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Volumn 139, Issue 3, 2003, Pages 567-574

The antipsychotic drug chlorpromazine inhibits HERG potassium channels

Author keywords

Antipsychotic drug; Arrhythmia; Chlorpromazine; Ion channels; Long QT syndrome; Xenopus oocytes

Indexed keywords

CHLORPROMAZINE; NEUROLEPTIC AGENT; POTASSIUM CHANNEL;

EID: 0038678580     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705283     Document Type: Article
Times cited : (70)

References (31)
  • 1
    • 0023681828 scopus 로고
    • Chlorpromazine accumulation and sudden death in a patient with renal insufficiency
    • DORSON, P.G. & CRISMON, M.L. (1988). Chlorpromazine accumulation and sudden death in a patient with renal insufficiency. Drug Intell. Clin. Pharm., 22, 776 - 778.
    • (1988) Drug Intell. Clin. Pharm. , vol.22 , pp. 776-778
    • Dorson, P.G.1    Crismon, M.L.2
  • 5
    • 0035150202 scopus 로고    scopus 로고
    • Antipsychotic drugs: Prolonged QTc interval, torsade de pointes, and sudden death
    • GLASSMANN, A.H. & BIGGER JR, J.T. (2001). Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. Am. J. Psychiatry., 158, 1774 - 1782.
    • (2001) Am. J. Psychiatry. , vol.158 , pp. 1774-1782
    • Glassmann, A.H.1    Bigger J.T., Jr.2
  • 6
    • 0036322892 scopus 로고    scopus 로고
    • Antipsychotic-related QTc prolongation, torsade de pointes and sudden death
    • HADDAD, P.M. & ANDERSON, I.M. (2002). Antipsychotic-related QTc prolongation, torsade de pointes and sudden death. Drugs, 62, 1649 - 1671.
    • (2002) Drugs , vol.62 , pp. 1649-1671
    • Haddad, P.M.1    Anderson, I.M.2
  • 7
    • 0034963201 scopus 로고    scopus 로고
    • Torsades de pointes associated with chlorpromazine: Case report and review of associated ventricular arrhythmias
    • HOEHNS, J.D., STANFORD, R.H., GERAETS, D.R., SKELLY, K.S., LEE, H.C. & GAUL, B.L. (2001). Torsades de pointes associated with chlorpromazine: case report and review of associated ventricular arrhythmias. Pharmacotherapy, 21, 871 - 883.
    • (2001) Pharmacotherapy , vol.21 , pp. 871-883
    • Hoehns, J.D.1    Stanford, R.H.2    Geraets, D.R.3    Skelly, K.S.4    Lee, H.C.5    Gaul, B.L.6
  • 10
    • 0029825403 scopus 로고    scopus 로고
    • Molecular physiology and pharmacology of HERG
    • KIEHN, J., LACERDA, A.E., WIBLE, B.A. & BROWN, A.M. (1996). Molecular physiology and pharmacology of HERG. Circulation, 94, 2572 - 2579.
    • (1996) Circulation , vol.94 , pp. 2572-2579
    • Kiehn, J.1    Lacerda, A.E.2    Wible, B.A.3    Brown, A.M.4
  • 11
    • 0033026763 scopus 로고    scopus 로고
    • Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels
    • KIEHN, J., THOMAS, D., KARLE, C.A., SCHOLS, W. & KUBLER, W. (1999). Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels. Naunyn-Schmiedeberg's Arch. Pharmacol., 359, 212 - 219.
    • (1999) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.359 , pp. 212-219
    • Kiehn, J.1    Thomas, D.2    Karle, C.A.3    Schols, W.4    Kubler, W.5
  • 12
    • 0034801389 scopus 로고    scopus 로고
    • Comparison of block among cloned cardiac potassium channels by non-antiarrhythmic drugs
    • LACERDA, A.E., KRAMER, J., SHEN, K.Z., THOMAS, D. & BROWN, A.M. (2001). Comparison of block among cloned cardiac potassium channels by non-antiarrhythmic drugs. Eur. Heart J., 3 (Suppl. K), K23 - K30.
    • (2001) Eur. Heart J. , vol.3 , Issue.SUPPL. K
    • Lacerda, A.E.1    Kramer, J.2    Shen, K.Z.3    Thomas, D.4    Brown, A.M.5
  • 14
    • 0033818157 scopus 로고    scopus 로고
    • Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate
    • MITCHESON, J.S., CHEN, J. & SANGUINETTI, M.C. (2000). Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate. J. Gen. Physiol., 115, 229 - 240.
    • (2000) J. Gen. Physiol. , vol.115 , pp. 229-240
    • Mitcheson, J.S.1    Chen, J.2    Sanguinetti, M.C.3
  • 16
    • 0028115856 scopus 로고
    • Torsade de pointes: Mechanism and management
    • NAPOLITANO, C., PRIORI, S. & SCHWARTZ, P. (1994). Torsade de pointes: mechanism and management. Drugs, 47, 51 - 65.
    • (1994) Drugs , vol.47 , pp. 51-65
    • Napolitano, C.1    Priori, S.2    Schwartz, P.3
  • 17
    • 0031045925 scopus 로고    scopus 로고
    • Chlorpromazine activates chloride currents in Xenopus oocytes
    • QUAMME, G.A. (1997). Chlorpromazine activates chloride currents in Xenopus oocytes. Biochim. Biophys. Acta, 1324, 18 - 26.
    • (1997) Biochim. Biophys. Acta , vol.1324 , pp. 18-26
    • Quamme, G.A.1
  • 18
    • 0034712552 scopus 로고    scopus 로고
    • QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients
    • REILLY, J.G., AYIS, S.A., FERRIER, I.N., JONES, S.J. & THOMAS, S.H.L. (2000). QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients. Lancet, 355, 1048 - 1052.
    • (2000) Lancet , vol.355 , pp. 1048-1052
    • Reilly, J.G.1    Ayis, S.A.2    Ferrier, I.N.3    Jones, S.J.4    Thomas, S.H.L.5
  • 20
    • 0030025308 scopus 로고    scopus 로고
    • The inward rectification mechanism of the HERG cardiac potassium channel
    • SMITH, P.L., BAUKROWITZ, T. & YELLEN, G. (1996). The inward rectification mechanism of the HERG cardiac potassium channel. Nature, 379, 833 - 836.
    • (1996) Nature , vol.379 , pp. 833-836
    • Smith, P.L.1    Baukrowitz, T.2    Yellen, G.3
  • 21
    • 0030898598 scopus 로고    scopus 로고
    • The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes
    • SUESSBRICH, H., SCHONHERR, R., HEINEMANN, S.H., ATTALI, B., LANG, F. & BUSCH, A.E. (1997). The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes. Br. J. Pharmacol., 120, 968 - 974.
    • (1997) Br. J. Pharmacol. , vol.120 , pp. 968-974
    • Suessbrich, H.1    Schonherr, R.2    Heinemann, S.H.3    Attali, B.4    Lang, F.5    Busch, A.E.6
  • 22
    • 0029994611 scopus 로고    scopus 로고
    • Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole
    • SUESSBRICH, H., WALDEGGER, S., LANG, F. & BUSCH, A.E. (1996). Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole. FEBS Lett., 385, 77 - 80.
    • (1996) FEBS Lett. , vol.385 , pp. 77-80
    • Suessbrich, H.1    Waldegger, S.2    Lang, F.3    Busch, A.E.4
  • 23
    • 0032853542 scopus 로고    scopus 로고
    • Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline
    • TESCHEMACHER, A.G., SEWARD, E.P., HANCOX, J.C. & WITCHEL, H.J. (1999). Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline. Br. J. Pharmacol., 128, 479 - 485.
    • (1999) Br. J. Pharmacol. , vol.128 , pp. 479-485
    • Teschemacher, A.G.1    Seward, E.P.2    Hancox, J.C.3    Witchel, H.J.4
  • 24
    • 0036151533 scopus 로고    scopus 로고
    • The antidepressant drug fluoxetine is an inhibitor of human ether-a-go-go-related gene (HERG) potassium channels
    • THOMAS, D., GUT, B., WENDT-NORDAHL, G. & KIEHN, J. (2002). The antidepressant drug fluoxetine is an inhibitor of human ether-a-go-go-related gene (HERG) potassium channels. J. Pharmacol. Exp. Ther., 300, 543 - 548.
    • (2002) J. Pharmacol. Exp. Ther. , vol.300 , pp. 543-548
    • Thomas, D.1    Gut, B.2    Wendt-Nordahl, G.3    Kiehn, J.4
  • 25
    • 0035028834 scopus 로고    scopus 로고
    • High-affinity blockade of HERG human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872
    • THOMAS, D., WENDT-NORDAHL, G., ROCKL, K., FICKER, E., BROWN, A.M. & KIEHN, J. (2001). High-affinity blockade of HERG human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872. J. Pharmacol. Exp. Ther., 297, 753 - 761.
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , pp. 753-761
    • Thomas, D.1    Wendt-Nordahl, G.2    Rockl, K.3    Ficker, E.4    Brown, A.M.5    Kiehn, J.6
  • 26
    • 0033600758 scopus 로고    scopus 로고
    • Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A
    • THOMAS, D., ZHANG, W., KARLE, C.A., KATHOFER, S., SCHOLS, W., KUBLER, W. & KIEHN, J. (1999). Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A. J. Biol. Chem., 274, 27457 - 27462.
    • (1999) J. Biol. Chem. , vol.274 , pp. 27457-27462
    • Thomas, D.1    Zhang, W.2    Karle, C.A.3    Kathofer, S.4    Schols, W.5    Kubler, W.6    Kiehn, J.7
  • 29
    • 0033530381 scopus 로고    scopus 로고
    • Long QT syndromes and torsade de pointes
    • VISKIN, S. (1999). Long QT syndromes and torsade de pointes. Lancet, 354, 1625 - 1633.
    • (1999) Lancet , vol.354 , pp. 1625-1633
    • Viskin, S.1
  • 30
    • 0028292927 scopus 로고
    • A family of potassium channel genes related to eag in Drosophila and mammals
    • WARMKE, J.W. & GANETZKY, B. (1994). A family of potassium channel genes related to eag in Drosophila and mammals. Proc. Natl. Acad. Sci. U.S.A., 91, 3438 - 3442.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 3438-3442
    • Warmke, J.W.1    Ganetzky, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.