Expression of sonic hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis

Developmental Dynamics

Volumn 220, Issue 2, 2001, Pages 99-111

  Gofflot, Franoise ^a   Gaoua, Wassila ^a   Bourguignon, Loc ^a,b   Roux, Charles ^b   Picard, Jacques J ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b HÔPITAL SAINT ANTOINE   (France)

Author keywords

AY9944; Gli1; HNF3 ; Holoprosencephaly; Ptc; Shh; Smith Lemli Opitz syndrome

Indexed keywords

1,4 BIS(2 CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE; SONIC HEDGEHOG PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FOREBRAIN; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; HOLOPROSENCEPHALY; MESENCEPHALON; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; RHOMBENCEPHALON; SIGNAL TRANSDUCTION; SOMITE; SPINAL CORD;

ABNORMALITIES; ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; CHOLESTEROL, DIETARY; DEHYDROCHOLESTEROLS; EMBRYONIC AND FETAL DEVELOPMENT; EMBRYONIC INDUCTION; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; HOLOPROSENCEPHALY; HUMANS; IN SITU HYBRIDIZATION; PREGNANCY; PROTEINS; RATS; TRANS-1,4-BIS(2-CHLOROBENZAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE; TRANS-ACTIVATORS;

ERINACEIDAE; MAMMALIA;

EID: 0035142843     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1092>3.0.CO;2-G     Document Type: Article

References (68)

1. Teratogenic effect of AY 9944 in rats: Importance of the day of administration and maternal plasma cholesterol level
2. Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain
3. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
4. Identification of Sonic Hedgehog as a candidate gene responsible for holoprosencephaly
5. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
6. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified Hedgehog from signaling cells
7. Extracellular modulation of the Hedgehog, Wnt and TGF-β signalling pathways during embryonic development
8. Niemann-Pick C1 disease gene: Homology to mediators of cholesterol homeostasis
9. Axial (HNF3b) and retinoic acid receptors are regulators of the zebrafish sonic hedgehog promoter
10. Cyclopia and defective axial patterning in mice lacking Sonic Hedgehog gene function
11. Teratogen-mediated inhibition of target tissue response to Shh signalling
12. Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
13. Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm
14. Sonic hedgehog, a member of a family of putative signalling molecules, is implicated in the regulation of CNS polarity
15. Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and independent mechanisms
16. Sonic Hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube
17. Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity
18. Graded Sonic Hedgehog signaling and the specification of cell fate in the ventral neural tube
19. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
20. Mutations in the δ7-sterol reductase gene in patients with the Smith-Lemli-Opitz syndrome
21. Steroidal alkaloid teratogens: Molecular probes for investigation of craniofacial malformations
22. Cholesterol deficit but not accumulation of aberrant sterols is the major cause of the teratogenic activity in the Smith-Lemli-Opitz animal model
23. Absence of ventral cell populations in the developing brain in a rat model of the Smith-Lemli-Opitz syndrome
24. Holoprosencephaly: A defect in brain patterning
25. Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
26. Physical mapping of the holoprosencephaly critical region of 7q36
27. Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation
28. The world according to hedgehog
29. Cholesterol and signal transduction
30. The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction
31. Inhibition of 7-dehydrocholesterol reductase by the teratogen AY9944: A rat model for Smith-Lemli-Opitz syndrome
32. Cholesterol biosynthesis inhibited by BM15.766 induces holoprosencephaly in the rat
33. Autoproteolysis in hedgehog protein biogenesis
34. Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
35. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
36. Murine model of Niemann-Pick C disease: Mutation in a cholesterol homeostasis gene
37. Cloning, expression, and chromosomal location of SHH and IHH: Two human homologues of the Drosophila segment polarity gene hedgehog
38. Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
39. Holoprosencephaly: From Homer to Hedgehog
40. Linkage of a human malformation, familial holoprosencephaly, to chromosome 7 and evidence for genetic heterogeneity
41. Intronic enhancers control expression of zebrafish sonic hedgehog in floor plate and notochord
42. The mutational spectrum of the Sonic Hedgehog gene in holoprosencephaly: SHH mutations cause a significant proportion of autosomal dominant holoprosencephaly
43. Expression of the Sonic hedgehog (SHH) gene during early human development and phenotypic expression of new mutations causing holoprosencephaly
44. Cholesterol metabolism in the RSH/Smith-Lemli-Opitz syndrome: Summary of an NICHD conference
45. Related membrane domains in proteins of sterol sensing and cell signaling provide a glimpse of treasures still buried within the dynamic realm of intracellular metabolic regulation
46. The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
47. Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain
48. Cholesterol modification of hedgehog signalling proteins in animal development
49. Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain
50. Association of sterol and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains
51. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
52. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis
53. Mutations in the human Sonic Hedgehog gene cause holoprosencephaly
54. Action tératogène du triparanol chez l'animal
55. Action tératogène chez le rat d'un inhibiteur de la synthèse du cholestérol, le AY 9944
56. Interpretation of isolated agenesis of the pituitary
57. Teratogenic action and embryo lethality of AY 9944: Prevention by a hypercholesterolemia-provoking diet
58. Patterning of the embryonic forebrain
59. Early stages of notochord and floor plate development in the chick embryo defined by normal and induced expression of HNF-3β
60. A binding site for Gli proteins is essential for HNF3β floor plate enhancer activity in transgenics and can respond to Shh in vitro
61. A newly organized syndrome of multiple congenital anomalies
62. Diversity and pattern in the developing spinal cord
63. Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan
64. Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome
65. Mutations in the human sterol delta7-reductase gene at 11q12-13 cause Smith-Lemli-Opitz syndrome
66. Changes in serum sterols of rats treated with 7-dehydrocholesterol-δT-reductase inhibitors: Comparison to levels in humans with Smith-Lemli-Opitz syndrome
67. Reproducing abnormal cholesterol biosynthesis as seen in the Smith-Lemli-Opitz syndrome by inhibiting the conversion of 7-dehydrocholesterol to cholesterol in rats