메뉴 건너뛰기




Volumn 57, Issue 5, 1999, Pages 559-566

In vivo iron mobilisation evaluation of hydroxypyridinones in 59Fe-ferritin-Loaded rat model

Author keywords

59Fe ferritin; Hydroxypyridinone; Iron chelators; Prodrug

Indexed keywords

FERRITIN; IRON 59; IRON CHELATING AGENT; PYRIDINOL;

EID: 0033105983     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00319-0     Document Type: Article
Times cited : (22)

References (27)
  • 1
    • 0017886984 scopus 로고
    • Prevention of iron loading in transfusion-dependent thalassaemia
    • Pippard M.J., Callender S.T., Letsky E.A., Weatherall D.J. Prevention of iron loading in transfusion-dependent thalassaemia. Lancet. i:1978;1178-1180.
    • (1978) Lancet , vol.1 , pp. 1178-1180
    • Pippard, M.J.1    Callender, S.T.2    Letsky, E.A.3    Weatherall, D.J.4
  • 2
    • 0018777993 scopus 로고
    • Studies in desferrioxamine and ferrioxamine metabolism in normal and iron-loaded subjects
    • Summers M.R., Jacobs A., Tudway D., Perera P., Ricketts C. Studies in desferrioxamine and ferrioxamine metabolism in normal and iron-loaded subjects. Br J Haematol. 42:1979;547-555.
    • (1979) Br J Haematol , vol.42 , pp. 547-555
    • Summers, M.R.1    Jacobs, A.2    Tudway, D.3    Perera, P.4    Ricketts, C.5
  • 3
    • 0018183383 scopus 로고
    • Intensive iron-chelation therapy with desferrioxamine in iron-loading anaemias
    • Pippard M.J., Callender S.T., Weatherall D.J. Intensive iron-chelation therapy with desferrioxamine in iron-loading anaemias. Clin Sci Mol Med. 54:1978;99-106.
    • (1978) Clin Sci Mol Med , vol.54 , pp. 99-106
    • Pippard, M.J.1    Callender, S.T.2    Weatherall, D.J.3
  • 4
    • 0017083507 scopus 로고
    • The use of Chang cells cultured in vitro to evaluate potential iron chelating drugs
    • White G.P., Jacobs A., Grady R.W., Cerami A. The use of Chang cells cultured in vitro to evaluate potential iron chelating drugs. Br J Haematol. 33:1976;487-494.
    • (1976) Br J Haematol , vol.33 , pp. 487-494
    • White, G.P.1    Jacobs, A.2    Grady, R.W.3    Cerami, A.4
  • 5
    • 0023811903 scopus 로고
    • Iron mobilisation from hepatocyte monolayer cultures by chelators: The importance of membrane permeability and the iron binding constant
    • Porter J.B., Gyparaki M., Burke L.C. Iron mobilisation from hepatocyte monolayer cultures by chelators the importance of membrane permeability and the iron binding constant . Blood. 72:1988;1497-1503.
    • (1988) Blood , vol.72 , pp. 1497-1503
    • Porter, J.B.1    Gyparaki, M.2    Burke, L.C.3
  • 6
    • 0016107787 scopus 로고
    • The identification of 2,3-hydroxybenzoic acid as a potentially useful iron-chelating drug
    • Graziano J.H., Grady R.W., Cerami A. The identification of 2,3-hydroxybenzoic acid as a potentially useful iron-chelating drug. J Pharmacol Exp Ther. 190:1974;570-575.
    • (1974) J Pharmacol Exp Ther , vol.190 , pp. 570-575
    • Graziano, J.H.1    Grady, R.W.2    Cerami, A.3
  • 9
    • 0013618824 scopus 로고
    • Efforts to develop a bioassay system for detecting compounds which actively deplete iron stores
    • (Eds. Anderson WF and Hille M) DHEW Publication, Bethesda, MD
    • Gralla EJ, Efforts to develop a bioassay system for detecting compounds which actively deplete iron stores. In: Proceedings of the Symposium on the Development of Iron Chelators for Clinical Use (Eds. Anderson WF and Hille M), pp. 229-245. DHEW Publication, Bethesda, MD, 1975.
    • (1975) In: Proceedings of the Symposium on the Development of Iron Chelators for Clinical Use , pp. 229-245
    • Gralla, E.J.1
  • 11
    • 0013590646 scopus 로고
    • Hydroxypyridinone iron chelators; In vitro and in vivo evaluation
    • G. Sirshia, & A. Zanella. Milan: Maggiore Policlinico Di Milano
    • Gyparaki M., Hider R.C., Huehns E.R., Porter J.B. Hydroxypyridinone iron chelators; in vitro and in vivo evaluation. Sirshia G., Zanella A. Thalassaemia Today, the Mediterranean Experience. 1987;521-526 Maggiore Policlinico Di Milano, Milan.
    • (1987) Thalassaemia Today, the Mediterranean Experience , pp. 521-526
    • Gyparaki, M.1    Hider, R.C.2    Huehns, E.R.3    Porter, J.B.4
  • 12
  • 13
    • 0023037399 scopus 로고
    • An animal model of iron overload and its application to study hepatic ferritin iron mobilisation by chelators
    • Longueville A., Crichton R.R. An animal model of iron overload and its application to study hepatic ferritin iron mobilisation by chelators. Biochem Pharmacol. 35:1986;3669-3678.
    • (1986) Biochem Pharmacol , vol.35 , pp. 3669-3678
    • Longueville, A.1    Crichton, R.R.2
  • 15
    • 0026698175 scopus 로고
    • Studies of in vivo iron mobilization by chelators in the ferrocene-loaded rat
    • Florence A., Ward R.J., Peters T.J., Crichton R.R. Studies of in vivo iron mobilization by chelators in the ferrocene-loaded rat. Biochem Pharmacol. 44:1992;1023-1027.
    • (1992) Biochem Pharmacol , vol.44 , pp. 1023-1027
    • Florence, A.1    Ward, R.J.2    Peters, T.J.3    Crichton, R.R.4
  • 16
    • 0015631510 scopus 로고
    • Storage iron kinetics III. Study of desferrioxamine action by selective radioiron labels of RE and parenchymal cell
    • Hershko C., Cook J.D., Finch C.A. Storage iron kinetics III. Study of desferrioxamine action by selective radioiron labels of RE and parenchymal cell. J Lab Clin Med. 81:1973;876-886.
    • (1973) J Lab Clin Med , vol.81 , pp. 876-886
    • Hershko, C.1    Cook, J.D.2    Finch, C.A.3
  • 17
    • 0016813341 scopus 로고
    • A study of the chelating agent diethylenetriaminepentacetic acid using selective radioiron probes of reticuloendothelial and parenchymal iron stores
    • Hershko C. A study of the chelating agent diethylenetriaminepentacetic acid using selective radioiron probes of reticuloendothelial and parenchymal iron stores. J Lab Clin Med. 85:1975;913-921.
    • (1975) J Lab Clin Med , vol.85 , pp. 913-921
    • Hershko, C.1
  • 18
    • 0017883237 scopus 로고
    • Determinants of faecal and urinary iron excretion in rats
    • Hershko C. Determinants of faecal and urinary iron excretion in rats. Blood. 51:1978;415-423.
    • (1978) Blood , vol.51 , pp. 415-423
    • Hershko, C.1
  • 19
    • 0023700267 scopus 로고
    • Selection of hydroxypyridin-4-ones for the treatment of iron overload using in vitro and in vivo models
    • Huehns E.R., Porter J.B., Hider R.C. Selection of hydroxypyridin-4-ones for the treatment of iron overload using in vitro and in vivo models. Haematology. 12:1988;593-600.
    • (1988) Haematology , vol.12 , pp. 593-600
    • Huehns, E.R.1    Porter, J.B.2    Hider, R.C.3
  • 20
    • 0014440997 scopus 로고
    • Clinical usefulness of iron chelating agents
    • Waxman H.S., Brown E.B. Clinical usefulness of iron chelating agents. Prog Hematol. 6:1969;338-373.
    • (1969) Prog Hematol , vol.6 , pp. 338-373
    • Waxman, H.S.1    Brown, E.B.2
  • 21
    • 0019411460 scopus 로고
    • A rapid assay for evaluation of iron chelating agents in rats
    • Pippard M.J., Johnson D.K., Finch C.A. A rapid assay for evaluation of iron chelating agents in rats. Blood. 58:1981;685-692.
    • (1981) Blood , vol.58 , pp. 685-692
    • Pippard, M.J.1    Johnson, D.K.2    Finch, C.A.3
  • 23
    • 0027328530 scopus 로고
    • Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: Orally active iron chelators with clinical potential
    • Dobbin P.S., Hider R.C., Hall A.D., Taylor P.D., Sarpong P., Porter J.B., Xiao G., van der Helm D. Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones Orally active iron chelators with clinical potential . J Med Chem. 36:1993;2448-2458.
    • (1993) J Med Chem , vol.36 , pp. 2448-2458
    • Dobbin, P.S.1    Hider, R.C.2    Hall, A.D.3    Taylor, P.D.4    Sarpong, P.5    Porter, J.B.6    Xiao, G.7    Van Der Helm, D.8
  • 24
    • 0344390894 scopus 로고    scopus 로고
    • Synthesis, physicochemical properties, and biological evaluation of hydrophobic esters of hydroxypyridin-4-ones: Design of orally active chelators with clinical potential
    • (in press
    • Rai BL, Liu ZD and Hider RC, Synthesis, physicochemical properties, and biological evaluation of hydrophobic esters of hydroxypyridin-4-ones: Design of orally active chelators with clinical potential. Eur J Med Chem (in press, 1999).
    • (1999) Eur J Med Chem
    • Rai, B.L.1    Liu, Z.D.2    Hider, R.C.3
  • 25
    • 0014959061 scopus 로고
    • Sex difference in the ferritin content of rat liver
    • Bjorklid E., Helgeland L. Sex difference in the ferritin content of rat liver. Biochim Biophys Acta. 221:1970;583-592.
    • (1970) Biochim Biophys Acta , vol.221 , pp. 583-592
    • Bjorklid, E.1    Helgeland, L.2
  • 26
    • 0029554843 scopus 로고
    • An improved simple colorimetric method for quantitation of non-transferrin-bound iron in serum
    • Zhang D., Okada S., Kawabata T., Yasada T. An improved simple colorimetric method for quantitation of non-transferrin-bound iron in serum. Biochem Mol Biol Int. 35:(3):1995;635-641.
    • (1995) Biochem Mol Biol Int , vol.35 , Issue.3 , pp. 635-641
    • Zhang, D.1    Okada, S.2    Kawabata, T.3    Yasada, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.