Functional genomics in the mouse

Functional and Integrative Genomics

Volumn 2, Issue 3, 2002, Pages 81-91

  Perkins, Archibald S ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Developmental biology; Genomics; Mutagenesis

Indexed keywords

CHEMICAL MUTAGENESIS; CHROMOSOMAL LOCALIZATION; CHROMOSOME INVERSION; FUNCTIONAL GENOMICS; GENE DELETION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE SEQUENCE; GENE TARGETING; GENETIC ANALYSIS; MOLECULAR CLONING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SOMATIC CELL; ANIMAL; BIOLOGY; GENOMICS; HUMAN; METABOLISM; METHODOLOGY; MOUSE; MUTAGENESIS;

ALKYLATING AGENT; ETHYLNITROSOUREA;

ALKYLATING AGENTS; ANIMALS; COMPUTATIONAL BIOLOGY; ETHYLNITROSOUREA; GENE TARGETING; GENOMICS; HUMANS; INVERSION, CHROMOSOME; MICE; MUTAGENESIS; PHENOTYPE;

EID: 0036689003     PISSN: 1438793X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10142-002-0049-3     Document Type: Review

References (65)

1. Anderson KV (2000) Finding the genes that direct mammalian development. ENU mutagenesis in the mouse. Trends Genet 16:99-102
2. Angrand P-O, Daigle N, van der Hoeven F, Schoeler H, Stewart A (1999) Simplified generation of targeting constructs using ET recombination. Nucleic Acids Res 27:e16
3. Antoch M, Song E-J, Chang A-M, Vitaterna M, Zhao Y, Wilsbacher L, Sangoram A, King D, Pinto L, Takahashi J (1997) Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell 89:655-667
4. Beck J, Lloyd S, Hafenparast M, Lennon-Pierce M, Eppig J, Festing M, Fisher E (2000) Genealogies of mouse inbred strains. Nat Genet 24:23-25
5. Bjorheim J, Lystad S, Lindblom A, Kressner U, Westring S, Wahlberg S, Lindmark G, Gaudernack G, Ekstrom G, Roe JP, Thilly W, Borresen-Dale A (1998) Mutation analyses of KRAS exon 1 comparing three different techniques: temporal temperature gradient electrophoresis, constant denaturant capillary electrophoresis and allele specific polymerase chain reaction. Mutat Res 403:103-112
6. Bouchard L, Lamarre L, Tremblay P, Jolicoeur P (1989) Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene. Cell 57:931-936
7. Callahan R, Smith G (2000) MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways. Oncogene 19:992-1001
8. Chen Y, Schimenti J, Magnuson T (2000a) Toward the yeastification of mouse genetics: chemical mutagenesis of embryonic stem cells. Mamm Genome 11:598-602
9. Chen Y, Yee D, Dains K, Chatterjee A, Cavalcoli J, Schneider E, Om J, Woychik R, Magnuson T (2000b) Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells. Nat Genet 24:314-317
10. Copeland N, Jenkins N, Gilbert D, Eppig J, Maltais L, Miller J, Dietrich W, Weaver A, Lincoln S, Steen R, Stein L, Nadeau J, Lander E (1993) A genetic linkage map of the mouse: current applications and future prospects. Science 262:57-66
11. Copeland N, Jenkins N, Court D (2001) Recombineering: a powerful new tool for mouse functional genomics. Nat Rev Genet 2:769-779
12. Cox R, Hugill A, Shedovsky A, Noveroske J, Best S, Justice M, Lehrach H, Dove W (1998) Contrasting effects of ENU-induced embryonic lethal mutations of the quaking gene. Genomics 57:333-341
13. Dievart A, Beaulieu N, Jolicoeur P (1999) Involvement of Notch1 in the development of mouse mammary tumors. Oncogene 18:5973-81
14. Friedrich G, Soriano P (1991) Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 5:1513-1523
15. Giraldo P, Montoliu E (2001) Size matters: use of YACs, BACs and PACs in transgenic animals. Transgenic Res 10:83-103
16. Hrabe de Angelis M, et al (2000) Genome wide large scale production of mutant mice by ENU mutagenesis. Nat Genet 25: 444-447
17. Ioannou P, Amemiya C, Garnes J, Kroisel P, Shizuya H, Chen C, et al (1994) A new bacteriophage P1-derived vector for the propagation of large human DNA fragments. Nat Genet 6: 84-89
18. Judd B, Shen M, Kaufman T (1972) The anatomy and function of a segment of the X chromosome of Drosophila melanogaster. Genetics 71:139-156
19. Justice M (2000) Capitalizing on large-scale mouse mutagenesis screens. Nat Rev Genet 1:109-115
20. Justice M, Zheng B, Woychik R, Bradley A (1997) Using targeted large deletions and high-efficiency N-ethyl-N-nitrosourea mutagenesis for functional analyses of the mammalian genome. Methods 13:423-436
21. Kasarskis A, Manova K, Anderson K (1998) A phenotype-based screen for embryonic lethal mutations in the mouse. Proc Natl Acad Sci USA 95:7485-7490
22. Kaufman R, Pham C, Ley T (1999) Transgenic analysis of a 100-kb human beta-globin cluster containing DNA fragment propagated as a bacterial artificial chromosome. Blood 94:3178-3184
23. Kratochwil K, von der Mark K, Kollar E, Jaenisch R, Mooslehner K, Schwarz M, Haase K, Gmachl I, Harbers K (1989) Retrovirus-induced insertional mutation in Mov13 mice affects collagen I expression in a tissue-specific manner. Cell 57:807-816
24. Largaespada D (2000) Genetic heterogeneity in acute myeloid leukemia: maximizing information flow from MuLV mutagenesis studies. Leukemia 14:1174-1184
25. Lee E-C, Yu D, Velasco J, Tessarollo L, Swing D, Court D, Jenkins N, Copeland N (2001) A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 73:56-65
26. Lee F, Lane T, Kuo A, Shackleford G, Leder P (1995) Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice. Proc Natl Acad Sci USA 92:2268-2272
27. Li J, Shen H, Himmel K, Dupuy A, Largaespada D, Nakamura T, Shaughnessy J Jr, Jenkins N, Copeland N (1999) Leukaemia disease genes: large-scale cloning and pathway predictions. Nat Genet 23:348-353
28. Lohuizen M, van Verbeek S, Scheijen B, Wientjens E, van der Gulden H, Berns A (1991) Identification of cooperating oncogenes in Eμ-myc transgenic mice by pro virus tagging. Cell 65: 737-752
29. MacArthur C, Shankar D, Shackleford D (1995) Fgf-8, activated by proviral insertion, cooperates with the Wnt-1 transgene in murine mammary tumorigenesis. J Virol 69:2501-2507
30. Majumder K, Shawlot W, Schuster G, Harrison W, Elder F, Overbeek P (1998) YAC rescue of downless locus mutations in mice. Mamm Genome 9:863-868
31. McKendry R, John J, Flavell D, Muller M, Kerr I, Stark G (1991) High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons. Proc Natl Acad Sci USA 88:11455-11459
32. Mills AA, Bradley A (2001) From mouse to man: generating megabase chromosome rearrangements. Trends Genet 17:331-339
33. Mitchell K, Pinson K, et al (2001) Functional analysis of secreted and transmembrane proteins critical to mouse development. Nat Genet 25 241-249
34. Muller U (1999) Ten years of gene targeting: targeted mouse mutants, from vector design to phenotype analysis. Mech Dev 82: 3-21
35. Mullins L, Kotelsvtseva N, Boyd A, Mullins J (1997) Efficient Cre-lox linearisation of BACs: applications to physical mapping and generation of transgenic animals. Nucleic Acids Res 25:2539-2540
36. Muyrers J, Zhang Y, Benes V, Testa G, Ansorge W, Stewart A (2000) Point mutation of bacterial artificial chromosomes by ET recombination. EMBO Rep 1:239-243
37. Muyrers J, Zhang Y, Stewart A (2001) Techniques: recombinogenic engineering - new options for cloning and manipulating DNA. Trends Biochem Sci 26:325-331
38. Nefedov M, Williamson R, Ioannou P (2000) Insertion of disease-causing mutations in BACs by homologous recombination in Escherichia coli. Nucleic Acids Res 28:E79
39. Nolan P (2000) Generation of mouse mutants as tools for functional genomics. Pharmacogenetics 1:243-255
40. Nolan P, Peters J, et al (2000) A systematic genome-wide phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet 25:440-443
41. Nusse R (1991) Insertional mutagenesis in mouse mammary tumorigenesis. Curr Top Microbiol Immunol 171:44-65
42. Oefner P, Underbill P (1998) DNA mutation detection using denaturing high-performance liquid chromatography (DHPLC). In: Dracopoli N, Haines J, Korf B, Moir D, Morton Cea (eds) Current protocols in human genetics, suppl 19. Wiley, New York, pp 7.10.11-7.10.12
43. Ramirez-Solis R, Liu P, Bradley A (1995) Chromosome engineering in mice. Nature 378:720-724
44. Rathkolb B, Fuchs E, Kolb H, Renner-Muller I, Krebs O, Balling R, Hrabe de Angelis H, Wolf E (2000) Large-scale JV-ethyl-JV-nitrosourea mutagenesis of mice - from phenotypes to genes. Exp Physiol 85:635-644
45. Rinchik E (2000) Developing genetic reagents to facilitate recovery, analysis, and maintenance of mouse mutations. Mamm Genome 11:489-499
46. Rogers D, Fisher E, Brown S, Peters J, Hunter A, Martin J (1997) Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment. Mamm Genome 8:711-713
47. Schimenti J, Bucan M (1998) Functional genomics in the mouse: phenotype-based mutagenesis screens. Genome Res 8:698-710
48. Shackleford G, MacArthur C, Kwan H, Varmus H (1993) Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4. Proc Natl Acad Sci USA 90:740-744
49. Shizuya H, Birren B, Kim U, Mancino V, Slepak T, Tachiiri Y, et al (1992) Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. Proc Natl Acad Sci USA 89:8794-8797
50. Silver L (1995) Mouse genetics. Oxford University Press, New York
51. Stanford W, Caruana G, Vallis K, Inamdar M, Hidaka M, Bautch V, Bernstein A (1998) Expression trapping: identification of novel genes expressed in hematopoietic and endothelial lineages by gene trapping in ES cells. Blood 92:4622-4631
52. Steingrimsson E, Moore K, Lamoreaux M, Ferre-D'Amare A, Burley S, Zimring D, Skow L, Arnheiter H, Copeland N, Jenkins N (1994) Molecular basis of mouse microphthalmia (mi) mutations help explain their developmental and phenotypic consequences. Nat Genet 8:256
53. Swaminathan S, Ellis H, Waters L, Yu D, Lee E-C, Court D, Sharan S (2001) Rapid engineering of bacterial artificial chromosomes using oligonucleotides. Genesis 29:14-21
54. Symula D, Shedlovsky A, Guillery E, Dove W (1997) A candidate mouse model for Hartnup disorder deficient in neutral amino acid transport. Mamm Genome 8:102-107
55. Taft S, Liber H, Skopek T (1994) Mutational spectrum of ICR-191 at the hprt locus in human lymphoblastoid cells. Environ Mol Mutagen 23:96-100
56. Vitaterna M, King D, Chang A-M, Kornhauser J, Lowrey P, McDonald J, Dove W, Pinto L, Turek F, Takahashi J (1994) Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264:719-725
57. Wells C, Brown S (2000) Genomics meets genetics: towards a mutant map of the mouse. Mamm Genome 11:472-477
58. Yang X, Model P, Heintz N (1997) Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome. Nat Biotech 15:860-864
59. You Y, Bergstrom R, Klemm M, Lederman B, Nelson H, Ticknor C, Jaenisch R, Schimenti J (1997) Chromosomal deletion complexes in mice by radiation of embryonic stem cells. Nat Genet 15:285-288
60. You Y, Bersgtram R, Klemm M, Nelson H, Jaenisch R, Schimenti J (1998) Utility of C57BL/6Jxl29/SvJae embryonic stem cells for generating chromosomal deletions: tolerance to gamma radiation and microsatellite polymorphism. Mamm Genome 9:232-234
61. Zambrowicz B, Friedrich G, Buxton E, Lilleberg S, Person C, Sands A (1998) Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature 392:608-611
62. Zelazny E, Anagnostopolous A-M, Coleman A, Perkins A (2001) Cooperating oncogenic events in murine mammary tumorigenesis: assessment of ErbB2, mutant p53, and MMTV. Exp Mol Pathol 70:183-193
63. Zhang Y, Buchholz F, Muyrers J, Stewart A (1998) A new logic for DNA engineering using recombination in Escherichia coli. Nat Genet 20:123-128
64. Zhang Y, Muyrers J, Testa G, Stewart A (2000) DNA cloning by homologous recombination in Escherichia coli. Nat Biotech 18:1314-1317
65. Zheng B, Mills A, Bradley A (1999) A system for rapid generation of coat color-tagged knockouts and defined chromosomal rearrangements in mice. Nucleic Acids Res 27:2354-2360