-
1
-
-
0036894290
-
Random mutagenesis in the mouse as a tool in drug discovery
-
Russ, A. et al. Random mutagenesis in the mouse as a tool in drug discovery. Drug Discov. Today 7, 1175-1183 (2002).
-
(2002)
Drug Discov. Today
, vol.7
, pp. 1175-1183
-
-
Russ, A.1
-
2
-
-
0036221481
-
Signal transduction mediated by the T cell antigen receptor: The role of adapter proteins
-
Samelson, L. E. Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. Annu. Rev. Immunol. 20, 371-394 (2002).
-
(2002)
Annu. Rev. Immunol.
, vol.20
, pp. 371-394
-
-
Samelson, L.E.1
-
3
-
-
0035525572
-
Positive and negative regulation of T-cell activation by adaptor proteins
-
Koretzky, G. A. & Myung, P. S. Positive and negative regulation of T-cell activation by adaptor proteins. Nature Rev. Immunol. 1, 95-107 (2001).
-
(2001)
Nature Rev. Immunol.
, vol.1
, pp. 95-107
-
-
Koretzky, G.A.1
Myung, P.S.2
-
4
-
-
0035895501
-
Sequence interpretation. Functional annotation of mouse genome sequences
-
Nadeau, J. H. et al. Sequence interpretation. Functional annotation of mouse genome sequences. Science 291, 1251-1255 (2001).
-
(2001)
Science
, vol.291
, pp. 1251-1255
-
-
Nadeau, J.H.1
-
5
-
-
0036689003
-
Functional genomics in the mouse
-
Perkins, A. S. Functional genomics in the mouse. Funct. Integr. Genomics 2, 81-91 (2002).
-
(2002)
Funct. Integr. Genomics
, vol.2
, pp. 81-91
-
-
Perkins, A.S.1
-
6
-
-
0031717379
-
Inducible gene targeting in mice using the Cre/lox system
-
Sauer, B. Inducible gene targeting in mice using the Cre/lox system. Methods 14, 381-392 (1998).
-
(1998)
Methods
, vol.14
, pp. 381-392
-
-
Sauer, B.1
-
8
-
-
0036885067
-
The lineage decisions of helper T cells
-
Murphy, K. M. & Reiner, S. L. The lineage decisions of helper T cells. Nature Rev. Immunol. 2, 933-944 (2002).
-
(2002)
Nature Rev. Immunol.
, vol.2
, pp. 933-944
-
-
Murphy, K.M.1
Reiner, S.L.2
-
9
-
-
0030281442
-
Combining mutagenesis and genomics in the mouse-closing the phenotype gap
-
Brown, S. D. & Peters, J. Combining mutagenesis and genomics in the mouse-closing the phenotype gap. Trends Genet. 12, 433-435 (1996). This paper introduces the concept of the 'phenotype gap' - the disparity between the available mouse mutant resource and the range of additional phenotypes that are required to fully exploit the mouse as a model of human disease.
-
(1996)
Trends Genet.
, vol.12
, pp. 433-435
-
-
Brown, S.D.1
Peters, J.2
-
10
-
-
0037079014
-
The structure of the protein universe and genome evolution
-
Koonin, E. V., Wolf, Y. I. & Karev, G. P. The structure of the protein universe and genome evolution. Nature 420, 218-223 (2002).
-
(2002)
Nature
, vol.420
, pp. 218-223
-
-
Koonin, E.V.1
Wolf, Y.I.2
Karev, G.P.3
-
11
-
-
2042437650
-
Initial sequencing and analysis of the human genome
-
Lander, E. S. et al. Initial sequencing and analysis of the human genome. Nature 409, 860-921 (2001).
-
(2001)
Nature
, vol.409
, pp. 860-921
-
-
Lander, E.S.1
-
12
-
-
0024955312
-
Lymphocyte activation
-
Samelson, L. E. Lymphocyte activation. Curr. Opin. Immunol. 2, 210-214 (1989).
-
(1989)
Curr. Opin. Immunol.
, vol.2
, pp. 210-214
-
-
Samelson, L.E.1
-
13
-
-
0036007120
-
An allelic series at the PDGFαR locus indicates unequal contributions of distinct signaling pathways during development
-
Klinghoffer, R. A., Hamilton, T. G., Hoch, R. & Soriano, P. An allelic series at the PDGFαR locus indicates unequal contributions of distinct signaling pathways during development. Dev. Cell 2, 103-113 (2002).
-
(2002)
Dev. Cell
, vol.2
, pp. 103-113
-
-
Klinghoffer, R.A.1
Hamilton, T.G.2
Hoch, R.3
Soriano, P.4
-
14
-
-
0037180505
-
Anh allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N-nitrosourea-mutagenized mouse embryonic stem cells
-
Vivian, J. L., Chen, Y., Yee, D., Schneider, E. & Magnuson, T. Anh allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N-nitrosourea-mutagenized mouse embryonic stem cells. Proc. Natl Acad. Sci. USA 99, 15542-15547 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 15542-15547
-
-
Vivian, J.L.1
Chen, Y.2
Yee, D.3
Schneider, E.4
Magnuson, T.5
-
15
-
-
0028221043
-
Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila
-
Perrimon, N. Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila. Curr. Opin. Cell Biol. 6, 260-266 (1994).
-
(1994)
Curr. Opin. Cell Biol.
, vol.6
, pp. 260-266
-
-
Perrimon, N.1
-
16
-
-
0031081140
-
Vulval development in Caenorhabditis elegans
-
Kornfeld, K. Vulval development in Caenorhabditis elegans. Trends Genet. 13, 55-61 (1997).
-
(1997)
Trends Genet.
, vol.13
, pp. 55-61
-
-
Kornfeld, K.1
-
17
-
-
0034425410
-
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse
-
Nolan, P. M. et al. A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nature Genet. 25, 440-443 (2000). An excellent overview of one of the first two large-scale programmes that use ethylnitrosourea (ENU).
-
(2000)
Nature Genet.
, vol.25
, pp. 440-443
-
-
Nolan, P.M.1
-
18
-
-
0036533338
-
Novel approaches for identifying genes regulating lymphocyte development and function
-
Loy, A. L. & Goodnow, C. C. Novel approaches for identifying genes regulating lymphocyte development and function. Curr. Opin. Immunol. 14, 260-265 (2002).
-
(2002)
Curr. Opin. Immunol.
, vol.14
, pp. 260-265
-
-
Loy, A.L.1
Goodnow, C.C.2
-
19
-
-
0034425715
-
Genome-wide, large-scale production of mutant mice by ENU mutagenesis
-
Hrabe de Angelis, M. H. et al. Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nature Genet. 25, 444-447 (2000). An overview of the pioneering ENU-mutagenesis programme carried out as part of the German Human Genome Project. It accompanies reference 17, which describes a corresponding effort carried out in the United Kingdom.
-
(2000)
Nature Genet.
, vol.25
, pp. 444-447
-
-
Hrabe de Angelis, M.H.1
-
20
-
-
0033858522
-
The mutagenic action of N-ethyl-N-nitrosourea in the mouse
-
Noveroske, J. K., Weber, J. S. & Justice, M. J. The mutagenic action of N-ethyl-N-nitrosourea in the mouse. Mamm. Genome 11, 478-483 (2000).
-
(2000)
Mamm. Genome
, vol.11
, pp. 478-483
-
-
Noveroske, J.K.1
Weber, J.S.2
Justice, M.J.3
-
21
-
-
0033860483
-
Effects of ENU dosage on mouse strains
-
Justice, M. J. et al. Effects of ENU dosage on mouse strains. Mamm. Genome 11, 484-488 (2000).
-
(2000)
Mamm. Genome
, vol.11
, pp. 484-488
-
-
Justice, M.J.1
-
22
-
-
0012156457
-
Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse
-
Russell, W. L. et al. Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse. Proc. Natl Acad. Sci. USA 16, 5818-5819 (1979).
-
(1979)
Proc. Natl Acad. Sci. USA
, vol.16
, pp. 5818-5819
-
-
Russell, W.L.1
-
23
-
-
0033860152
-
Identification of immunological relevant phenotypes in ENU mutagenized mice
-
Flaswinkel, H. et al. Identification of immunological relevant phenotypes in ENU mutagenized mice. Mamm. Genome 11, 526-527 (2000). The first description of a large-scale ENU screen for mutations that affect the development of the immune system. This entire volume of Mammalian Genome is devoted to ENU mutagenesis.
-
(2000)
Mamm. Genome
, vol.11
, pp. 526-527
-
-
Flaswinkel, H.1
-
24
-
-
0034813659
-
Genome-wide ENU mutagenesis to reveal immune regulators
-
Nelms, K. A. & Goodnow, C. C. Genome-wide ENU mutagenesis to reveal immune regulators. Immunity 15, 409-418 (2001).
-
(2001)
Immunity
, vol.15
, pp. 409-418
-
-
Nelms, K.A.1
Goodnow, C.C.2
-
25
-
-
0037015906
-
ENU mutagenesis: A work in progress
-
Beier, D. R. ENU mutagenesis: a work in progress. Physiol. Genomics 11, 111-113 (2002).
-
(2002)
Physiol. Genomics
, vol.11
, pp. 111-113
-
-
Beier, D.R.1
-
26
-
-
0037152174
-
Analysis of an ethylnitrosourea-generated mouse mutation defines a cell intrinsic role of nuclear factor κB2 in regulating circulating B cell numbers
-
Miosge, L. A., Blasioti, J., Blery, M. & Goodnow, C. C. Analysis of an ethylnitrosourea-generated mouse mutation defines a cell intrinsic role of nuclear factor κB2 in regulating circulating B cell numbers. J. Exp. Med. 196, 1113-1119 (2002).
-
(2002)
J. Exp. Med.
, vol.196
, pp. 1113-1119
-
-
Miosge, L.A.1
Blasioti, J.2
Blery, M.3
Goodnow, C.C.4
-
27
-
-
0037155688
-
+ T cell development in the thymus
-
+ T cell development in the thymus. Cell 108, 755-767 (2002).
-
(2002)
Cell
, vol.108
, pp. 755-767
-
-
Fujimoto, Y.1
-
28
-
-
0034758539
-
Conditional transgenic technologies
-
Ryding, A. D., Sharp, M. G. & Mullins, J. J. Conditional transgenic technologies. J. Endocrinol. 171, 1-14 (2001).
-
(2001)
J. Endocrinol.
, vol.171
, pp. 1-14
-
-
Ryding, A.D.1
Sharp, M.G.2
Mullins, J.J.3
|