Emerging understanding of the advantage of small molecules such as hydroxypyridinones in the treatment of iron overload

Current Medicinal Chemistry

Volumn 10, Issue 12, 2003, Pages 1051-1064

  Hider, Robert C ^a   Liu, Zu D ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Hydroxypyridinone; Iron chelators; pFe3+ value; Prodrug

Indexed keywords

1,2 DIETHYL 3 HYDROXY 4 PYRIDONE; 3 HYDROXY 4 PYRIDONE DERIVATIVE; ACETOHYDROXAMIC ACID; CATECHOL DERIVATIVE; CITRIC ACID; CP 162; CP 165; CP 251; CP 280; CP 283; CP 361; CP 502; DEFERIPRONE; DEFEROXAMINE; DEFERRIFERRITHIOCIN; DETERIPRONE; ENTEROCHELIN; FLUTROLINE; HYDROXAMIC ACID DERIVATIVE; ICL 6702; IRON; IRON CHELATING AGENT; LIGAND; MALTOL; N,N DIMETHYL 2,3 DIHYDROXYBENZAMIDE; N,N' BIS(2 HYDROXYBENZYL)ETHYLENEDIAMINE N,N' DIACETIC ACID; PENTETIC ACID; PRODRUG; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

BINDING AFFINITY; CLINICAL TRIAL; DRUG BINDING; DRUG CLASSIFICATION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENTIATION; DRUG STRUCTURE; HUMAN; IRON CHELATION; IRON OVERLOAD; MOLECULAR SIZE; NONHUMAN; REVIEW; SIDE EFFECT;

ANIMALS; HUMANS; IRON; IRON CHELATING AGENTS; IRON OVERLOAD; MODELS, MOLECULAR; PYRIDONES;

EID: 0038663082     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867033457629     Document Type: Review

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