380-11388
    • (1993) J Biol Chem , vol.268 , pp. 11380-11388
    • Hayashi, T.1    Ueno, Y.2    Okamoto, T.3
  • 45
    • 0033782756 scopus 로고    scopus 로고
    • LMP2 expression and proteasome activity in NOD mice
    • Hayashi T, Kodama S, Faustman D 2000 LMP2 expression and proteasome activity in NOD mice. Nat Med 6:1064-1066
    • (2000) Nat Med , vol.6 , pp. 1064-1066
    • Hayashi, T.1    Kodama, S.2    Faustman, D.3
  • 47
    • 0030837598 scopus 로고    scopus 로고
    • Failure of lymphopoiesis after adoptive transfer of NF-κ B-deficient fetal liver cells
    • Horwitz BH, Scott ML, Cherry SR, Bronson RT, Baltimore D 1997 Failure of lymphopoiesis after adoptive transfer of NF-κB-deficient fetal liver cells. Immunity 6:765-772
    • (1997) Immunity , vol.6 , pp. 765-772
    • Horwitz, B.H.1    Scott, M.L.2    Cherry, S.R.3    Bronson, R.T.4    Baltimore, D.5
  • 49
    • 0033537767 scopus 로고    scopus 로고
    • Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase
    • Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M, Johnson R, Karin M 1999 Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase [see comments]. Science 284:316-320
    • (1999) Science , vol.284 , pp. 316-320
    • Hu, Y.1    Baud, V.2    Delhase, M.3    Zhang, P.4    Deerinck, T.5    Ellisman, M.6    Johnson, R.7    Karin, M.8
  • 52
    • 0028960483 scopus 로고
    • Defective maturation and function of antigen-presenting cells in type I diabetes
    • Jansen A, Van Hagen M, Drexhage HA 1995 Defective maturation and function of antigen-presenting cells in type I diabetes. Lancet 345:491-492
    • (1995) Lancet , vol.345 , pp. 491-492
    • Jansen, A.1    Van Hagen, M.2    Drexhage, H.A.3
  • 53
    • 0032499286 scopus 로고    scopus 로고
    • Role of Rel/NF-κB transcription factors during the outgrowth of the vertebrate limb
    • Kanegae Y, Tavares AT, Izpisua Belmonte JC, Verma IM 1998 Role of Rel/NF-κB transcription factors during the outgrowth of the vertebrate limb. Nature 392:611-614
    • (1998) Nature , vol.392 , pp. 611-614
    • Kanegae, Y.1    Tavares, A.T.2    Izpisua Belmonte, J.C.3    Verma, I.M.4
  • 54
    • 0030842535 scopus 로고    scopus 로고
    • Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction
    • Kang SM, Schneider DB, Lin Z, Hanahan D, Dichek DA, Stock PG, Baekkeskov S 1997 Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction [see conunents], Nat Med 3:738-743
    • (1997) Nat Med , vol.3 , pp. 738-743
    • Kang, S.M.1    Schneider, D.B.2    Lin, Z.3    Hanahan, D.4    Dichek, D.A.5    Stock, P.G.6    Baekkeskov, S.7
  • 55
    • 0031968696 scopus 로고    scopus 로고
    • Fas ligand expression on islets as well as multiple cell lines results in accelerated neutrophilic rejection
    • Kang SM, Lin Z, Ascher NL, Stock PG 1998 Fas ligand expression on islets as well as multiple cell lines results in accelerated neutrophilic rejection. Transplant Proc 30:538
    • (1998) Transplant Proc , vol.30 , pp. 538
    • Kang, S.M.1    Lin, Z.2    Ascher, N.L.3    Stock, P.G.4
  • 56
    • 0025953735 scopus 로고
    • Overexpression of class I major histocompatibiity complex accompanies insulitis in the nonobese diabetic mouse and is prevented by anti-interferon-γ antibody
    • Kay TWH, Campbell IL, Oxbrow L, Harrison LC 1991 Overexpression of class I major histocompatibiity complex accompanies insulitis in the nonobese diabetic mouse and is prevented by anti-interferon-γ antibody. Diabetologia 34:779-785
    • (1991) Diabetologia , vol.34 , pp. 779-785
    • Kay, T.W.H.1    Campbell, I.L.2    Oxbrow, L.3    Harrison, L.C.4
  • 58
    • 0032586826 scopus 로고    scopus 로고
    • Apoptosis of pancreatic beta-cells detected in accelerated diabetes of NOD mice: No role of Fas-Fas ligand interaction in autoimmune diabetes
    • Kim YH, Kim S, Kim KA, Yagita H, Kayagaki N, Kim KW, Lee MS 1999 Apoptosis of pancreatic beta-cells detected in accelerated diabetes of NOD mice: no role of Fas-Fas ligand interaction in autoimmune diabetes. Eur J Immunol 29:455-465
    • (1999) Eur J Immunol , vol.29 , pp. 455-465
    • Kim, Y.H.1    Kim, S.2    Kim, K.A.3    Yagita, H.4    Kayagaki, N.5    Kim, K.W.6    Lee, M.S.7
  • 59
    • 0029150389 scopus 로고
    • Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    • Kontgen F, Grumont RJ, Strasser A, Metcalf D, Li R, Tarlinton D, Gerondakis S 1995 Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev 9:1965-1977
    • (1995) Genes Dev , vol.9 , pp. 1965-1977
    • Kontgen, F.1    Grumont, R.J.2    Strasser, A.3    Metcalf, D.4    Li, R.5    Tarlinton, D.6    Gerondakis, S.7
  • 60
    • 0029862164 scopus 로고    scopus 로고
    • Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes
    • Koshy M, Berger D, Crow MK 1996 Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes. J Clin Invest 98:826-837
    • (1996) J Clin Invest , vol.98 , pp. 826-837
    • Koshy, M.1    Berger, D.2    Crow, M.K.3
  • 61
    • 0030839580 scopus 로고    scopus 로고
    • Increased expression of functional Fas-ligand in activated T cells from patients with systemic lupus erythematosus
    • Kovacs B, Liossis SN, Dennis GJ, Tsokos GC 1997 Increased expression of functional Fas-ligand in activated T cells from patients with systemic lupus erythematosus. Autoimmunity 25:213-221
    • (1997) Autoimmunity , vol.25 , pp. 213-221
    • Kovacs, B.1    Liossis, S.N.2    Dennis, G.J.3    Tsokos, G.C.4
  • 62
    • 0031912361 scopus 로고    scopus 로고
    • Resistance of T-cells to apoptosis in autoimmune diabetic (NOD) mice is increased early in life and is associated with dysregulated expression of Bcl-x
    • Lamhamedi-Cherradi SE, Luan JJ, Eloy L, Fluteau G, Bach JF, Garchon HJ 1998 Resistance of T-cells to apoptosis in autoimmune diabetic (NOD) mice is increased early in life and is associated with dysregulated expression of Bcl-x. Diabetologia 41:178-184
    • (1998) Diabetologia , vol.41 , pp. 178-184
    • Lamhamedi-Cherradi, S.E.1    Luan, J.J.2    Eloy, L.3    Fluteau, G.4    Bach, J.F.5    Garchon, H.J.6
  • 63
    • 0029166019 scopus 로고
    • Reduced expression of peplideloaded HLA class I molecules on multiple sclerosis lymphocytes
    • Li F, Hauser SL, Linan MJ, Stein MC, Faustman DL 1995 Reduced expression of peplideloaded HLA class I molecules on multiple sclerosis lymphocytes. Ann Neurol 38:147-154
    • (1995) Ann Neurol , vol.38 , pp. 147-154
    • Li, F.1    Hauser, S.L.2    Linan, M.J.3    Stein, M.C.4    Faustman, D.L.5
  • 65
    • 0033537739 scopus 로고    scopus 로고
    • Severe liver degeneration in mice lacking the IκB kinase 2 gene
    • Li Q, Van Antwerp D, Mercurio F, Lee KF, Verma IM 1999b Severe liver degeneration in mice lacking the IκB kinase 2 gene [see comments]. Science 284:321-325
    • (1999) Science , vol.284 , pp. 321-325
    • Li, Q.1    Van Antwerp, D.2    Mercurio, F.3    Lee, K.F.4    Verma, I.M.5
  • 66
    • 0027470127 scopus 로고
    • Use of donor β2-microglobulin-deficient transgenic mouse liver cells for isografts, allografts, and xenografts
    • Li X, Faustman D 1993 Use of donor β2-microglobulin-deficient transgenic mouse liver cells for isografts, allografts, and xenografts. Transplantation 55:940-946
    • (1993) Transplantation , vol.55 , pp. 940-946
    • Li, X.1    Faustman, D.2
  • 67
    • 0031555482 scopus 로고    scopus 로고
    • Three-dimensional structures of proteins involved in programmed cell death
    • Liang H, Fesik SW 1997 Three-dimensional structures of proteins involved in programmed cell death. J Mol Biol 274:291-302
    • (1997) J Mol Biol , vol.274 , pp. 291-302
    • Liang, H.1    Fesik, S.W.2
  • 68
    • 0014954212 scopus 로고
    • Abrin and ricin: New anti-tumor substances
    • Lin J, Tserng K, Chen C, Lin L, Tung T 1970 Abrin and ricin: new anti-tumor substances. Nature 227:562-563
    • (1970) Nature , vol.227 , pp. 562-563
    • Lin, J.1    Tserng, K.2    Chen, C.3    Lin, L.4    Tung, T.5
  • 69
    • 0032549815 scopus 로고    scopus 로고
    • Co-translational biogenesis of NF-κB p50 by the 26S proteasome
    • Lin L, DeMartino GN, Greene WC 1998 Co-translational biogenesis of NF-κB p50 by the 26S proteasome. Cell 92:819-828
    • (1998) Cell , vol.92 , pp. 819-828
    • Lin, L.1    DeMartino, G.N.2    Greene, W.C.3
  • 70
    • 1842334483 scopus 로고    scopus 로고
    • In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases
    • Lorenz HM, Grunke M, Hieronymus T, Herrmann M, Kuhnel A, Manger B, Kalden JR 1997 In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases [see comments]. Arthritis Rheum 40:306-317
    • (1997) Arthritis Rheum , vol.40 , pp. 306-317
    • Lorenz, H.M.1    Grunke, M.2    Hieronymus, T.3    Herrmann, M.4    Kuhnel, A.5    Manger, B.6    Kalden, J.R.7
  • 72
    • 0029866197 scopus 로고    scopus 로고
    • Phosphorylation of p105 PEST sequences via a redox-insensitive pathway up-regulates processing of p50 NF-κB
    • MacKichan ML, Logeat F, Israel A 1996 Phosphorylation of p105 PEST sequences via a redox-insensitive pathway up-regulates processing of p50 NF-κB. J Biol Chem 271:6084-6091
    • (1996) J Biol Chem , vol.271 , pp. 6084-6091
    • MacKichan, M.L.1    Logeat, F.2    Israel, A.3
  • 74
    • 0033106149 scopus 로고    scopus 로고
    • A ubiquitin ligase complex essential for the NF-κB, Wnt/Wingless, and Hedgehog signaling pathways
    • Maniatis T 1999 A ubiquitin ligase complex essential for the NF-κB, Wnt/Wingless, and Hedgehog signaling pathways. Genes Dev 13:505-510
    • (1999) Genes Dev , vol.13 , pp. 505-510
    • Maniatis, T.1
  • 78
    • 0024237382 scopus 로고
    • IDDM in BB rats. Enhanced MHC class I heavy-chain gene expression in pancreatic islets
    • Ono SJ, Issa-Chergui B, Colle E, Guttmann RD, Seemayer TA, Fuks A 1988 IDDM in BB rats. Enhanced MHC class I heavy-chain gene expression in pancreatic islets. Diabetes 37:1411-1418
    • (1988) Diabetes , vol.37 , pp. 1411-1418
    • Ono, S.J.1    Issa-Chergui, B.2    Colle, E.3    Guttmann, R.D.4    Seemayer, T.A.5    Fuks, A.6
  • 79
    • 0033526068 scopus 로고    scopus 로고
    • In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor α
    • Pakala SV, Chivetta M, Kelly CB, Katz JD 1999 In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor α. J Exp Med 189:1053-1062
    • (1999) J Exp Med , vol.189 , pp. 1053-1062
    • Pakala, S.V.1    Chivetta, M.2    Kelly, C.B.3    Katz, J.D.4
  • 80
    • 0027980321 scopus 로고
    • The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
    • Palombella V, Rando OJ, Goldberg AL, Maniatis T 1994 The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78:773-785
    • (1994) Cell , vol.78 , pp. 773-785
    • Palombella, V.1    Rando, O.J.2    Goldberg, A.L.3    Maniatis, T.4
  • 81
    • 0033560024 scopus 로고    scopus 로고
    • A critical role for the RelA subunit of nuclear factor κB in regulation of multiple immune-response genes and in Fas-induced cell death
    • Quaaz F, Li M, Beg AA 1999 A critical role for the RelA subunit of nuclear factor κB in regulation of multiple immune-response genes and in Fas-induced cell death. J Exp Med 189:999-1004
    • (1999) J Exp Med , vol.189 , pp. 999-1004
    • Quaaz, F.1    Li, M.2    Beg, A.A.3
  • 82
    • 0031871335 scopus 로고    scopus 로고
    • An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus
    • Rabinovitch A 1998 An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus. Diabetes Metab Rev 14:129-151
    • (1998) Diabetes Metab Rev , vol.14 , pp. 129-151
    • Rabinovitch, A.1
  • 85
    • 0034080750 scopus 로고    scopus 로고
    • Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape
    • Restifo NP 2000 Not so Fas: re-evaluating the mechanisms of immune privilege and tumor escape. Nat Med 6:493-495
    • (2000) Nat Med , vol.6 , pp. 493-495
    • Restifo, N.P.1
  • 88
    • 0025738076 scopus 로고
    • Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65
    • Schmid RM, Perkins ND, Duckett CS, Andrews PC, Nabel GJ 1991 Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65. Nature 352:733-736
    • (1991) Nature , vol.352 , pp. 733-736
    • Schmid, R.M.1    Perkins, N.D.2    Duckett, C.S.3    Andrews, P.C.4    Nabel, G.J.5
  • 89
    • 0031892786 scopus 로고    scopus 로고
    • NF-κB p105 processing via the ubiquitin-proteasome pathway
    • Sears C, Olesen J, Rubin D, Finley D, Maniatis T 1998 NF-κB p105 processing via the ubiquitin-proteasome pathway. J Biol Chem 273:1409-1419
    • (1998) J Biol Chem , vol.273 , pp. 1409-1419
    • Sears, C.1    Olesen, J.2    Rubin, D.3    Finley, D.4    Maniatis, T.5
  • 90
    • 0028804551 scopus 로고
    • Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
    • Sha WC, Liou HC, Tuomanen EI, Baltimore D 1995 Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80:321-330
    • (1995) Cell , vol.80 , pp. 321-330
    • Sha, W.C.1    Liou, H.C.2    Tuomanen, E.I.3    Baltimore, D.4
  • 93
    • 0031171741 scopus 로고    scopus 로고
    • Protection of NIT-1 pancreatic beta-cells from immune attack by inhibition of NF-κB
    • Stephens LA, Thomas HE, Kay TW 1997 Protection of NIT-1 pancreatic beta-cells from immune attack by inhibition of NF-κB. J Autoimmunity 10:293-298
    • (1997) J Autoimmunity , vol.10 , pp. 293-298
    • Stephens, L.A.1    Thomas, H.E.2    Kay, T.W.3
  • 94
    • 0032932324 scopus 로고    scopus 로고
    • Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets
    • Suarez-Pinzon W, Sorensen O, Bleackley RC, Elliott JF, Rajotte RV, Rabinovitch A 1999 Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets. Diabetes 48:21-28
    • (1999) Diabetes , vol.48 , pp. 21-28
    • Suarez-Pinzon, W.1    Sorensen, O.2    Bleackley, R.C.3    Elliott, J.F.4    Rajotte, R.V.5    Rabinovitch, A.6
  • 95
    • 0028181243 scopus 로고
    • Autoregulation of the NF-κB transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs
    • Sun SC, Ganchi PA, Beraud C, Ballard DW, Greene WC 1994 Autoregulation of the NF-κB transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs. Proc Natl Acad Sci USA 91:1346-1350
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1346-1350
    • Sun, S.C.1    Ganchi, P.A.2    Beraud, C.3    Ballard, D.W.4    Greene, W.C.5
  • 98
    • 0026665460 scopus 로고
    • κB site dependent activation of the interleukin-2 receptor α-chain gene promoter by human c-Rel
    • Tan TH, Huang GP, Sica A, Ghosh P, Young HA, Longo DL, Rice NR 1992 κB site dependent activation of the interleukin-2 receptor α-chain gene promoter by human c-Rel. Mol Cell Biol 12:4067-4075
    • (1992) Mol Cell Biol , vol.12 , pp. 4067-4075
    • Tan, T.H.1    Huang, G.P.2    Sica, A.3    Ghosh, P.4    Young, H.A.5    Longo, D.L.6    Rice, N.R.7
  • 100
    • 0028986193 scopus 로고
    • NF-κB: A lesson in family values
    • Thanos D, Maniatis T 1995 NF-κB: a lesson in family values. Cell 80:529-532
    • (1995) Cell , vol.80 , pp. 529-532
    • Thanos, D.1    Maniatis, T.2
  • 101
    • 0033178741 scopus 로고    scopus 로고
    • Evidence that beta cell death in the nonobese diabetic mouse is Fas independent
    • Thomas HE, Darwiche R, Corbett JA, Kay TW 1999 Evidence that beta cell death in the nonobese diabetic mouse is Fas independent. J Immunol 163:1562-1569
    • (1999) J Immunol , vol.163 , pp. 1562-1569
    • Thomas, H.E.1    Darwiche, R.2    Corbett, J.A.3    Kay, T.W.4
  • 105
    • 0028556564 scopus 로고
    • Tolerance to peripheral tissue is transient and maintained by tissue specific class I expression
    • Vidal-Puig A, Faustman DL 1994 Tolerance to peripheral tissue is transient and maintained by tissue specific class I expression. Transplant Proc 26:3314-3316
    • (1994) Transplant Proc , vol.26 , pp. 3314-3316
    • Vidal-Puig, A.1    Faustman, D.L.2
  • 106
    • 0029887188 scopus 로고    scopus 로고
    • Expression of transporter associated with antigen processing-1 in the endocrine cells of human pancreatic islets: Effect of cytokines and evidence of hyperexpression in IDDM
    • Vives-Pi M, Armengol MP, Alcaide L, Costa M, Somoza N, Vargas F, Jaraquemada D, Pujol-Borrell R 1996 Expression of transporter associated with antigen processing-1 in the endocrine cells of human pancreatic islets: effect of cytokines and evidence of hyperexpression in IDDM. Diabetes 45:779-788
    • (1996) Diabetes , vol.45 , pp. 779-788
    • Vives-Pi, M.1    Armengol, M.P.2    Alcaide, L.3    Costa, M.4    Somoza, N.5    Vargas, F.6    Jaraquemada, D.7    Pujol-Borrell, R.8
  • 107
    • 0028196601 scopus 로고
    • The B cell-specific transcription factor BSAP regulates B cell proliferation
    • Wakatsuki Y, Neurath MF, Max EE, Strober W 1994 The B cell-specific transcription factor BSAP regulates B cell proliferation. J Exp Med 179:1099-1108
    • (1994) J Exp Med , vol.179 , pp. 1099-1108
    • Wakatsuki, Y.1    Neurath, M.F.2    Max, E.E.3    Strober, W.4
  • 109
    • 0029858387 scopus 로고    scopus 로고
    • TNF- and cancer therapy-induced apoptosis potentiation by inhibition of NF-κB
    • Wang CY, Mayo MW, Baldwin AS 1996 TNF- and cancer therapy-induced apoptosis potentiation by inhibition of NF-κB. Science 274:784-787
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.Y.1    Mayo, M.W.2    Baldwin, A.S.3
  • 110
    • 0026568919 scopus 로고
    • Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
    • Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S 1992 Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314-317
    • (1992) Nature , vol.356 , pp. 314-317
    • Watanabe-Fukunaga, R.1    Brannan, C.I.2    Copeland, N.G.3    Jenkins, N.A.4    Nagata, S.5
  • 112
    • 0028817585 scopus 로고
    • Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family
    • Weih F, Carrasco D, Durham SK, Barton DS, Rizzo CA, Ryseck RP, Lira SA, Bravo R 1995 Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family. Cell 80:331-340
    • (1995) Cell , vol.80 , pp. 331-340
    • Weih, F.1    Carrasco, D.2    Durham, S.K.3    Barton, D.S.4    Rizzo, C.A.5    Ryseck, R.P.6    Lira, S.A.7    Bravo, R.8
  • 113
    • 0023747665 scopus 로고
    • Identification of T cell subsets and class I and class II antigen expression in islet grafts and pancreatic islets of diabetic BioBreeding/Worcester rats
    • Weringer EJ, Like AA 1988 Identification of T cell subsets and class I and class II antigen expression in islet grafts and pancreatic islets of diabetic BioBreeding/Worcester rats. Am J Pathol 132:292-303
    • (1988) Am J Pathol , vol.132 , pp. 292-303
    • Weringer, E.J.1    Like, A.A.2
  • 114
    • 0033179001 scopus 로고    scopus 로고
    • Abnormal NF-κB activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression
    • Wong HK, Kammer GM, Dennis G, Tsokos GC 1999 Abnormal NF-κB activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression. J Immunol 163:1682-1689
    • (1999) J Immunol , vol.163 , pp. 1682-1689
    • Wong, H.K.1    Kammer, G.M.2    Dennis, G.3    Tsokos, G.C.4
  • 115
    • 0029737324 scopus 로고    scopus 로고
    • Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease
    • Wu J, Wilson J, He J, Xiang L, Schur PH, Mountz JD 1996a Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease. J Clin Invest 98:1107-1113
    • (1996) J Clin Invest , vol.98 , pp. 1107-1113
    • Wu, J.1    Wilson, J.2    He, J.3    Xiang, L.4    Schur, P.H.5    Mountz, J.D.6
  • 117
    • 0031571790 scopus 로고    scopus 로고
    • Reduced expression of Tap1 and Lmp2 antigen processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter
    • Yan G, Fu Y, Faustman DL 1997 Reduced expression of Tap1 and Lmp2 antigen processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter. J Immunol 159:3068-3080
    • (1997) J Immunol , vol.159 , pp. 3068-3080
    • Yan, G.1    Fu, Y.2    Faustman, D.L.3
  • 118
    • 0027990811 scopus 로고
    • Effect of tumor necrosis factor a on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process
    • Yang XD, Tisch R, Singer SM, Cao ZA, Liblau RS, Schreiber RD, McDevitt HO 1994 Effect of tumor necrosis factor a on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J Exp Med 180:995-1004
    • (1994) J Exp Med , vol.180 , pp. 995-1004
    • Yang, X.D.1    Tisch, R.2    Singer, S.M.3    Cao, Z.A.4    Liblau, R.S.5    Schreiber, R.D.6    McDevitt, H.O.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.