Chlorpromazine-induced inhibition of catecholamine secretion by a differential blockade of nicotinic receptors and L-type Ca2+ channels in rat pheochromocytoma cells

Biochemical Pharmacology

Volumn 58, Issue 6, 1999, Pages 1017-1024

  Lee, Ihn Soon ^a   Park, Tae Ju ^a   Suh, Byung Chang ^a   Kim, Yong Sik ^b   Rhee, In Ja ^c   Kim, Kyong Tai ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Catholic University of Daegu   (South Korea)

Author keywords

Catecholamine secretion; Chlorpromazine; L type Ca2+ channels; Nicotinic receptor; PC12 cells

Indexed keywords

1,1 DIMETHYL 4 PHENYLPIPERAZINIUM; BRADYKININ; CALCIUM; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CATECHOLAMINE; CHLORPROMAZINE; INOSITOL 1,4,5 TRISPHOSPHATE; NEUROLEPTIC AGENT; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NIFEDIPINE; NORADRENALIN; OMEGA CONOTOXIN; SODIUM; SULFINPYRAZONE; TRITIUM;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CATECHOLAMINE RELEASE; CELL STRAIN; CONTROLLED STUDY; DRUG INHIBITION; DRUG RECEPTOR BINDING; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; SODIUM CELL LEVEL;

ANIMALS; BRADYKININ; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; CATECHOLAMINES; CHLORPROMAZINE; DIMETHYLPHENYLPIPERAZINIUM IODIDE; DOPAMINE ANTAGONISTS; NICOTINIC ANTAGONISTS; NOREPINEPHRINE; PC12 CELLS; POTASSIUM; RATS; RECEPTORS, CHOLINERGIC; RECEPTORS, NICOTINIC; TRITIUM;

EID: 0032798014     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00181-1     Document Type: Article

References (38)

1. Seeman P. Brain dopamine receptors. Pharmacol Rev. 32:1981;229-313.
2. Rosenzweig MR, Leiman AL and Breedlove SM, Psychobiology of mental disorders. In: Biological Psychology, pp. 581-587. Sinauer Associates, Inc., Sunderland, MA, 1996.
3. Prozialeck W.C., Weiss B. Inhibition of calmodulin by phenothiazines and related drugs Structure-activity relationships . J Pharmacol Exp Ther. 222:1982;509-516.
4. Klockner U., Isenberg G. Calmodulin antagonists depress calcium and potassium currents in ventricular and vascular myocytes. Am J Physiol. 253:1987;H1601-H1611.
5. Ogata N., Yoshii M., Narahashi T. Psychotropic drugs block voltage-gated ion channels in neuroblastoma cells. Brain Res. 476:1989;140-144.
6. Ogata N., Yoshii M., Narahasi T. Differential block of sodium and calcium channels by chlorpromazine in mouse neuroblastoma cells. J Physiol. 420:1990;165-183.
7. Wooltorton J.R.A., Mathie A. Block of potassium currents in rat isolated sympathetic neurons by tricyclic antidepressants and structurally related compounds. Br J Pharmacol. 110:1993;1126-1132.
8. Jacobs E.R., DeCoursey T.E. Mechanisms of potassium channel blocker in rat alveolar epithelial cells. J Pharmacol Exp Ther. 255:1990;459-472.
9. + current in rat phaeochromocytoma cells. Br J Pharmacol. 116:1995;2603-2610.
10. Benoit P., Changeux J.P. Voltage dependencies of the effects of chlorpromazine on the nicotinic receptor channel from mouse muscle cell line So 18. Neurosci Lett. 160:1993;81-84.
11. Park T.J., Kim K.T. Cyclic AMP-independent inhibition of voltage-sensitive calcium channels by forskolin in PC12 cells. J Neurochem. 66:1996;83-88.
12. Di Virgilio F., Fasolato C., Steinberg T.H. Inhibitors of membrane transport system for organic anions block fura-2 excretion from PC12 and N2A cells. Biochem J. 256:1988;959-963.
13. 2+ indicators with greatly improved fluorescence properties. J Biol Chem. 260:1985;3440-3450.
14. 2A adenosine receptor in PC12 cells. J Neurochem. 71:1998;1251-1260.
15. Greene L.A., Sobeih M.M., Teng K.K. Methodologies for the culture and experimental use of the PC12 rat pheochromocytoma cell line. Banker G., Goslin K. Culturing Nerve Cells. 1991;207-226 The MIT Press, Cambridge.
16. 2+ influx in PC12 cells by involving protein kinase A. J Neurochem. 68:1997;2177-2185.
17. 3H]inositol 1,4,5-triphosphate binding sites in adrenal-cortical membranes. Biochem J. 265:1990;421-427.
18. Park T.J., Shin S.Y., Suh B.C., Suh E.K., Lee I.S., Kim Y.S., Kim K.T. Differential inhibition of catecholamine secretion by amitriptyline through blockage of nicotinic receptors, sodium channels, and calcium channels in bovine adrenal chromaffin cells. Synapse. 29:1998;248-256.
19. 3H]-nicotine binding on bovine adrenal chromaffin cells. J Neurosci. 8:1988;1436-1446.
20. De Lean A., Munson P.J., Rodbard D. Simultaneous analysis of families of sigmoidal curves Application to bioassay, radioligand assay, and physiological dose-response curves . Am J Physiol. 235:1978;E97-E102.
21. 3H]chlorpromazine Additional evidence for the open channel conformation . Biochemistry. 25:1986;6109-6113.
22. 3H]chlorpromazine labels three amino acids of the acetylcholine receptor γ subunit Implications for the α-helical organization of regions MII and for the structure of the ion channel . Proc Natl Acad Sci USA. 87:1990;4675-4679.
23. 3H)norepinephrine from a clonal line of pheochromocytoma cells (PC12) by nicotinic cholinergic stimulation. Brain Res. 138:1977;521-528.
24. Stallcup W.B. Sodium and calcium fluxes in a clonal nerve cell line. J Physiol (Lond). 286:1979;525-540.
25. 2+ channels in PC12 cells. Biochem Pharmacol. 47:1994;1262-1266.
26. Suh B.C., Lee C.O., Kim K.T. Signal flows from two phospholipase C-linked receptors are independent in PC12 cells. J Neurochem. 64:1995;1071-1079.
27. Boireau A., Chambry J., Dubedat P., Farges G., Carruette A.M., Zundel J.L., Blanchard J.C. Enhancing effect of dopamine blockers on evoked acetylcholine release in rat striatal slices A classical D-2 antagonist response? Eur J Pharmacol. 128:1986;93-98.
28. Blaha C.D., Lane R.F. Chronic treatment with classical and atypical antipsychotic drugs differentially decreases dopamine release in striatum and nucleus accumbens in vivo. Neurosci Lett. 78:1987;199-204.
29. 3H]-noradrenaline secretion in guinea-pig isolated urethra. Br J Pharmacol. 105:1992;142-146.
30. Breier A., Su T.P., Saunders R., Carson R.E., Kolachana B.S., de Bartolomeis A., Weinberger D.R., Weisenfeld N., Malhotra A.K., Eckelman W.C., Pickar D. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations Evidence from a novel positron emission tomography method . Proc Natl Acad Sci USA. 94:1997;2569-2574.
31. Sternberg D.E., Charney D.S., Heninger G.R., Leckman J.F., Hafstad K.M., Landis D.H. Impaired presynaptic regulation of norepinephrine in schizophrenia. Effects of clonidine in schizophrenic patients and normal controls. Arch Gen Psychiatry. 39:1982;285-289.
32. Rifkin A. Extrapyramidal side effects A historical perspective . J Clin Psychiatry. 48:(Suppl):1987;3-6.
33. Owens D.G. Adverse effects of antipsychotic agents. Do newer agents offer advantages? Drugs. 51:1996;895-930.
34. Lena C., Changeux J.P. Allosteric modulations of the nicotinic acetylcholine receptor. Trends Neurosci. 16:1993;181-186.
35. Heidmann T., Changeux J.P. Time-resolved photolabeling by the noncompetitive blocker chlorpromazine of the acetylcholine receptor in its transiently open and closed ion channel conformations. Proc Natl Acad Sci USA. 6:1984;1897-1901.
36. Takayama H., Majewska M.D., London E.D. Interactions of noncompetitive inhibitors with nicotinic receptors in the rat brain. J Pharmacol Exp Ther. 251:1989;1083-1089.
37. 3H]acetylcholine binding sites. J Pharmacol Exp Ther. 253:1990;51-57.
38. Wode-Helgodt B., Borg S., Fyro B., Sedvall G. Clinical effects and drug concentrations in plasma and cerebrospinal fluid in psychotic patients treated with fixed doses of chlorpromazine. Acta Psychiatr Scand. 58:1978;149-173.