Structure-activity investigation of the inhibition of 3-hydroxypyridin-4-ones on mammalian tyrosine hydroxylase

Biochemical Pharmacology

Volumn 61, Issue 3, 2001, Pages 285-290

  Liu, Zu Dong ^a   Lockwood, Michelle ^b   Rose, Sarah ^b   Theobald, Anthony E ^a   Hider, Robert C ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Hydroxypyridinone; Iron chelators; Lipophilicity; Tyrosine hydroxylase

Indexed keywords

1,2 DIETHYL 3 HYDROXY 4 PYRIDONE; 3 HYDROXY 4 PYRIDONE DERIVATIVE; CP 357; CP 374; CP 502; CP 507; CP 60; CP 69; DEFERIPRONE; IRON CHELATING AGENT; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROPHOBICITY; IRON CHELATION; LIPOPHILICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BRAIN; ENZYME INHIBITORS; IRON CHELATING AGENTS; LEVODOPA; MALE; PYRIDINES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE 3-MONOOXYGENASE;

EID: 0035254844     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00551-7     Document Type: Article

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