메뉴 건너뛰기




Volumn 21, Issue 1, 1996, Pages 33-41

Metabolism and pharmacokinetics of 1-(2'-hydroxyethyl)- and 1-(3'-hydroxypropyl)-2-ethyl-3-hydroxypyridin-4-ones in the rat

Author keywords

3 hydroxypyridin 4 one; Chelator; Iron; Metabolism; Pharmacokinetics

Indexed keywords

2 ETHYL 3 HYDROXY 1 (2 HYDROXYETHYL) 4 PYRIDINONE; 3 HYDROXY 4 PYRIDONE DERIVATIVE; CHELATING AGENT; CP 106; CP 110; DRUG METABOLITE; UNCLASSIFIED DRUG;

EID: 0030056173     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03190276     Document Type: Article
Times cited : (17)

References (17)
  • 1
    • 77956799357 scopus 로고
    • Therapeutic iron-chelating agents
    • Rice-Evans C.A., Burdon R.H. (Eds). Amsterdam, Elsevier
    • Singh S. Hider R.C. (1994) : Therapeutic iron-chelating agents. In: Rice-Evans C.A., Burdon R.H. (Eds). Free Radical Damage and its Control. Amsterdam, Elsevier, pp. 189-213.
    • (1994) Free Radical Damage and Its Control , pp. 189-213
    • Singh, S.1    Hider, R.C.2
  • 2
    • 0025543246 scopus 로고
    • The development of hydroxypyndin-4-ones as orally active iron chelators
    • Hider R.C., Singh S., Porter J.B., Huehns E.R. (1990) : The development of hydroxypyndin-4-ones as orally active iron chelators Ann NY Acad. Sci., 612, 327-338.
    • (1990) Ann NY Acad. Sci. , vol.612 , pp. 327-338
    • Hider, R.C.1    Singh, S.2    Porter, J.B.3    Huehns, E.R.4
  • 3
    • 0017886984 scopus 로고
    • Prevention of iron loading in transfusion-dependent thalassaemia
    • Pippard M J., Letsky E.A., Callender S.T., Weatherall D.J. (1978) Prevention of iron loading in transfusion-dependent thalassaemia Lancet, i. 1178-1180.
    • (1978) Lancet , vol.1 , pp. 1178-1180
    • Pippard, M.J.1    Letsky, E.A.2    Callender, S.T.3    Weatherall, D.J.4
  • 4
    • 0017622851 scopus 로고
    • Continuous subcutaneous administration of desferrioxamine in thalassaemia major
    • Propper R D., Cooper B., Rufo R., et al. (1977) : Continuous subcutaneous administration of desferrioxamine in thalassaemia major. N Engl. J. Med., 297. 418-423.
    • (1977) N Engl. J. Med. , vol.297 , pp. 418-423
    • Propper, R.D.1    Cooper, B.2    Rufo, R.3
  • 5
    • 0027291099 scopus 로고
    • Intravenous infusion pharmacokinetics of desferrioxamine in thalassaemic patients
    • Lee P. Mohammed N., Marshall L., et al. (1993) : Intravenous infusion pharmacokinetics of desferrioxamine in thalassaemic patients Drug Metab Dispos., 21, 640-644.
    • (1993) Drug Metab Dispos. , vol.21 , pp. 640-644
    • Lee, P.1    Mohammed, N.2    Marshall, L.3
  • 6
    • 0001152992 scopus 로고
    • The design of therapeutically useful iron chelators
    • Bergeron R.J., Brittenham G.M. (Eds) Florida, CRC Press
    • Hider R C., Porter J.B., Singh S (1994) : The design of therapeutically useful iron chelators. In: Bergeron R.J., Brittenham G.M. (Eds) The Development of Iron Chelators for Clinical Use. Florida, CRC Press, pp. 353-371.
    • (1994) The Development of Iron Chelators for Clinical Use , pp. 353-371
    • Hider, R.C.1    Porter, J.B.2    Singh, S.3
  • 8
    • 0023489829 scopus 로고
    • Effective chelation of iron in β-thalassaemia with the oral iron chelator 1,2-dimethyl-3-hydroxypyridin-4-one
    • Kontoghiorghes G.J., Aldouri M.A., Hoffbrand A V., et al. (1987) : Effective chelation of iron in β-thalassaemia with the oral iron chelator 1,2-dimethyl-3-hydroxypyridin-4-one. BMJ, 295, 1509-1512.
    • (1987) BMJ , vol.295 , pp. 1509-1512
    • Kontoghiorghes, G.J.1    Aldouri, M.A.2    Hoffbrand, A.V.3
  • 9
    • 0025066690 scopus 로고
    • Comparison of oral iron chelator L1 and desferrioxamine in iron-loaded patients
    • Oliveri N.F., Koren G., Hermann C., et al. (1990) : Comparison of oral iron chelator L1 and desferrioxamine in iron-loaded patients, Lancet, 336, 1275.
    • (1990) Lancet , vol.336 , pp. 1275
    • Oliveri, N.F.1    Koren, G.2    Hermann, C.3
  • 10
    • 0026668939 scopus 로고
    • Longterm assessment of efficacy and safety of L1, an oral iron chelator in transfusion dependent thalassaemia: Indian trial
    • Agarwal M.B., Gupta S.S., Visvanathan C., et al. (1992) : Longterm assessment of efficacy and safety of L1, an oral iron chelator in transfusion dependent thalassaemia: Indian trial. Br. J. Haematol., 82, 460-466.
    • (1992) Br. J. Haematol. , vol.82 , pp. 460-466
    • Agarwal, M.B.1    Gupta, S.S.2    Visvanathan, C.3
  • 11
    • 0025605569 scopus 로고
    • L1 (1,2-dimethyl-3-hydroxypyridin-4-one) for oral iron chelation in patients with β-thalassaemia major
    • Tondury P., Kontoghiorghes G. J., Ridolfi-Luthy A , et al. (1990) : L1 (1,2-dimethyl-3-hydroxypyridin-4-one) for oral iron chelation in patients with β-thalassaemia major. Br. J. Haematol., 76, 550.
    • (1990) Br. J. Haematol. , vol.76 , pp. 550
    • Tondury, P.1    Kontoghiorghes, G.J.2    Ridolfi-Luthy, A.3
  • 12
    • 1842314414 scopus 로고
    • Oral efficacy and metabolism of 1,2-diethyl-3-hydroxypyridin-4-one in thalassaemia major
    • Porter J B., Abeysinghe R.D., Barra C., et al. (1991) : Oral efficacy and metabolism of 1,2-diethyl-3-hydroxypyridin-4-one in thalassaemia major (Abstract). Blood, 78, 2071.
    • (1991) Blood , vol.78 , pp. 2071
    • Porter, J.B.1    Abeysinghe, R.D.2    Barra, C.3
  • 13
    • 0026519768 scopus 로고
    • Urinary metabolic profiles in man and rat of 1,2-dimethyl- And 1,2-diethyl substituted 3-hydroxypyridin-4-ones
    • Singh S., Epemolu R.O., Dobbin P.S., et al. (1992) : Urinary metabolic profiles in man and rat of 1,2-dimethyl- and 1,2-diethyl substituted 3-hydroxypyridin-4-ones. Drug Metab. Dispos., 20, 25.
    • (1992) Drug Metab. Dispos. , vol.20 , pp. 25
    • Singh, S.1    Epemolu, R.O.2    Dobbin, P.S.3
  • 15
    • 0028446038 scopus 로고
    • Therapeutically useful iron chelators
    • Singh S (1994) : Therapeutically useful iron chelators, Chem. Ind., 452-455.
    • (1994) Chem. Ind. , pp. 452-455
    • Singh, S.1
  • 16
    • 0027328530 scopus 로고
    • Synthesis, physiochemical properties and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4-(1H)-pyridinones: Orally active iron chelators with clinical potential
    • Dobbin P.S., Hider R.C., Hall A.D., et al. (1993) : Synthesis, physiochemical properties and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4-(1H)-pyridinones: orally active iron chelators with clinical potential. J. Med. Chem., 36, 2448-2458.
    • (1993) J. Med. Chem. , vol.36 , pp. 2448-2458
    • Dobbin, P.S.1    Hider, R.C.2    Hall, A.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.