Mechanistic analysis of a type II polyketide synthase. Role of conserved residues in the β-ketoacyl synthase-chain length factor heterodimer

Biochemistry

Volumn 39, Issue 8, 2000, Pages 2088-2095

  Dreier, Juerg ^a   Khosla, Chaitan ^a,b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; ACTINORHODINE; ACYL CARRIER PROTEIN; CYSTEINE; DOXORUBICIN; FATTY ACID SYNTHASE; MALONYL COENZYME A; MUTANT PROTEIN; PANTETHEINE; POLYKETIDE SYNTHASE; TETRACENOMYCIN C;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CHEMICAL BOND; DECARBOXYLATION; DISSOCIATION; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME MECHANISM; PRIORITY JOURNAL; STOICHIOMETRY;

ACYL-CARRIER PROTEIN S-MALONYLTRANSFERASE; ACYLTRANSFERASES; BACTERIAL PROTEINS; BINDING SITES; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; KINETICS; MODELS, CHEMICAL; MULTIENZYME COMPLEXES; MUTAGENESIS; POLYKETIDE SYNTHASES; PROTEIN BINDING; STREPTOMYCES;

EID: 0034728380     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992121l     Document Type: Article

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