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Volumn 286, Issue 5444, 1999, Pages 1571-1577

Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1

(32)  White, Owen a   Eisen, Jonathan A a   Heidelberg, John F a   Hickey, Erin K a   Peterson, Jeremy D a   Dodson, Robert J a   Haft, Daniel H a   Gwinn, Michelle L a   Nelson, William C a   Richardson, Delwood L a   Moffat, Kelly S a   Qin, Haiying a   Jiang, Lingxia a   Pamphile, Wanda a   Crosby, Marie a   Shen, Mian a   Vamathevan, Jessica J a   Lam, Peter a   McDonald, Lisa a   Utterback, Terry a   more..


Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME; DEINOCOCCUS RADIODURANS; DNA DAMAGE; DNA DEGRADATION; DNA REPAIR; FOOD PROCESSING; GENE SEQUENCE; NONHUMAN; OXIDATIVE STRESS; PHYLOGENY; PLASMID; PRIORITY JOURNAL; RADIOSENSITIVITY; STARVATION;

EID: 13044313472     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.286.5444.1571     Document Type: Article
Times cited : (815)

References (46)
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    • Protein sequences were filtered for low complexity [J. C. Wootton and S. Federhen, Methods Enzymol. 266, 554 (1996)] and grouped by single-linkage clusters in pairwise comparisons by PSI-BLAST [S. F. Altschul et al., Nucleic Adds Res. 25, 3389 (1997)] with the use of GROUPER [E. V. Koonin, A. R. Mushegian, M. Y. Calperin, D. R. Walker, Mol. Microbiol. 25, 619 (1997)]. Resulting multiple alignments of gene families were used to find additional family members in D. radiodurans, and related families were joined into superfamilies. Genes with multiple domains were placed into more than one family.
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    • Protein sequences were filtered for low complexity [J. C. Wootton and S. Federhen, Methods Enzymol. 266, 554 (1996)] and grouped by single-linkage clusters in pairwise comparisons by PSI-BLAST [S. F. Altschul et al., Nucleic Adds Res. 25, 3389 (1997)] with the use of GROUPER [E. V. Koonin, A. R. Mushegian, M. Y. Calperin, D. R. Walker, Mol. Microbiol. 25, 619 (1997)]. Resulting multiple alignments of gene families were used to find additional family members in D. radiodurans, and related families were joined into superfamilies. Genes with multiple domains were placed into more than one family.
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    • Searches were done as in (7)
    • Searches were done as in (7).
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    • note
    • 2 test, with each other, and with similarly sized samples of chromosome I chosen uniformly at random. These tests indicate that all three elements have significantly different trinucleotide composition (P < 0.01). Although the size of the plasmid is too small to obtain statistically meaningful comparisons of trinucleotide composition, its CC content is significantly different from the remaining genome (56% compared with 67%) (Tables 1 to 5).
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    • thesis, Stanford University, Stanford, CA
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    • note
    • A gene is considered recently duplicated if its greatest degree of similarity is to another gene in the D. radiodurans genome relative to genes from other completed genomes.
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    • note
    • - cells.
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    • The predicted molecular weight and isoelectric point are consistent with a protein that increases in abundance after irradiation (18). This protein is likely the nuclease reported by R. E. Mitchel [Biochim. Biophys. Acta 621, 138 (1980)].
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    • note
    • Supported by the U.S. Department of Energy, Office of Biological and Environmental Research, Cooperative Agreement DE-FCOZ-95ER61962. We thank E. V. Koonin for thoughtful contributions to this manuscript. Correspondence and requests for material should be addressed to C.M.F. (E-mail: drdb@tigr.org). The sequences have been deposited in GenBank with accession numbers AE00513, AE001825, AE001826, and AE001827 for chromosome I, chromosome II, the megaplasmid, and the plasmid, respectively.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.