Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: Three new products generated in the mithramycin producer streptomyces argillaceus through combinatorial biosynthesis

Journal of the American Chemical Society

Volumn 125, Issue 19, 2003, Pages 5745-5753

  Remsing, Lily L ^a   González, Ana M ^b   Nur e Alam, Mohammad ^a   Fernández Lozano, M José ^b   Braña, Alfredo F ^b   Rix, Uwe ^a   Oliveira, Marcos A ^a   Méndez, Carmen ^b   Salas, José A ^b   Rohr, Jürgen ^a  

^a University of Kentucky   (United States)

^b DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; ASSAYS; BIOSYNTHESIS; ENZYMES; GENES;

ANTITUMOR DRUGS;

DRUG PRODUCTS;

ALCOHOL; ANTINEOPLASTIC AGENT; CARBONYL DERIVATIVE; DEMYCAROSYL MITHRAMYCIN SK; FUNCTIONAL GROUP; MITHRAMYCIN; MITHRAMYCIN SA; MITHRAMYCIN SK; OXIDOREDUCTASE; PENTOBARBITAL; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIUM MUTANT; CANCER CELL CULTURE; CATALYSIS; CHEMICAL REACTION; DRUG DETERMINATION; DRUG SYNTHESIS; GENE ACTIVATION; GENE INSERTION; GENE LOCATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; STREPTOMYCES; STRUCTURE ACTIVITY RELATION;

ANTIBIOTICS, ANTINEOPLASTIC; CARBOHYDRATE SEQUENCE; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG SCREENING ASSAYS, ANTITUMOR; GENE SILENCING; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXIDOREDUCTASES; PLICAMYCIN; STREPTOMYCES; TRISACCHARIDES; TUMOR CELLS, CULTURED;

EID: 0038701795     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja034162h     Document Type: Article

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