Site-specific mutagenesis and domain substitutions in the loading module of the nystatin polyketide synthase, and their effects on nystatin biosynthesis in Streptomyces noursei

Journal of Biological Chemistry

Volumn 278, Issue 17, 2003, Pages 14913-14919

  Brautaset, Trygve ^a   Borgos, Sven E F ^a   Sletta, Håvard ^b   Ellingsen, Trond E ^b   Zotchev, Sergey B ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b SINTEF   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCATALYSTS; BIOSYNTHESIS; CARBOXYLATION; GENES; PROTEINS; SUBSTRATES;

MUTAGENESIS;

BIOCHEMISTRY;

ACETYL COENZYME A; ACYLTRANSFERASE; CARRIER PROTEIN; HYDROLYASE; NYSTATIN; POLYKETIDE SYNTHASE; SERINE;

ARTICLE; DECARBOXYLATION; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME MECHANISM; GENE DELETION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; STREPTOMYCES; STREPTOMYCES NOURSEI; WILD TYPE;

ACYL-CARRIER PROTEIN S-MALONYLTRANSFERASE; ACYLTRANSFERASES; ANTI-BACTERIAL AGENTS; BINDING SITES; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; NYSTATIN; PROTEIN STRUCTURE, TERTIARY; STREPTOMYCES;

ACTINOBACTERIA (CLASS); STREPTOMYCES; STREPTOMYCES NOURSEI; UNCULTURED ACTINOMYCETE;

EID: 0038690204     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212611200     Document Type: Article

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