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Volumn 12, Issue 10, 2003, Pages 1187-1198

Molecular mechanisms underlying limb anomalies associated with cholesterol deficiency during gestation: Implications of Hedgehog signaling

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GENE PRODUCT; SONIC HEDGEHOG PROTEIN; TRIPARANOL; UNCLASSIFIED DRUG;

EID: 0038778353     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddg129     Document Type: Article
Times cited : (64)

References (53)
  • 1
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • Ingham, P.W. and McMahon, A.P. (2001) Hedgehog signaling in animal development: paradigms and principles. Genes Dev., 15, 3059-3087.
    • (2001) Genes Dev. , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 3
    • 0029019627 scopus 로고
    • Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
    • Marti, E., Bumcrot, D.A., Takada, R. and McMahon, A.P. (1995) Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature, 375, 322-325.
    • (1995) Nature , vol.375 , pp. 322-325
    • Marti, E.1    Bumcrot, D.A.2    Takada, R.3    McMahon, A.P.4
  • 4
    • 0028948811 scopus 로고
    • The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
    • Porter, J.A., von Kessler, D.P., Ekker, S.C., Young, K.E., Lee, J.J., Moses, K. and Beachy, P.A. (1995) The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature, 374, 363-366.
    • (1995) Nature , vol.374 , pp. 363-366
    • Porter, J.A.1    von Kessler, D.P.2    Ekker, S.C.3    Young, K.E.4    Lee, J.J.5    Moses, K.6    Beachy, P.A.7
  • 5
    • 0029004233 scopus 로고
    • Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis
    • Roelink, H., Porter, J.A., Chiang, C., Tanabe, Y., Chang, D.T., Beachy, P.A. and Jessel, T.M. (1995) Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell, 81, 445-455.
    • (1995) Cell , vol.81 , pp. 445-455
    • Roelink, H.1    Porter, J.A.2    Chiang, C.3    Tanabe, Y.4    Chang, D.T.5    Beachy, P.A.6    Jessel, T.M.7
  • 7
    • 0029844192 scopus 로고    scopus 로고
    • Cholesterol modification of hedgehog signalling proteins in animal development
    • Porter, J.A., Young, K.E. and Beachy, P.A. (1996) Cholesterol modification of hedgehog signalling proteins in animal development. Science, 274, 255-259.
    • (1996) Science , vol.274 , pp. 255-259
    • Porter, J.A.1    Young, K.E.2    Beachy, P.A.3
  • 9
    • 0034092240 scopus 로고    scopus 로고
    • Cholesterol and signal transduction
    • Incardona, J.P. and Eaton, S. (2000) Cholesterol and signal transduction. Curr. Opin. Cell Biol., 12, 193-203.
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 193-203
    • Incardona, J.P.1    Eaton, S.2
  • 10
    • 0033679003 scopus 로고    scopus 로고
    • The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly
    • Incardona, J.P. and Roelink, H. (2000) The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly. Cell. Mol. Life Sci., 57, 1709-1719.
    • (2000) Cell. Mol. Life Sci. , vol.57 , pp. 1709-1719
    • Incardona, J.P.1    Roelink, H.2
  • 11
    • 0036534286 scopus 로고    scopus 로고
    • The sterol-sensing domain: Multiple families, a unique role
    • Kuwabara, P.E. and Labouesse, M. (2002) The sterol-sensing domain: multiple families, a unique role. Trends Genet., 18, 193-201.
    • (2002) Trends Genet. , vol.18 , pp. 193-201
    • Kuwabara, P.E.1    Labouesse, M.2
  • 12
    • 0032474837 scopus 로고    scopus 로고
    • Tout-velu is a Drosophilahomologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
    • Bellaiche, Y., The, I. and Perrimon, N. (1998) Tout-velu is a Drosophilahomologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature, 394, 85-88.
    • (1998) Nature , vol.394 , pp. 85-88
    • Bellaiche, Y.1    The, I.2    Perrimon, N.3
  • 13
    • 0033212987 scopus 로고    scopus 로고
    • Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan
    • The, I., Bellaiche, Y. and Perrimon, N. (1999) Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan. Mol. Cell, 4, 633-639.
    • (1999) Mol. Cell , vol.4 , pp. 633-639
    • The, I.1    Bellaiche, Y.2    Perrimon, N.3
  • 14
    • 0033598964 scopus 로고    scopus 로고
    • Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified Hedgehog from signaling cells
    • Burke, R., Nellen, D., Bellotto, M., Hafen, E., Senti, K.-A., Kickson, B.J. and Basler, K. (1999) Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified Hedgehog from signaling cells. Cell, 99, 803-815.
    • (1999) Cell , vol.99 , pp. 803-815
    • Burke, R.1    Nellen, D.2    Bellotto, M.3    Hafen, E.4    Senti, K.-A.5    Kickson, B.J.6    Basler, K.7
  • 15
  • 16
    • 0037542123 scopus 로고    scopus 로고
    • Defects in cholesterol biosynthesis and abnormal embryonic development
    • Fliesler, S.J. (ed.), Research Signpost, Trivandrum
    • Gofflot, F. (2002) Defects in cholesterol biosynthesis and abnormal embryonic development. In Fliesler, S.J. (ed.), Sterols and Oxysterols: Chemistry, Biology and Pathobiology. Research Signpost, Trivandrum, pp. 47-76.
    • (2002) Sterols and Oxysterols: Chemistry, Biology and Pathobiology , pp. 47-76
    • Gofflot, F.1
  • 17
    • 0033607623 scopus 로고    scopus 로고
    • Absence of ventral cell populations in the developing brain in a rat model of the Smith-Lemli-Opitz syndrome
    • Gofflot, F., Kolf-Clauw, M., Clotman, F., Roux, C. and Picard, J.J. (1999) Absence of ventral cell populations in the developing brain in a rat model of the Smith-Lemli-Opitz syndrome. Am. J. Med. Genet., 87, 207-216.
    • (1999) Am. J. Med. Genet. , vol.87 , pp. 207-216
    • Gofflot, F.1    Kolf-Clauw, M.2    Clotman, F.3    Roux, C.4    Picard, J.J.5
  • 18
    • 0035142843 scopus 로고    scopus 로고
    • Expression of sonic hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis
    • Gofflot, F., Gaoua, W., Bourguignon, L., Roux, C. and Picard, J.J. (2001) Expression of sonic hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis. Dev. Dyn., 220, 99-111.
    • (2001) Dev. Dyn. , vol.220 , pp. 99-111
    • Gofflot, F.1    Gaoua, W.2    Bourguignon, L.3    Roux, C.4    Picard, J.J.5
  • 19
    • 0031895371 scopus 로고    scopus 로고
    • Disorders of cholesterol biosynthesis
    • Clayton, P.T. (1998) Disorders of cholesterol biosynthesis. Arch. Dis. Chil., 78, 185-189.
    • (1998) Arch. Dis. Chil. , vol.78 , pp. 185-189
    • Clayton, P.T.1
  • 20
    • 0031044525 scopus 로고    scopus 로고
    • Clinical and biochemical spectrum of patients with RSH/Smith-Lemli-Opitz syndrome and abnormal cholesterol metabolism
    • Cunniff, C., Kratz, L.E., Moser, A., Natowicz, M.R. and Kelley, R.I. (1997) Clinical and biochemical spectrum of patients with RSH/Smith-Lemli-Opitz syndrome and abnormal cholesterol metabolism. Am. J. Med. Genet., 68, 263-269.
    • (1997) Am. J. Med. Genet. , vol.68 , pp. 263-269
    • Cunniff, C.1    Kratz, L.E.2    Moser, A.3    Natowicz, M.R.4    Kelley, R.I.5
  • 23
    • 0027419979 scopus 로고
    • Smith-Lemli-Opitz syndrome type II: Report of a case with additional radiographic findings
    • Herman, T.E., Siegel, M.J., Lee, B.C.P. and Dowton, S.B. (1993) Smith-Lemli-Opitz syndrome type II: report of a case with additional radiographic findings. Pediatr Radiol., 23, 37-40.
    • (1993) Pediatr Radiol. , vol.23 , pp. 37-40
    • Herman, T.E.1    Siegel, M.J.2    Lee, B.C.P.3    Dowton, S.B.4
  • 24
    • 0025313376 scopus 로고
    • Smith-Lemli-Opitz syndrome II: A disorder of the fetal adrenal
    • McKeever, P.A. and Young, I.D. (1990) Smith-Lemli-Opitz syndrome II: a disorder of the fetal adrenal. J. Med. Genet., 27, 465-466.
    • (1990) J. Med. Genet. , vol.27 , pp. 465-466
    • McKeever, P.A.1    Young, I.D.2
  • 27
    • 0038217674 scopus 로고
    • Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29
    • Avigan, J., Steinberg, D., Vroman, H.E., Thompson, M.J. and Mosettig, E. (1960) Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29. J. Biol. Chem., 235, 3123-3126.
    • (1960) J. Biol. Chem. , vol.235 , pp. 3123-3126
    • Avigan, J.1    Steinberg, D.2    Vroman, H.E.3    Thompson, M.J.4    Mosettig, E.5
  • 29
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St Jacques, B., Hammerschmidt, M. and McMahon, A.P. (1999) Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev., 13, 2072-2086.
    • (1999) Genes Dev. , vol.13 , pp. 2072-2086
    • St Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 30
    • 0029750190 scopus 로고    scopus 로고
    • Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    • Vortkamp, A., Lee, K., Lanske, B., Segre, G.V., Kronenberg, H.M. and Tabin, C.J. (1996) Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science, 273, 613-622.
    • (1996) Science , vol.273 , pp. 613-622
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.J.6
  • 31
    • 0029876835 scopus 로고    scopus 로고
    • Requirement for BMP signaling in interdigital apoptosis and scale formation
    • Zou, H. and Niswander, L. (1996) Requirement for BMP signaling in interdigital apoptosis and scale formation. Science, 272, 738-741.
    • (1996) Science , vol.272 , pp. 738-741
    • Zou, H.1    Niswander, L.2
  • 33
    • 0027760995 scopus 로고
    • Sonic hedgehog mediates the polarizing activity of the ZPA
    • Riddle, R.D., Johnson, R.L., Laufer, E. and Tabin, C. (1993) Sonic hedgehog mediates the polarizing activity of the ZPA. Cell, 75, 1401-1416.
    • (1993) Cell , vol.75 , pp. 1401-1416
    • Riddle, R.D.1    Johnson, R.L.2    Laufer, E.3    Tabin, C.4
  • 34
    • 0035368725 scopus 로고    scopus 로고
    • Cholesterol modification of Sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
    • Lewis, P.M., Dunn, M.P., McMahon, J.A., Logan, M., Martin, J.F., St-Jacques, B. and McMahon, A.R (2001) Cholesterol modification of Sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell, 105, 599-612.
    • (2001) Cell , vol.105 , pp. 599-612
    • Lewis, P.M.1    Dunn, M.P.2    McMahon, J.A.3    Logan, M.4    Martin, J.F.5    St-Jacques, B.6    McMahon, A.R.7
  • 35
    • 0029975823 scopus 로고    scopus 로고
    • Conservation in hedgehog signaling: Induction of a chicken patched homolog by Sonic hedgehog in the developing limb
    • Marigo, V., Scott, M.P., Johnson, R.L., Goodrich, L.V. and Tabin, C.J. (1996) Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development, 122, 1225-1233.
    • (1996) Development , vol.122 , pp. 1225-1233
    • Marigo, V.1    Scott, M.P.2    Johnson, R.L.3    Goodrich, L.V.4    Tabin, C.J.5
  • 36
    • 0030027059 scopus 로고    scopus 로고
    • Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched by Hedgehog
    • Goodrich, L.V., Johnson, R.L., Milenkovic, L., McMahon, J.A. and Scott, M.P. (1996) Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched by Hedgehog. Genes Dev., 10, 301-312.
    • (1996) Genes Dev. , vol.10 , pp. 301-312
    • Goodrich, L.V.1    Johnson, R.L.2    Milenkovic, L.3    McMahon, J.A.4    Scott, M.P.5
  • 37
    • 0033402727 scopus 로고    scopus 로고
    • The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb
    • Merino, R., Rodriguez-Leon, J., Macias, D., Ganan, Y., Economides, A.N. and Hurle, J.M. (1999) The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb. Development, 126, 5515-5522.
    • (1999) Development , vol.126 , pp. 5515-5522
    • Merino, R.1    Rodriguez-Leon, J.2    Macias, D.3    Ganan, Y.4    Economides, A.N.5    Hurle, J.M.6
  • 38
    • 0041030051 scopus 로고    scopus 로고
    • Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate lim buds
    • Zuniga, A., Haramis, A.-P.G., McMahon, A.P. and Zeller, R. (1999) Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate lim buds. Science, 401, 598-602.
    • (1999) Science , vol.401 , pp. 598-602
    • Zuniga, A.1    Haramis, A.-P.G.2    McMahon, A.P.3    Zeller, R.4
  • 39
    • 2642595047 scopus 로고    scopus 로고
    • The roles of FGFs in the early development of vertebrates limbs
    • Martin, G.R. (1998) The roles of FGFs in the early development of vertebrates limbs. Genes Dev., 12, 1571-1586.
    • (1998) Genes Dev. , vol.12 , pp. 1571-1586
    • Martin, G.R.1
  • 40
    • 0036690917 scopus 로고    scopus 로고
    • Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis
    • Chevy, F., Illien, F., Wolf, C. and Roux, C. (2002) Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis. J Lipid Res., 43, 1192-1200.
    • (2002) J. Lipid Res. , vol.43 , pp. 1192-1200
    • Chevy, F.1    Illien, F.2    Wolf, C.3    Roux, C.4
  • 41
    • 0033996257 scopus 로고    scopus 로고
    • Cholesterol deficit but not accumulation of aberrant sterols is the major cause of the teratogenic activity in the Smith-Lemli-Opitz animal model
    • Gaoua, W., Wolf, C., Chevy, F. Ilien, F., and Roux, C. (2000) Cholesterol deficit but not accumulation of aberrant sterols is the major cause of the teratogenic activity in the Smith-Lemli-Opitz animal model. J. Lipid Res., 41, 637-646.
    • (2000) J. Lipid Res. , vol.41 , pp. 637-646
    • Gaoua, W.1    Wolf, C.2    Chevy, F.3    Ilien, F.4    Roux, C.5
  • 42
    • 0028951117 scopus 로고
    • Dorsalizing signal Wnt7a required for normal polarity of D-V and A-P axes of mouse limb
    • Parr, B.A. and McMahon, A.P. (1995) Dorsalizing signal Wnt7a required for normal polarity of D-V and A-P axes of mouse limb. Nature, 374, 350-353.
    • (1995) Nature , vol.374 , pp. 350-353
    • Parr, B.A.1    McMahon, A.P.2
  • 43
    • 0032695265 scopus 로고    scopus 로고
    • Mouse patched 1 controls body size determination and limb patterning
    • Milenkovic, L., Goodrich, L.V., Higgins, K.M. and Scott, M.P. (1999) Mouse patched 1 controls body size determination and limb patterning. Development, 126, 4431-4440.
    • (1999) Development , vol.126 , pp. 4431-4440
    • Milenkovic, L.1    Goodrich, L.V.2    Higgins, K.M.3    Scott, M.P.4
  • 44
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for Patched in sequestering and transducing hedgehog
    • Chen, Y. and Struhl, G. (1996) Dual roles for Patched in sequestering and transducing hedgehog. Cell, 87, 553-563.
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 46
    • 0033042804 scopus 로고    scopus 로고
    • BMPs negatively regulates structure and function of the limb apical ectodermal ridge
    • Pizette, S. and Niswander, L. (1999) BMPs negatively regulates structure and function of the limb apical ectodermal ridge. Development, 126, 883-894.
    • (1999) Development , vol.126 , pp. 883-894
    • Pizette, S.1    Niswander, L.2
  • 47
    • 0033637672 scopus 로고    scopus 로고
    • Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulation polarising activity during chick limb development
    • Sanz-Ezquerro, J.J. and Tickle, C. (2000) Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulation polarising activity during chick limb development. Development, 127, 4811-4823.
    • (2000) Development , vol.127 , pp. 4811-4823
    • Sanz-Ezquerro, J.J.1    Tickle, C.2
  • 48
    • 0035822098 scopus 로고    scopus 로고
    • A freely diffusible form of Sonic hedgehog mediates long-range signalling
    • Zeng, X., Goetz, J.A., Suber, L.M., Scott, W.J., Schreiner, C.M. and Robbins, D.J. (2001) A freely diffusible form of Sonic hedgehog mediates long-range signalling. Nature, 411, 716-720.
    • (2001) Nature , vol.411 , pp. 716-720
    • Zeng, X.1    Goetz, J.A.2    Suber, L.M.3    Scott, W.J.4    Schreiner, C.M.5    Robbins, D.J.6
  • 49
    • 0026465664 scopus 로고
    • Homeotic transformations in the mouse induced by overexpression of a human Hox3.3 transgene
    • Jegalian, B.G. and De Robertis, G.M. (1992) Homeotic transformations in the mouse induced by overexpression of a human Hox3.3 transgene. Cell, 71, 901-910.
    • (1992) Cell , vol.71 , pp. 901-910
    • Jegalian, B.G.1    De Robertis, G.M.2
  • 50
    • 0003496492 scopus 로고
    • In Situ Hybridization: A Practical Approach
    • Oxford University Press, Oxford
    • Wilkinson, D.G. (1992) In Situ Hybridization: a Practical Approach. Oxford University Press, Oxford.
    • (1992)
    • Wilkinson, D.G.1
  • 51
    • 0036011241 scopus 로고    scopus 로고
    • Mouse Twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesis
    • Zuniga, A., Quillet, R., Perrin-Schmitt, F., and Zeller, R. (2002) Mouse Twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesis. Mech. Dev., 114, 51-59.
    • (2002) Mech. Dev. , vol.114 , pp. 51-59
    • Zuniga, A.1    Quillet, R.2    Perrin-Schmitt, F.3    Zeller, R.4
  • 52
    • 0028989016 scopus 로고
    • Notch 1 is required for the coordinate segmentation of somites
    • Conlon, R.A., Reaume, A.G. and Rossant, J. (1995) Notch 1 is required for the coordinate segmentation of somites. Development, 121, 1533-1545.
    • (1995) Development , vol.121 , pp. 1533-1545
    • Conlon, R.A.1    Reaume, A.G.2    Rossant, J.3
  • 53
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • Ohlsson, H., Karlsson, K. and Edlund, T. (1993) IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J., 12, 4251-4259.
    • (1993) EMBO J. , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3


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