Synthesis, physicochemical properties and biological evaluation of ester prodrugs of 3-hydroxypyridin-4-ones: Design of orally active chelators with clinical potential

European Journal of Medicinal Chemistry

Volumn 34, Issue 6, 1999, Pages 475-485

  Rai, Bijaya L ^a   Liu, Zu Dong ^a   Liu, Ding Yong ^a   Lu, Shu Li ^a   Hider, Robert C ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Hydroxypyridinone; Iron chelators; Prodrug

Indexed keywords

3 HYDROXY 4 PYRIDONE DERIVATIVE; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG EFFICACY; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG STRUCTURE; IRON KINETICS; LIPOPHILICITY; LIVER HOMOGENATE; NONHUMAN; PHYSICAL CHEMISTRY; RAT; SYNTHESIS;

EID: 0344390894     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)80097-X     Document Type: Article

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